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| 1 | Magma mixing of granites at Lianghe:In-situ zircon analysis for trace elements, U-Pb ages and Hf isotopes显示文摘In this paper, we report an integrated study of trace element, U-Pb age and Hf isotopic composition of zircons from alkali feldspar granites, granodiorites and diorite enclaves in a recently discovered ring complex at Lianghe in western Yunnan, Chi na. The granitoids showed identical U-Pb ages of 127, 115 and 122 Ma, from felsic to mafic, but had different zircon trace el ements and Hf isotopic compositions. Trace element content decreased with a gradual increase in εHf(t) values of ?9.1 to ?5.4, ?4.5 to 0, and 3.6 to 6.2, respectively. Results indicate that changes in zircon trace elements generally correlate with changes in Hf isotope signatures within single samples and among various granitoids. These relationships reflect the mixing of felsic and mafic magmas. Evidence indicates that depleted mantle-derived mafic magma underplating caused ancient crustal melting, and then formed large-scale granites in Lianghe during the Early Cretaceous. These granodiorites were formed mainly by the mix ing of mafic magma and granitic magma. | CONG Feng LIN ShiLiang ZOU GuangFu LI ZaiHui XIE Tao PENG ZhiMin LIANG Ting | 2011 | Science China Earth Sciences2011，54，9： | 26 |
| 2 | Capsule endoscopy and single-balloon enteroscopy in small bowel diseases: Competing or complementary?显示文摘AIM To evaluate diagnostic yields of capsule endoscopy(CE) and/or single-balloon enteroscopy(SBE) in patients with suspected small bowel diseases.METHODS Were trospectively analyzed 700 patients with suspected small bowel diseases from September 2010 to March 2016. CE, SBE, or SBE with prior CE was performed in 401, 353, and 47 patients, respectively. Data from clinical and endoscopy records were collected for analysis. Indications, procedure times, diagnostic yields, and complications were summarized and evaluated.RESULTS The overall diagnostic yield for the CE group was 57.6%. The diagnostic yield of CE in patients with obscure gastroin testinal bleeding(OGIB) was significantly greater than that in patients with no bleeding(70.5% vs 43.8%, P < 0.01). The overall diagnostic yield of SBE was 69.7%. There was no difference in the diagnostic yield of SBE between patients with OGIB and those with no bleeding(72.5% vs 68.9%, P = 0.534). Forty-seven patients underwent CE prior to SBE. Among them, the diagnostic yield of SBE with positive findings on prior CE was 93.3%. In addition, SBE detected two cases with superficial ulcer and erosive lesions in the small bowel, which were missed by CE. However, one case with lymphoma and two with Crohn's disease were not confirmed by SBE. The rate of capsule retention was 2.0%. There were no significant complications during or after SBE examinations.CONCLUSION SBE is a safe and effective technique for diagnosing small bowel diseases. SBE with prior CE seemed to improve the diagnostic yield of small bowel diseases. | Jing-Jing Ma Ying Wang Xiao-Min Xu Jie-Wen Su Wen-Yu Jiang Jian-Xia Jiang Lin Lin Dao-Quan Zhang Jing Ding Li Chen Ting Jiang Ying-Hong Xu Gui Tao Hong-Jie Zhang | 2016 | World Journal of Gastroenterology2016，22，48： | 7 |
| 3 | Synergetic effect of FeVO_4 andα-Fe_2O_3 in Fe-V-O catalysts for liquid phase oxidation of toluene to benzaldehyde显示文摘Synergistic effect of FeVO_4 withα-Fe_2O_3 was found in Fe-V-O catalyst,which was responsible for the high apparent formation rate(A.F.R.) of benzaldehyde in liquid phase oxidation of toluene by hydrogen peroxide.The synergistic effect might create VO_πspecies as active sites;moreover,it improved the reducibility and the reactivity of Fe-V-O catalyst.In order to gain the high A.F.R. of benzaldehyde,the catalyst should have the moderate reducibihty. | Gui Quan Zhang Xin Zhang Tao Lin Ting Gong Min Qi | 2012 | Chinese Chemical Letters2012，23，2： | 4 |
| 4 | Efficacy and safety of high-dose esomeprazole–amoxicillin dual therapy for Helicobacter pylori rescue treatment:a multicenter,prospective,randomized,controlled trial显示文摘Background:High-dose dual therapy(HDDT)with proton pump inhibitors(PPIs)and amoxicillin has attracted widespread attention due to its favorable efficacy in eradicating Helicobacter pylori(H.pylori).This study aimed to compare the efficacy and safety of high-dose PPI-amoxicillin dual therapy and bismuth-containing quadruple therapy for H.pylori rescue treatment.Methods:This was a prospective,randomized,multicenter,non-inferiority trial.Patients recruited from eight centers who had failed previous treatment were randomly(1:1)allocated to two eradication groups:HDDT(esomeprazole 40 mg and amoxicillin 1000 mg three times daily;theHDDTgroup)and bismuth-containing quadruple therapy(esomeprazole 40 mg,bismuth potassium citrate 220 mg,and furazolidone 100 mg twice daily,combined with tetracycline 500 mg three times daily;the tetracycline,furazolidone,esomeprazole,and bismuth[TFEB]group)for 14 days.The primary endpoint was the H.pylori eradication rate.The secondary endpoints were adverse effects,symptom improvement rates,and patient compliance.Results:A total of 658 patients who met the criteria were enrolled in this study.The HDDT group achieved eradication rates of 75.4%(248/329),81.0%(248/306),and 81.3%(248/305)asdetermined by the intention-to-treat(ITT),modified intention-totreat(MITT),and per-protocol(PP)analyses,respectively.The eradication rates were similar to those in the TFEB group:78.1%(257/329),84.2%(257/305),and 85.1%(257/302).The lower 95%confidence interval boundary(9.19%in the ITT analysis,9.21%in the MITT analysis,and9.73%in the PP analysis)was greater than the predefined non-inferiority margin of10%,establishing a non-inferiority of the HDDT group vs.the TFEB group.The incidence of adverse events in the HDDT group was significantly lower than that in the TFEB group(11.1%vs.26.8%,P<0.001).Symptom improvement rates and patients’compliance were similar between the two groups.Conclusions:Fourteen-day HDDT is non-inferior to bismuth-containing quadruple therapy,with fewer adverse effects and good treatment compliance,suggesting HDDT as an alternative for H.pylori rescue treatment in the local region.Trial registration:Clinicaltrials.gov,NCT04678492. | Hanxin Bi Xingxing Chen Yuxin Chen Xin Zhao Shasha Wang Jiehong Wang Ting Lyu Shuang Han Tao Lin Mingquan Li Donghong Yuan Junye Liu Yongquan Shi | 2022 | Chinese Medical Journal2022，，14： | 3 |
| 5 | Synergistic catalysis of isolated Fe^(3+) and Fe_2O_3 on FeO_x/HZSM-5 catalysts for Friedel-Crafts benzylation of benzene显示文摘FeO_x/HZSM-5 catalyst with 8 wt.%Fe-loading(8-FeZ) exhibited significantly higher reactivity in the benzylation of benzene with benzyl chloride than FeO_x/HZSM-5 catalyst with 2.5 wt.%Fe-loading(2.5-FeZ) because the synergistic catalysis between isolated Fe^(3+) and superfine Fe_2O_3 occurred on 8-FeZ in the reaction. | Tao Lin Xin Zhang Rong Li Ting Bai Si Ying Yang | 2011 | Chinese Chemical Letters2011，22，6： | 3 |
| 6 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 7 | Autophagy suppresses tumorigenesis of hepatitis B virus‐associated hepatocellular carcinoma through degradation of microRNA‐224显示文摘 | Sheng‐Hui Lan Shan‐Ying Wu Roberto Zuchini Xi‐Zhang Lin Ih‐Jen Su Ting‐Fen Tsai Yen‐Ju Lin Cheng‐Tao Wu Hsiao‐Sheng Liu | 2014 | Hepatology2014，，2： | 1 |
| 8 | Analysis and Simulation of Micro-Fluidic Inertial Switch显示文摘 | Lin Yi Yang Tao Liu Ting Ting Chen Guang Yan Wang Chao | 2012 | Key Engineering Materials2012，，503： | 1 |
| 9 | Eosinophils promote pulmonary matrix destruction and emphvsema via Cathepsin L显示文摘Patients with chronic obstructive pulmonary disease(COPD)who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema.This implies the potential involvement of eosinophils in the development of emphysema.However,the precise mechanisms underlying the development of eosinophil-mediated emphysema remain unclear.In this study,we employed single-cell RNA sequencing to identify eosinophil subgroups in mouse models of asthma and emphysema,followed by functional analyses of these subgroups.Assessment of accumulated eosinophils unveiled distinct transcriptomes in the lungs of mice with elastase-induced emphysema and ovalbumin-induced asthma.Depletion of eosinophils through the use of anti-interleukin-5 antibodies ameliorated elastase-induced emphysema.A particularly noteworthy discovery is that eosinophil-derived cathepsin L contributed to the degradation of the extracellular matrix,thereby leading to emphysema in pulmonary tissue Inhibition of cathepsin L resulted in a reduction of elastase-induced emphysema in a mouse model.Importantly,eosinophil levels correlated positively with serum cathepsin L levels,which were higher in emphysema patients than those without emphysema.Expression of cathepsin L in eosinophils demonstrated a direct association with lung emphysema in COPD patients.Collectively,these findings underscore the significant role of eosinophil-derived cathepsin L in extracellular matrix degradation and remodeling,and its relevance to emphysema in coPD patients.Consequently,targeting eosinophil-derived cathepsin L could potentially offer a therapeutic avenue for emphysema patients.Further investigations are warranted to explore therapeutic strategies targeting cathepsin L in emphysema patients. | Xia Xu Tao Yu Lingling Dong Rainer Glauben Siyuan Wu Ronghua Huang Shiwei Qumu Chenli Chang Jing Guo Lin Pan Ting Yang Xin Lin Ke Huang Zhihua Chen Chen Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 1 |
| 10 | Observation of elevated fungal tracers due to biomass burning in the Sichuan Basin at Chengdu City, China显示文摘 | Yihong Yang Chuen-yu Chan Jun Tao Mang Lin Guenter Engling Zhisheng Zhang Ting Zhang Lin Su | 2012 | Science of the Total Environment2012，，： | 1 |
| 11 | Immunological and metabolic characteristics of the Omicron variants infection显示文摘The Omicron variants of SARS-CoV-2,primarily authenticated in November 2021 in South Africa,has initiated the 5th wave of global pandemics.Here,we systemically examined immunological and metabolic characteristics of Omicron variants infection.We found Omicron resisted to neutralizing antibody targeting receptor binding domain(RBD)of wildtype SARS-CoV-2.Omicron could hardly be neutralized by sera of Corona Virus Disease 2019(COVID-19)convalescents infected with the Delta variant.Through mass spectrometry on MHC-bound peptidomes,we found that the spike protein of the Omicron variants could generate additional CD8+T cell epitopes,compared with Delta.These epitopes could induce robust CD8+T cell responses.Moreover,we found booster vaccination increased the cross-memory CD8+T cell responses against Omicron.Metabolic regulome analysis of Omicron-specific T cell showed a metabolic profile that promoted the response of memory T cells.Consistently,a greater fraction of memory CD8+T cells existed in Omicron stimulated peripheral blood mononuclear cells(PBMCs).In addition,CD147 was also a receptor for the Omicron variants,and CD147 antibody inhibited infection of Omicron.CD147-mediated Omicron infection in a human CD147 transgenic mouse model induced exudative alveolar pneumonia.Taken together,our data suggested that vaccination booster and receptor blocking antibody are two effective strategies against Omicron. | Jiejie Geng Xu Yang Kun Wang Ke Wang Ruo Chen Zhi-Nan Chen Chuan Qin Guizhen Wu Youchun Wang Ke Xu Peng Du Jiangning Liu Shirui Chen Tao Zhang Xiuxuan Sun Ting Guo Ying Shi Zheng Zhang Ding Wei Peng Lin Qingyi Wang Jing Yuan Jiuxin Qu Jin Zou Yingxia Liu Hongzhou Lu Ping Zhu Huijie Bian Liang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 12 | Factors associated with dysglycemia and its post-surgical resolution in patients with pheochromocytomas显示文摘Dear Editor,Pheochromocytomas are rare neuroendocrine tumors originating from chromaffin cells in the adrenal medulla(Neumann et al., 2019). A number of case reports and small cohorts have reported the association between dysglycemia and pheochromocytomas(Elenkova et al., 2020;Khatiwada et al., 2020;Krumeich et al., 2021). However, there are few large sample studies reporting the outcomes of dysglycemia in patients with pheochromocytomas after resection. | Lin Zhao Xu Meng Qiongyu Zhang Yi Zhou Ting Zhang Tao Tian Hua Fan Huadong Zhu Yecheng Liu Fang Luo Linping Wang Weixian Yang Xianliang Zhou | 2023 | Science China(Life Sciences)2023，66，2： | 0 |
| 13 | Bio-Manufacturing Research Center at Tsinghua University显示文摘Overview and research infrastructure As one of the leading laboratories in the interdisciplinary field of additive manufacturing and bio-3D printing,the Bio-Manufacturing Center at Tsinghua University is highly dedicated to conducting cutting-edge research in the emerging field of bio-manufacturing.The latter is comprised of research involving biomaterials,living cells,proteins,and/or other biological compounds as basic building blocks to fabricate biomimetic structures,in vitro functional biological models and/or cellular systems with application to tissue engineering,regenerative medicine,disease pathogenesis,drug screening,and tissue/organ-on-a-chip. | Ting Zhang Feng Lin Tao Xu Lei Zhang Rui Yao Yuan Pang Shengli Mi Shaohua Ma Wei Sun | 2019 | Bio-Design and Manufacturing2019，2，2： | 0 |
| 14 | Safety and Current Status of the COVID-19 Vaccine among Patients with Breast cancer: A Cross-Sectional Study from China显示文摘In this study,we aimed to explore the safety and vaccination coverage data of Chinese patients with breast cancer receiving coronavirus disease 2019(COVID-19)vaccination.The patients were recruited from 41 hospitals across 20 Chinese provinces.The vaccination coverage was approximately 22.4%,and the frequency of total adverse events was 13.3%after the first dose and 9.9%after the second dose.The most frequent adverse reaction within 14 days of the first dose was local pain(5.7%).Unvaccinated patients were very likely to reject the vaccine rather than be hesitant in patients with old age(odds ratio[OR],1.238;95%confidence interval[CI],1.101-1.391),chronic disease history(OR,1.189;95%CI,1.057-1.337),and cancer relapse(OR,1.398;95%CI,1.233-1.585).Of the unvaccinated patients with breast cancer,54.1%opted to receive COVID-19 vaccines if more data were available.Considering the safety but low vaccination coverage for breast cancer,increased positive attitudes and acceptance toward COVID-19 vaccines are important. | Shaohua Zhang Jianbin Li Ruonan Xu Qianjun Chen Gang Sun Ying Lin Feng Jin Xinlan Liu Zhimin Fan Yiding Chen Yali Cao Xinzheng Li Jianyun Nie Guiying Xu Xiaojia Wang Yuee Teng Tao Sun Hong Liu Jing Luo Cuizhi Geng Man Li Ting Luo Yinhua Liu Fu-Sheng Wang Zefei Jiang | 2023 | Infectious Diseases & Immunity2023，3，3： | 0 |
| 15 | Pre-pregnant Overweight Interacts with ADIPOQ Genetic Variants to Influence Polyunsaturated Fatty Acids in Human Milk显示文摘Adiponectin,a specific hormone protein secreted by adipocytes,is a protective factor in the human body and has attracted great attention due to its anti-obesity activity[1,2].The adiponectin gene(ADIPOQ),which is located on human chromosome 3q27,is a single-copy gene.Various single-nucleotide polymorphisms(SNPs)of the human ADIPOQ play an important role in energy balance and are associated with body mass index(BMI)and obesity[3,4].Longchain polyunsaturated fatty acids(LC-PUFAs)have been identified to exert an important role during the first 1,000 days of life on infant growth,neurodevelopment,and visual acuity.Fatty acids,such asα-linoleic acid(ALA,C18:3n-3)and linoleic acid(LA,C18:2n-6),which cannot be synthesized de novo from other lipids,are necessary for biological reactions.Some fatty acids such as docosahexaenoic acid(DHA,C22:6n-3)and eicosapentaenoic acid(EPA,C20:5n-3)can be synthesized in neonates from their precursors(LA and ALA).Because of the very low conversion rates in the neonatal liver,it is crucial to provide adequate LC-PUFAs in the diet from early infancy. | CHEN Yi Ru LI Yue Ting CHEN Yi Fei GONG Jia Yu YANG Jing Yu YU Hai Tao XU Wen Hui PIAO Chun Ji XIE Lin | 2023 | Biomedical and Environmental Sciences2023，36，7： | 0 |
| 16 | A Novel p.Tyr129His Variant in SIX1 Leads to Dominant,Delayed-onset Hearing Loss with Possible Association with Congenital Anosmia显示文摘SIX1(OMIM 601205),as a member of the SIX homeobox transcription factor family,belongs to homologs of the Drosophila‘sine oculis’gene that expresses primarily in the developing visual system of the fly.The SIX family includes six members(SIX1–SIX6),which share a homologous DNA-binding homeodomain(HD)and a highly conserved protein–protein interacting SIX domain(SD)[1]. | PANG Xiu Hong ZHENG Xiao Yong LIN Yun ZHENG Hao XU Jun LIU Dong JIN Chun Yan ZHANG Lu Ping ZHANG Yu Ting CHU Jiu Sheng CHAI Yong Chuan YANG Tao | 2021 | Biomedical and Environmental Sciences2021，34，4： | 0 |
| 17 | Chemotactic nanomotor for multimodal combined therapy of glioblastoma显示文摘Glioblastoma(GBM) is the most aggressive malignant brain tumor. Due to the infiltration and heterogeneity of GBM, the obstruction of the blood-brain barrier(BBB) and the unique immunosuppressive mechanism, it is hard to achieve significant effects of GBM treatment. Here, a kind of chemotactic nanomotor that loaded with glucose oxidase(GOx) and carboxylated cisplatin(Pt(IV)) prodrug on the L-arginine-derived polymer is proposed. The nanomotors are driven by catalysis of glucose decomposition and the positive chemotaxis towards the GBM microenvironment where inducible nitric oxide synthase and reactive oxygen species are highly expressed. This facilitates the BBB crossing and GBM targeting of the nanomotors. In addition, the released nitric oxide(NO) during propulsion as well as the loaded GOx and Pt(IV) can exert combined NO/starvation/chemotherapy. Meanwhile, it is able to induce and enhance the immune response through multiple pathways, thus better coping with the complexities of GBM treatment. | Ting Li Lin Chen Yunxin Xue Xiangyu Xiao Wenjun Dai Kaiyuan Tan Tiantian Chen Yingfang Tao Chun Mao Jian Shen Mimi Wan | 2024 | Science China Chemistry2024，67，4： | 0 |
| 18 | Growing curly graphene layer boosts hard carbon with superior sodium-ion storage显示文摘Benefiting from the distinctive ordering degree and local microstructure characteristics,hard carbon(HC)is considered as the most promising anode for sodium-ion batteries(SIBs).Unfortunately,the low initial Coulombic efficiency(ICE)and limited reversible capacity severely impede its extensive application.Here,a homogeneous curly graphene(CG)layer with a micropore structure on HC is designed and executed by a simple chemical vapor deposition method(without catalysts).CG not only improves the electronic/ionic conductivity of the hard carbon but also effectively shields its surface defects,enhancing its ICE.In particular,due to the spontaneous curling structural characteristics of CG sheets(CGs),the micropores(≤2 nm)formed provide additional active sites,increasing its capacity.When used as a sodium-ion battery anode,the HC-CG composite anode displayed an outstanding reversible capacity of 358 mAh·g^(-1),superior ICE of 88.6%,remarkable rate performance of 145.8 mAh·g^(-1)at 5 A·g^(-1),and long cycling life after 1000 cycles with 88.6%at 1 A·g^(-1).This work provides a simple defect/microstructure turning strategy for hard carbon anodes and deepens the understanding of Na+storage behavior in the plateau region,especially on the pore-filling mechanism by forming quasi-metallic clusters. | Minghao Song Qiang Song Tao Zhang Xiaomei Huo Zezhou Lin Zhaowen Hu Lei Dong Ting Jin Chao Shen Keyu Xie | 2023 | Nano Research2023，16，7： | 0 |
| 19 | Anti-leprosy drug Clofazimine binds to human Rafl kinase inhibitory protein and enhances ERK phosphorylation显示文摘 | Chenyun Guo Ting Chang Tao Sun Zhihua Wu Yazhuang Dai Hongwei Yao Donghai Lin | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 0 |
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