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| 1 | The Serum Exosome Derived MicroRNA-135a,-193b, and-384 Were Potential Alzheimer's Disease Biomarkers显示文摘Objective MicroR NAs(mi Rs) are attractive molecules to be considered as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer's disease(AD). The goal of this study was to explore their potential value as biomarkers for the diagnosis of AD. Methods The expression levels of exosomal miR-135 a,-193 b, and-384 in the serum from mild cognitive impairment(MCI), dementia of Alzheimer-type(DAT), Parkinson's disease with dementia(PDD), and vascular dementia(VaD) patients were measured with a real-time quantitative reverse transcriptase PCR(qR T-PCR) method. Results Both serum exosome mi R-135 a and miR-384 were up-regulated while miR-193 b was down-regulated in serum of AD patients compared with that of normal controls. Exosome miR-384 was the best among the three miR s to discriminate AD, VaD, and PDD. Using the cut-off value could better interpret these laboratory test results than reference intervals in the AD diagnosis. ROC curve showed that the combination of mi R-135 a,-193 b, and-384 was proved to be better than a particular one for early AD diagnosis. Conclusion Our results indicated that the exosomal miR s in the serum were not only potential biomarker of AD early diagnosis, but might also provide novel insights into the screen and prevention of the disease. | YANG Ting Ting LIU Chen Geng GAO Shi Chao ZHANG Yi WANG Pei Chang | 2018 | Biomedical and Environmental Sciences2018，31，2： | 35 |
| 2 | m^6A mRNA methylation sustains Treg suppressive functions显示文摘 | Jiyu Tong Guangchao Cao Ting Zhang Esen Sefik Maria Carolina Amezcua Vesely James P Broughton Shu Zhu Huabin Li Bin Li Lei Chen Howard Y Chang Bing Su Richard A Flavell Hua-Bing Li | 2018 | Cell Research2018，28，2： | 30 |
| 3 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 4 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 5 | Friction and Wear Behavior of Resin/Graphite Composite under Dry Sliding显示文摘The friction and wear behavior of resin/graphite composite has been investigated using a pin-on-disc configuration under dry sliding condition. The results showed that the resin/graphite composite exhibited much better mechanical and tribological properties compared with the unimpregnated graphite. The friction coefficient was reduced by addition of furan resin, which could also prevent the'dusting' wear at loads more than 15 MPa. The steady and lubricated transfer film was easily formed on the counterpart surface due to the interaction of furan resin and wear debris of graphite, which was useful to reduce the wear rate of the resin/graphite composite. The composite is highly promising for mechanical sealing application and can be used at high load for long time sliding. | Zhenguo Zhu Shuo Bai Junfeng Wu Li Xu Ting Li Yong Ren Chang Liu | 2015 | Journal of Materials Science & Technology2015，31，3： | 14 |
| 6 | MiR-124 retards bladder cancer growth by directly targeting CDK4显示文摘MicroRNAs (miRNAs ) 是由绑定充当基因表示的否定管理者到目标 mRNAs 的 3-untranslated 区域(3UTR ) 的非编码的小 RNA 的一个类。以便在膀胱癌症调查 miR-124 的生理的角色, miR-124 的目标基因被 TargetScan 预言软件,和 cyclin 依赖的 kinase (CDK4 ) ,作为房间周期的一个管理者被含有,为进一步的学习被选择。MiR-124 能显著地镇压由在 vitro 在 CDK4 的 3UTR 指向它的有约束力的地点的 CDK4 表示。在两根膀胱癌症房间线和纸巾, miR-124 的表示是显著地下面调整的,当 CDK4 表示是起来调整的时。在移植 HT1197 房间的 miR-124 的宫外的表示在老鼠肿瘤异种皮移植导致了肿瘤生长的延迟。并且 miR-124 和 CDK4 的表示证明在这些异种皮移植纸巾的明显的反的关联,它是也在人的膀胱癌症观察到组织取样。一起拿,我们的结果强烈建议 miR-124 能逮捕房间周期并且由直接指向 CDK4 制止膀胱癌症的生长。 | Ting Zhang Jingyao Wang Xiaofeng Zhai Hongjie Changying Li Jiwu Chang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 12 |
| 7 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 8 | Decreased Average Albumin-to-Globulin Ratio During Radiotherapy Worsens the Prognosis of Esophageal Squamous Cell Carcinoma:Implications for Nutritional Management显示文摘Objective Malnutrition and cachexia are common in esophageal squamous cell carcinoma(ESCC)patients undergoing radiotherapy.This study evaluated how malnutrition-and cachexia-related indicators,including the albumin-to-globulin ratio(AGR),and their changes during radiotherapy predict the treatment outcomes.Methods We reviewed a total of 172 ESCC patients receiving radiotherapy(as a primary cohort)and performed a Cox regression analysis on potential prognostic factors,including the AGR,as well as the TNM stage and concomitant chemotherapy.A subsequent receiver operating characteristics(ROC)curve and Kaplan Meier survival analysis was performed for ESCC patients stratified by the average AGR cut-off point.Results In addition to the well-documented factors(i.e.TNM stage and concomitant chemotherapy),the average AGR was a significant prognostic factor for ESCC patients receiving radiotherapy.By plotting the ROC curve of the average AGR with regard to the ESCC prognosis,we obtained cut-off points for the overall patients(cut-off point:1.5,AUC:0.636),for patients with stageⅡ/Ⅲdisease(cut-off point:1.5,AUC:0.611),and for patients with stageⅣdisease(cut-off point:1.84,AUC:0.900).The ESCC patients with higher average AGR had a significantly more favorable OS compared with those with a lower average AGR.Notably,ESCC patients who had an increasingΔAGR during radiotherapy had a considerably more favorable OS compared with those with a decreasingΔAGR.All of these findings were reproducible in the validation cohort.Conclusion A lower average AGR is indicative of a poorer prognosis for ESCC patients following radiotherapy.Improving the nutritional status and preventing or ameliorating cachexia might contribute to improving the prognosis of ESCC patients. | Fen Cai Xiu Lian Zhang Xiao Ling Wu Ting Ting Zhuang Lei Huang Yi Fei Tu Yuan Yuan Lu Min Xia Jiang Qing Ying Zhang Yan Lin Chang Chun Ma | 2021 | Journal of Nutritional Oncology2021，6，2： | 8 |
| 9 | Predictive validity of BODE index for anxious and depressive symptoms in patients with chronic obstructive pulmonary disease显示文摘背景焦虑和消沉是长期的妨碍的肺的疾病(COPD ) 的二最普通、很可修改的 comorbidities 并且在健康和预后上有独立效果。FEV1% 被显示了是焦虑和消沉的一个差的预言者。身体团索引,气流阻塞的度,呼吸困难,和锻练能力(预示) 索引是可以在 COPD 病人预言健康结果的一个多维的评价系统。这研究的目的是在这是的 COPD patients.Methods 为焦急、压抑的症状调查 BODE 索引的预兆的有效性 multicenter 在有稳定的 COPD 的 256 个病人的未来的代表性的学习。焦急、压抑的症状用医院焦虑和消沉规模(HADS ) 被估计。在焦虑,消沉和潜在的预言者之间的关系(包括 BODE 索引) 被一个二进制逻辑回归模型分析。焦急、压抑的结果题目走了更短的六分钟的走距离(6MWD ) ,有更多的呼吸困难,一更高预示索引,并且降低生活的健康相关的质量(P < 0.01 ) 。焦虑和萧条分数显著地被相关与预示指数,分别地(r=0.335, P < 0.001;r=0.306, P < 0.001 ) 。焦虑和消沉的流行增加了与预示舞台增加(P < 0.05 ) 。根据二进制逻辑回归,因为它包括了呼吸困难和 6MWD, BODE 索引是焦虑和消沉的一个好、独立的预言者,它被显示是主要 determinants.Conclusions 为焦虑和消沉的 BODE 索引的预兆的有效性被表明。我们建议 BODE 索引应该在对 COPD 严厉的评价被包括。 | AN Li LIN Ying-xiang YANG Ting ZHANG Hong JIAO Xia ZHANG Shu CHANG Xiao-hong WANG Zhao-mei WANG Chen | 2010 | Chinese Medical Journal2010，，14： | 8 |
| 10 | Removal of VOCs from gas streams with double perovskite-type catalysts显示文摘Double perovskite-type catalysts including La2 CoMnO_6 and La_2 CuMnO_6 are first evaluated for the effectiveness in removing volatile organic compounds(VOCs), and single perovskites(La CoO_3, LaMnO_3, and La Cu O3) are also tested for comparison. All perovskites are tested with the gas hourly space velocity(GHSV) of 30,000 hr^(-1), and the temperature range of100–600°C for C_7H_8 removal. Experimental results indicate that double perovskites have better activity if compared with single perovskites. Especially, toluene(C_7H_8) can be completely oxidized to CO_2 at 300°C as La2 Co MnO_6 is applied. Characterization of catalysts indicates that double perovskites own unique surface properties and are of higher amounts of lattice oxygen,leading to higher activity. Additionally, apparent activation energy of 68 k J/mol is calculated using Mars-van Krevelen model for C7 H8 oxidation with La2 Co Mn O6 as catalyst. For durability test, both La2 Co Mn O6 and La_2 CuMnO_6 maintain high C7 H8 removal efficiencies of 100% and98%, respectively, at 300°C and 30,000 hr^(-1), and they also show good resistance to CO_2(5%) and H2 O(g)(5%) of the gas streams tested. For various VOCs including isopropyl alcohol(C_3H_8 O),ethanal(C_2H_4O), and ethylene(C_2H_4) tested, as high as 100% efficiency could be achieved with double perovskite-type catalysts operated at 300–350°C, indicating that double perovskites are promising catalysts for VOCs removal. | Kuan Lun Pan Guan Ting Pan Siewhui Chong Moo Been Chang | 2018 | Journal of Environmental Sciences2018，30，7： | 8 |
| 11 | Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins显示文摘Most mammalian cells take up cholesterol from low-density lipoproteins(LDLs) via receptor-mediated endocytosis.After reaching lysosomes,LDL-derived cholesterol continues to transport to downstream organelles including the ER for specific structural and functional needs.Peroxisomes are recently found to receive cholesterol from lysosomes through lysosomeperoxisome membrane contacts.However,whether and how cholesterol is conveyed from peroxisomes to the ER remain unknown.Here,by combining high-resolution microscopic analyses and in vitro reconstitution of highly purified organelles or artificial liposomes,we demonstrate that peroxisomes form membrane contacts with the ER through the interaction between peroxisomal PI(4,5)P2 and ER-resident extended synaptotagmin-1,2 and 3(E-Syts).Depletion of peroxisomal PI(4,5)P2 or ESyts markedly decreases peroxisome-ER membrane contacts and induces cholesterol accumulation in lysosomes.Furthermore,we show that cholesterol is delivered from 3H-labeled peroxisomes or PI(4,5)P2-containing liposomes to the ER in vitro,and that the presence of peroxisomes augments cholesterol transfer from lysosomes to the ER.Together,our study reveals a new cholesterol transport pathway along the lysosome-peroxisome-ER membrane contacts in the cell. | Jian Xiao Jie Luo Ao Hu Ting Xiao Meixin Li Zekai Kong Luyi Jiang Zimu Zhou Yacheng Liao Chang Xie Beibei Chu Honghua Miao Boliang Li Xiongjie Shi Bao-Liang Song | 2019 | Science China(Life Sciences)2019，62，9： | 8 |
| 12 | Crystalline Silica Promotes Rat Fibrocyte Differentiation in Vitro,and Fibrocytes Participate in Silicosis in Vivo显示文摘Objective The aim of this study was to investigate the effects of Si O2 on fibrocytes and whether fibrocytes participate in silicosis in vivo. Methods A macrophagocyte(AM)/fibrocyte coculture system was established, and AMs were treated with 100 μg/mL SiO 2. Flow cytometry was used to detect the number of fibrocytes. Real‐time PCR was performed to measure the expression of collagen I, collagen III, and α‐SMA mR NA. The levels of collagen I, collagen III, and TGF‐β1 protein were determined by ELISA. Immunohistochemical staining was performed to measure α‐SMA protein expression. A rat silicosis model was induced by intratracheal instillation of SiO 2. Lung histopathological evaluation was conducted using HE and Masson's trichrome staining after 1 and 9 weeks. The number of fibrocytes in peripheral blood or lung tissue of rat was detected by flow cytometry. Double‐color immunofluorescence was applied to identify fibrocytes in the lung tissue. Results Peripheral blood monocytes were found to differentiate into fibrocytes in vitro in a time‐dependent manner, and exposure to crystalline silica might potentiate fibrocyte differentiation. In addition, fibrocytes were able to migrate from peripheral blood to the lung tissue, and the number of fibrocytes was increased after SiO 2 exposure. Conclusion Silica exposure potentiates fibrocyte differentiation, and fibrocytes may participate in silicosis in vivo. | LI Juan YAO Wu HOU Jian Yong Zhang Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao HAO Chang Fu | 2017 | Biomedical and Environmental Sciences2017，30，9： | 7 |
| 13 | Capacitive sensing technique for silt suspended sediment concentration monitoring显示文摘Automated, real-time, and continuous techniques for monitoring suspended sediment concentration in rivers and reservoirs can play an important role in the improvement of the quantity and quality of sediment data, and are valuable to the management of water environment, water conservancy, hazard prevention, and water resources. Research in the monitoring techniques has examined the possibility of using the characteristics of dielectric constants for detecting soil moisture and concentration of air-water two-phase flow, based on the fact that dielectric constants of sediment, air and water are different. A capacitance sensor was developed to monitor the silt suspended sediment concentration (SSSC) in a recent study, following the principle that as SSSC increases in the sediment-water mixture, the apparent dielectric constant of the water sample also increases and therefore the capacitance detected by the sensing system also increases. It is demonstrated that the variations in the concentration of silt sediment correlates positively with the variations in observed capacitance in a linear fashion, and correlates negatively with voltage outputs but also in a linear fashion. The correlation coefficients reached above 0.98. The overall errors in estimated concentrations range between 0.26% and 2.91%. Elements in the capacitance sensor system such as the frequencies of the signal generating system, areas of the electrode plates, and effects of sample temperature have also been evaluated. The results illustrated that the capacitance sensor techniques can be applied to monitoring SSSC automatically and continuously. Also, the range of SSSC in the experiment reached 200 kg/m3; therefore, the application of this technique in practical SSSC monitoring is worthy of further research. | Yin-Sung HSU Chi-ma WEI Yuan-Chi TING Shih-Yi YUAN Chia-Ling CHANG Kao-Chung CHANG | 2010 | International Journal of Sediment Research2010，25，2： | 7 |
| 14 | Genomic-wide analysis of lymphatic metastasis-associated genes in human hepatocellular carcinoma显示文摘AIM:To identify the genes related to lymph node metastasis in human hepatocellular carcinoma(HCC),32 HCC patients with or without lymph node metastasis were investigated by high-throughput microarray comprising 886 genes.METHODS:The samples of cancerous and non-cancerous paired tissue were taken from 32 patients with HCC who underwent hepatectomy with lymph node dissection.Total RNA was extracted from the cells obtained by means of laser microdissection(LCM) and was amplified by the T7-based amplification system.Then,the amplifi ed samples were applied in the cDNA microarray comprising of 886 genes.RESULTS:The results demonstrated that 25 up-regulated genes such as cell membrane receptor,intracellular signaling and cell adhesion related genes,and 48 down-regulated genes such as intracellular signaling and cell cycle regulator-related genes,were correlated with lymph node metastasis in HCC.Amongst them were included some interesting genes,such as MET,EPHA2,CCND1,MMP2,MMP13,CASP3,CDH1,and PTPN2.Expression of 16 genes(MET,CCND1,CCND2,VEGF,KRT18,RFC4,BIRC5,CDC6,MMP2,BCL2A1,CDH1,VIM,PDGFRA,PTPN2,SLC25A5 and DSP) were further confirmed by real-time quantitative reverse transcriptional polymerase chain reaction(RT-PCR).CONCLUSION:Tumor metastasis is an important biological characteristic,which involves multiple genetic changes and cumulation.This genome-wide information contributes to an improved understanding of molecular alterations during lymph node metastasis in HCC.It may help clinicians to predict metastasis of lymph nodes and assist researchers in identifying novel therapeutic targets for metastatic HCC patients. | Chun-Feng Lee Zhi-Qiang Ling Ting Zhao Shih-Hua Fang Weng-Cheng Chang San-Chih Lee Kuan-Rong Lee | 2009 | World Journal of Gastroenterology2009，15，3： | 7 |
| 15 | Effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats显示文摘Objective To study the effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats. Methods Rat tail-suspension model was used to simulate the physiological effects of microgravity and changes in pulmonary blood vessel morphology, pulmonary arterial and venous blood pressure, pulmonary vascular resistance, pulmonary vasomotoricity, as well as the regulation of pulmonary circulation by cytokines produced and released by the lung of rats were measured. Results The walls of pulmonary blood vessels of rats were thickened, and the pulmonary artery was reconstructed with increased pulmonary vascular resistance. The pulmonary blood vessels of rats became more prone to dilation as contractions increased. Rat epithelial Adrenomedulin gene transcription and protein expression were upregulated. The level of basic fibroblast growth Factor of rat was also elevated. Conclusion Findings from the present study on rats revealed that the microgravity can affect pulmonary blood vessel structure, pulmonary arterial pressure, and pulmonary blood vessel self-regulation and cytokine production. | LI Tian Zhi YUAN Ming CHEN Zhen Hong GUO Ying Hua KANG Chun Yan WANG Jing Yu LI Zhi Li WANG De Sheng WANG Hui Juan YUAN Min LIU Chang Ting | 2013 | Biomedical and Environmental Sciences2013，26，2： | 6 |
| 16 | Three-dimensional printing technique assisted cognitive fusion in targeted prostate biopsy显示文摘Objective:To explore the effect of 3-dimensional(3D)printing-assisted cognitive fusion on improvement of the positive rate in prostate biopsy.Methods:From August to December 2014,16 patients with suspected prostatic lesions detected by multiparametric magnetic resonance imaging(MRI)were included.Targeted prostate biopsy was performed with the use of prostate 3D reconstruction modeling,computersimulated biopsy,3D printing,and cognitive fusion biopsy.All patients had received 3.0 T multiparametric MRI before biopsy.The DICOM MRI files were imported to medical imaging processing software for 3D reconstruction modeling to generate a printable.stl file for 3D printing with use of transparent resin as raw material.We further performed a targeted 2-to 3-core biopsy at suspected lesions spotted on MRI.Results:For the 16 patients in the present study,3D modeling with cognitive fusion-based targeted biopsy was successfully performed.For a single patient,1e2 lesions(average:1.1 lesions)were discovered,followed by 2-6 cores(average:2.4 cores)added as targeted biopsy.Systematic biopsies accounted for 192 cores in total,with a positive rate of 22.4%;targeted biopsies accounted for 39 cores in total,with a positive rate of 46.2%.Among these cases,10 patients(62.5%)were diagnosed with prostate adenocarcinoma,in which seven were discovered by both systematic and targeted biopsy,one was diagnosed by systematic biopsy only,and two were diagnosed by targeted biopsy only.For systematic biopsy,Gleason score ranged from 6 to 8(average:7),while that for targeted biopsy ranged from 6 to 9(average:7.67).Among the seven patients that were diagnosed by both systematic and targeted biopsy,three(42.8%)were reported with a higher Gleason score in targeted therapy than in systematic biopsy.Conclusion:3D printing-assisted cognitive fusion technique markedly promoted positive rate in prostate biopsy,and reduced missed detection in high-risk prostate cancer. | Yan Wang Xu Gao Qingsong Yang Haifeng Wang Ting Shi Yifan Chang Chuanliang Xu Yinghao Sun | 2015 | Asian Journal of Urology2015，2，4： | 6 |
| 17 | A Novel Dimeric Coumarin from Clausena lenis显示文摘A novel dimeric coumarin (1), a dimeric of seselin named diseselin A, was isolated from the aerial part of Clausena lenis. The structure was elucidated based on the MS, 1D and 2D NMR data. | Hong Ping HE1, Shun Ting CHEN1, Yue Mao SHEN1, Chang Xiang CHEN1, Yi Bin ZHAO1, Xiao Jiang HAO 1,2 * 1 The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 2The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002 | 2003 | Chinese Chemical Letters2003，14，11： | 5 |
| 18 | Long‐term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B显示文摘 | Ting‐Tsung Chang Yun‐Fan Liaw Shun‐Sheng Wu Eugene Schiff Kwang‐Hyub Han Ching‐Lung Lai Rifaat Safadi Samuel S. Lee Waldemar Halota Zachary Goodman Yun‐Chan Chi Hui Zhang Robert Hindes Uchenna Iloeje Suzanne Beebe Bruce Kreter | 2010 | Hepatology2010，，： | 4 |
| 19 | Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma显示文摘BACKGROUND Cellular senescence is a recognized barrier for progression of chronic liver diseases to hepatocellular carcinoma(HCC). The expression of a cluster of genes is altered in response to environmental factors during senescence. However, it is questionable whether these genes could serve as biomarkers for HCC patients.AIM To develop a signature of senescence-associated genes(SAGs) that predicts patients' overall survival(OS) to improve prognosis prediction of HCC.METHODS SAGs were identified using two senescent cell models. Univariate COX regression analysis was performed to screen the candidate genes significantly associated with OS of HCC in a discovery cohort(GSE14520) for the least absolute shrinkage and selection operator modelling. Prognostic value of this seven-gene signature was evaluated using two independent cohorts retrieved from the GEO(GSE14520) and the Cancer Genome Atlas datasets, respectively.Time-dependent receiver operating characteristic(ROC) curve analysis was conducted to compare the predictive accuracy of the seven-SAG signature and serum α-fetoprotein(AFP).RESULTS A total of 42 SAGs were screened and seven of them, including KIF18 B, CEP55,CIT, MCM7, CDC45, EZH2, and MCM5, were used to construct a prognostic formula. All seven genes were significantly downregulated in senescent cells andupregulated in HCC tissues. Survival analysis indicated that our seven-SAG signature was strongly associated with OS, especially in Asian populations, both in discovery and validation cohorts. Moreover, time-dependent ROC curve analysis suggested the seven-gene signature had a better predictive accuracy than serum AFP in predicting HCC patients' 1-, 3-, and 5-year OS.CONCLUSION We developed a seven-SAG signature, which could predict OS of Asian HCC patients. This risk model provides new clinical evidence for the accurate diagnosis and targeted treatment of HCC. | Xiao-Hong Xiang Li Yang Xing Zhang Xiao-Hua Ma Run-Chen Miao Jing-Xian Gu Yu-Nong Fu Qing Yao Jing-Yao Zhang Chang Liu Ting Lin Kai Qu | 2019 | World Journal of Gastroenterology2019，25，14： | 4 |
| 20 | Rotablation in the treatment of high-risk patients with heavily calcified left-main coronary lesions显示文摘Objective Heavily calcified left-main coronary diseases (LMCA) remain a formidable challenge for percutaneous interventions (PCI). This study was to investigate the safety and efficacy of using rotational atherectomy (RA) in treating such lesions in actual practice. Methods From February 2004 to March 2012, all consecutive patients who received RA for heavily-calcified LMCA lesions in our cath lab were en-rolled. The relevant clinical and angiographic characteristics at the time of index PCI, as well as the clinical follow-up outcomes, were re-trieved and analyzed. Results A total of 34 consecutive patients were recruited with a mean age 77.2 ± 10.2 years. There were 82.4%pre-sented with acute coronary syndrome and 11.8%with cardiogenic shock. Chronic renal disease and diabetes were seen in 64.7%and 52.9%, respectively. Triple-vessel coronary disease was found in 76.5%of them. The mean SYNTAX score was 50 ± 15 and EuroSCORE II scale 5.6 ± 4.8. The angiographic success rate was 100%with a procedural success rate of 91.2%. The mean number of burrs per patient was 1.7 ± 0.5. Crossing-over stenting was used in 64.7%. Most stents were drug-eluting (67.6%). Intra-aortic ballon pump was used in 20.6%of the procedures. Three patients died during hospitalization, all due to presenting cardiogenic shock. No major complication occurred. Among 31 hospital survivors, the major adverse cardiac events (MACE) rate was 16.1%, all due to target lesion revascularization or target vessel revas-cularization. Conclusions In high-surgical-risk elderly patients, plaque modification with RA in PCI of heavily-calcified LMCA could be safely accomplished with a minimal complication rate and low out-of-hospital MACE. | Meng-Hsiu Chiang Hung-Tao Yi Cheng-Rong Tsao Wei-Chun Chang Chieh-Shou Su Tsun-Jui Liu Kae-Woei Liang Chih-Tai Ting Wen-Lieng Lee | 2013 | Journal of Geriatric Cardiology2013，10，3： | 4 |
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