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| 1 | 血清乙型肝炎病毒DNA水平的生物学梯度与肝细胞肝癌的风险性相关显示文摘Context: Serum hepatitis B virus (HBV) DNA level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis B. Objective: To evaluate the relationship between serum HBV DNA level and risk of hepatocellular carcinoma. Design, Setting, and Participants: Prospective cohort study of 3653 participants (aged 30-65 years), who were seropositive for the hepatitis B surface antigen and seronegative for antibodies against the hepatitis C virus, recruited to a community-based cancer screening program in Taiwan between 1991 and 1992. Main Outcome Measure: Incidence of hepatocellular carcinoma during follow-up examination and by data linkage with the national cancer registry and the death certification systems. Results: There were 164 incident cases of hepatocellular carcinoma and 346 deaths during a mean follow-up of 11.4 years and 41 779 person-years of follow-up. The incidence of hepatocellular carcinoma increased with serum HBV DNA level at study entry in a dose-response relationship ranging from 108 per 100 000 person-years for an HBV DNA level of less than 300 copies/mL to 1152 per 100 000 person-years for an HBV DNA level of 1 million copies/mL or greater. The corresponding cumulative incidence rates of hepatocellular carcinoma were 1.3%and 14.9%, respectively. The biological gradient of hepatocellular carcinoma by serum HBV DNA levels remained significant (P< .001) after adjustment for sex, age, cigarette smoking, alcohol consumption, serostatus for the hepatitis B e antigen (HBeAg), serum alanine aminotransferase level, and liver cirrhosis at study entry. The dose-response relationship was most prominent for participants who were seronegative for HBeAg with normal serum alanine aminotransferase levels and no liver cirrhosis at study entry. Participants with persistent elevation of serum HBV DNA level during follow-up had the highest hepatocellular carcinoma risk. Conclusion: Elevated serum HBV DNA level (>10 000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis. | Chen C.-J. Yang H. -I. Su J. 王铮(译) 陈云茹(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，6： | 204 |
| 2 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 3 | Schistosoma japonicum egg antigens stimulate CD4(+) CD25(+) T cells and modulate airway inflammation in a murine model of asthma显示文摘 | Yang, J. H. Zhao, J. Q. Yang, Y. F. Zhang, L. Yang, X. Zhu, X. Ji, M. J. Sun, N. X. Su,C. | 2007 | 南京医科大学学报(自然科学版)2007，27，4： | 25 |
| 4 | Uplift, climate and biotic changes at the Eocene-Oligocene transition in south-eastern Tibet显示文摘The uplift history of south-eastern Tibet is crucial to understanding processes driving the tectonic evolution of the Tibetan Plateau and surrounding areas.Underpinning existing palaeoaltimetric studies has been regional mapping based in large part on biostratigraphy that assumes a Neogene modernization of the highly diverse,but threatened,Asian biota.Here,with new radiometric dating and newly collected plant-fossil archives,we quantify the surface height of part of the south-eastern margin of Tibet in the latest Eocene(~34 Ma)to be^3 km and rising,possibly attaining its present elevation(3.9 km)in the early Oligocene.We also find that the Eocene–Oligocene transition in south-eastern Tibet witnessed leaf-size diminution and a floral composition change from sub-tropical/warm temperate to cool temperate,likely reflective of both uplift and secular climate change,and that,by the latest Eocene,floral modernization on Tibet had already taken place,implying modernization was deeply rooted in the Palaeogene. | Tao Su Robert A. Spicer Shi-Hu Li He Xu Jian Huang Sarah Sherlock Yong-Jiang Huang Shu-Feng Li Li Wang Lin-Bo Jia Wei-Yu-Dong Deng Jia Liu Cheng-Long Deng Shi-Tao Zhang Paul J. Valdes Zhe-Kun Zhou | 2019 | National Science Review2019，6，3： | 16 |
| 5 | Infection of hepatitis B virus in extrahepatic endothelial tissues mediated by endothelial progenitor cells显示文摘 | Rong, Q. F. Huang, J. Su, E. B. Li, J. Li, J. Y. Zhang, L. L. Cao, K. J. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 9 |
| 6 | Optimisation of cultivation conditions of a mutant of Trichosporon laibachii CBS 5791 for enantioselective resolution of ketoprofen ester显示文摘 | Zhang, Y. Y. Liu, J. H. Qiu, L. H. Shi, Y. J. Su, Z. L. Xia, Y. M. Li, F. M. | 2007 | 中国生物学文摘2007，21，2： | 9 |
| 7 | Phylogeny of the Rosidae: A dense taxon sampling analysis显示文摘Rosidae,被子植物的约 90 000 种类的 clade,在产地和生活形式展出显著词法差异和非凡的异质。决定在 Rosidae 以内的种系发生的关系是困难的,在由于嵌套的放射和 clade 的庞大的尺寸的大部分。发展史的当前的估计包含差的分辨率或支持的区域,并且在那里有是很少尝试综合可得到的数据进 Rosidae 的一个全面看法发展史。我们试图从叶绿体 rbcL, atpB,和 matK 基因和 mitochondrial matR 基因的 GenBank 用两最新产生的顺序和数据与一个稠密的采样计划改进 Rosidae 的发展史的理解。我们从 9300 种类联合了序列,代表进 supermatrix 的 2775 个类, 138 个家庭,和 17 目。尽管在 supermatrix 的 59.26% 房间没有数据,我们的结果通常同意 Rosidae 发展史的以前的估计并且在拓扑学的几个区域提供更大的分辨率和支持。几种引人注目的种系发生的关系被恢复,包括一些新奇关系。二个家庭(Euphorbiaceae 和 Salvadoraceae ) 和 467 个类在我们的采样作为 non-monophyletic 被恢复,建议对未来的需要这些组的系统的研究。我们的学习为解决 rosid 关系显示出一条植物地明智的生物信息学途径和稠密的分类采样的价值。产生的树在 Rosidae 以内为进化模式的大规模分析提供一个起点。 | Miao Sun Rehan Naeem Jun-Xia Su Zhi-Yong Cao J. Gordon Burleigh Pamela S. Soltis Douglas E. Soltis Zhi-Duan Chen | 2016 | Journal of Systematics and Evolution2016，54，4： | 6 |
| 8 | Bone marrow-derived mesenchymal stem cells are capable of mediating hepatitis B virus infection in injured tissues显示文摘 | Rong, Q. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 5 |
| 9 | Schistosoma japonicum egg antigens stimulate CD4(+) CD25(+) T cells and modulate airway inflammation in a murine model of asthma显示文摘 | Yang, J. H. Zhao, J. Q. Yang, Y. F. Zhang, L. Yang, X. Zhu, X. Ji, M. J. Sun, N. X. Su, C. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 4 |
| 10 | A Light-Independent Allele of Phytochrome B Faithfully Recapitulates Photomorphogenic Transcriptional Networks显示文摘Arabidopsis phytochrome B 的主导的 gain-of-function 等位基因最近被显示授与光无关的、组成的 photomorphogenic (警察) 显型到转基因的植物(苏和 Lagarias, 2007 ) 。在现在的学习,介绍实验的比较抄写被执行估计这些等位基因精确地调整的基因表示的模式是否在野类型的 Arabidopsis 反映 photomorphogenesis 的过程。表示 phyB (YHB ) 的 Y276H 异种的黑暗成年的 phyAphyB 幼苗的整个染色体的抄写侧面揭示了那 YHB 改编以一种光无关的方式的大约 13% Arabidopsis transcriptome。调整 YHB 的 transcriptome 证明品质上类似到但是不到 15 或 50 种的野类型的幼苗的比那些大的份量上 ? 摩尔 ? m ? 2 ? m ? 1 盏连续的红灯(Rc ) 。在 2977 基因之中统计上重要双重(SSTF ) 当光不在时由 YHB 调整了包括光合的仪器, tetrapyrrole/pigment biosynthetic 小径,和早光应答的发信号因素的那些编码部件。Rc 调整的约 80% 基因 SSTF 也是调整 YHB 的。346 调整 YHB 的基因的一个著名子集的表示证明了被 Rc 强烈稀释,显示补偿由 phyC-E 或另外的 Rc 依赖的进程的规定。因为这 346 基因的多数被生理节奏的钟调整,这些结果建议 phyA 独立、 phyB 独立的轻发信号小径强烈影响钟输出。和黑暗成年的 YHB 幼苗的唯一的质体形态学,这些分析显示 YHB 异种经由以一种光无关的方式表明小径的 phyB 的忠诚重建导致组成的 photomorphogenesis。 | Wei Hu Yi-Shin Su J. Clark Lagarias | 2009 | Molecular Plant2009，2，1： | 4 |
| 11 | Design and Mechanics Simulation of Bionic Lubrication System of Artificial Joints显示文摘We propose a new structure for artificial joints with a joint capsule which is designed to overcome the drawback of current prostheses that omit many functions of the lubricant and the joint capsule. The new structure is composed of three components: lubricant, artificial joint and artificial joint capsule. The lubricant sealed in the capsule can not only reduce the wear of the arti- ficial joint but also prevents the wear particles leaking into the body. So unexpected reactions between the wear particles and body can be avoided completely. A three-dimensional (3-D) finite element analysis (FEA) model was created for a bionic knee joint with capsule. The stresses and their distribution in the artificial capsule were simulated with different thickness, loadings, and flexion angles. The results show that the maximum stress occurs in the area between the artificial joint and the capsule. The effects of capsule thickness and the angles of flexion on stress are discussed in detail. | S. H. Su Z. K. Hua J. H. Zhang | 2006 | Journal of Bionic Engineering2006，3，3： | 3 |
| 12 | Estimating organic carbon storage in temperate wetland profiles in Northeast China显示文摘 | Wen-Ju Zhang He-Ai Xiao Cheng-Li Tong Yi-Rong Su Wan-sheng Xiang Dao-You Huang J. Keith Syers Jinshui Wu | 2008 | Geoderma2008，，1： | 2 |
| 13 | Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in american patients显示文摘 | Jorge A. Marrero Grace L. Su Wei Wei Dawn Emick Hari S. Conjeevaram Robert J. Fontana Anna S. Lok | 2003 | Hepatology2003，，5： | 2 |
| 14 | Correlation of Posterior Ligamentous Complex Injury and Neurological Injury to Loss of Vertebral Body Height, Kyphosis, and Canal Compromise显示文摘 | Kristen Radcliff Brian W. Su Christopher K. Kepler Todd Rubin Adam L. Shimer Jeffrey A. Rihn James A. Harrop Todd J. Albert Alexander R. Vaccaro | 2012 | Spine2012，，13： | 2 |
| 15 | Exohiss wave enhancement following substorm electron injection in the dayside magnetosphere显示文摘Exohiss is a low-frequency structureless whistler-mode emission potentially contributing to the precipitation loss of radiation belt electrons outside the plasmasphere. Exohiss is usually considered the plasmaspheric hiss leaked out of the dayside plasmapause.However, the evolution of exohiss after the leakage has not been fully understood. Here we report the prompt enhancements of exohiss waves following substorm injections observed by Van Allen Probes. Within several minutes, the energetic electron fluxes around 100 keV were enhanced by up to 5 times, accompanied by an up to 10-time increase of the exohiss wave power. These substorm-injected electrons are shown to produce a new peak of linear growth rate in the exohiss band(< 0.1 f_(ce)). The corresponding path-integrated growth rate of wave power within 10° latitude of the magnetic equatorial plane can reach 13.4, approximately explaining the observed enhancement of exohiss waves. These observations and simulations suggest that the substorm-injected energetic electrons could amplify the preexisting exohiss waves. | ZhongLei Gao ZhenPeng Su FuLiang Xiao HuiNan Zheng YuMing Wang Shui Wang H. E. Spence G.D. Reeves D. N. Baker J. B. Blake H.O. Funsten | 2018 | Earth and Planetary Physics2018，2，5： | 2 |
| 16 | Estimating surface fluxes over middle and upper streams of the Heihe River Basin with ASTER imagery显示文摘 | Ma W. Ma Y. Hu Z. Su Z. Wang J. Ishikawa H | 2011 | Hydrology and Earth System Sciences2011，，139： | 2 |
| 17 | NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States显示文摘 | Jorge A. Marrero Robert J. Fontana Grace L. Su Hari S. Conjeevaram Dawn M. Emick Anna S. Lok | 2002 | Hepatology2002，，6： | 2 |
| 18 | Transforming bilayer MoS2 into single-layer with strong photoluminescence using UV-ozone oxidation显示文摘在射出设备的光的单个层的瞬间 2 的使用要求创新方法提高它的低光致发光(PL ) 量产量。在这个工作,我们报导有强壮的 PL 的单个层的瞬间 2 能被氧化准备用紫外臭氧的氧化的 bilayer 瞬间 2 。当与剥落得机械地的单个层的瞬间 2, 相比紫外臭氧的氧化准备的单个层的瞬间 2 的 PL 紧张到 2030 次被提高,我们显示出那。我们证明中立激子和 trions (控告的激子) 的 PL 紧张能极大地在氧化瞬间 2 样品被提高。这些结果提供新奇卓见进单个层的瞬间 2 的 PL 改进。 | Weitao Su Naresh Komar Steve J. Spencer Ning Dai Debdulal Roy | 2015 | Nano Research2015，8，12： | 2 |
| 19 | Serological Investigation of Laboratory-Confirmed and Suspected Ebola Virus Disease Patients During the Late Phase of the Ebola Outbreak in Sierra Leone显示文摘This study aimed to investigate the serological characteristics of Ebola virus(EBOV) infection during the late phase of the Ebola outbreak in Sierra Leone. In total, 877 blood samples from 694 suspected Ebola virus disease(EVD) cases assessed from March to December 2015, were analyzed via real-time reverse transcription polymerase chain reaction(RT-PCR) for viral RNA and enzyme-linked immunosorbent assay(ELISA) and Luminex to detect antibodies against EBOV. Viral load and EBOV-specific IgM/IgG titers displayed a declining trend during March to December 2015. Viral RNA load decreased rapidly at earlier stages after disease onset, while EBOV-specific IgM and IgG still persisted in 58.1%(18/31) and 93.5%(29/31) of the confirmed EVD patients and in 3.8%(25/663) and 17.8%(118/663) of the RNA-negative suspected patients in the later phase, respectively. Dynamic analysis of longitudinally collected samples from eight EVD patients revealed typically reversed trends of declining viral load and increasing IgM and/or IgG titers in response to the EBOV infection.The present results indicate that certain populations of Sierra Leone developed immunity to an EBOV infection in the late phase of the outbreak, providing novel insights into the risk assessment of EBOV infections among human populations. | Yang Liu YuLan Sun Wei Wu AQian Li XianDa Yang Shuo Zhang Chuan Li QiuDong Su ShaoJian Cai DaPeng Sun HaiYang Hu Zhe Zhang XiuXu Yang Idrissa Kamara Sheku Koroma Gerald Bangura Alie Tia Abdul Kamara Matt Lebby Brima Kargbo Jiandong Li Shiwen Wang XiaoPing Dong YueLong Shu WenBo Xu George F. Gao GuiZhen Wu DeXin Li William J. Liu MiFang Liang | 2018 | Virologica Sinica2018，33，4： | 2 |
| 20 | Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability显示文摘 | Dao-Yi Yu Stephen J. Cringle Chandrakumar Balaratnasingam William H. Morgan Paula K. Yu Er-Ning Su | 2013 | Progress in Retinal and Eye Research2013，，： | 2 |
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