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| 1 | β-Ⅲ-Tubulin: a reliable marker for retinal ganglion cell labeling in experimental models of glaucoma显示文摘·AIM: To evaluate the reliability of β-III-Tubulin protein as a retinal ganglion cell(RGC) marker in the experimental glaucoma model.·METHODS: Glaucoma mouse models were established by injecting polystyrene microbeads into the anterior chamber of C57BL/6J mice, then their retinas were obtained 14 d and 28 d after the intraocular pressure(IOP)was elevated. Retinal flat mounts and sections were double-labeled by fluorogold(FG) and β-III-Tubulin antibody or single-labeled by β-III-Tubulin antibody,then RGCs were counted and compared respectively.· RESULTS: IOP of the injected eyes were elevated significantly and reached the peak at 22.8 ±0.7 mm Hg by day 14 after injection, then dropped to 11.3 ±0.7 mm Hg by day 28. RGC numbers counted by FG labeling and β-III- Tubulin antibody labeling were 64 807 ± 4930 and64 614 ±5054 respectively in the control group, with no significant difference. By day 14, RGCs in the experimental group decreased significantly compared to the control group, but there was no significant difference between the FG labeling counting and the β-III-Tubulin antibody labeling counting either in the experimental group or in the control group. The result was similar by day 28, with further RGC loss.·CONCLUSION: Our result suggested that the β-III-Tubulin protein was not affected by IOP elevation and can be used as a reliable marker for RGC in experimental models of glaucoma. | Shan-Ming Jiang Li-Ping Zeng Ji-Hong Zeng Li Tang Xiao-Ming Chen Xin Wei | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 6 |
| 2 | Effect of suction on macular thickness and retinal nerve fiber layer thickness during LASIK used femtosecond laser and Moria M2 microkeratome显示文摘·AIM: To compare the effect of suction on the macular thickness and retinal nerve fiber layer(RNFL) thickness during laser in situ keratomileusis(LASIK) used Ziemer FEMTO LDV femtosecond laser(Ziemer group) and Moria M2 automated microkeratome(Moria group) for flap creation.· METHODS: Fourier-domain optical coherence tomography(FD-OCT) was used to measure macular thickness, ganglion cell complex thickness and RNFL thickness of 204 eyes of 102 patients with the Ziemer femtosecond laser(102 eyes) and the Moria M2microkeratome(102 eyes) before surgery and 30min; 1,3d; 1wk; 1, 3mo; 1y after surgery.· RESULTS: The average foveal thickness and parafoveal retinal thickness 30 min after the surgery were statistically more than that before surgery(Ziemer P <0.001,P =0.003 and Moria P=0.001, P=0.006) and the effect was less in the Ziemer group than that in the Moria group(P all <0.05). The ganglion cell complex thickness was not significantly changed in both groups(P all >0.05). The RNFL thickness was statistically less 30 min after surgery in both groups(P=0.014, P <0.001), but the influence was less in Ziemer group than that in Moria group(P =0.038).However, the RNFL thickness had recovered to the preoperative level only 1d after surgery.·CONCLUSION: The suction of femtosecond laser and mechanical microkeratome led to the increase in macular central fovea thickness and the decrease in RNFL thickness values at the early stage after LASIK. The effect of suction on macular and the RNFL thicknesses in Ziemer group is smaller than that in Moria group. | Jing Zhang Yue-Hua Zhou | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 6 |
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