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| 1 | Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia显示文摘Venetoclax,an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia(AML),is tolerated well in elderly patients with AML and has good overall response rates;however,resistance remains a concern.In this study,we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient samples.CDK9 inhibition enhances venetoclax activity through downregulation of Mcl-1 and c-Myc.However,downregulation of Mcl-1 is transient,which necessitates an intermittent treatment schedule to allow for repeated downregulation of Mcl-1.Accordingly,an every other day schedule of the CDK9 inhibitor is effective in vitro and in vivo in enhancing the efficacy of venetoclax.Our preclinical data provide a rationale for an intermittent drug administration schedule for the clinical evaluation of the combination treatment for AML. | Daniel A.Luedtke Yongwei Su Jun Ma Xinyu Li Steven ABuck Holly Edwards Lisa Polin Juiwanna Kushner Sijana HDzinic Kathryn White Hai Lin Jeffrey WTaub Yubin Ge | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 2 | Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis显示文摘 | David H. Adams Jeffrey J. Popma Michael J. Reardon Steven J. Yakubov Joseph S. Coselli G. Michael Deeb Thomas G. Gleason Maurice Buchbinder James Hermiller Neal S. Kleiman Stan Chetcuti John Heiser William Merhi George Zorn Peter Tadros Newell Robinson Ge | 2014 | The New England Journal of Medicine2014，，19： | 1 |
| 3 | Measurement of human postur al sway显示文摘 | Stevens DL Tomlinson GE | 1971 | Proc R Soc Med1971，64，6： | 1 |
| 4 | Modeling actual evapotranspiration from forested Watersteds across the southeastern united states显示文摘 | Jianbiao Lu Ge Sun Steven G | 2003 | Journal of the American Water Resources Association2003，39，4： | 1 |
| 5 | Surface storm flow prediction on hillslopes based on topography and hydrologic connectivity显示文摘Background:Hillslopes provide critical watershed ecosystem services such as soil erosion control and storm flow regulation through collecting,storing,and releasing rain water.During intense rainstorms,rainfall intensity and infiltration capacity on the hillslope control Hortonian runoff while the topographic attributes of the hillslope(e.g.,slope,aspect,curvature)and the channel network define the structural hydraulic connectivity that determines how rapidly excess water is transferred.This paper discusses literature on the link between topographic attributes and hydrologic connectivity and demonstrates how this link can be used to define a parsimonious model for predicting surface runoff during high intensity rainfall.Main text:First,we provide a topographic characterization of the hillslope necessary to determine the structural hydrologic connectivity of surface flow based on existing literature.Subsequently,we demonstrate a hydrologic surface response model that routes the geomorphologic unit hydrograph(GIUH)through a spatial domain of representative elementary hillslopes reflecting the structural hydrologic connectivity.Topographic attributes impact flow and travel time distributions by affecting gravitational acceleration of overland flow and channel,solar irradiance,flow deceleration by vegetation,and flow divergence/convergence.Conclusions:We show with an example where we apply the GIUH-based model to hypothetical hillslopes that the spatial organization of the channel network is critical in the flow and travel time distribution,and that topographic attributes are key in obtaining simple yet accurate representations of hydrologic connectivity.Parsimonious GIUH models of surface runoff that use this hydrologic connectivity have the advantage of low data requirements,being scalable and applicable regardless of the spatial complexity of the hillslope,and have the potential to fundamentally improve flood forecasting tools used in the assessment of ecosystem services. | Dennis W.Hallema Roger Moussa Ge Sun Steven G.McNulty | 2016 | Ecological Processes2016，5，1： | 1 |
| 6 | Extension of survival of rat 显示文摘 | Allen DB Steven GE Honar4d MG | 1987 | parathylantation1987，44，2： | 1 |
| 7 | Distribution of IFN- gamma, IL-4 and TNF-alpha protein and CD8 T cells producing IL-12p40 mRNA in human lung tuberculous granulomas 显示文摘 | Fenhalls G Stevens L Bezuidenhout J Amphlett GE Duncan K Bardin P Lukey PT | 2002 | Immunology2002，105，3： | 1 |
| 8 | Transgenic expression of phytase and acid phosphatase genes in alfalfa ( Medicago sativa ) leads to improved phosphate uptake in natural soils显示文摘 | Xue-Feng Ma Steven Tudor Twain Butler Yaxin Ge Yajun Xi Joseph Bouton Maria Harrison Zeng-Yu Wang | 2012 | Molecular Breeding2012，，1： | 1 |
| 9 | A novel Brn3-like POU transcription factor expressed in subsets of rat sensory and spinal cord neurons显示文摘 | Ninkina NN Stevens GE Wood JN Richardson WD | 1993 | Nucleic Acids Res1993，21，14： | 1 |
| 10 | Modeling actual evapotranspiration from forested Watersteds across the southeastern united states显示文摘 | Jianbiao Lu Ge Sun Steven G | 2003 | Journal of the American Water Resources Association2003，39，4： | 1 |
| 11 | Desmosomal Dysfunction due to Mutations in Desmoplakin Causes Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy显示文摘 | Zhao Yang Neil E. Bowles Steven E. Scherer Michael D. Taylor Debra L. Kearney Shuping Ge Vyacheslav V. Nadvoretskiy Gilberto DeFreitas Blasé Carabello Lois I. Brandon Lisa M. Godsel Kathleen J. Green Jeffrey E. Saffitz Hua Li Gian Antonio Danieli Hugh Cal | 2006 | Circulation Research2006，，6： | 1 |
| 12 | Elimination of the yellow pigment gene PSY-E2 tightly linked to the Fusarium head blight resistance gene Fhb7 from Thinopyrum ponticum显示文摘Fhb7 is a major gene that was transferred from Thinopyrum ponticum to chromosome 7D of wheat(Triticum aestivum)and confers resistance to both Fusarium head blight(FHB)and Fusarium crown rot(FCR).However,Fhb7 is tightly linked to the PSY-E2 gene,which causes yellow flour,limiting its application in breeding.To break this linkage,marker K-PSY was developed for tagging PSY-E2 and used with Fhb7 markers to identify recombination between the two genes.Screening 21,000 BC1F2 backcross progeny(Chinese Spring ph1bph1b*2/SDAU 2028)revealed two Fhb7^(+)wheat-Tp7el_(2)L lines,Shannong 2–16and Shannong 16–1,that carry a desired truncated Fhb7^(+)translocation segment without PSY-E2.The two lines show levels of resistance to FHB and FCR similar to those of the original translocation line SDAU 2028,but have white flour.To facilitate Fhb7 use in wheat breeding,STS markers were developed and used to isolate Fhb7 on a truncated Tp7el_(2) translocation segment.Near-isogenic lines carrying the Fhb7^(+)segment were generated in the backgrounds of three commercial cultivars,and Fhb7^(+)lines showed increased FHB and FCR resistance without yield penalty.The breakage of the tight linkage between Fhb7 and PSY-E2 via homoeologous recombination provides genetic resources for improvement of wheat resistance to FHB and FCR and permit the large-scale deployment of Fhb7 in breeding using marker-assisted selection. | Xuefeng Li Dong Li Yu Xuan Ziming He Lanfei Zhao Yongchao Hao Wenyang Ge Shoushen Xu Bingqian Hou Biao Wang Jun Guo Wenwen Liu Mingzhu Li Yi Han Cunyao Bo Yinguang Bao Zengjun Qi Steven S.Xu Guihua Bai Hongwei Wang Lingrang Kong | 2023 | The Crop Journal2023，11，3： | 0 |
| 13 | 岩墙群:古地理重建的钥匙(英文)显示文摘第七届国际岩墙会议于2016年8月在北京召开.会议的主题为'岩墙群——古地理重建的钥匙'.大会认为,过去10年,学术界在岩墙群和相关单元区域地质填图,以及通过大型岩墙群等大岩浆岩省进行超大陆/古大陆重建等方面取得了重要成就.另外一些方向是未来几年有发展潜力并可望取得重大进展的领域,如(1)岩墙群/岩床群(杂岩)的侵位机制;(2)岩墙群的岩石成因、构造背景和地质意义;(3)地外星体上的岩墙群和相关建造;(4)岩墙群及相关建造和矿产资源的联系. | 彭澎 Richard E.Erns 侯贵廷 Ulf S?derlund 张拴宏 Michael Hamilton 徐义刚 Steven Denyszyn Daniel Mège Sergei Pisarevsky Rajesh Srivastava Timothy M.Kusky | 2016 | Science Bulletin2016，61，21： | 0 |
| 14 | Observatory science with eXTP显示文摘In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s. | Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig Alessandro Riggio Jerome Rodriguez Pablo Rodríguez-Gil Patrizia Romano Agata Rózańska Takanori Sakamoto Tuomo Salmi Ruben Salvaterra andrea Sanna andrea Santangelo Tuomas Savolainen Stéphane Schanne Hendrik Schatz LiJing Shao andy Shearer Steven N.Shore Ben W.Stappers Tod E.Strohmayer Valery F.Suleimanov Jirí Svoboda F.-K.Thielemann Francesco Tombesi Diego F.Torres Eleonora Torresi Sara Turriziani andrea Vacchi Stefano Vercellone Jacco Vink Jian-Min Wang JunFeng Wang Anna L.Watts ShanShan Weng Nevin N.Weinberg Peter J.Wheatley Rudy Wijnands Tyrone E.Woods Stan E.Woosley ShaoLin Xiong YuPeng Xu Zhen Yan George Younes WenFei Yu Feng Yuan Luca Zampieri Silvia Zane andrzej A.Zdziarski Shuang-Nan Zhang Shu Zhang Shuo Zhang Xiao Zhang Michael Zingale | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 0 |
| 15 | 先栅和替代栅方案中的高k/金属栅堆叠显示文摘以先栅和替代栅二种集成方案制造了有代表性的高k/金属栅MOS电容堆叠。除了TiN金属栅外,基于铝和镧的覆盖层(二者均广泛在产业中用于Vt调整覆盖层)能分别调整PMOS和NMOS的有效功函数。改变TiN中Ti:N化学组分比能引起TiN功函数改变>250mV。在替代栅方案中筛选不同的功函数材料能获得NMOS和PMOS之间1V间隔。在铝生长过程中衬底的修正是在窄栅沟槽中获得无空洞铝间隙填充的关键。 | Sree Kesapragada Rongjun Wang Dave Liu Gaojun Liu Zhigang Xie Zhenbin Ge Haichun Yang Yu Lei Xinliang Lu Xianmin Tang Jianxin Lei Millen Allen Srinivas Gandikota Kevin Moraes Steven Hung Naomi Yoshida Chorng-Ping Chang | 2013 | 功能材料与器件学报2013，19，3： | 0 |
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