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| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | Effect of permafrost degradation on hydrological processes in typical basins with various permafrost coverage in Western China显示文摘Monthly discharge of four rivers with various permafrost coverage and little anthropogenic influence was used to identify effects of permafrost degradation during the last 50 years,which has occurred because of significant increases in air temperature in the river regions.The basins of the Shule,Heihe,Shiyang and upper Yellow Rivers in northwestern China have 73%,58%,33% and 43% permafrost coverage,respectively.There is snow cover in the basins and no rain to supply rivers during winter. The monthly recession coefficient(RC) in winter reflects groundwater conditions.The RC has increased obviously for the Shule and Heihe rivers with 73% and 58% permafrost coverage,respectively,but did not increase for the Shiyang River,and decreased insignificantly for the upper Yellow River,which had less permafrost coverage.There is a distinct positive relationship between RC and annual negative degree-day temperature(NDDT) at the meteorological stations in the basins with high permafrost coverage.These results imply that permafrost degradation due to climate warming affects hydrological processes in winter.The effect is obvious in the basins with high permafrost coverage but negligible in those with low permafrost coverage. Permafrost degradation increases infiltration,enlarges the groundwater reservoir,and leads to slow discharge recession.The result means that hydrological processes are affected strongly by permafrost degradation in river basins with high permafrost coverage,but less in river basins with less permafrost coverage. | NIU Li YE BaiSheng LI Jing SHENG Yu | 2011 | Science China Earth Sciences2011，54，4： | 19 |
| 3 | Measurement-device-independent quantum communication without encryption显示文摘Security in communication is vital in modern life. At present, security is realized by an encryption process in cryptography. It is unbelievable if a secure communication is achievable without encryption. In quantum cryptography, there is a unique form of quantum communication, quantum secure direct communication, where secret information is transmitted directly over a quantum channel. Quantum secure direct communication is drastically distinct from our conventional concept of secure communication, because it does not require key distribution, key storage and ciphertext transmission, and eliminates the encryption procedure completely. Hence it avoids in principle all the security loopholes associated with key and ciphertext in traditional secure communications. For practical implementation, defects always exist in real devices and it may downgrade the security. Among the various device imperfections, those with the measurement devices are the most prominent and serious ones. Here we report a measurementdevice-independent quantum secure direct communication protocol using Einstein-Podolsky-Rosen pairs. This protocol eradicates the security vulnerabilities associated with the measurement device,and greatly enhances the practical security of quantum secure direct communication. In addition to the security advantage, this protocol has an extended communication distance, and a high communication capacity. | Peng-Hao Niu Zeng-Rong Zhou Zai-Sheng Lin Yu-Bo Sheng Liu-Guo Yin Gui-Lu Long | 2018 | Science Bulletin2018，63，20： | 19 |
| 4 | Energy-Optimal and Delay-Bounded Computation Offloading in Mobile Edge Computing with Heterogeneous Clouds显示文摘By Mobile Edge Computing(MEC), computation-intensive tasks are offloaded from mobile devices to cloud servers, and thus the energy consumption of mobile devices can be notably reduced. In this paper, we study task offloading in multi-user MEC systems with heterogeneous clouds, including edge clouds and remote clouds. Tasks are forwarded from mobile devices to edge clouds via wireless channels, and they can be further forwarded to remote clouds via the Internet. Our objective is to minimize the total energy consumption of multiple mobile devices, subject to bounded-delay requirements of tasks. Based on dynamic programming, we propose an algorithm that minimizes the energy consumption, by jointly allocating bandwidth and computational resources to mobile devices. The algorithm is of pseudo-polynomial complexity. To further reduce the complexity, we propose an approximation algorithm with energy discretization, and its total energy consumption is proved to be within a bounded gap from the optimum. Simulation results show that, nearly 82.7% energy of mobile devices can be saved by task offloading compared with mobile device execution. | Tianchu Zhao Sheng Zhou Linqi Song Zhiyuan Jiang Xueying Guo Zhisheng Niu | 2020 | China Communications2020，17，5： | 18 |
| 5 | Quantitative computed tomography analysis for stratifying the severity of Coronavirus Disease 2019显示文摘To examine the feasibility of using a computer tool for stratifying the severity of Coronavirus Disease 2019(COVID-19)based on computed tomography(CT)images.We retrospectively examined 44 confirmed COVID-19 cases.All cases were evaluated separately by radiologists(visually)and through an in-house computer software.The degree of lesions was visually scored by the radiologist,as follows,for each of the 5 lung lobes:0,no lesion present;1,<1/3 involvement;2,>1/3 and<2/3 involvement;and 3,>2/3 involvement.Lesion density was assessed based on the proportion of ground-glass opacity(GGO),consolidation and fibrosis of the lesions.The parameters obtained using the computer tool included lung volume(mL),lesion volume(mL),lesion percentage(%),and mean lesion density(HU)of the whole lung,right lung,left lung,and each lobe.The scores obtained by the radiologists and quantitative results generated by the computer software were tested for correlation.A Chi-square test was used to test the consistency of radiologist-and computer-derived lesion percentage in the right/left lung,upper/lower lobe,and each of the 5 lobes.The results showed a strong to moderate correlation between lesion percentage scores obtained by radiologists and the computer software(r ranged from 0.7679 to 0.8373,P<0.05),and a moderate correlation between the proportion of GGO and mean lesion density(r=-0.5894,P<0.05),and proportion of consolidation and mean lesion density(r=0.6282,P<0.05).Computer-aided quantification showed a statistical significant higher lesion percentage for lower lobes than that assessed by the radiologists(x^2=8.160,P=0.004).Our experiments demonstrated that the computer tool could reliably and accurately assess the severity and distribution of pneumonia on CT scans. | Cong Shen Nan Yu Shubo Cai Jie Zhou Jiexin Sheng Kang Liu Heping Zhou Youmin Guo Gang Niu | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 13 |
| 6 | Viral and Bacterial Etiology of Acute Febrile Respiratory Syndrome among Patients in Qinghai, China显示文摘Objective This study was conducted to investigate the viral and bacterial etiology and epidemiology of patients with acute febrile respiratory syndrome(AFRS) in Qinghai using a commercial routine multiplex-ligation-nucleic acid amplification test(NAT)-based assay. Methods A total of 445 nasopharyngeal swabs specimens from patients with AFRS were analyzed using the RespiFinderSmart22 kit(PathoFinder BV, Netherlands) and the LightCycler 480 real-time PCR system. Results Among the 225(225/445, 51%) positive specimens, 329 positive pathogens were detected, including 298(90.58%) viruses and 31(9%) bacteria. The most commonly detected pathogens were influenza virus(IFV;37.39%;123/329), adenovirus(AdV;17.02%;56/329), human coronaviruses(HCoVs;10.94%;36/329), rhinovirus/enterovirus(RV/EV;10.03%;33/329), parainfluenza viruses(PIVs;8.51%;28/329), and Mycoplasma pneumoniae(M. pneu;8.51%;28/329), respectively. Among the co-infected cases(17.53%;78/445), IFV/AdV and IFV/M. pneu were the most common co-infections. Most of the respiratory viruses were detected in summer and fall. Conclusion In our study, IFV-A was the most common respiratory pathogen among 22 detected pathogens, followed by AdV, HCoV, RV/EV, PIV, and M. pneu. Bacteria appeared less frequently than viruses, and co-infection was the most common phenomenon among viral pathogens. Pathogens were distributed among different age groups and respiratory viruses were generally active in July, September, and November. Enhanced surveillance and early detection can be useful in the diagnosis, treatment, and prevention of AFRS, as well as for guiding the development of appropriate public health strategies. | LIU Gao Shan LI Hong ZHAO Sheng Cang LU Rou Jian NIU Pei Hua TAN Wen Jie | 2019 | Biomedical and Environmental Sciences2019，32，6： | 8 |
| 7 | Measurement-device-independent quantum secure direct communication显示文摘Quantum secure direct communication(QSDC)is a unique technique,which supports the secure transmission of confidential information directly through a quantum channel without the need for a secret key and for ciphertext.Hence this secure communication protocol fundamentally differs from its conventional counterparts.In this article,we report the first measurement-deviceindependent(MDI)QSDC protocol relying on sequences of entangled photon pairs and single photons.Explicitly,it eliminates the security loopholes associated with the measurement device.Additionally,this MDI technique is capable of doubling the communication distance of its conventional counterpart operating without using our MDI technique.We also conceive a protocol associated with linear optical Bell-basis measurements,where only two of the four Bell-basis states could be measured.When the number of qubits in a sequence reduces to 1,the MDI-QSDC protocol degenerates to a deterministic MDI quantum key distribution protocol. | ZengRong Zhou Yu Bo Sheng PengHao Niu LiuGuo Yin GuiLu Long Lajos Hanzo | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 6 |
| 8 | Genetic dissection of rice appearance quality and cooked rice elongation by genome-wide association study显示文摘Appearance and cooked rice elongation are key quality traits of rice. Although some QTL for these traits have been identified, understanding of the genetic relationship between them remains limited. In the present study, large phenotypic variation was observed in 760 accessions from the 3 K Rice Genomes Project for both appearance quality and cooked rice elongation. Most component traits of appearance quality and cooked rice elongation showed significant pairwise correlations, but a low correlation was found between appearance quality and cooked rice elongation. A genome-wide association study identified 74 QTL distributed on all 12 chromosomes for grain length, grain width, length to width ratio, degree of endosperm with chalkiness, rice elongation difference, and elongation index. Thirteen regions containing QTL stably expressed in multiple environments and/or exerting pleiotropic effects on multiple traits were detected. By gene-based association analysis and haplotype analysis, 46 candidate genes, including five cloned genes, and 49 favorable alleles were identified for these 13 QTL. The effect of the candidate gene Wx on rice elongation difference was validated by a transgenic strategy. These results shed light on the genetic bases of appearance quality and cooked rice elongation and provide gene resources for improving rice quality by molecular breeding. | Xianjin Qiu Jing Yang Fan Zhang Yanan Niu Xiuqing Zhao Congcong Shen Kai Chen Sheng Teng Jianlong Xu | 2021 | The Crop Journal2021，9，6： | 5 |
| 9 | Effect of contact- and sliding-mode electrification on nanoscale charge transfer for energy harvesting显示文摘费用转移的过程最近作为收获技术的一个新、有希望的精力的基础基于 triboelectrification (TE ) 和接触充电(CE ) 被利用了,即,摩擦电 nanogenerators,以及 selfpowered 传感器和系统。在二表面之间的静电的费用转移能发生在 TE 和取决于相对滑动磨擦的参与的 CE 模式。在 TE 的滑动行为从 CE 在费用转移导致任何基本差别吗?因为挑战,很少研究在这比较上是可得到的。这份报纸基于扫描探查在 nanoscale 在 CE 和 TE 在基本差别上提供第一研究显微镜的方法。在相等的接触时间和力量的二进程的量的比较被提供,并且结果建议从 TE 的费用转移从 CE,而是转移费用密度的浸透值是比那快得多的是一样。11 eV 的测量摩擦精力驱散尖端什么时候在 1 的距离上扫描?使潜在的机制清楚些:磨擦可以经由电子刺激便于费用转移过程。这些结果提供基本指导让材料和设备结构的选择在不同应用启用 TE 或 CE;CE 模式为象收获的颤动精力那样的经常的中等接触是有利的, TE 模式为象从人的走精力收获那样的立刻的运动是有利的。 | Yu Sheng Zhou Shengming Li Simiao Niu Zhong Lin Wang | 2016 | Nano Research2016，9，12： | 5 |
| 10 | A transceptor-channel complex couples nitrate sensing to calcium signaling in Ambidopsis显示文摘Nitrate-induced Ca^(2+) signaling is crucial for the primary nitrate response in plants.However,the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains unknown.We report here that a cyclic nucleotide-gated channel(CNGC)protein,CNGC15,and the nitrate transceptor(NRT1.1)constitute a molecular switch that controls calcium influx depending on nitrate levels.The expression of CNGC15 is induced by nitrate,and its protein is localized at the plasma membrane after establishment of young seedlings.We found that disruption of CNGC15 results in the loss of the nitrate-induced Ca^(2+) signature(primary nitrate response)and retards root growth,reminiscent of the phenotype observed in the nrt1.1 mutant.We further showed that CNGC15 is an active Ca^(2+)-permeable channel that physically interacts with the NRT1.1 protein in the plasma membrane.Importantly,we discovered that CNGC15-NRT1.1 interaction silences the channel activity of the heterocomplex,which dissociates upon a rise in nitrate levels,leading to reactivation of the CNGC15 channel.The dynamic interactions between CNGC15 and NRT1.1 therefore control the channel activity and Ca^(2+) influx in a nitrate-dependent manner.Our study reveals a new nutrient-sensing mechanism that utilizes a nutrient transceptor-channel complex assembly to couple nutrient status to a specific Ca^(2+) signature. | Xiaohan Wang Changxin Feng LiLi Tian Congcong Hou Wang Tian Bin Hu Qian Zhang Zhijie Ren Qi Niu Jiali Song Dongdong Kong Liangyu Liu Yikun He Ligeng Ma Chengcai Chu Sheng Luan Legong Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 11 | Plasma-grating-induced breakdown spectroscopy显示文摘.Laser-induced breakdown spectroscopy(LIBS)is a useful tool for determination of elements in solids,liquids,and gases.For nanosecond LIBS(ns-LIBS),the plasma shielding effect limits its reproducibility,repeatability,and signal-to-noise ratios.Although femtosecond laser filament induced breakdown spectroscopy(FIBS)has no plasma shielding effects,the power density clamping inside the filaments limits the measurement sensitivity.We propose and demonstrate plasma-grating-induced breakdown spectroscopy(GIBS).The technique relies on a plasma excitation source-a plasma grating generated by the interference of two noncollinear femtosecond filaments.We demonstrate that GIBS can overcome the limitations of standard techniques such as ns-LIBS and FIBS.Signal intensity enhancement with GIBS is observed to be greater than 3 times that of FIBS.The matrix effect is also significantly reduced with GIBS,by virtue of the high power and electron density of the plasma grating,demonstrating great potential for analyzing samples with complex matrix. | Mengyun Hu Junsong Peng Sheng Niu Heping Zeng | 2020 | Advanced Photonics2020，2，6： | 5 |
| 12 | Phosphine production in anaerobic wastewater treatment under tetracycline antibiotic pressure显示文摘The influence of tetracycline(TC) antibiotics on phosphine(PH_3) production in the anaerobic wastewater treatment was studied. A lab-scale anaerobic baffled reactor with three compartments was employed to simulate this process. The reactor was operated in a TC-absence wastewater and 250 μg/L TC-presence wastewater for three months after a start-up period,respectively. The responses of p H, oxidation–reduction potential(ORP), chemical oxygen demand(COD), total phosphorus(TP), enzymes activity(dehydrogenase and acid phosphatase),and microbial community were investigated to reveal the effect of TC on PH_3 production.Results suggested that the dehydrogenase(DH) activity, acid phosphatase(ACP) activity and COD have positive relationship with PH_3 production, while p H, ORP level and the TP in liquid phase have negative relationship with PH_3 production. With prolonged TC exposure, decrease in p H and increase in DH activity are beneficial to PH_3 production, while decrease in COD and ACP activity are not the limiting factors for PH_3 production. | Meiqing Lu Xiaojun Niu Weiyi Chen Zhu Liang Sheng You Xiaohong Gu | 2018 | Journal of Environmental Sciences2018，30，7： | 5 |
| 13 | Novel Wx alleles generated by base editing for improvement of rice grain quality显示文摘Amylose content(AC),which is regulated by the Waxy(Wx)gene,is a major indicator of eating and cooking quality(ECQ)in rice(Oryza sativa).Thus far,only a limited number of mutations in the N-terminal domain of Wx were found to have a major impact on the AC of rice grains and no mutations with such effects were reported for other regions of the Wx protein.Here,nucleotide substitutions in the middle region of Wx were generated by adenine and cytosine base editors.The nucleotide substitutions led to changes in 15 amino acid residues of Wx,and a series of novel Wx alleles with ACs of 0.3%-29.43%(wild type with AC of 19.87%)were obtained.Importantly,the waxy~(abe2)allele showed a'soft rice'AC,improved ECQ,favorable appearance,and no undesirable agronomic traits.The transgenes were removed from the waxy~(abe2)progeny,generating a promising breeding material for improving rice grain quality. | Xiaorui Huang Fei Su Sheng Huang Fating Mei Xiaomu Niu Changle Ma Hui Zhang Xiaoguo Zhu Jian-Kang Zhu Jinshan Zhang | 2021 | Journal of Integrative Plant Biology2021，63，9： | 4 |
| 14 | Simulation and test of the SLEGS TOF spectrometer at SSRF显示文摘The Shanghai laser electron gamma source(SLEGS)is a powerful tool for exploring photonuclear physics,such as giant dipole resonance(GDR)and pygmy dipole resonance,which are the main mechanisms of collective nuclear motion.The goal of the SLEGS neutron time-of-flight(TOF)spectrometer is to measure GDR and specific nuclear structures in the energy region above the neutron threshold.The SLEGS TOF spectrometer was designed to hold 20 sets of EJ301 and LaBr3 detectors.Geant4 was used to simulate the efficiency of each detector and the entire spectrometer,which provides a reference for the selection of detectors and layout of the SLEGS TOF spectrometer.Under the events of 208Pb,implementations of coincidence and time-of-flight technology for complex experiments are available;thus,and neutron decay events can be separated.The performance of SLEGS TOF spectrometer was systematically evaluated using offline experiments,in which the time resolution reached approximately 0.9 ns. | Kai-Jie Chen Long-Xiang Liu Zi-Rui Hao Yu-Gang Ma Hong-Wei Wang Gong-Tao Fan Xi-Guang Cao Hang-Hua Xu Yi-Fei Niu Xin-Xiang Li Xin-Rong Hu Yu-Xuan Yang Sheng Jin Pan Kuang | 2023 | Nuclear Science and Techniques2023，34，3： | 3 |
| 15 | Radio Resource Allocation for Bidirectional Offloading in Space-Air-Ground Integrated Vehicular Network显示文摘Aerial platforms and edge servers have been recognized as two promising building blocks to improve the quality of service(QoS)in space-air-ground integrated vehicular networks(SAGIN).Communication intensive tasks can be offloaded to aerial platforms via broadcasting,while computation intensive tasks can be offloaded to ground edge servers.However,the key issues including how to allocate radio resources and how to determine the task offloading strategy for the two types of tasks,are yet to be solved.In this paper,the joint optimization of radio resource allocation and bidirectional offloading configuration is investigated.To deal with the non-convex nature of the original problem,we decouple it into a two-step optimization problem.In the first step,we optimize the bidirectional offloading configuration in the case of the radio resource allocation known in advance,which is proved to be a convex optimization problem.In the second step,we optimize the radio resource allocation through a brute-force search method.We use queuing theories to analyze the average delay of the two tasks with respect to the broadcasting capacity and task arrival rate.The offloading strategies with closed-form expressions of communication intensive tasks are proposed.We then propose a heuristic algorithm which is shown to perform better than interior point algorithm in simulations.The numerical results also demonstrate that the aerial platforms and edge servers can significantly reduce the average delay of the tasks under different network conditions. | Guangchao Wang Sheng Zhou Zhisheng Niu | 2019 | Journal of Communications and Information Networks2019，4，4： | 3 |
| 16 | Landing site topographic mapping and rover localization for Chang’e-4 mission显示文摘This paper presents the techniques and results of landing-site topographic mapping and rover localization using orbital,descent and rover images in the Chang’e-4 mission.High-resolution maps of the landing site are generated from orbital and descent images.Local digital elevation models and digital orthophoto maps with 0.02 m resolution are generated at each waypoint.The location of the lander is determined as(177.588?E,45.457?S)using festure-matching techniques.The cross-site visual localization method is routinely used to localize the rover at each waypoint to reduce error accumulation from wheel slippage and IMU drift in dead reckoning.After the first five lunar days,the rover travels 186.66 m from the lander,according to the cross-site visual localization.The developed methods and results have been directly utilized to support the mission’s operations.The maps and localization information are also valuable for supporting multiple scientific explorations of the landing site. | Zhaoqin LIU Kaichang DI Jian LI Jianfeng XIE Xiaofeng CUI Luhua XI Wenhui WAN Man PENG Bin LIU Yexin WANG Sheng GOU Zongyu YUE Tianyi YU Lichun LI Jia WANG Chuankai LIU Xin XIN Mengna JIA Zheng BO Jia LIU Runzhi WANG Shengli NIU Kuan ZHANG Yi YOU Bing LIU Jiangang LIU | 2020 | Science China(Information Sciences)2020，63，4： | 3 |
| 17 | Scheduling Policies for Federated Learning in Wireless Networks: An Overview显示文摘Due to the increasing need for massive data analysis and machine learning model training at the network edge, as well as the rising concerns about data privacy, a new distrib?uted training framework called federated learning (FL) has emerged and attracted much at?tention from both academia and industry. In FL, participating devices iteratively update the local models based on their own data and contribute to the global training by uploading mod?el updates until the training converges. Therefore, the computation capabilities of mobile de?vices can be utilized and the data privacy can be preserved. However, deploying FL in re?source-constrained wireless networks encounters several challenges, including the limited energy of mobile devices, weak onboard computing capability, and scarce wireless band?width. To address these challenges, recent solutions have been proposed to maximize the convergence rate or minimize the energy consumption under heterogeneous constraints. In this overview, we first introduce the backgrounds and fundamentals of FL. Then, the key challenges in deploying FL in wireless networks are discussed, and several existing solu?tions are reviewed. Finally, we highlight the open issues and future research directions in FL scheduling. | SHI Wenqi SUN Yuxuan HUANG Xiufeng ZHOU Sheng NIU Zhisheng | 2020 | ZTE Communications2020，18，2： | 2 |
| 18 | The mitochondrial function was impaired in APP knockout mouse embryo fibroblast cells显示文摘The amyloid precursor protein (APP) is recognized as the source of Aβ, which plays an important role in Alzheimer’s disease. However, the biological function of APP is obscure. Previous studies showed that mitochondria could be a target of APP. In this work, APP knockout mouse embryo fibroblast (MEF) cells were used to test if APP plays any role in maintaining the mitochondrial function. As the result, APP knockout MEF cells (APP-/- cells) showed the abnormal mitochondrial function, including slower cell proliferation, lower mitochondrial membrane potential, lower intracellular ROS, higher mitochondrial membrane fluidity and lower cytochrome c oxidase activity than their wild-type counterparts. However, no change was found in the amount of mitochondria in MEF APP-/-cells. | SHENG BaiYang NIU Ying ZHOU Hui ZHOU Hui YAN JiaXin ZHAO NanMing ZHANG XiuFang GONG YanDao | 2009 | Chinese Science Bulletin2009，54，10： | 2 |
| 19 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 20 | High-efficient crystal particle manufacture by microscale process intensification technology显示文摘High-end crystal manufacture has drawn a permanent concern on the high-efficient manufacture of crystal particles,especially in fine chemical,pharmaceutical,electronics,biological and relative engineering fields.In recent years,a series of microscale process intensification(MPI)technologies have been widely used in crystal particles preparation via addressing the control of nucleation and growth process.Herein,we review the research progresses of microscale process intensification technology from three aspects,microfluidics devices,microscale force field technology and membrane-based microchannels and interface transfer process.Firstly,the principle of microfluidic and relative microscale device on improving micro-mixing and mass transfer are briefly described.The advantage of microfluidic in continuous nano particle preparation is outlined.Microscale external force field(ultrasonic,high-gravity,electric and magnetic fields)is then introduced as another novel approach for ultrafine nanoparticles and continuous drug crystallization process.Further,in view of the micro-scale intensified mass transfer and microscale interfacial force field established on membrane technology,the basic mechanism of membrane crystallization(microscale 2D supersaturation degree control,auto seed detachment,microporous membrane dispersion,etc.)is reviewed.The process coupling and design strategy aiming for enhancing the manufacture capacity is also illustrated.Finally,the developing tendency and key challenges of high-efficient crystal particle preparation technology via microscale processes are overviewed. | Yuchao Niu Shaofu Du Lei Sheng Wu Xiao Xiaobin Jiang Gaohong He | 2021 | Green Chemical Engineering2021，2，1： | 2 |
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