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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘 | Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou | 2015 | Cell Research2015，25，2： | 39 |
| 3 | Contemporary crustal deformation of the Chinese continent and tectonic block model显示文摘We obtain the preliminary result of crustal deformation velocity field for the Chinese con-tinent by analyzing GPS data from the Crustal Motion Observation Network of China (CMONOC), particularly the data from the regional networks of CMONOC observed in 1999 and 2001. We de-lineate 9 tectonically active blocks and 2 broadly distributed deformation zones out of a denseGPS velocity field, and derive block motion Euler poles for the blocks and their relative motionrates. Our result reveals that there are 3 categories of deformation patterns in the Chinese conti-nent. The first category, associated with the interior of the Tibetan Plateau and the Tianshan oro-genic belt, shows broadly distributed deformation within the regions. The third category, associatedwith the Tarim Basin and the region east of the north-south seismic belt of China, shows block-likemotion, with deformation accommodated along the block boundaries only. The second category, mainly associated with the borderland of the Tibetan Plateau, such as the Qaidam, Qilian, Xining(in eastern Qinghai), and the Diamond-shaped (in western Sichuan and Yunnan) blocks, has thedeformation pattern between the first and the third, i.e. these regions appear to deform block-like,but with smaller sizes and less strength for the blocks. Based on the analysis of the lithosphericstructures and the deformation patterns of the regions above, we come to the inference that thedeformation modes of the Chinese continental crust are mainly controlled by the crustal structure.The crust of the eastern China and the Tarim Basin is mechanically strong, and its deformationtakes the form of relative motion between rigid blocks. On the other hand, the northward indentation of the Indian plate into the Asia continent has created the uplift of the Tibetan Plateau and the Tianshan Mountains, thickened their crust, and raised the temperature in the crust. The lower crust thus has become ductile, evidenced in low seismic velocity and high electric conductivity observed. The brittle part of the crust, driven by the visco-plastic flow of the lower crust, deforms extensively at all scales. The regions of the second category located at the borderland of the Tibetan Plateau are at the transition zone between the regions of the first and the third categories in terms of the crustal structure. Driven by the lateral boundary forces, their deformation style is also between the two, in the form of block motion and deformation with smaller blocks and less internal strength. | WANG Min (王 敏) SHEN Zhengkang (沈正康) NIU Zhijun (牛之俊) ZHANG Zusheng (张祖胜) SUN Hanrong (孙汉荣) GAN Weijun (甘卫军) WANG Qi (王 琪) REN Qun (任 群) | 2003 | Science China Earth Sciences2003，46，z2： | 33 |
| 4 | Shunting branch of portal vein and stent position predict survival after transjugular intrahepatic portosystemic shunt显示文摘AIM:To evaluate the effect of the shunting branch of the portal vein(PV)(left or right)and the initial stent position(optimal or suboptimal)of a transjugular intrahepatic portosystemic shunt(TIPS).METHODS:We retrospectively reviewed 307 consecu5tive cirrhotic patients who underwent TIPS placement for variceal bleeding from March 2001 to July 2010 at our center.The left PV was used in 221 patients and the right PV in the remaining 86 patients.And,224 and83 patients have optimal stent position and sub-optimal stent positions,respectively.The patients were followed until October 2011 or their death.Hepatic encephalopathy,shunt dysfunction,and survival were evaluated as outcomes.The difference between the groups was compared by Kaplan-Meier analysis.A Cox regression model was employed to evaluate the predictors.RESULTS:Among the patients who underwent TIPS to the left PV,the risk of hepatic encephalopathy(P=0.002)and mortality were lower(P<0.001)compared to those to the right PV.Patients who underwent TIPS with optimal initial stent position had a higher primary patency(P<0.001)and better survival(P=0.006)than those with suboptimal initial stent position.The shunting branch of the portal vein and the initial stent position were independent predictors of hepatic encephalopathy and shunt dysfunction after TIPS,respectively.And,both were independent predictors of survival.CONCLUSION:TIPS placed to the left portal vein with optimal stent position may reduce the risk of hepatic encephalopathy and improve the primary patency rates,thereby prolonging survival. | Ming Bai Chuang-Ye He Xing-Shun Qi Zhan-Xin Yin Jian-Hong Wang Wen-Gang Guo Jing Niu Jie-Lai Xia Zhuo-Li Zhang Andrew C Larson Kai-Chun Wu Dai-Ming Fan Guo-Hong Han | 2014 | World Journal of Gastroenterology2014，20，3： | 26 |
| 5 | Serum vascular endothelial growth factor is a potential biomarker of metastatic recurrence after curative resection of hepatocellular carcinoma显示文摘INTRODUCTIONHepatocellular carcinoma(HCC)is one of the mostcommon malignancies in China.To date,surgery is stillthe best solution to it.However,metastatic recurrencesafter curative hepatic resections are very common.Tang etal have reported that recurrence rate within 5 years | Qi Niu Zhao You Tang Zeng Chen Ma Lun Xiu Qin Lian Hai Zhang | 2000 | World Journal of Gastroenterology2000，6，4： | 20 |
| 6 | Implementation and security analysis of practical quantum secure direct communication显示文摘Rapid development of supercomputers and the prospect of quantum computers are posing increasingly serious threats to the security of communication.Using the principles of quantum mechanics,quantum communication offers provable security of communication and is a promising solution to counter such threats.Quantum secure direct communication(QSDC)is one important branch of quantum communication.In contrast to other branches of quantum communication,it transmits secret information directly.Recently,remarkable progress has been made in proof-of-principle experimental demonstrations of QSDC.However,it remains a technical feat to bring QSDC into a practical application.Here,we report the implementation of a practical quantum secure communication system.The security is analyzed in the Wyner wiretap channel theory.The system uses a coding scheme of concatenation of lowdensity parity-check(LDPC)codes and works in a regime with a realistic environment of high noise and high loss.The present system operates with a repetition rate of 1 MHz at a distance of 1.5 kilometers.The secure communication rate is 50 bps,sufficient to effectively send text messages and reasonably sized files of images and sounds. | Ruoyang Qi Zhen Sun Zaisheng Lin Penghao Niu Wentao Hao Liyuan Song Qin Huang Jiancun Gao Liuguo Yin Gui-Lu Long | 2019 | Light(Science & Applications)2019，8，1： | 15 |
| 7 | Vacuum brazing of GH99 superalloy using graphene reinforced BNi-2 composite filler显示文摘A novel graphene reinforced BNi-2 composite filler was developed for brazing GH99 superalloy. The interfacial microstructure of brazed joints was analyzed by field emission scanning electron microscope and a transmission electron microscope. The effects of graphene addition on the microstructure evolution and mechanical properties of brazed joints were investigated, and the strengthening mechanism of graphene was analyzed. The results revealed that due to the addition of graphene, M23(C,B)6 compounds were synthesized in the solid solution and brittle boride precipitates near the brazing seam decreased.Graphene was effective in retarding solute atoms diffusion thus impeding the precipitation of borides.Furthermore, the low coefficient of thermal expansion(CTE) of graphene was conducive to relieve stress concentration of the brazed joints during the cooling process. The shear strengths of brazed joints were significantly improved by exerting the strengthening effect of graphene. The maximum shear strengths of the brazed joints were 410.4 MPa and 329.7 MPa at room temperature and 800?C, respectively. | Duo Liu Yanyu Song Bin Shi Qi Zhang Xiaoguo Song Hongwei Niu Jicai Feng | 2018 | Journal of Materials Science & Technology2018，34，10： | 10 |
| 8 | Molecular Cytogenetic Characterization and Stem Rust Resistance of Five Wheat-Thinopyrum ponticum Partial Amphiploids显示文摘Partial amphiploids created by crossing common wheat(Triticum aestivum L.) and Thinopyrum ponticum(Podp.) Barkworth & D.R.Dewey are important intermediates in wheat breeding because of their resistance to major wheat diseases.In this study,we examined the chromosome compositions of five Xiaoyan-series wheat-Th.ponticum partial amphiploids(Xiaoyan 68.Xiaoyan 693,Xiaoyan 784,Xiaoyan 7430,and Xiaoyan 7631) using GISH,multicolor-GISH.and multicolor-FISH.We found several chromosome changes in these lines.For example,wheat chromosomes 1B and 2B were added in Xiaoyan 68 and Xiaoyan 7430,respectively,while wheat chromosome6 B was eliminated from Xiaoyan 693 and Xiaoyan 7631.Chromosome rearrangements were also detected in these amphiploids.including an interspecific translocation involving chromosome 4D and some inlergenomic translocations,such as A-B and A-D translocations,among wheat genomes.Analysis of the Th.ponticum chromosomes in the amphiploids showed that some lines shared the same alien chromosomes.We also evaluated these partial amphiploids for resistance to nine races of stem rust,including TTKSK(commonly known as Ug99).Three lines,Xiaoyan 68,Xiaoyan 784,and Xiaoyan 7430,exhibited excellent resistance to ail nine races,and could therefore be valuable sources of stem rust resistance in wheat breeding. | Qi Zheng Zhenling Lv Zhixia Niu Bin Li Hongwei Li Steven S.Xu Fangpu Han Zhensheng Li | 2014 | Journal of Genetics and Genomics2014，41，11： | 9 |
| 9 | Interface-modulated fabrication of hierarchical yolk-shell Co3O4/C dodecahedrons as stable anodes for lithium and sodium storage显示文摘转变金属氧化物(TMO ) 逐渐地为锂离子电池(解放) 和钠离子电池(亲族) 作为阳极材料从研究人员吸引了注意因为他们的高理论的能力。然而,他们的差的骑车稳定性和晚辈评估能力在 lithiation/sodiation 进程和他们的低内在的电子传导性限制期间源于大卷变化他们的应用程序。解决 TMO 的问题,有从金属器官的框架(MOF ) 导出的复杂结构的基于碳的金属氧化物 composites 为解放和亲族作为有希望的电极材料出现了。在这研究,我们采用了一个灵巧的调制接口的方法综合蛋黄壳基于碳的公司 3 O 4 十二面体源于 ZIF-67 zeolitic imidazolate 框架。这策略在热分解过程期间基于在 ZIF-67 核心和基于碳的壳之间的接口分离。唯一的蛋黄壳结构有效地在 lithiation 或 sodiation 期间提供体积扩大,并且碳矩阵改进电极的电的传导性。作为为解放的阳极,蛋黄壳公司 3 O 4/C 十二面体展出一个高特定的能力和优秀骑车稳定性(1,100 mAh 潦? | Yuzhu Wu Jiashen Meng Qi Li Chaojiang Niu Xuanpeng wang Wei Yang Wei Li Liqiang Mai | 2017 | Nano Research2017，10，7： | 8 |
| 10 | Human pharmacokinetics of ginkgo terpene lactones and impact of carboxylation in blood on their platelet-activating factor antagonistic activity显示文摘Terpene lactones are a class of bioactive constituents of standardized preparations of Ginkgo biloba leaf extract, extensively used as add-on therapies in patients with ischemic cardiovascular and cerebrovascular diseases. This investigation evaluated human pharmacokinetics of ginkgo terpene lactones and impact of their carboxylation in blood. Human subjects received oral YinXing- TongZhi tablet or intravenous ShuXueNing, two standardized ginkgo preparations. Their plasma protein-binding and plateletactivating factor antagonistic activity were assessed in vitro. Their carboxylation was assessed in phosphate-buffered saline (pH 7.4) and in human plasma. After dosing YinXing-TongZhi tablet, ginkgolides A and B and bilobalide exhibited significantly higher systemic exposure levels than ginkgolides C and J; after dosing ShuXueNing, ginkgolides A, B, C, and J exhibited high exposure levels. The compounds’ unbound fractions in plasma were 45–92%. Apparent oral bioavailability of ginkgolides A and B was mostly >100%, while that of ginkgolides C and J was 6–15%. Bilobalide’s bioavailability was probably high but lower than that of ginkgolides A/B. Terminal half-lives of ginkgolides A, B, and C (4–7 h) after dosing ShuXueNing were shorter than their respective values (6–13 h) after dosing YinXing-TongZhi tablet. Half-life of bilobalide after dosing the tablet was around 5 h. Terpene lactones were roughly evenly distributed in various body fluids and tissues; glomerular-filtration-based renal excretion was the predominant elimination route for the ginkgolides and a major route for bilobalide. Terpene lactones circulated as trilactones and monocarboxylates. Carboxylation reduced platelet-activating factor antagonistic activity of ginkgolides A, B, and C. Ginkgolide J, bilobalide, and ginkgo flavonoids exhibited no such bioactivity. Collectively, differences in terpene lactones’ exposure between the two preparations and influence of their carboxylation in blood should be considered in investigating the relative contributions of terpene lactones to ginkgo preparations’ therapeutic effects. The results here will inform rational clinical use of ginkgo preparations. | Xin-wei Liu Jun-ling Yang Wei Niu Wei-wei Jia Olajide E.Olaleye Qi Wen Xiao-na Duan Yu-hong Huang Feng-qing Wang Fei-fei Du Chen-chun Zhong Yan-fen Li Fang Xu Qi Gao Li Li Chuan Li | 2018 | Acta Pharmacologica Sinica2018，39，12： | 8 |
| 11 | Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys显示文摘 | Yongchang Chen Yiqiang Cui Bin Shen Yuyu Niu Xiaoyang Zhao Lei Wang Jianying Wang Wei Li Qi Zhou Weizhi Ji Jiahao Sha Xingxu Huang | 2015 | Cell Research2015，25，2： | 8 |
| 12 | Aerodynamic control of NACA 0021 airfoil model with spark discharge plasma synthetic jets显示文摘Spark discharge plasma synthetic jets(SPJs) have been used for the active flow control study on an NACA 0021 straight-wing model in a wind tunnel. The model forces and moments were measured using a six-component sting balance at a 20 m/s wind speed. The aim was to explore the SPJ's effect on airfoil aerodynamic by examining SPJ generators' position along the chordwise and the jet flow direction about the chord. Near the wing leading edge, two SPJ generators raised the stall angle by 2° and increased the maximum lift coefficient by 9%. The drag coefficient was decreased by 33.1%, and the lift-drag ratio was increased by 104.2% at an angle of attack above 16°. The rolling-moment coefficient was modified by 0.002, and the yawing-moment coefficient was changed by 0.0007 at angles of attack in the range of 0°–16°. The results showed that SPJs can control wing aerodynamic forces at a high angle of attack and moments at a low angle of attack. | LIU RuBing NIU ZhongGuo WANG MengMeng HAO Ming LIN Qi | 2015 | Science China(Technological Sciences)2015，58，11： | 8 |
| 13 | Interleukin-18 exacerbates skin inflammation and affects microabscesses and scale formation in a mouse model of imiquimod-induced psoriasis显示文摘Background: As a potent pro-inflammatory cytokine of the interleukin (IL)-1 family, IL-18 was elevated in early active progressive plaque-type psoriatic lesions and that serum or plasma levels of IL-18 correlated with the Psoriasis Area and Severity Index (PASI). Although results from previous studies have established that IL-18 may aggravate psoriatic inflammation, the mechanisms of this process remain unknown. In this study, IL-18 knock out (KO) mice and wild-type (WT) mice were used to investigate the effects of IL-18 within a mouse model of psoriasis. Methods: WT and IL-18 KO mice were divided into four groups, including imiquimod (IMQ)-treated IL-18 KO group (w = 11) and WT group (n = 13) as well as their respectively gene-matched control mice (receiving vaseline;w = 12). PASI scores were used to evaluate psoriatic lesions in IMQ-treated mice. Pathological features and dermal cellular infiltration were investigated by hematoxylin and eosin staining. The levels of psoriasis-related cytokines including IL-23, IL-17, IL-12, IL-10, IFNγ, IL-15, IL-27, and IL-4 were tested by real-time polymerase chain reaction (PCR). The protein level of IL-1β, IL-27, CXCL1, and Ly6g were investigated by immunohistochemistry (IHC). Results: Acanthosis (98.46±14.12 vs. 222.68土71.10μm, P<0.01) and dermal cell infiltration (572.25±47.45 vs. 762.47土 59.59cells/field, P< 0.01) were significantly milder in IMQ-induced IL-18 KO mice compared with that in WT mice. IMQ-induced IL-18 KO mice manifested larger areas of Munro microabscesses (11,467.83±5112.09 vs. 4093.19±2591.88 pirn2, P< 0.01) and scales (100,935.24 ±41,167.77 vs. 41,604.41 ± 14,184.10 μm, P<0.01) as compared with WT mice. In skin lesions ot IL-18 KO mice, the expressions of IL-1β, IL-4, and IL-27 were all significantly upregulated but IL-17 was decreased. Histologically, strong positive signals of Ly6g were observed within the epidermis of IL-18 KO mice but expressions of CXCL1 were decreased. Conclusions: IL-18 may exacerbate prominent inflammation and influence pathological features in IMQ-induced mouse model of psoriasis. IL-18 may upregulate pro-inflammatory cytokines and reduce protective cytokines, thus aggravating psoriatic inflammation. In addition, IL-18 may be involved in the formation of Munro microabscesses and scales. | Xue-Li Niu Yu Huang Ya-Li Gao Yu-Zhe Sun Yang Han Hong-Duo Chen Xing-Hua Gao Rui-Qun Qi | 2019 | Chinese Medical Journal2019，，6： | 8 |
| 14 | The vernalization-induced long non-coding RNA VAS functions with the transcription factor TaRF2b to promote TaVRN1 expression for flowering in hexaploid wheat显示文摘Vernalization is a physiological process in which prolonged cold exposure establishes flowering competence in winter plants. In hexaploid wheat, TaVRN1 is a cold-induced key regulator that accelerates floral transition. However, the molecular mechanism underlying the gradual activation of TaVRN1 during the vernalization process remains unknown. In this study, we identified the novel transcript VAS (TaVRN1 alternative splicing) as a non-coding RNA derived from the sense strand of the TaVRN1 gene only in winter wheat, which regulates TaVRN1 transcription for flowering. VAS was induced during the early period of vernalization, and its overexpression promoted TaVRN1 expression to accelerate flowering in winter wheat. VAS physically associates with TaRF2b and facilitates docking of the TaRF2b-TaRF2a complex at the TaVRN1 promoter during the middle period of vernalization. TaRF2b recognizes the Sp1 motif within the TaVRN1 proximal promoter region, which is gradually exposed along with the disruption of a loop structure at the TaVRN1 locus during vernalization, to activate the transcription of TaVRN1. The tarf2b mutants exhibited delayed flowering, whereas transgenic wheat lines overexpressing TaRF2b showed earlier flowering. Taken together, our data reveal a distinct regulatory mechanism by which a long non-coding RNA facilitates the transcription factor targeting to regulate wheat flowering, providing novel insights into the vernalization process and a potential target for wheat genetic improvement. | Shujuan Xu Qi Dong Min Deng Dexing Lin Jun Xiao Peilei Cheng Lijing Xing Yuda Niu Caixia Gao Wenhao Zhang Yunyuan Xu Kang Chong | 2021 | Molecular Plant2021，14，9： | 7 |
| 15 | Mesenchymal stem cell-derived small extracellular vesicles in the treatment of human diseases:Progress and prospect显示文摘Mesenchymal stem cells(MSCs)are self-renewing,multipotent cells that could differentiate into multiple tissues.MSC-based therapy has become an attractive and promising strategy for treating human diseases through immune regulation and tissue repair.However,accumulating data have indicated that MSC-based therapeutic effects are mainly attributed to the properties of the MSC-sourced secretome,especially small extracellular vesicles(sEVs).sEVs are signaling vehicles in intercellular communication in normal or pathological conditions.sEVs contain natural contents,such as proteins,mRNA,and microRNAs,and transfer these functional contents to adjacent cells or distant cells through the circulatory system.MSC-sEVs have drawn much attention as attractive agents for treating multiple diseases.The properties of MSC-sEVs include stability in circulation,good biocompatibility,and low toxicity and immunogenicity.Moreover,emerging evidence has shown that MSC-sEVs have equal or even better treatment efficacies than MSCs in many kinds of disease.This review summarizes the current research efforts on the use of MSC-sEVs in the treatment of human diseases and the existing challenges in their application from lab to clinical practice that need to be considered. | Jie Shi Yu-Chen Zhao Zhi-Fang Niu Hao-Jun Fan Shi-Ke Hou Xiao-Qin Guo Lu Sang Qi Lv | 2021 | World Journal of Stem Cells2021，13，1： | 7 |
| 16 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 17 | Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells显示文摘 | Chong Li Song Wu Zhao Yang Xiaolong Zhang Qi Zheng Ling Lin Zexiong Niu Ruiqiang Li Zhiming Cai Lei Li | 2017 | Cell Research2017，27，4： | 7 |
| 18 | Bacillus cereus AR156 primes induced systemic resistance by suppressing miR825/825 and activating defense-related genes in Arabidopsis显示文摘Small RNAs play an important role in plant immune responses. However, their regulatory function in induced systemic resistance(ISR) is nascent. Bacillus cereus AR156 is a plant growth-promoting rhizobacterium that induces ISR in Arabidopsis against bacterial infection. Here,by comparing small RNA profiles of Pseudomonas syringae pv. tomato(Pst) DC3000-infected Arabidopsis with and without AR156 pretreatment, we identified a group of Arabidopsis micro RNAs(mi RNAs) that are differentially regulated by AR156 pretreatment. mi R825 and mi R825 are two mi RNA generated from a single mi RNA gene.Northern blot analysis indicated that they were significantly downregulated in Pst DC3000-infected plants pretreated with AR156, in contrast to the plants without AR156 pretreatment. mi R825 targets two ubiquitin-protein ligases,while mi R825 targets toll-interleukin-like receptor(TIR)-nucleotide binding site(NBS) and leucine-rich repeat(LRR)type resistance(R) genes. The expression of these target genes negatively correlated with the expression of mi R825 and mi R825. Moreover, transgenic plants showing reduced expression of mi R825 and mi R825 displayed enhanced resistance to Pst DC3000 infection, whereas transgenic plants overexpressing mi R825 and mi R825 were more susceptible. Taken together, our data indicates that Bacillus cereus AR156 pretreatment primes ISR to Pst infection by suppressing mi R825 and mi R825 and activating the defense related genes they targeted. | Dongdong Niu Jing Xia Chunhao Jiang Beibei Qi Xiaoyu Ling Siyuan Lin Weixiong Zhang Jianhua Guo Hailing Jin Hongwei Zhao | 2016 | Journal of Integrative Plant Biology2016，58，4： | 6 |
| 19 | Temperature field reconstruction of 3D luminous flames based on light field tomography theory显示文摘Standard plenoptic camera can be used to capture multi-dimensional radiation information of high temperature luminous flame to reconstruct the temperature distribution. In this study, a novel method for reconstructing three-dimensional temperature field is proposed. This method is based on the optical tomography combined with standard plenoptic camera. The flame projection information from different planes is contained in one radiation image. In this model, we introduced the effective concept of the nearest neighbor method in the frequency domain to strip the interference of redundant information in the projection and to realize three-dimensional deconvolution. The flame emission intensity received by the pixels on the charge-coupled device sensor can be obtained according to the optical tomographic model. The temperature distributions of the axisymmetric and nonaxisymmetric flames can be reconstructed by solving the mathematical model with the nearest neighbor method. The numerical results show that three-dimensional temperature fields of high temperature luminous flames can be retrieved, proving the validity of the proposed method. | NIU ZhiTian QI Hong SHI JingWen ZHANG JuQi REN YaTao | 2021 | Science China(Technological Sciences)2021，64，2： | 6 |
| 20 | A transceptor-channel complex couples nitrate sensing to calcium signaling in Ambidopsis显示文摘Nitrate-induced Ca^(2+) signaling is crucial for the primary nitrate response in plants.However,the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains unknown.We report here that a cyclic nucleotide-gated channel(CNGC)protein,CNGC15,and the nitrate transceptor(NRT1.1)constitute a molecular switch that controls calcium influx depending on nitrate levels.The expression of CNGC15 is induced by nitrate,and its protein is localized at the plasma membrane after establishment of young seedlings.We found that disruption of CNGC15 results in the loss of the nitrate-induced Ca^(2+) signature(primary nitrate response)and retards root growth,reminiscent of the phenotype observed in the nrt1.1 mutant.We further showed that CNGC15 is an active Ca^(2+)-permeable channel that physically interacts with the NRT1.1 protein in the plasma membrane.Importantly,we discovered that CNGC15-NRT1.1 interaction silences the channel activity of the heterocomplex,which dissociates upon a rise in nitrate levels,leading to reactivation of the CNGC15 channel.The dynamic interactions between CNGC15 and NRT1.1 therefore control the channel activity and Ca^(2+) influx in a nitrate-dependent manner.Our study reveals a new nutrient-sensing mechanism that utilizes a nutrient transceptor-channel complex assembly to couple nutrient status to a specific Ca^(2+) signature. | Xiaohan Wang Changxin Feng LiLi Tian Congcong Hou Wang Tian Bin Hu Qian Zhang Zhijie Ren Qi Niu Jiali Song Dongdong Kong Liangyu Liu Yikun He Ligeng Ma Chengcai Chu Sheng Luan Legong Li | 2021 | Molecular Plant2021，14，5： | 5 |
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