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| 1 | Engineering application of membrane bioreactor for wastewater treatment in China: Current state and future prospect显示文摘中国是大规模膜生物反应器(MBR ) 的 forerunner 申请。自从第一大规模 MBR (10 000 m < 啜 class= “ a-plus-plus ” > 3 湩朠潯 ? 慦瑩? | Kang XIAO Ying XU Shuai LIANG Ting LEI Jianyu SUN Xianghua WEN Hongxun ZHANG Chunsheng CHEN Xia HUANG | 2014 | Frontiers of Environmental Science & Engineering2014，8，6： | 26 |
| 2 | The effect of subcutaneous injection duration on patients receiving low-molecular-weight heparin:Evidence from a systematic review显示文摘To assess the effect of the injection duration of subcutaneous low-molecular-weight heparin(LMWH)on pain and bruising in patients.Randomized controlled trials and quasiexperimental studies were searched for in four electronic databases.The pooled effect size was expressed as relative risk(RR)andmeandifference(MD)with95%confidence intervals(CI)for dichotomous and continuous data.Cochrane Q and p value were used to assess heterogeneity and the I2 statistic was adopted to quantify the level.Finally,eight studies involving a total of 532 participants met our inclusion criteria.The slow(30 second)injection was associated with a reduction in pain intensity and duration,and lower bruising occurrence at 48-72 hours and 48 hours post injection.The bruising area was also smaller at 48 hours and 60 hours post injection.Nodifferenceswere identified betweenthe slowand fast(10 second)injectionin bruising area and bruising occurrence at 24 hours and 60 hours post injection.With present evidences,slow injection of LMWH is beneficial to the patient's well being,but further studies to identify the feasibility and standardization of the technique is recommended. | Li-juan Yi Ting Shuai Xu Tian Zi Zeng Li Ma Guo-min Song | 2016 | International Journal of Nursing Sciences2016，3，1： | 12 |
| 3 | Very high baseline HIV viremia impairs efficacy of non-nucleoside reverse transcriptase inhibitor-based ART:a longterm observation in treatment-naïve patients显示文摘Background:It is not completely clear whether a very high pre-therapy viral load(≥500000 copies/ml)can impair the virological response.The aim of this study was to examine the influence of very high baseline HIV-RNA levels on long-term virological responses under one type of regimen.Methods:A retrospective study was performed based on data from two multicenter cohorts in China from January to November 2009,and from May 2013 to December 2015.Untreated HIV infected adults between 18 and 65 years old were recruited before receiving non-nucleoside reverse transcriptase inhibitor-based regimen.All patients had baseline HIV-RNA levels over 500 copies/ml,good adherence,and were followed for at least 24 weeks.Virological suppression was defined as the first HIV-RNA<50 copies/ml.Virological failure was defined as any of incomplete viral suppression(HIV-RNA≥200 copies/ml without virological suppression within 24 weeks of treatment)and viral rebound(confirmed HIV-RNA level≥50 copies/ml after virological suppression).Chi-square test,Kaplan–Meier analysis,Cox proportional hazards model and Logistic regression were used to compare virological response between each pretreated viral load stratum.Results:A total of 758 treatment-naïve HIV patients in China were enlisted.Median follow-up time(IQR)was 144(108–276)weeks.By week 48,rates of virological suppression in three groups(<100000,100000–500000 and≥500000 copies/ml)were 94.1,85.0,and 63.8%,respectively(P<0.001).Very high baseline HIV viremia over 500000 copies/ml were found to be associated with delayed virological suppression(≥500000 vs<100000,adjusted relative hazard=0.455,95%CI:0.32–0.65;P<0.001)as well as incomplete viral suppression(≥500000 vs<100000,adjusted odds ratio[aOR]=6.084,95%CI:2.761–13.407;P<0.001)and viral rebound(≥50000 vs<100000,aOR=3.671,95%CI:1.009–13.355,P=0.048).Conclusions:Very high levels of pre-treatment HIV-RNA were related with delayed efficacy of NNRTI-based ART and increased risk of treatment failure.More potent initial regimens should be considered for those with this clinical character. | Shuai Chen Yang Han Xiao-Jing Song Yan-ling Li Ting Zhu Hong-Zhou Lu Xiao-Ping Tang Tong Zhang Min Zhao Yun He Sheng-Hua He Min Wang Yong-Zhen Li Shao-Biao Huang Yong Li Jing Liu Wei Cao Tai-Sheng Li | 2020 | Infectious Diseases of Poverty2020，9，3： | 10 |
| 4 | Forest canopy height mapping over China using GLAS and MODIS data显示文摘The Geoscience Laser Altimeter System(GLAS)accurately detects the vertical structural information of a target within its laser spot and is a promising system for the inversion of structural features and other biophysical parameters of forest ecosystems.Since the GLAS footprints are discontinuously distributed with a relativity low density,continuous vegetation height distributions cannot be mapped with a high accuracy using GLAS data alone.The MODIS BRDF product provides more forest structural information than other optical remote sensing data.This study aimed to map forest canopy heights over China from the GLAS and MODIS BRDF data.Firstly,the waveform characteristic parameters were extracted from the GLAS data by the method of wavelet analysis,and the terrain index was calculated using the ASTER GDEM data.Secondly,the model reducing the topographic influence was constructed from the waveform characteristic parameters and terrain index.Thirdly,the final canopy height estimation model was constructed from the neural network combining the canopy height estimated with the GLAS point and the MODIS BRDF data,and applied to get the continuous canopy height map over China.Finally,the map was validated by the measured data and the airborne Li DAR data,and the validation results indicated that forest canopy heights can be estimated with high accuracy from combined GLAS and MODIS data. | YANG Ting WANG Cheng LI GuiCai LUO SheZhou XI XiaoHuan GAO Shuai ZENG HongCheng | 2015 | Science China Earth Sciences2015，58，1： | 8 |
| 5 | nvolvement of collagen-binding heat shock protein 47 in scleroderma-associated fibrosis显示文摘 | Haiyan Chu Ting Wu Wenyu Wu Wenzhen Tu Shuai Jiang Sidi Chen Yanyun Ma Qingmei Liu Xiaodong Zhoua Li Jin Jiucun Wang | 2015 | Protein & Cell2015，6，8： | 5 |
| 6 | Gradient distribution of radial structure of PAN-based carbon fiber treated by high temperature显示文摘High-performance graphite fibers were prepared and analyzed. The gradient distribution of radial structure of PAN-based carbon fibers was characterized by two different Raman test methods(incident laser beam perpendicular to and parallel to the fiber axis) and studied by the distribution of graphitization degree. Meanwhile difference between the two Raman test methods was used to describe the orientation of the graphite crystallite along the fiber axis. The results showed that the radial structure of PAN-based carbon fiber presented different gradient distribution states at different heat treatment temperatures,and the graphitization degree in the skin region changed more rapidly compared with the core region since the skin region was more affected by temperature which resulted in the obvious difference between skin and core structures.The difference of graphitization degree(Δg) characterized by two different Raman test methods increased with heat treatment temperature,indicating that the high temperature treatment(HTT) promoted further stacking of graphite crystallite,and the orientation degree of the graphite crystallite along the fiber axis was continuously increased. | Haitao Wang Yu Wang Ting Li Shuai Wu Lianghua Xu | 2014 | Progress in Natural Science:Materials International2014，24，1： | 5 |
| 7 | Rapid Identification of Legionella Pathogenicity by Surface-Enhanced Raman Spectroscopy显示文摘Objective To establish Surface-enhanced Raman Spectroscopy(SERS) can be used as a rapid and reliable method to distinguish virulent strain and mild strain of L. pneumophila. Methods We isolated and characterized of bacterial strains from ATCC and water samples strains, while we analyzed data from SERS technology using gold nanoparticles as a base and cell infections were employed to rapidly detect L. pneumophila strains. Origin 8.0 was used to collect Raman spectra, smooth and homogenize data, and to contrast spectra. Principal component analysis(PCA) was conducted to discriminate differences between groups using the multivariate analysis package Py Chem 3.0.5. Results Our results indicated that the peaks of high virulence strains reached ≥4000. This criterion was verified by subsequent cell experiments. In addition, we also conducted SERS rapid identification on the virulence of several collected clinical strains and obtained accurate results. Conclusion The present study indicates that the established SERS protocol can be used as a rapid and reliable method to distinguish virulent and mildly virulent strains of L. pneumophila, which can be further used in clinical samples. | LI Jing QIN Tian JIA Xiao Xiao DENG Ai Hua ZHANG Xu FAN Wen Hui HUO Shuai Dong WEN Ting Yi LIU Wen Jun | 2015 | Biomedical and Environmental Sciences2015，28，6： | 4 |
| 8 | A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis显示文摘A new derivative of triterpene named Erigeronol 1 was isolated from the EtOH extract of the aerial part of Conyza canadensis together with 15 known compounds for the first time from this plant.The structure of Erigeronol 1 was elucidated as 3-O-(hydroxyacetyl) -23,28-dihydroxy-β-amyrin by hydrolysis and spectroscopic analysis.Erigeronol 1 showed potent cytotoxic activity with IC_(50) value of 7.77±0.47μg/mL against melanoma B16 determined by the 3-(4,5-dimethylthiazo-2-yl)-2,5-diphenyltetrazolium bromide(MTT) method. | Ming Ming Yan Ting You Li Da Qing Zhao Shuai Shao Sheng Nan Bi | 2010 | Chinese Chemical Letters2010，21，7： | 4 |
| 9 | Shape-Controlled CuCl Crystallite Catalysts for Aniline Coupling显示文摘The catalytic activity of crystallites depends mainly upon the arrangement of surface atoms,the number of dangling bonds,and defect site distribution on different crystal planes.Here,we report the shape-controlled synthesis of CuCl crystallites,including tetrahedra,face-centered-etched tetrahedra,tripod dendrites,and tetrapods.These different morphologies of CuCl crystallites expose different proportions of{111}and{110}crystal planes,and materials with a preponderance of{111}crystal planes have better catalytic activity in aniline coupling than those with more{110}planes. | Ting Xie Ming Gong Zhiqiang Niu Shuai Li Xiaoyu Yan Yadong Li | 2010 | Nano Research2010，3，3： | 4 |
| 10 | ERF4 affects fruit ripening by acting as a JAZ interactor between ethylene and jasmonic acid hormone signaling pathways显示文摘The regulation of apple(Malus domestica)fruit texture during ripening is complex and a fundamental determinant of its commercial quality.In climacteric fruit,ripening-related processes are regulated by ethylene(ET),and jasmonate(JA)is also involved in the ethylene biosynthesis pathway,mainly through the transcription factor MYC2.However,the molecular genetic mechanism for fruit ripening processes between the JA and ET signaling pathways still needs to be elucidated.In order to explore how JA regulates apple fruit ripening through ERF4,we used’Gala’and’Ralls Janet’fruit at different developmental stages as experimental materials to determine the fruit firmness and related gene expression analysis.Meanwhile,we carried out different hormone treatments on’Gala’fruit at ripening stage.Here,we show that ERF4 is a core JA signaling hub protein JASMONATE ZIM-DOMAIN(JAZ)interactor that affects ethylene signaling pathways.During fruit development,ERF4 represses the expression of ACS1 and ACO1 by interacting with JAZ,as well as with the JA-activated transcription factor MYC2.Ripening is promoted in JAZ-suppressed apples.Thus,ERF4 acts as a molecular link between ethylene and JA hormone signals,and the natural variation of the ERF4Ethylene-responsive binding factor-associated amphiphilic repression(EAR)motif decreases repression of ethylene biosynthesis genes. | Yanan Hu Hualin Sun Zhenyun Han Shuai Wang Ting Wang Qiqi Li Ji Tian Yi Wang Xinzhong Zhang Xuefeng Xu Zhenhai Han Ting Wu | 2022 | Horticultural Plant Journal2022，8，6： | 2 |
| 11 | Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy显示文摘UTX(also known as KDM6A),a histone 3 lysine 27 demethylase,is among the most frequently mutated epigenetic regulators in myelodysplastic syndrome(MDS)and acute myeloid leukemia(AML).Recent studies have suggested that UTX mutations promote MDS and AML by blocking the differentiation of hematopoietic stem and progenitor cells(HSPCs).Here,we performed an epigenetic drug library screening for small molecules able to release the differentiation block on HSPCs induced by UTX deficiency.We found that SP2509,a selective inhibitor of LSD1,specifically promoted the differentiation of Utx-null HSPCs while sparing wild-type HSPCs.Transcriptome profiling showed that Utx loss reduced the expression of differentiation-related and tumor suppressor genes,correlating with their potential roles in HSPC self-renewal and leukemogenesis.In contrast,SP2509 treatment reversed these changes in gene expression in Utx-null HSPCs.Accordingly,Utx loss decreased H3K4 methylation level probably through the COMPASS-like complex,while LSD1 inhibition by SP2509 partially reversed the reduction of H3K4 methylation in Utx-deficient HSPCs.Further,SP2509 promoted the differentiation of Utx-null AML cells in vitro and in vivo and,therefore,extended the survival of these leukemic mice.Thus,our study identified a novel strategy to specifically target both premalignant and malignant cells with Utx deficiency for differentiation therapy and provided insights into the molecular mechanisms underlying the role of Utx in regulating HSPCs and related diseases. | Baohong Wu Xiangyu Pan Xuelan Chen Mei Chen Kaidou Shi Jing Xu Jianan Zheng Ting Niu Chong Chen Xiao Shuai Yu Liu | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 12 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 13 | A- nalysis and Numerical Simulation of GFP-SN An- chorage Mechanism on Laboratory Pullout Tests 显示文摘 | ZHU Chuancheng FU Shaojun SHUAI Ting | 2011 | Applied Mechanics and Materials2011，6668，： | 1 |
| 14 | Chewing gum for postoperative ileus after colorectal surgery:A systematic review of overlapping meta-analyses显示文摘Background:Many meta-analyses investigating gum chewing for postoperative recovery after colorectal surgery have been published with inconsistent findings.Therefore,we performed this study to systematically review these overlapping meta-analyses and offer clinical recommendations based on the current best evidence for decision makers.Methods:Multiple databases,including PubMed,EMBASE,Cochrane Library,Chinese BioMedical Literature on disc(CBMdisc),China National Knowledge Infrastructure(CNKI),Chinese Wanfang and Chinese VIP,were searched through October 2016.We included meta-analyses investigating the effectiveness of chewing gum for postoperative ileus after colorectal resection.Two investigators independently scanned and evaluated eligible meta-analyses,extracted essential information,assessed the methodological quality with the Assessment of Multiple Systematic Reviews(AMSTAR) tool and Oxford Levels of Evidence,and used the Jadad decision algorithm at each step for all procedures.Heterogeneity ≤50%was accepted.Results:Ten meta-analyses were included in our study.The AMSTAR scores varied from 5 to 9,with a median of 7.7.Most heterogeneity fell into the acceptable range.After implementing the Jadad decision algorithm,two meta-analyses of RCTs were selected based on search strategies and the implications of selection.The available best evidence indicated that gum chewing significantly reduced time to first flatus,time to first bowel movement,time to first bowel sounds and length of hospital stay.However,these two meta-analyses reached inconsistent conclusions as to the complications and economic benefits.Conclusions:With the current best available evidence,we suggest gum chewing is beneficial for gastrointestinal function and reducing postoperative ileus. | Hui Zhang Yong-Hong Deng Ting Shuai Guo-Min Song | 2017 | Chinese Nursing Research2017，4，2： | 1 |
| 15 | A high-quality genome provides insights into the new taxonomic status and genomic characteristics of Cladopus chinensis(Podostemaceae)显示文摘The Podostemaceae are ecologically and morphologically unusual aquatic angiosperms that survive only in rivers with pristine hydrology and high water quality and are at a relatively high risk of extinction.The taxonomic status of Podostemaceae has always been controversial.Here,we report the first high-quality genome assembly for Cladopus chinensis of Podostemaceae,obtained by incorporating Hi-C,Illumina and PacBio sequencing.We generated an 827.92 Mb genome with a contig N50 of 1.42 Mb and 27,370 annotated protein-coding genes.The assembled genome size was close to the estimated size,and 659.42 Mb of the assembly was assigned to 29 superscaffolds(scaffold N5021.22 Mb).A total of 59.20%repetitive sequences were identified,among which long terminal repeats(LTRs)were the most abundant class(28.97%of the genome).Genome evolution analysis suggested that the divergence time of Cladopus chinensis(106 Mya)was earlier than that of Malpighiales(82 Mya)and that this taxon diverged into an independent branch of Podestemales.A recent whole-genome duplication(WGD)event occurred 4.43 million years ago.Comparative genomic analysis revealed that the expansion and contraction of oxidative phosphorylation,photosynthesis and isoflavonoid metabolism genes in Cladopus chinensis are probably related to the genomic characteristics of this growing submerged species.Transcriptome analysis revealed that upregulated genes in the shoot group compared to the root group were enriched in the NAC gene family and transcription factors associated with shoot development and defense responses,including WUSCHEL(WUS),ASYMMETRIC LEAVES(ASL),SHOOT MERISTEMLESS(STM),NAC2,NAC8,NAC29,NAC47,NAC73,NAC83 and NAC102.These findings provide new insights into the genomic diversity of unusual aquatic angiosperms and serve as a valuable reference for the taxonomic status and unusual shoot apical meristem of Podostemaceae. | Ting Xue Xuehai Zheng Duo Chen Limin Liang Nan Chen Zhen Huang Wenfang Fan Jiannan Chen Wan Cen Shuai Chen Jinmao Zhu Binghua Chen Xingtan Zhang Youqiang Chen | 2020 | Horticulture Research2020，7，1： | 1 |
| 16 | Charge resolution in the isochronous mass spectrometry and the mass of ^(51)Co显示文摘Isochronous mass spectrometry(IMS)of heavyion storage rings is a powerful tool for the mass measurements of short-lived nuclei.In IMS experiments,masses are determined through precision measurements of the revolution times of the ions stored in the ring.However,the revolution times cannot be resolved for particles with nearly the same mass-to-charge(m/q)ratios.To overcome this limitation and to extract the accurate revolution times for such pairs of ion species with very close m/q ratios,in our early work on particle identification,we analyzed the amplitudes of the timing signals from the detector based on the emission of secondary electrons.Here,the previous data analysis method is further improved by considering the signal amplitudes,detection efficiencies,and number of stored ions in the ring.A sensitive Z-dependent parameter is introduced in the data analysis,leading to a better resolution of ^(34)Ar^(18+) and ^(51)Co^(27+) with A/Z=17/9.The mean revolution times of ^(34)Ar^(18+) and ^(51)Co^(27+) are deduced,although their time difference is merely 1.8 ps.The uncorrected,overlapped peak of these ions has a full width at half maximum of 7.7 ps.The mass excess of ^(51)Co was determined to be-27;332e41T keV,which is in agreement with the previous value of-27;342e48T keV. | Xu Zhou Meng Wang Yu-Hu Zhang Hu-Shan Xu You-Jin Yuan Jian-Cheng Yang Yu.A.Litvinov S.A.Litvinov Bo Mei Xin-Liang Yan Xing Xu Peng Shuai Yuan-Ming Xing Rui-Jiu Chen Xiang-Cheng Chen Chao-Yi Fu Qi Zeng Ming-Ze Sun Hong-Fu Li Qian Wang Tong Bao Min Zhang Min Si Han-Yu Deng Ming-Zheng Liu Ting Liao Jin-Yang Shi Yu-Nan Song | 2021 | Nuclear Science and Techniques2021，32，4： | 1 |
| 17 | Functional Characteristics of Beijing Subway Stations Based on POI Data:Taking Beijing Metro Line 6 as An Example显示文摘Urban subway station is a key node related to urban social,political,economic and cultural activities.There are some differences in the location,function orientation,land use and flow characteristics of different types of stations in the city.This paper mainly used Tyson’s edge,kernel density analysis,chart analysis and other methods to classify the functional types of 412,393 POI data of 26 stations along Metro he results showed that the spatial distribution of Beijing Metro Line 6 was mainly divided into 3 categories,subway stations were divided into 4 categories.Among them,type A sites were divided into composite and single types,and the distribution characteristics of the 6 types of sites were quite different.Based on the qualitative and quantitative analysis of POI point data,this method can quickly classify and analyze the characteristics of stations along Line 6 in Beijing,which also has theoretical and practical value for the planning of urban subway lines. | SUN Shuai LIU Ting AI Jie | 2023 | Journal of Landscape Research2023，15，3： | 1 |
| 18 | Screening for musculoskeletal system malformations and birth injuries in newborns:Results of a screening program in two hospitals in Shenzen,China显示文摘Importance:There are a variety of musculoskeletal malformations and injuries that can occur in newborns.These can be a significant cause of perinatal death or a reason for miscarriage and can lead to long-term functional issues if not managed appropriately.There is no systematic and well-established screening program for neonatal musculoskeletal malformations and injuries in China now.Objective:To report the incidence and types of congenital musculoskeletal malformations in two hospitals in Shenzhen City,to explore and discuss the details of the screening procedure and improve future prevention and treatment.Methods:From October 2013 to May 2014,2564 one-day-old newborns were screened by a pediatric orthopedic physical examination,in combination with ultrasonography when required,and the incidence and variety of diseases were recorded statistically.Results:Among 2564 screened newborns,the following musculoskeletal conditions were identified:congenital muscular torticollis(CMT)(seven cases,0.27%),hip subluxation(four cases,0.16%),hip dysplasia(47 cases,1.83%),congenital talipes equinovarus(CTEV)(two cases,0.08%),congenital talipes calcaneovalgus(15 cases,0.58%),polydactyly(nine cases,0.35%),syndactyly(one case,0.04%),and spinal hemivertebra(one case,0.04%).Additionally,there were five(0.19%)neonates with birth injuries.Interpretation:It is feasible to carry out neonatal screening and identification of musculoskeletal malformations and birth injuries in China.This is helpful as timely detection and early intervention for many of these conditions can avoid permanent functional impairment in these children. | Zhu Xiong Zhenhui Zhao Hansheng Deng Xin Qiu Weiqing Li Xiaodi Chen Yu Tang Shuai Han Jiaxin Zhao Ting Cai Xian Liu Shuaidan Zeng Shengping Tang | 2022 | Pediatric Investigation2022，6，3： | 1 |
| 19 | Ex vivo expanded human circulating Vδ1 γδT cells exhibit favorable therapeutic potential for colon cancer显示文摘 | Dang Wu Pin Wu Xianguo Wu Jun Ye Zhen Wang Shuai Zhao Chao Ni Guoming Hu Jinghong Xu Yuehua Han Ting Zhang Fuming Qiu Jun Yan Jian Huang | 2015 | OncoImmunology2015，，3： | 1 |
| 20 | Geometrical design of variable ratio tooth profile based on Boolean subtraction operation and a novel modification method显示文摘Variable transmission ratio racks show great potential in rice transplanters as a key component of variable transmission ratio steering to balance steering portability and sensitivity.The objective of this study was to develop a novel geometrical design method to achieve quick,high-quality modeling of the free curvilinear tooth profile of a variable transmission ratio rack.First,a discrete envelope motion 3D model was established between the pinion-sector and the variable transmission ratio rack blank based on the mapping relationship between the rotation angle of the pinion-sector and the displacement of the rack,according to the variable transmission ratio function.Based on the loop Boolean subtraction operation,which removed the pinion-sector from the rack blank during all moments of the discrete motion process,the final complex changing tooth shape of the variable transmission ratio rack was enveloped.Then,since Boolean cutting residues made the variable ratio tooth surface fluctuant and eventually affected the precision of the model,this study proposed a modification method for establishing a smooth and continuous tooth profile.First,a novel fitting algorithm used approximate variable ratio tooth profile points extracted from the Boolean cutting marks and generated a series of variable ratio tooth profiles by utilizing B-spline with different orders.Next,based on a transmission stability simulation,the variable ratio tooth profile with optimal dynamic performance was selected as the final design.Finally,tests contrasting the transmission stability of the machining samples of the initial variable ratio tooth profile and the final variable ratio tooth profile were conducted.The results indicated that the final variable ratio tooth profile is more effective than the initial variable ratio tooth profile.Therefore,the proposed variable ratio tooth profile modeling and modification method for eliminating Boolean cutting residues and improving surface accuracy is proved to be feasible. | Ziru Niu Jianlei Li Shuai Xin Liangliang Zou Yuhua Li Jialin Hou Ming Tu Ting Sun | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 1 |
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