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| 1 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 2 | Low-cost and high-strength Mg-Al-Ca-Zn-Mn wrought alloy with balanced ductility显示文摘A novel low-cost Mg-Al-Ca-Zn-Mn-based alloy was developed to simultaneously improve its strength and ductility.The high yield strength of 411 MPa and the high elongation to failure of~8.9%have been achieved in the as-extruded Mg-1.3Al-1.2Ca-0.5Zn-0.6Mn(wt%)sample.Microstructure characterizations showed that the high strength is mainly associated with the ultra-fined dynamically recrystallized(DRXed)grains.Moreover,high-density dislocations in the un-DRXed region and nano-precipitates are distributed among theα-Mg matrix.The high ductility property can be ascribed to the high volume fraction of DRXed grains with a much randomized texture,as well as the formations of high-density subgrains in the un-DRXed grain regions. | Kun Yang Hucheng Pan Sen Du Man Li Jingren Li Hongbo Xie Qiuyan Huang Huajun Mo Gaowu Qin | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，7： | 3 |
| 3 | An Fe-N/S-C hybrid electrocatalyst derived from bimetal-organic framework for efficiently electrocatalyzing oxygen reduction reaction in acidic media显示文摘Heteroatoms doped Fe-N-C electrocatalysts have been widely acknowledged as one of the most promising candidates to replace Pt-based materials for electrocatalyzing oxygen reduction reaction(ORR).However,the complicated synthesis method and controversial catalytic mechanism represent a substantial impediment as of today.Herein,a very facile strategy to prepare Fe-N/S-C hybrid through pyrolyzing Zn and Fe bimetallic MOFs is rationally designed.The electrocatalytic ORR performance shows a volcanotype curve with the increment of added Fe content.The half-wave potential(E1/2) for ORR at optimized Fe-N/S-C-10%(10%=n(Fe)/(n(Fe)+n(Zn)),n(Fe) and n(Zn) represent the moles of Fe2+ and Zn2+ in the precursors,respectively) shifts significantly to the positive direction of 19.6 mV with respect to that of Pt/C in acidic media,as well as a high 4 e selectivity and methanol tolerance.After 10,000 potential cycles,E1/2 exhibits a small negative shift of-27.5 mV at Fe-N/S-C-10% compared favorably with Pt/C(~141.0 mV).This can be attributed to:(ⅰ) large specific surface area(849 m^(2)/g) and hierarchically porous structure are favorable for the rapid mass transfer and active sites exposure;(ⅱ) the embedded Fecontaining nanoparticles in porous carbon are difficult to be moved and further agglomerated during the electrochemical accelerated aging test,further improving its stability;(ⅲ) there exist small Fecontaining nanoparticles,uniformly doped N and S,abundant Fe-N as efficiently active sites.This work represents a breakthrough in the development of high-efficient non-precious-metal catalysts(NPMCs)to address the current Pt-based electrocatalysts challenges. | Shuqin Song Mingmei Wu Junwei Chen Zhuohua Mo Rui Chen Kun Wang Tongwen Yu | 2021 | Journal of Energy Chemistry2021，30，1： | 2 |
| 4 | Influence of lunar regolith compressibility on sampling performance of thick wall spiral drills显示文摘A 2 m class robotic drill was sent to the Moon and successfully collected and returned regolith samples in late 2020 by China.It was a typical thick wall spiral drill(TWSD)with a hollow auger containing a complex coring system to retain subsurface regolith samples.Before the robotic drill was launched,a series of laboratory tests were carried out to investigate and predict the possible drilling loads it may encounter in the lunar environment.This work presents how the sampling performance of the TWSD is affected by the regolith compressibility.Experiments and analysis during the drilling and sampling process in a simulated lunar regolith environment were conducted.The compressibility of a typical lunar regolith simulant(LRS)was measured through unidirectional compression tests to study the relationship between its inner regolith stress and bulk density.A theoretical model was established to elucidate the cutting discharge behavior by auger flights based on the aforementioned relationship.Experiments were conducted with the LRS,and the results show that the sampling performance is greatly affected by the flux of the drilled cuttings into the spiral flight channels.This work helped in scheduling reasonable drilling parameters to promote the sampling performance of the robotic drill in the Chinese Chang’E 5 mission. | Yong PANG Tao ZHANG Hongyu WEI Ting ZENG Yinliang ZHANG Guidong MO Kun XU Shen YIN Guoxin WANG Xingwang ZHANG Xiaoming LAI Xilun DING | 2023 | Chinese Journal of Aeronautics2023，36，2： | 2 |
| 5 | Defective point data reconstruction based on improved process of morphological operations显示文摘In industry,the defective point data often make most surface reconstruction methods suffer from inherent problems that some specific aided information is difficult to obtain. To solve the problem,a novel implicit reconstruction method without any such information is proposed. This approach extends morphological operations into 3D space and provides an improved procedure to construct off-set gradient functions for indirect approximation. By this method,the dual relative functions guarantee a minimal crust surrounding the point data. They can generate a smooth and watertight resulting surface,filling holes and merging overlapping samples reasonably. Compared with other existing methods,the proposed method is better suited to handle defective point clouds in a convenient and efficient manner. The feasibility and effectiveness of the method are demonstrated through a series of practical examples. | YIN ZhouPing MO Kun XIONG YouLun | 2011 | Science China(Technological Sciences)2011，54，12： | 2 |
| 6 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 7 | Estimation of the environment credit for the recycling of granulated blast furnace slag based on LCA显示文摘 | Kun - Mo Lee Pil - Ju Park | 2005 | Resources Conservation & Recycling2005，44，： | 1 |
| 8 | Eco- efficien- cy for Pollution Prevention in Small to Medium-Sized Enterprises: A Case from South Korea显示文摘 | Sangwon Suh Kun Mo Lee Sangsun Ha | 2005 | Journalof In- dustrial Ecology2005，，4： | 1 |
| 9 | Extracorporeal endotoxin removal by novel l -serine grafted PVDF membrane modules显示文摘 | Mo Zhang Lin Zhang Li-Hua Cheng Kun Xu Qiu-Ping Xu Huan-Lin Chen Juin-Yih Lai Kuo-Lun Tung | 2012 | Journal of Membrane Science2012，，： | 1 |
| 10 | Combined performance of biochar sorption and magnetic separation processes for treatment of chromium-contained electroplating wastewater显示文摘 | Sheng-ye Wang Yan-kui Tang Kun Li Ya-yuan Mo Hao-feng Li Zhan-qi Gu | 2014 | Bioresource Technology2014，，： | 1 |
| 11 | Miscibility and Shape Memory Effect of Thermoplastic Polyurethane Blends with Phenoxy Resin 显示文摘 | Han Mo Jeong Byounq Kun Ahn Byounq Kun Kim | 2001 | European Polymer Journal2001，37，11： | 1 |
| 12 | Highly conductive SiC ceramics containing Ti 2 CN显示文摘 | Kwang Joo Kim Kun Mo Kim Young-Wook Kim | 2013 | Journal of the European Ceramic Society2013，，： | 1 |
| 13 | Shape memory polyurethane containing amorphous reversible phase显示文摘 | Hah Mo Jeong Byoung Kun Ahn Seong Mo Cho | 2000 | Journal of polymer science: part B:polymer physics2000，38，2： | 1 |
| 14 | Highly conductive SiC ceramics containing TiE CN 显示文摘 | Kwang Joo Kim Kun Mo Kim Young-Wook Kim | 2014 | Journal of the European Ceram- ic Society2014，34，5： | 1 |
| 15 | Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells显示文摘Ovarian cancer is one of the most common gynecologic malignancies in women and has a poor prognosis.Taxanes are a class of standard first-line chemotherapeutic agents for the treatment of ovarian cancer.However,tumor-intrinsic and acquired resistance to taxanes poses major challenges to improving clinical outcomes.Hence,there is an urgent clinical need to understand the mechanisms of resistance in order to discover potential biomarkers and therapeutic strategies to increase taxane sensitivity in ovarian cancer.Here,we report the identification of an association between the TP53 status and taxane sensitivity in ovarian cancer cells through complementary experimental and informatics approaches.We found that TP53 inactivation is associated with taxane resistance in ovarian cancer cells,supported by the evidence from(i)drug sensitivity profiling with bioinformatic analysis of large-scale cancer therapeutic response and genomic datasets and(ii)gene signature identification based on experimental isogenic cell line models.Further,our studies revealed TP53-dependent gene expression patterns,such as overexpression of ACSM3,as potential predictive biomarkers of taxane resistance in ovarian cancer.The TP53-dependent hyperactivation of the WNT/β-catenin pathway discovered herein revealed a potential vulnerability to exploit in developing combination therapeutic strategies.Identification of this genotype-phenotype relationship between the TP53 status and taxane sensitivity sheds light on TP53-directed patient stratification and therapeutic discoveries for ovarian cancer treatment. | Changfa Shu Xi Zheng Alafate Wuhafu Danielle Cicka Sean Doyle Qiankun Niu Dacheng Fan Kun Qian Andrey AIvanov Yuhong Du Xiulei Mo Haian Fu | 2022 | Acta Pharmacologica Sinica2022，43，9： | 1 |
| 16 | Two- and three-dimensional numerical simulations of natural convection in a cylindrical envelope with an internal concentric cylinder with slots显示文摘 | Kun Zhang Mo Yang Yuwen Zhang | 2014 | International Journal of Heat and Mass Transfer2014，，： | 1 |
| 17 | Spatial and temporal patterns of the sensitivity of radial growth response by Picea schrenkiana to regional climate change in the Tianshan Mountains显示文摘Climate change significantly impacts forest ecosystems in arid and semi-arid regions.However,spatiotemporal patterns of climate-sensitive changes in individual tree growth under increased climate warming and precipitation in north-west China is unclear.The dendrochronological method was used to study climate response sensitivity of radial growth of Picea schrenkiana from 158 trees at six sites during 1990-2020.The results show that climate warming and increased precipitation significantly promoted the growth of trees.The response to temperature first increased,then decreased.However,the response to increased precipitation and the self-calibrating Palmer Drought Severity Index(scPDSI)increased significantly.In most areas of the Tianshan Mountains,the proportion of trees under increased precipitation and scPDSI positive response was relatively high.Over time,small-diameter trees were strongly affected by drought stress.It is predicted that under continuous warming and increased precipitation,trees in most areas of the Tianshan Mountains,especially those with small diameters,will be more affected by precipitation. | Zhongtong Peng Yuandong Zhang Liangjun Zhu Mingming Guo Qingao Lu Kun Xu Hui Shao Qifeng Mo Shirong Liu | 2023 | Journal of Forestry Research2023，34，6： | 1 |
| 18 | Eco-efficiency for Pol-lution Prevention in Small to Medium-Sized Enterprises:A Casefrom South Korea显示文摘 | Sangwon Suh Kun Mo Lee Sangsun Ha | 2005 | Journal of Industrial Ecology2005，9，4： | 1 |
| 19 | Shape memory polyurethane containing amorphous reversible phase显示文摘 | Jeong Han Mo Ahn Byoung Kun Cho Scong Mo | 2000 | Journal of Polymer Science:Part B:Polymer Physics2000，38，： | 1 |
| 20 | Metal-organic frameworks as photocatalysts for aerobic oxidation reactions显示文摘Metal-organic frameworks(MOFs)are emerging as one of the most intriguing classes of heterogeneous photocatalysts owing to their abundant structures,tunable porosity,and versatile functions.The advantages of bottom-up design and reticular synthesis render MOF materials with desired photocatalytic properties for targeted reactions.In this review,we discussed the design and synthesis of MOF-based photocatalysts as well as strategies for enhancing photocatalytic performance.Recent progress on MOFs as platforms for photocatalytic aerobic oxidation reactions was summarized and categorized according to the types of bond formation.We hope this review will give an in-depth insight into MOF-based photocatalytic systems for not only aerobic oxidation reactions but also other organic transformations.A brief outlook on the challenges and opportunities of MOFs as heterogeneous photocatalysts is provided at the end of the review. | Kun Wu Xin-Yi Liu Pei-Wen Cheng Mo Xie Weigang Lu Dan Li | 2023 | Science China Chemistry2023，66，6： | 0 |
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