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| 1 | Constitutive expression of pathogen-inducible OsWRKY31 enhances disease resistance and affects root growth and auxin response in transgenic rice plants显示文摘WRKY 抄写因素响应关於生命、不能生活的压力有许多规章的角色。在这研究,我们孤立被稻瘟病真菌 Magnaporthe grisea 和植物生长素导致的米饭 WRKY 基因(OsWRKY31 ) 。这基因编码 211 氨基酸的残余的多肽并且属于可能在单音的简易窄床和 dicot 植物的分叉以后发源的米饭 WRKY 基因家庭的亚群。OsWRKY31 被发现对洋葱外皮房间的原子核局部性短暂地表示 OsWRKY31-eGFP 熔化蛋白质。与一个 Gal4 DNA 有约束力的领域熔化的 OsWRKY31 和它的异种的分析显示 OsWRKY31 在酵母举办 transactivation 活动。OsWRKY31 基因的 Overexpression 被发现与 M 对感染提高抵抗。grisea,和展出的转基因的线减少了侧根形成和延伸与相比野类型并且 RNAi 植物。线与在表示上显示出许多防卫相关的基因的组成的表示例如 PBZ1 和 OsSci2,以及早植物生长素反应基因,例如 OsIAA4 和 OsCrl1 基因。而且,植物与对在高集中的外长地供应的 IBA, NAA 和 2,4-D 在表示上不太敏感,在 OsWRKY31 基因的表示上建议那可能改变植物生长素反应或运输。这些结果也建议 OsWRKY31 可能在米饭是在植物生长素反应和防卫反应的信号转导小径的一个普通部件。 | Juan Zhang Youliang Peng Zejian Guo | 2008 | Cell Research2008，18，4： | 60 |
| 2 | 血浆同型半胱氨酸水平升高与心血管疾病及各种死亡风险因子的meta分析(英文)显示文摘目的:探讨普通人群血浆同型半胱氨酸水平升高是否能独立预测死亡风险。创新点:通过汇总12篇前瞻性研究,定量分析血浆同型半胱氨酸水平升高与心血管疾病及各种死亡风险因子的关系。方法:通过检索Pub Med和Embase数据库,收集普通人群中血浆同型半胱氨酸水平与死亡关系的前瞻性观察性研究,采用STATA统计软件进行meta分析。结论:血浆同型半胱氨酸水平升高是心血管疾病及各种原因死亡风险增加的一个独立预测因素,在老年人群中尤为明显。 | Hui-yong PENG Chang-feng MAN Juan XU Yu FAN | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，1： | 46 |
| 3 | IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation显示文摘 | Juan Peng Xuexian O Yang Seon Hee Chang Jiong Yang Chen Dong | 2010 | Cell Research2010，20，1： | 31 |
| 4 | Denitrifying phosphorus removal in a step-feed CAST with alternating anoxic-oxic operational strategy显示文摘A bench-scale cyclic activated sludge technology(CAST) was operated to study the biological phosphorus removal performance and a series of batch tests was carried out to demonstrate the accumulation of denitrifying polyphosphate-accumulating organisms(DNPAOs) in CAST system.Under all operating conditions,step-feed CAST with enough carbon sources in influent had the highest nitrogen and phosphorus removal effciency as well as good sludge settling performance.The average removal rate of COD,NH4+-N,PO43--P and total nitrogen(TN) was 88.2%,98.7%,97.5% and 92.1%,respectively.The average sludge volume index(SVI) was 133 mL/g.The optimum anaerobic/aerobic/anoxic(AOA) conditions for the cultivation of DNPAOs could be achieved by alternating anoxic/oxic operational strategy,thus a significant denitrifying phosphorus removal occurred in step-feed CAST.The denitrification of NOx--N completed quickly due to step-feed operation and enough carbon sources,which could enhance phosphorus release and further phosphorus uptake capability of the system.Batch tests also proved that polyphosphate-accumulating organisms(PAOs) in the step-feed process had strong denitrifying phosphorus removal capacity.Both nitrate and nitrite could be used as electron acceptors in denitrifying phosphorus removal.Low COD supply with step-feed operation strategy would favor DNPAOs accumulation. | MA Juan PENG Yongzhen WANG Shuying WANG Li LIU Yangt MA Ningpin | 2009 | Journal of Environmental Sciences2009，21，9： | 27 |
| 5 | Different Effects of Homocysteine and Oxidized Low Density Lipoprotein on Methylation Status in the Promoter Region of the Estrogen Receptor α Gene显示文摘我们调查了人的效果半胱氨酸(Hcy ) 和在雌激素受体高山的倡导者区域的 DNA methylation 上的氧化低密度脂蛋白(ox-LDL ) 哈(ERalpha ) 基因,和它在动脉粥样硬化的致病的潜在的机制。人的有教养的光滑的肌肉房间(SMC ) 被 Hcy 和 ox-LDL 为时间的不同经期与不同集中对待。DNA methylation 地位是由嵌套的 methylation 特定的聚合酶链反应的 assayed,在 SMC 和泡沫房间形成积累了的类脂化合物被检验,油红 O 染色。SMC 的增长是由 the3-(4,5-dimethylthiazol-2-yl ) 的 assayed -2,5-diphenyltetrazolium 溴化物方法。结果证明 ox-LDLin 节制导致的集中(10-40 mg/L ) 在 SMCs.However 的 ERagene 的倡导者区域的 de novo methylation, ox-LDL 的高集中(50 mg/L ) ,导致了时代的 demethylation。 Hcytreatment 与 aconcentration 在时代基因的倡导者区域导致了 de novo methylation --并且对待时间依赖者举止,并且在 SMCproliferation.These 数据上支持效果的一个剂量依赖者显示为动脉粥样硬化的二个风险因素有在 SMCs.However 的时代基因的倡导者区域导致 de novo methylation 的功能, ox-LDL 的高集中( 50 mg/L )导致了 demethylation ,显示有不同力量力量的动脉粥样硬化的不同风险因素在时代基因的倡导者区域引起不同异常 methylation 模式。Hcy 的 atherogenic 机制可能包含 hypermethylationof 时代基因,在动脉粥样硬化患者损害导致 SMC 的增长。 | Yushan HUANG~1 Kejun PENG~2 Juan SU~1 Yuping HUANG~3 Yizhon XU~1 and Shuren WANG~1 ~1Department of Pathophysiology,West China School of Preclinic Medical Sciences & Forensic Medicine,Sichuan University,Chengdu 610041.China ~2Department of Laboratory Medicine,Chengdu Medical College,Chengdu 610500,China ~3Department of Biochemistry and Molecular Bilogy,Gannan Medical College,Ganzhou 341000,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，1： | 25 |
| 6 | Achieving nitritation at low temperatures using free ammonia inhibition on Nitrobacter and real-time control in an SBR treating landfill leachate显示文摘Free ammonia(FA) inhibition on nitrite-oxidized bacteria(NOB) and real-time control are used to achieve nitrogen removal from landfill leachate via nitrite pathway at low temperatures in sequencing batch reactor. The inhibition of FA on NOB activity during the aerobic period was prolonged using real-time control. The degree of nitrite accumulation was monitored along with variations of the ammonia-oxidizing bacteria and NOB population using fluorescence in situ hybridization techniques. It is demonstrated that the end-point of ammonia oxidization is detected from the on-line measured dissolved oxygen,oxidization–reduction potential, and p H signals, which could avoid the loss the FA inhibition on NOB caused by excess aeration. At low temperature(13.0–17.6°C), the level of nitrite pathway rapidly increased from 19.8% to 90%, suggesting that nitritation was successfully started up at low temperature by applying syntrophic association of the FA inhibition and real-time control, and then this high level of nitrite pathway was stably maintained for as long as 233 days. Mechanism analysis shows that the establishment of nitritation was primarily the result of predominant ammonia-oxidizing bacteria developed in the nitrifying bacteria population compared to NOB. This was mainly due to a gradual reduction of nitrite amount that is available to provide energy for the growth of NOB,eventually leading to the elimination of NOB from the bacterial clusters in sequencing batch reactor sludge system. | Hongwei Sun Yongzhen Peng Shuying Wang Juan Ma | 2015 | Journal of Environmental Sciences2015，27，4： | 20 |
| 7 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 8 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 9 | Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs显示文摘 | Jun Song Juan Zhong Xiaogang Guo Yongqiang Chen Qingjian zou Jiao Huang Xiaoping Li Quanjun Zhang Zhiwu Jiang Chengcheng Tang Huaqiang Yang Tao Liu Peng Li Duanqing Pei Liangxue Lai | 2013 | Cell Research2013，23，8： | 15 |
| 10 | Singular Boolean networks:Semi-tensor product approach显示文摘Singular Boolean networks are introduced in this paper.Via semi-tensor product of matrices and the matrix expression of logical functions,two kinds of the condensed algebraic expressions of singular Boolean networks are obtained.The normalization problem of singular Boolean networks is addressed;that is,under what condition singular Boolean networks can be converted into normal Boolean networks with algebraic restrictions.Then one sufcient condition and one necessary and sufcient condition are derived for the normalization problem.Furthermore,the solvability of singular Boolean networks is discussed and the concept of admissible initial values of singular Boolean networks is presented.Finally,fxed points and cycles of singular Boolean networks are also investigated. | FENG JunE YAO Juan CUI Peng | 2013 | Science China(Information Sciences)2013，56，11： | 15 |
| 11 | Arabidopsis F-box gene FOA1 involved in ABA signaling显示文摘The expression of FOA1(F-box overexpressed/oppressed ABA signaling) in different organs of Arabidopsis,and in response to ABA and NaCl,was analyzed.The expression level of FOA1 is higher in the root and is lower in the stem,and is induced rapidly by ABA and NaCl.The phenotypes of T-DNA insertion mutant foa1 and FOA1 overexpression lines FOA1ox1 and FOA1ox2 were analyzed.The foa1 mutant exhibited a lower germination rate,shorter root length,more stomatal opening,increased proline accumulation and hypersensitivity to ABA compared with the wild type.In contrast,the overexpression lines showed lower sensitivity to ABA than the wild type.The expression levels of several ABA and stress-responsive transcription factors and genes were altered in the foa1 mutant in response to ABA.Compared with the wild type,the expression levels of ABA-responsive transcription factors were higher,but ABA and stress-responsive genes were lower in foa1 mutant.This study demonstrates that FOA1 is an ABA signaling-related gene,and may play a negative role in ABA signaling. | PENG Juan YU DaShi WANG LiQun XIE MinMin YUAN CongYing WANG Yu TANG DongYing ZHAO XiaoYing LIU XuanMing | 2012 | Science China(Life Sciences)2012，55，6： | 12 |
| 12 | Downregulation of serum mi R-17 and mi R-106b levels in gastric cancer and benign gastric diseases显示文摘Altered micro RNA(mi RNA) associated with gastric cancer(GC) development and mi R-17 and mi R-106 b were differentially expressed in GC tissues. This study detected serum levels of mi R-17 and mi R-106 b expression in GC, benign gastric disease(BGD) and healthy controls to assess them as tumor markers for GC. Serum samples from 40 GC, 32 BGD(10 gastric ulcer, 14 gastric polyps, and 8 gastric ulcer with polyps) and 36 healthy individuals were subjected to quantitative reverse transcription polymerase chain reaction(q RT-PCR) analysis of mi R-17 and mi R-106 b expression. The data showed that the serum levels of mi R-17 and mi R-106 b were significantly reduced in healthy individuals and BGD patients compared to GC patients. There was a significant association of mi R-17 and mi R-106 b expression with age, but not with other clinicopathological features, such as gender, tumor differentiation, stage and lymphatic metastasis. Further analysis showed that, in discriminating GC patients from healthy controls, mi R-17 could yield a receiver-operating characteristic(ROC) area under the curve(AUC) of 0.879 with 80.6% sensitivity and 87.5% specificity and mi R-106 b could yield an AUC of 0.856 with 75.0% sensitivity and 92.5% specificity. The combined AUC of mi R-17 and mi R-106 b was 0.913 with 83.3% sensitivity and 87.5% specificity. Collectively, these data suggest that detection of serum mi R-17 and mi R-106 b levels should be further evaluated as novel non-invasive biomarkers in early GC detection and surveillance of disease progression. | Qinghai Zeng Cuihong Jin Wenhang Chen Fang Xia Qi Wang Fan Fan Juan Du Yihang Guo Changwei Lin Kaiyan Yang Jingjing Li Xiaowei Peng Xiaorong Li Ke Cao | 2014 | Chinese Journal of Cancer Research2014，26，6： | 12 |
| 13 | Codon 249 mutations of p53 gene in non-neoplastic liver tissues显示文摘Subjectheadingsliver;p53gene;codon249mutation;liverneoplasms;hepatitis,viral;livercirhosis;polymerasechainreactionAbstractAIM... | PENG Xiao Mou, YAO Chun Lan, CHEN Xue Juan, PENG Wen Wei and GAO Zhi Liang | 1999 | World Journal of Gastroenterology1999，5，4： | 12 |
| 14 | Outpatient Experience of Human Caring Scale (OEHC-Scale): Improvement by Delphi Method显示文摘 | Chun-yan GUAN Yi-lan LIU Hui HUANG Xia YANG Juan-juan XU Xin-qiao FU De-ying HU Cai-hong LU Zhi-guo ZHANG Juan XU Peng HAN | 2018 | Current Medical Science2018，38，2： | 12 |
| 15 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 16 | Advanced imaging techniques in the therapeutic response of transarterial chemoembolization for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transarterial chemoembolization(TACE) can significantly improve the survival rate of patients with HCC and is the first treatment choice for patients who are not suitable for surgical resections. The evaluation of the response to TACE treatment affects not only the assessment of the therapy efficacy but also the development of the next step in the treatment plan. The use of imaging to examine changes in tumor volume to assess the response of solid tumors to treatment has been controversial. In recent years, the emergence of new imaging technology has made it possible to observe the response of tumors to treatment prior to any morphological changes. In this article, the advances in studies reporting the use of computed tomography perfusion imaging, diffusionweighted magnetic resonance imaging(MRI), intravoxel incoherent motion, diffusion kurtosis imaging, magnetic resonance spectroscopy, magnetic resonance perfusionweighted imaging, blood oxygen level-dependent MRI, positron emission tomography(PET)/computed tomography and PET/MRI to assess the TACE treatment response are reviewed. | Ke Yang Xiao-Ming Zhang Lin Yang Hao Xu Juan Peng | 2016 | World Journal of Gastroenterology2016，22，20： | 11 |
| 17 | Effects of urea mixed with nitrapyrin on leaf photosynthetic and senescence characteristics of summer maize(Zea mays L.)waterlogged in the field显示文摘Waterlogging is one of the major abiotic stresses in agricultural crop production.However,the application of 2-chloro-6-(trichloromethyl)pyridine(nitrapyrin)can effectually mitigate the losses of nitrogen efficiency and grain yield of summer maize induced by waterlogging.In order to explore its role to alleviate waterlogging stress on leaf antioxidative system and photosynthetic characteristics of summer maize,a field experiment was executed to research effects of nitrapyrin application on leaf photosynthetic and senescent characteristics of waterlogged summer maize Denghai 605(DH605)and Zhengdan 958(ZD958).Experimental treatments consisted of waterlogging treatment that was applying only urea(WL),waterlogging treatment that was applying urea mixing with nitrapyrin(WL-N),and no waterlogging treatment that was only applying urea(NWL).Results showed that WL significantly decreased leaf area index(LAI),SPAD,photosynthetic rate(Pn),and protective enzyme activities,accelerated leaf aging,eventually led to a remarkable yield reduction by 38 and 42%for DH605 and ZD958,respectively,compared to NWL.However,the application of nitrapyrin was useful for relieving waterlogging damages on leaf photosynthetic ability.LAI,SPAD and Pn of WL-N for DH605 were 10,19 and 12-24%higher,and for ZD958 were 12,23 and 7-25%higher,compared to those of WL,respectively.Moreover,application of nitrapyrin effectually relieved waterlogging losses on antioxidative enzyme activities.Leaf superoxide dismutase(SOD),peroxidase(POD)and catalase(CAT)activities of WL-N were averagely increased by 24,15 and 30%,respectively,while malondialdehyde(MDA)content was averagely decreased by 13%,compared to those of WL.Visibly,nitrapyrin application could improve leaf photosynthetic characteristics and retard leaf aging induced by waterlogging,thereby leading to a yield increase of waterlogged maize. | REN Bai-zhao HU Juan ZHANG Ji-wang DONG Shu-ting LIU Peng ZHAO Bin | 2020 | Journal of Integrative Agriculture2020，19，6： | 10 |
| 18 | Model test on dynamic characteristics of invert and foundation soils of high-speed railway tunnel显示文摘A dynamic model test(CL = 4) at different velocities of train,namely different loading frequencies,is carried out to study the dynamic characteristics of a high-speed railway tunnel invert and its foundation soils.Not only are the accelerations,dynamic coefficients,dynamic stresses of the invert and foundation soils emphatically analyzed,their relationship with the velocity of the train are discussed in detail.Through laboratory testing,the attenuation of vibration propagating from up the rails is obtained and the calculation formula of the speed influence coefficient of the tunnel invert is preliminarily established.The depth of the foundation soils influenced by vibration is also determined in this study.It is shown that the responses of the tunnel invert and foundation soils to vibration are slightly increased with the velocity of the train;circumferential stresses in the bottom of the invert are tensile stresses and maximum stresses appear under the foot of the rails;the dynamic soil pressures of the foundation decrease quickly with the distance away from the tunnel invert and an exponential relationship exists between them. | Huang Juan Yuan Tieying Peng Limin Yu Jun Ding Zude | 2015 | Earthquake Engineering and Engineering Vibration2015，14，3： | 10 |
| 19 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 20 | Efficacy of maximal androgen blockade versus castration alone in the treatment of advanced prostate cancer: a retrospective clinical experience from a Chinese medical centre显示文摘在这回顾的研究,我们与先进前列腺癌症在中国病人独自评估了并且比较最大的雄激素封锁(MAB ) 对阉割的功效和毒性。从 1996 ~ 2004,有先进前列腺癌症的 608 个病人在学习被包括。病人们回顾地根据不同治疗学的政体被划分成二个组。608 个病人, 300 个病人与 MAB (加 nonsteroidal antiandrogens 的阉割) 并且留下被对待 308 独自与阉割被对待。这些病人的 2 年、 5 年的全面幸存率分别地是 73.7% 和 56% 。Multivariate 分析证明在有变形前列腺癌症的病人, MAB 与没有前进的幸存(PFS ) 的改进被联系不仅(到 10 个月增加了) 而且在死亡风险的 20.6% 减小与阉割相比独自一个。相反, MAB 的功效不比为有 nonmetastatic 前列腺癌症的病人独自一个的阉割优异。在有 MAB 的病人之中,有趣地,那些使用的 bicalutamide 用 flutamide 比那些有更长的 PFS;这是特别在有变形前列腺癌症的病人。几乎所有毒性,由于荷尔蒙,治疗对温和中等、可管理。得出结论在中国,荷尔蒙治疗,包括的 MAB 和阉割独自一个,是为先进前列腺癌症的标准治疗。为有 nonmetastatic 前列腺癌症的病人,阉割可能独自足够地实际、有效。在有变形前列腺癌症的病人,然而, MAB 独自在阉割上有优异功效。MAB 应该与变形前列腺癌症为病人被认为首要的标准治疗,是清楚的。 | Xue-Qin Chen Ying Huang Xiang Li Peng Zhang Rui Huang Juan Xia Ni Chen Qiang Wei Yu-Chun Zhu Yu-Ru Yang Hao Zeng | 2010 | Asian Journal of Andrology2010，12，5： | 9 |
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