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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 3 | Diet and gastric cancer:a case-control study in Fujian Province,China显示文摘NTRODUCTIONChangleandFuqingcitiesarelocatedinthesoutheasternpartofFujianProvince,Chinawithahighincidenceofgastriccancer.Howev... | YE Wei Min 1, YI Ying Nan 1, LUO Ren Xia 2, ZHOU Tian Shu 3, LIN Ru Tao 1 and CHEN Gui Dong 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 12 |
| 4 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 5 | Protective Effect of Angiotensin(1-7) on Silicotic Fibrosis in Rats显示文摘Objective Silicosis, caused by inhalation of silica dust, is the most serious occupational disease in China and the aim of present study was to explore the protective effect of Ang (1-7) on silicotic fibrosis and myofibroblast differentiation induced by Ang Ⅱ. Methods HOPE-MED 8050 exposure control apparatus was used to establish the rat silicosis model. Pathological changes and collagen deposition of the lung tissue were examined by H.E. and VG staining, respectively. The localizations of ACE2 and a-smooth muscle actin (a-SMA) in the lung were detected by immunohistochemistry. Expression levels of collagen type Ⅰ, a-SMA, ACE2, and Mas in the lung tissue and fibroblasts were examined by western blot. Levels of ACE2, Ang (1-7), and Ang Ⅱ in serum were determined by ELISA. Co-localization of ACE2 and a-SMA in fibroblasts was detected by immunofluorescenee. Results Ang (1-7) induced pathological changes and enhanced collagen deposition in vivo. Ang (1-7) decreased the expressions of collagen type Ⅰ and a-SMA and increased the expressions of ACE2 and Mas in the silicotic rat lung tissue and fibroblasts stimulated by Ang Ⅱ. Ang (1-7) in creased the levels of ACE2 and Ang (1-7) and decreased the level of Ang Ⅱ in silicotic rat serum. A779 enhanced the protective effect of Ang (1-7) in fibroblasts stimulated by Ang Ⅱ. Conclusion Ang (1-7) exerted protective effect on silicotic fibrosis and myofibroblast differentiation induced by Ang Ⅱ by regulating ACE2-Ang (l-7)-Mas axis. | ZHANG Bo Nan XU Hong GAO Xue Min ZHANG Gui Zhen ZHANG Xin YANG Fang | 2019 | Biomedical and Environmental Sciences2019，32，6： | 5 |
| 6 | Characterization of Class 1 Integron Gene Cassettes among Clinical Bacteria Isolated from One Large Hospital in Northern China显示文摘班在不同种类之中的 1 integron 和复杂基因盒子临床在北中国孤立在这研究被描绘。383 临床孤立从北中国,和包含广泛地在克之中散布的基因盒子的班 1 integrons 被获得否定临床孤立被观察。我们发现 1 integron 显示出的班与克的 multidrug 抵抗显型的积极关联否定细菌。另外,我们发现那孤立属于一种怀有基因盒子数组的不同类型,当基因盒子数组的一样的类型在不同种类被观察时孤立。在 isolates 之中的基因盒子数组的差异显示了 multidrug 抵抗的复杂性在临床在北中国孤立。 | CHEN Xia LI Gui Xi ZHANG Hong YUAN Min HOU Xiao Ping YU Hui Lan LI Juan | 2013 | Biomedical and Environmental Sciences2013，26，12： | 5 |
| 7 | 解脲脲原体脂质相关膜蛋白经Toll样受体2信号通路调控人羊膜上皮细胞诱导IL-6、IL-8和TNF-α的产生(英文)显示文摘目的:探讨解脲脲原体(Ureaplasma urealyticum)及其脂质相关膜蛋白(LAMPs)作用于人羊膜上皮细胞(HAECs)过程中白介素6(IL-6)、IL-8和肿瘤坏死因子α(TNF-α)的变化情况,阐明Toll样受体2(TLR2)的调控机制,明确解脲脲原体潜在的致病性。创新点:从解脲脲原体诱导炎症反应的分子机制入手,提出TLR2信号通路在其中的关键作用。方法:经TX-114处理萃取解脲脲原体获得LAMPs,将LAMPs和解脲脲原体分别感染HAECs,用酶联免疫吸附试验(ELISA)测定炎症细胞因子(IL-6、IL-8和TNF-α);采用实时聚合酶链反应(real-time PCR)测定TLR2 mRNA水平,用蛋白质印迹(Western blot)检测TLR2的表达量;经TLR2阻断剂(anti-h TLR2-IgA)处理后,测定相应炎症细胞因子。结论:解脲脲原体LAMPs能诱导HAECs的TLR2表达上调和炎症因子增加,从而发生炎症反应;TLR2受阻断后,炎症因子表达减少,炎症水平下降。TLR2在解脲脲原体LAMPs感染HAECs过程起关键作用。 | Guang-yong YE Ke-yi WANG Qiao-di GUI Min WANG | 2018 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2018，19，8： | 5 |
| 8 | Preparation and characterization of hexadecane microcapsule with polyurea-melamine formaldehyde resin shell materials显示文摘This paper gives a brief report of the preparation of hexadecane microcapsule with polyurea-melamine formaldehyde resin shell materials(HMPM).The sealing performance and thermal stability of HMPM was enhanced much more effectively than that of microcapsule with polyurea shell material(HPM).The results of microscopical imaging analysis system,DSC,TG,and laser particle analyzer were briefly introduced. | Gao, Gui Bo Qian, Chun Xiang Gao, Min Jie | 2010 | Chinese Chemical Letters2010，21，5： | 5 |
| 9 | Ferrous methanesulfonate as an efficient and recyclable catalyst for chemoselective synthesis of 1,1-diacetate from aldehydes显示文摘铁的 methanesulfonate catalysing 变换芳香,异种到在在没有溶剂的状况下面的房间温度的 1,1-diacetates 的芳香、不饱和、脂肪族的醛被开发了。十七金属 methanesulfonates 的催化活动在一样的条件下面被比较,铁的 methanesufonate 证明了是最好。它能容易被恢复并且再使用为若干次没有在催化活动的不同恶化。在在有交流 2 O,专门与醛组一起形成的 1,1-diacetate。 | Min Wang Gui Fu Tian Zhi Guo Song Heng Jiang | 2009 | Chinese Chemical Letters2009，20，9： | 5 |
| 10 | Two new eudesmane sesquiterpenes from Lactuca sativa var.anagustata L显示文摘<正>Two new eudesmane sesquiterpene lactones were isolated from the stalk of Lactuca sativa var.anagustata L and their structureswere elucidated by means of spectroscopic methods,including 2D NMR(~1H-~1H COSY,HMBC and NOESY) as 1β-O-β-D-glucopyranosyl-4α-hydroxyl-5α,6β,11βH-eudesma-12,6α-olide(1) and 1β-hydroxyl-15-O-(p-methoxyphenylacetyl)-5α,6β,11βH-eudesma-3-en-12,6α-olide(2). | Yi Feng Han Gui Xiu Cao Min Xia | 2009 | Chinese Chemical Letters2009，20，10： | 4 |
| 11 | Chinese medicine Yu-Ping-Feng-San attenuates allergic inflammation by regulating epithelial derived pro-allergic cytokines显示文摘This study aimed to investigate the mechanisms of Yu-Ping-Feng-San(YPFS) on attenuating allergic inflammation in the initial stage of atopic dermatitis(AD). AD mouse model was established with fluorescein isothiocyanate(FITC) sensitization and elicitation. Epithelial barrier structure was observed with transmission electron microscope. The populations of dendritic cells(DCs)and group 2 innate lymphoid cells(ILC2 s) were detected by flow cytometry. Human immortalized keratinocyte(Ha Ca T) cells were stimulated with Poly(I:C)/TNF-α in vitro to assess thymic stromal lymphopoietin(TSLP), interleukin(IL)-33 and nuclear factor-κB(NF-κB) levels or expressions by immunofluorescence, enzyme linked immunosorbent assay(ELISA) and western blot. In the initial stage of AD, ear swelling and infiltration of inflammatory cells in ear tissues were markedly attenuated with YPFS treatments. The damaged structures of ear epithelium and the increased levels of Th2-cytokines induced by FITC were significantly rescued in YPFS-treated mice. The production of pro-allergic cytokines, TSLP and IL-33, as well as the cell populations of their target cells DCs and ILC2 s were decreased in AD model, respectively. Likewise, the levels of TSLP and IL-33 in Poly(I:C)/TNF-α-stimulated HaCaT cells showed the same results. Lower levels of p-NF-κB were detected with YPFS treatment, and the expressions of TSLP and IL-33 could be further decreased with inhibiting of NF-κB. Therefore, YPFS attenuates allergic inflammation in the initial stage of AD probably through regulating NF-κB-TSLP/IL-33 pathway, which may provide a novel effective target for the prevention and treatment of allergic diseases. | WANG Xiao-Tong LIU Hai-Liang YU Xi WANG Can GUI Li-Li WANG Xiao-Yu HUA Yong-Qing ZHENG Jie HONG Min | 2019 | Chinese Journal of Natural Medicines2019，17，7： | 4 |
| 12 | Synergetic effect of FeVO_4 andα-Fe_2O_3 in Fe-V-O catalysts for liquid phase oxidation of toluene to benzaldehyde显示文摘Synergistic effect of FeVO_4 withα-Fe_2O_3 was found in Fe-V-O catalyst,which was responsible for the high apparent formation rate(A.F.R.) of benzaldehyde in liquid phase oxidation of toluene by hydrogen peroxide.The synergistic effect might create VO_πspecies as active sites;moreover,it improved the reducibility and the reactivity of Fe-V-O catalyst.In order to gain the high A.F.R. of benzaldehyde,the catalyst should have the moderate reducibihty. | Gui Quan Zhang Xin Zhang Tao Lin Ting Gong Min Qi | 2012 | Chinese Chemical Letters2012，23，2： | 4 |
| 13 | Colonic Mucosal Immune Activity in Irritable Bowel Syndrome: Comparison with Healthy Controls and Patients with Ulcerative Colitis显示文摘 | Ji Yong Ahn Kyung Hun Lee Chang Hwan Choi Ju Wan Kim Hyun Woong Lee Jeong Wook Kim Mi Kyung Kim Gui Young Kwon Seungbong Han Seong-Eun Kim Sung Min Kim Sae Kyung Chang | 2014 | Digestive Diseases and Sciences2014，，5： | 3 |
| 14 | New Diterpenoid Alkaloids from Spiraea fritschiana var. parvifolia显示文摘 | Min LI Xiu Bao DU Yue Mao SHEN Bin Gui WANG Xiao Jiang HAO ( The Beijing Institute of Pharmaceutical Chemistry, Beijing 102205 Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica. Kunming 650204)Abstrcat: Two new C20 hetisine | 1999 | Chinese Chemical Letters1999，10，10： | 3 |
| 15 | Modified Glasgow Prognostic Score, and Neutrophil/lymphocyte and Platelet/lymphocyte Ratios in Different Stages of Silicosis显示文摘Until now, although comprehensive management strategies have improved treatment, there are no treatments to alleviate symptoms and slow disease progression[1]. In the past few decades, there has been increasing evidence that inflammation plays a very important role in silicosis. Injury-induced inflammation is an effective strategy to remove harmful stimuli and initiate a healing process. However, it might be harmful to the organism and result in a permanent disease state if the inflammation is prolonged[2]. | HE La Gu WU Peng Fei PENG Yan Hua FENG Juan ZHONG Dai Ming ZHANG Gui Hua ZENG Lei ZHONG Yu Min WANG Xiao Ye YUAN Hua Min | 2019 | Biomedical and Environmental Sciences2019，32，5： | 3 |
| 16 | A New Hapten for Immunoassay of Aldicarb显示文摘A new hapten, aldicarb oxime succinic ester (AOSE), was synthesized for immunoassay of aldicarb. It was conjugated to proteins by active ester method. Polyclonal antibody was raised against AOSE-BSA (bovine serum albumin) conjugate. Enzyme-linked immunosorbent assays (ELISAs) showed that this antiserum had high affinity to aldicarb and can be used for sensitive and selective immunoassay of aldicarb. | Yan Feng ZHANG Zhi Xian GAO Qing Min ZHANG Shu Gui DAI | 2006 | Chinese Chemical Letters2006，17，8： | 3 |
| 17 | Numerical and experimental study on the response characteristics of warhead in the fast cook-off process显示文摘The response characteristics of the warhead under thermal stimuli conditions are important to the safety improvement.The goal of this study is to obtain data on the warhead in the fast cook-off process.In this paper,a numerical calculation method is proposed,whose reliability is supported by comparison with experimental results.Through the numerical calculation,the temperature distribution,temperature change,and ignition time are acquired.The numerical results show that the ignition time is 76 s after the warhead started to burn and that the maximum temperature of the explosive’s outer surface is 238.3℃ at the ignition time.The fast cook-off experiment of the warhead is implemented so as to get the flame temperature and reaction grades that are not available through numerical calculation.The experimental results show that the overpressure fails to reach the preset minimumvalue which is equivalent to 6 kg of TNT and that the reaction grade is deflagration.The research results have reference value for the design of the warhead and the reduction of detonation risks. | Min Zhu Sheng-ao Wang Huang Huang Gui Huang Fei Wu Shao-hua Sun Biao Li Zi-jian Xu | 2021 | Defence Technology(防务技术)2021，17，4： | 3 |
| 18 | Coupling phase field with creep damage to study γ’evolution and creep deformation of single crystal superalloys显示文摘A phase-field model coupling with elastoplastic de fo rmation and creep damage has been built to study the micro structural evolution and deformation behavior for Ni-Al single crystal alloy during the whole creep processing.The relevant experiments were conducted to verify the model validity.The simulation re sults show that under the tensile creep at 1223 K/100 MPa,cubic γ’phases coarsen along the direction parallel to the axis of tensile stress during the first two creep stages;and spindle-shaped and wavy γ’phases are fo rmed during tertiary creep,similar to the experimental results.The evolution mechanism of γ’phases is analyzed from the perspective of changes of stress and strain fields.The'is land-like'γ phase is observed and its formation mechanism is discussed.With the increase of creep stress,the directional coarsening of γ’phase is accelerated,the steady-state creep rate is increased and the creep life is decreased.The comparison between simulated and experimental creep curves shows that this phase-field model can effectively simulate the performance changes during the first two creep stages and predict the influence of creep stresses on creep properties.Our work provides a potential approach to synchronously simulate the creep microstructure and property of superalloys strengthened by γ’precipitates. | Min Yang Jun Zhang Weimin Gui Songsong Hu Zhuoran Li Min Guo Haijun Su Lin Liu | 2021 | Journal of Materials Science & Technology2021，，12： | 3 |
| 19 | Synthesis and Crystal Structure of a Binuclear Gadolinium(Ⅲ) Complex Bridged by Cucurbit[6]uril显示文摘A new cucurbit[6]uril bridged binuclear complex {[Gd(H2O)6]2[Q6(H2O)]}Cl6·4H2O, where Q6 represents cucurbit[6]uril, has been synthesized and characterized by X-ray diffraction. The crystal structure shows that the complex has an extended cucurbit[6]uril-bridged structure consisting of two gadolinium(III) ions, in which each gadolinium(III) ion is coordinated with two neighboring carbonylic oxygen atoms of Q6 and six oxygen atoms of water molecules that leans toward one side of the portal. One disordered guest water molecule resides in the Q6 molecule cavity and occupies two different positions. Hydrogen bonds assemble the complex to three- dimensional supramolecular structure. | Gui Ling ZHANG Zhi Yong WU Yan Tuan LI Da Qi WANG Jian Min DOU | 2006 | Chinese Chemical Letters2006，17，1： | 2 |
| 20 | Utility of in vitro interferon‐γ release assay in differential diagnosis between intestinal tuberculosis and C rohn’s disease显示文摘 | Yuan Lei Feng Ming Yi Jie Zhao Rishi Vishal Luckheeram Sha Huang Min Chen Mei Fang Huang Jin Li Rui Zhou Gui Fang Yang Bing Xia | 2013 | Journal of Digestive Diseases2013，，2： | 2 |
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