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| 1 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 2 | Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis显示文摘 | Yao Chen Yuxuan Zheng Yun Gao Zhen Lin Suming Yang Tongtong Wang Qiu Wang Nannan Xie Rong Hua Mingxi Liu Jiahao Sha Michael D. Griswold Jinsong Li Fuchou Tang Ming-Han Tong | 2018 | Cell Research2018，28，9： | 26 |
| 3 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 4 | Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an aggressive malignancy with extremely skewed ethnic and geographic distributions.Increasing evidence indicates that targeting the tumor microenvironment(TME)represents a promising therapeutic approach in NPC,highlighting an urgent need to deepen the understanding of the complex NPC TME.Here,we generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample.We revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells.Diverse immune cell subtypes were identified,including novel subtypes such as CLEC9A^+dendritic cells(DCs).We further revealed transcriptional regulators underlying immune cell diversity,and cell–cell interaction analyses highlighted promising immunotherapeutic targets in NPC.Moreover,we established the immune subtype-specific signatures,and demonstrated that the signatures of macrophages,plasmacytoid dendritic cells(pDCs),CLEC9A^+DCs,natural killer(NK)cells,and plasma cells were significantly associated with improved survival outcomes in NPC.Taken together,our findings represent a unique resource providing in-depth insights into the cellular heterogeneity of NPC TME and highlight potential biomarkers for anticancer treatment and risk stratification,laying a new foundation for precision therapies in NPC. | Yu-Pei Chen Jian-Hua Yin Wen-Fei Li Han-Jie Li Dong-Ping Chen Cui-Juan Zhang Jia-Wei Lv Ya-Qin Wang Xiao-Min Li Jun-Yan Li Pan-Pan Zhang Ying-Qin Li Qing-Mei He Xiao-Jing Yang Yuan Lei Ling-Long Tang Guan-Qun Zhou Yan-Ping Mao Chen Wei Ke-Xu Xiong Hong-Bo Zhang Shi-Da Zhu Yong Hou Ying Sun Michael Dean Ido Amit Kui Wu Dong-Ming Kuang Gui-Bo Li Na Liu Jun Ma | 2020 | Cell Research2020，30，11： | 19 |
| 5 | Nucleic acid-based diagnostics for infectious diseases in public health affairs显示文摘Infectious diseases,mostly caused by bacteria and viruses but also a result of fungal and parasitic infection,have been one of the most important public health concerns throughout human history.The first step in combating these pathogens is to get a timely and accurate diagnosis at an affordable cost.Many kinds of diagnostics have been developed,such as pathogen culture,biochemical tests and serological tests,to help detect and fight against the causative agents of diseases.However,these diagnostic tests are generally unsatisfactory because they are not particularly sensitive and specific and are unable to deliver speedy results.Nucleic acid-based diagnostics,detecting pathogens through the identification of their genomic sequences,have shown promise to overcome the above limitations and become more widely adopted in clinical tests.Here we review some of the most popular nucleic acid-based diagnostics and focus on their adaptability and applicability to routine clinical usage.We also compare and contrast the characteristics of different types of nucleic acid-based diagnostics. | Albert Cheung-Hoi Yu Greg Vatcher Xin Yue Yan Dong Mao Hua Li Patrick H.K.Tam Parker Y.L.Tsang April K.Y.Wong Michael H.K.Hui Bin Yang Hao Tang Lok-Ting Lau | 2012 | Frontiers of Medicine2012，6，2： | 8 |
| 6 | 乳腺癌发生模型MCF10各细胞系中APC基因启动子区甲基化及mRNA表达检测显示文摘目的探讨乳腺癌发生模型MCF10中抑癌基因APC启动子区甲基化状态及其对mRNA表达的影响。方法应用甲基化特异性聚合酶链反应(MSP)及双亚硫酸钠基因测序技术检测MCF10模型的乳腺增生细胞系MCF10A、癌前细胞系MCF10AT、导管内癌细胞系MCF10DC IS.com、浸润癌细胞系MCF10CA1 a、MCF10CA1d、MCF10CA1h及经典乳腺癌细胞系MCF-7和正常乳腺组织中APC基因启动子1A甲基化状态,然后用逆转录聚合酶链反应(RT-PCR)和实时PCR技术检测上述样品的mRNA表达水平。结果在MCF10模型的增生细胞系、癌前细胞系、导管内癌细胞系、浸润癌细胞系中,APC基因启动子1A处于低甲基化状态;与正常乳腺组织相比,各细胞系APC基因mRNA表达无明显减少,MCF10AT、MCF10CA1d、MCF10CA1h、MCF10DC IS.com的mRNA表达分别减少0.27、0.96、1.78、2.70、2.03倍,MCF10A和MCF-7分别增加0.02和0.33倍)。结论MCF10模型中乳腺癌的发生发展过程与APC基因启动子区异常甲基化无关。 | 杨举伦 David Klinkebiel Michael J Boland Lin Tang Judith K Christman | 2006 | 中华病理学杂志2006，35，1： | 7 |
| 7 | 乳腺癌发生模型MCF10各阶段细胞系中TIMP3基因启动子区甲基化分析显示文摘目的探讨抑癌基因TIMP3失活与乳腺癌发生和进展的关系。方法用甲基化特异性PCR技术和亚硫酸盐测序技术检测乳腺癌发生模型MCF10的增生细胞系MCF10A、癌前细胞系MCF10AT、导管内癌细胞系MCF10DCIS.com、浸润癌细胞系MCF10CA1a和转移癌细胞系MCF10CA1d、MCF10CA1h中TIMP3启动子区甲基化状态。结果甲基化特异性PCR分析显示,在上述各细胞系中,TIMP3启动子区均呈高度甲基化状态。亚硫酸盐测序显示,在上述各细胞系中,测序区内的68个CG位点几乎全部发生了甲基化,且甲基化累及了绝大部分等位基因。结论TIMP3基因启动子区甲基化在乳腺癌的发生和进展中起重要作用,可能成为早期诊断乳腺癌和判断乳腺癌预后的分子生物学标记。 | 杨举伦 David Klinkebiel Michael J Boland Lin Tang Judith K Christman | 2006 | 临床与实验病理学杂志2006，22，1： | 7 |
| 8 | 乳腺癌发生过程中NOEY2基因启动子区甲基化及mRNA表达显示文摘目的探讨乳腺癌发生过程中抑癌基因NOEY2启动子区甲基化状态及其对mRNA表达的影响。方法应用甲基化特异性PCR及双亚硫酸钠基因测序技术检测MCF10模型中乳腺增生细胞系MCF10A、癌前细胞系MCF10AT、导管内癌细胞系MCF10DC IS.com、浸润癌细胞系MCF10CA1 a、MCF10CA1d、MCF10CA1h及正常乳腺组织中NOEY2基因启动子区CpG岛I甲基化状态,然后用RT-PCR和实时PCR技术检测上述样品的mRNA表达水平。结果MCF10模型的增生细胞系、癌前细胞系、导管内癌细胞系、浸润癌细胞系均发生该基因启动子区CpG岛I高度甲基化;与正常乳腺组织相比,上述细胞系mRNA表达显著减少。结论NOEY2基因启动子区高度甲基化及相应的mRNA表达减少是乳腺癌发生过程中的早期事件,与乳腺癌发生有关,可能成为早期诊断乳腺癌的潜在分子生物学标记。 | 杨举伦 David Klinkebiel Michael J Boland Lin Tang Judith K Christman | 2005 | 临床与实验病理学杂志2005，21，5： | 6 |
| 9 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 10 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn’s and Colitis Epidemiology Study显示文摘 | Siew C. Ng Whitney Tang Jessica Y. Ching May Wong Chung Mo Chow A.J. Hui T.C. Wong Vincent K. Leung Steve W. Tsang Hon Ho Yu Mo Fong Li Ka Kei Ng Michael A. Kamm Corrie Studd Sally Bell Rupert Leong H. Janaka de Silva Anuradhani Kasturiratne M.N.F. Mufeen | 2013 | Gastroenterology2013，，1： | 6 |
| 11 | Changes in soil organic carbon contents and fractionations of forests along a climatic gradient in China显示文摘Background: Soil organic carbon(SOC) is a large reservoir of terrestrial carbon(C); it consists of different fractions of varying complexity and stability. Partitioning SOC into different pools of decomposability help better predict the trend of changes in SOC dynamics under climate change. Information on how physical fractions and chemical structures of SOC are related to climate and vegetation types is essential for spatial model ing of SOC processes and responses to global change factors.Method: Soil samples were col ected from multiple representative forest sites of three contrasting climatic zones(i.e. cool temperate, warm temperate, and subtropical) in eastern China. Measurements were made on SOC contents and physical fractions of the 0–20 cm soil layer, and the chemical composition of SOC of the 0–5 cm soil layer, along with measurements and compilation of the basic site and forest stand variables. The long-term effects of temperature, litter inputs, soil characteristics and vegetation type on the SOC contents and factions were examined by means of 'space for time substitution' approach and statistical analysis.Result: Mean annual temperature(MAT) varied from 2.1 °C at the cool temperate sites to 20.8 °C at the subtropical sites. Total SOC of the 0–20 cm soil layer decreased with increasing MAT, ranging from 89.2 g·kg^(-1) in cool temperate forests to 57.7 g·kg^(-1) in subtropical forests, at an average rate of 1.87% reduction in SOC with a 1 °C increase in MAT.With increasing MAT, the proportions of aromatic C and phenolic C displayed a tendency of decreases, whereas the proportion of alkyl C and A/O-A value(the ratio of alkyl C to the sum of O-alkyl C and acetal C) displayed a tendency of increases. Overall, there were no significant changes with MAT and forest type in either the physical fractions or the chemical composition. Based on the relationship between the SOC content and MAT, we estimate that SOC in the top 20 soil layer of forests potentially contribute 6.58–26.3 Pg C globally to the atmosphere if global MAT increases by 1 °C–4 °C by the end of the twenty-first century, with nearly half of which(cf. 2.87–11.5 Pg C) occurring in the 0–5 cm mineral soils.Conclusion: Forest topsoil SOC content decreased and became chemical y more recalcitrant with increasing MAT,without apparent changes in the physical fractions of SOC. | Xiaolu Sun Zuoxin Tang Michael G.Ryan Yeming You Osbert Jianxin Sun | 2019 | Forest Ecosystems2019，6，1： | 4 |
| 12 | Laparoscopic approach of surgical treatment for primary hepatolithiasis: a cohort study显示文摘 | Eric C.H. Lai Tang Chung Ngai George P.C. Yang Michael K.W. Li | 2010 | The American Journal of Surgery2010，，5： | 4 |
| 13 | Impact of Meteorological Drought on Streamflow Drought in Jinghe River Basin of China显示文摘Under global climate change, drought has become one of the most serious natural hazards, affecting the ecological environment and human life. Drought can be categorized as meteorological, agricultural, hydrological or socio-economic drought. Among the different categories of drought, hydrological drought, especially streamflow drought, has been given more attention by local governments, researchers and the public in recent years. Identifying the occurrence of streamflow drought and issuing early warning can provide timely information for effective water resources management. In this study, streamflow drought is detected by using the Standardized Runoff Index, whereas meteorological drought is detected by the Standardized Precipitation Index. Comparative analyses of frequency, magnitude, onset and duration are conducted to identify the impact of meteorological drought on streamflow drought. This study focuses on the Jinghe River Basin in Northwest China, mainly providing the following findings. 1) Eleven meteorological droughts and six streamflow droughts were indicated during 1970 and 1990 after pooling using Inter-event time and volume Criterion method. 2) Streamflow drought in the Jinghe River Basin lagged meteorological drought for about 127 days. 3) The frequency of streamflow drought in Jinghe River Basin was less than meteorological drought. However, the average duration of streamflow drought is longer. 4) The magnitude of streamflow drought is greater than meteorological drought. These results not only play an important theoretical role in understanding relationships between different drought categories, but also have practical implications for streamflow drought mitigation and regional water resources management. | ZHAO Lin LYU Aifeng WU Jianjun Michael HAYES TANG Zhenghong HE Bin LIU Jinghui LIU Ming | 2014 | Chinese Geographical Science2014，24，6： | 4 |
| 14 | 高温合金差示扫描量热分析(DSC)的影响因素:粉末粒度和显微组织显示文摘对固溶强化型625镍基高温合金粉末进行升、降温差示扫描量热分析(DSC)试验,研究了不同粉末粒度(<37,45~53,75~105,105~150,150~355μm)对相变温度的影响。采用场发射扫描电镜(FESEM)、电子探针(EPMA)和同步辐射X射线衍射(SXRD)对625合金粉末的形貌、元素分布和相组成进行表征。结果表明:不同粒径PM625粉末均为树枝晶结构,枝晶间距在2~10μm范围,元素Ni和Cr倾向分布于枝晶干,Mo和Nb偏析于枝晶间。不同粒度的PM625粉末中均仅存在基体γ相。PM625粉末DSC加热曲线固相线附近区域拐点尖锐,表现为合金开始熔化温度(偏离基线的拐点)与名义固相线温度(切线交点)差异很小,不同粒度间的差异仅为2~5℃。合金完全熔化后重新冷却的过程中原始粉末的低偏析特性消失,冷却曲线固相线区域圆弧较大,名义固相线和终凝温度差较大,为53~65℃。DSC试验升温过程中不同粒径粉末的固、液相线以及初熔温度最大差异分别为3, 2和2℃,降温过程不同粒径粉末固、液相线温度差分别为6和2℃。0~355μm粉末粒径范围内,粒径对固溶强化型PM625高温合金粉末相变温度无明显影响。 | 郑亮 刘玉峰 Gorley Michael J Hong Zuliang DaySarah Tang Chiu C 李周 张国庆 | 2019 | 稀有金属材料与工程2019，48，5： | 3 |
| 15 | 乳腺癌发生模型MCF10抑癌基因NOEY2启动子区甲基化及mRNA表达显示文摘 | 杨举伦 David Klinkebiel Michael J Boland Lin Tang Judith K Christman | 2005 | 中华病理学杂志2005，34，3： | 3 |
| 16 | Diabetic Cardiomyopathy: Insights into Pathogenesis, Diagnostic Challenges, and Therapeutic Options显示文摘 | Ashish Aneja W.H. Wilson Tang Sameer Bansilal Mario J. Garcia Michael E. Farkouh | 2008 | The American Journal of Medicine2008，，9： | 3 |
| 17 | Preoperative Nutritional Status Is an Important Predictor of Survival in Patients Undergoing Surgery for Renal Cell Carcinoma显示文摘 | Todd M. Morgan Dominic Tang Kelly L. Stratton Daniel A. Barocas Christopher B. Anderson Justin R. Gregg Sam S. Chang Michael S. Cookson S. Duke Herrell Joseph A. Smith Peter E. Clark | 2011 | European Urology2011，，6： | 2 |
| 18 | HMGB1 in health and disease显示文摘 | Rui Kang Ruochan Chen Qiuhong Zhang Wen Hou Sha Wu Lizhi Cao Jin Huang Yan Yu Xue-gong Fan Zhengwen Yan Xiaofang Sun Haichao Wang Qingde Wang Allan Tsung Timothy R. Billiar Herbert J. Zeh Michael T. Lotze Daolin Tang | 2014 | Molecular Aspects of Medicine2014，，： | 2 |
| 19 | Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary Syndrome显示文摘 | Junlan Zhang Bao Luo Liping Tang Yongming Wang Cecil R. Stockard Inga Kadish Thomas Van Groen William E. Grizzle Selvarangan Ponnazhagan Michael B. Fallon | 2009 | Gastroenterology2009，，3： | 2 |
| 20 | Effect of Cardiac Resynchronization on Myocardial Efficiency and Regional Oxidative Metabolism显示文摘 | Heikki Ukkonen Rob S.B. Beanlands Ian G. Burwash Robert A. de Kemp Claude Nahmias Ernest Fallen Michael R.S. Hill Anthony S.L. Tang | 2003 | Circulation: Journal of the American Heart Association2003，，1： | 2 |
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