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| 1 | Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis显示文摘 | Yao Chen Yuxuan Zheng Yun Gao Zhen Lin Suming Yang Tongtong Wang Qiu Wang Nannan Xie Rong Hua Mingxi Liu Jiahao Sha Michael D. Griswold Jinsong Li Fuchou Tang Ming-Han Tong | 2018 | Cell Research2018，28，9： | 26 |
| 2 | Parthenogenetic haploid embryonic stem cells efficiently support mouse generation by oocyte injection显示文摘 | YuxuanWu Li Yang Jinsong Li Cuiqing Zhong Zhenfei Xie Qi Yin Rui Dong Suming Yang | 2016 | Cell Research2016，26，1： | 13 |
| 3 | Role and effect of vein-transplanted human umbilical cord mesenchymal stem cells in the repair of diabetic foot ulcers in rats显示文摘Diabetic foot ulcer(DFU)is one of diabetic complications,which is frequently present and tormented in diabetes mellitus.Most multipotent mesenchymal stromal cells(MSCs)are capable of immune evasion,providing an allogeneic,ready-to-use,cell product option for therapeutic applications.The beneficial effect of MSCs for the treatment of a variety of traumatic injuries,such as open wounds,has been extensively explored.In this study,a rat DFU model was used to simulate the pathophysiology of clinical patients and to investigate the localization of human umbilical cord mesenchymal stem cells(hUC-MSCs)after intravenous transplantation and its role in DFU healing,so as to evaluate the potential of hUC-MSCs in the treatment of DFU.The diabetic rat model was established by streptozotocin injection,which was used to create full-thickness foot dorsal skin wounds to mimic DFU by a 6-mm skin biopsy punch and a Westcott scissor.The hUC-MSCs were transplanted through femoral vein,and the ulcer cicatrization situation and the fate of hUC-MSCs were evaluated.Our data suggest that intravenously transplantated hUC-MSCs have the ability to migrate and locate to the wound tissue and are helpful to wound healing in DFU rats,partly by regulating inflammation,trans-differentiation and providing growth factors that promote angiogenesis,cell proliferation and collagen deposition.Herein,we demonstrate that hUC-MSC transplantation is able to accelerate DFU healing in rats and transplantation of exogenous stem cells may be a potential strategy for clinical application in DFUs. | Rongfeng Shi Weishuai Lian Yinpeng Jin Chuanwu Cao Shilong Han Xiaohu Yang Suming Zhao Maoquan Li Hui Zhao | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 13 |
| 4 | Efficient generation of the mouse model with a defined point mutation through haploid cell-mediated gene editing显示文摘Generation of mouse models carrying a defined point mutation,especially disease-related point mutations,is of considerable interest for research in biology and medicine.The standard method based on embryonic stem cell(ESC)-mediated homologous recombination(HR)is time-and labor-consuming.CRISPR-Cas9 system has been rapidly developed recently and adopted for efficient gene-editing in different species(Mei et al.,2016).Remarkably。 | Leixin Wei Xiukun Wang Suming Yang Wen Yuan Jinsong Li | 2017 | Journal of Genetics and Genomics2017，44，9： | 6 |
| 5 | In vivo study on the histocompatibility and degradation behavior of biodegradable poly(trimethylene carbonate-co-D,L-lactide)显示文摘这研究的目的是探索在里面 vivo 行为和 histocompatibility poly (trimethylene carbonate-co-d, l 减水乳酸)(PDLLA/TMC ) 并且它生产心血管的 stents 的可行性。有 50/50 的共聚物臼齿的比率被戒指洞聚合综合与 TMC 和 d, l-LA 和 l-LA。(l 减水乳酸)(PLLA ) Poly 作为控制被综合。三聚合物的电影被植入进 144 只 Wistar 老鼠。在培植的不同时间点,聚合物电影用尺寸排除层析,原子磁性的回声,环境扫描电子显微镜,和光显微镜是为降级特征和 histocompatibility 的评估的 explanted。结果证明在房间在不同聚合物之间数的集体损失,分子的重量,形状和外观变化,和发炎的百分比有差别。与扩大的时间,这部电影的表面的结构不同地转变了,它在 PDLLA/TMC 的聚合物是相当明显的。另外,在 PDLLA/TMC 有相对更低的发炎房间计数并且(trimethylene carbonate-co-l-lactide )(PLLA/TMC ) poly 在 PLLA 组与那些比较在不同时间点组织。差别具有统计意义(P < 0.05 ) 在这个组 PDLLA/TMC 对 PLLA,和 PLLA/TMC 对 PLLA 的组,然而并非在 PDLLA/TMC 和 PLLA/TMC 组以内(P > 0.05 ) 。这些结果建议有有利降级性能和 histocompatibility 的 PDLLA/TMC (50/50 ) 的聚合物为生产植入的心血管的 stents 充分可被细菌破坏、合适。 | Qingkui Guo Zhiqian Lu Yi Zhang Suming Li Jian Yang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，6： | 5 |
| 6 | 显示文摘 | YANG Chunyang ZHANG Zhujun CHEN Suming | 2007 | Micro Chem Acta2007，159，34： | 1 |
| 7 | The role of galU and galE of Haemophilus parasuis SC096 in serum resistance and biofilm formation显示文摘 | Yi Zou Saixiang Feng Chenggang Xu Bin Zhang Suming Zhou Lingyun Zhang Xianhui He Jingyi Li Zhen Yang Ming Liao | 2012 | Veterinary Microbiology2012，，： | 1 |
| 8 | A comprehensive change detection method for updating the National Land Cover Database to circa 2011显示文摘 | Jin Suming Yang Limin Danielson Patrick | 2013 | Remote Sensing of Environment2013，132，15： | 1 |
| 9 | Micelles formed by self-assembling of polylactide/poly(ethylene glycol)block copolymers in aqueous solutions显示文摘 | Yang Liu Zhao Zhenxian Wei Jia El Ghzaoui Abdelslam Li Suming | | 0，，： | 1 |
| 10 | 经阴道超声联合CEA、CA125、CA153鉴别诊断子宫腔占位性病变良恶性显示文摘目的:探讨经阴道超声联合CEA、CA125、CA153鉴别子宫腔占位性病变良恶性的价值.方法:收集2021年2月-2023年5月本院疑似子宫腔占位性病变患者117例临床资料,根据刮宫或术后病理检查结果分为恶性组及良性组,其中恶性组56例,为子宫内膜癌;良性组61例,为子宫内膜良性息肉.比较两组经阴道超声及血清指标差异,受试者工作特征曲线(ROC)分析各指标鉴别诊断子宫腔占位性病变良恶性效能.结果:超声检查收缩期峰值血流速度两组无差异(P>0.05),恶性组阻力指数小于良性组、内膜厚度大于良性组;恶性组血清癌胚抗原(CEA)、糖类抗原125、CA153水平均高于良性组(均P<0.05).ROC曲线结果显示,经阴道超声、血清CEA、CA125、CA153各指标单独或联合应用鉴别诊断子宫腔占位性病良恶性的AUC分别为0.822、0.713、0.728、0.797及0.915,均有价值,但联合诊断价值最高.结论:经阴道超声、血清CEA、CA125、CA153联合应用对宫腔占位性病变良恶性鉴别诊断效能较高,有较好的临床应用价值. | 刘鑫 张友 张润 陈星 LIU Lu YANG Yan LI Suming | 2024 | 中国计划生育学杂志2024，32，1： | 0 |
| 11 | H2O2-mediated DNA damage and repair in the brain cells in the aging rats detected by comet assay显示文摘Objective: To identify the relation between DNA damage susceptibility/ DNA repair capability and aging process after insults, an observation of H2O2_induced DNA damage and the kinetics of DNA repair in senescent murine brain cells with the alkaline single cell gel electrophoresis (SCGE/Comet assay) was made. Methods: The dissociated brain cells harvested in the area of the cerebral cortex, hippocampus, basal gang]ion from 3-month (n=10), 8-month (n=8) and 26-month (n=5) old rats were respectively treated with H2O2 in gradient doses for 10 min, or without H2O2 as controls. The cells embedded in agarose were lysed, helix-untied, electrophoresed, stained with a fluorescence DNA binding stain, viewed under a fluorescence microscope. Individual image was optically recorded. The frequency of the tailed cells and the grade of tails wereused to analyze single strand breaks of DNA and injury intensity. Results: By the cell and DNA image like comets, a linear increase was noticed in vulnerability of DNA both to H2O2 doses and to the age. Regarding the damaged region of the brain, the cortex cells were more vulnerable to the insult than the hippocampus/basal ganglionic cells. Whatever aging or not the cells were, the maximum of ratio of DNA repair was only within 1 hour during the incubation for 0.5-4 hours after the insults. Furthermore, the more aging, the less ratio of DNA repair of sick cells. Conclusion: The DNA damagesusceptibility and the DNA repair capability of individual cells, whatever its age is, can be detected by this brain cell injury model. Comet assay is a sensitive way to find out DNA damage and repair of the cells. It should be more difficult for the cells to cope with an acute and excessive than with a persistent, chronic and mild DNA damage which is more related to an accumulating injury, the aging. | Suming ZhangM.D., Ph.D Zongchao Han, M.D. Siyu Fang, M.D. Ruan Yang, M.D Wei Wang, M.D., Ph. D | 2000 | 中国临床神经科学2000，8，z1： | 0 |
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