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| 1 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 2 | Deep Mineralization Background and Metallogenic Regularity of the Tongling Ore District显示文摘Based on the geological conditions and characteristics of mineralization present,three-dimensional geological modelling is used in conjunction with previous deep research results,in order to discuss the process of deep mineralization in the Tongling ore district.The structural analysis shows that surface deformation is strong,deep deformation is weak,the surface has mainly experienced brittle deformation,with the possibility of a large number of deep ductile deformations.There is a thrust nappe between the Tongling uplift and the Nanling basin,that is the boundary of the Tongling block,which has resulted in the southwest uplift of the Tongling block.Combined with the deep exploration data,the threedimensional shape of the main rock masses is interpreted,with three-layer structures in the deep magma chamber.The spatial distribution of magmatic rocks is mainly controlled by the structure.The movement of magmatic hydrothermal fluid is dominated by mesoscale seepage in the deep part and'dike'type upwelling in the shallow part.There is a certain coupling relationship between the ore-forming rock mass and the surrounding rock.The ore-forming age is dominated by the Yanshanian period.Based on the distribution,types and metallogenic characteristics of the deposits,the metallogenic model of'layer coupling'in the Tongling ore district is summarized,with the'one body,two belts and a multilayer metallogenic system'is established,which is significant for the future direction of deep prospecting in the Tongling area. | WAN Qiu DU Jianguo YANG Bo LAN Xueyi XIAO Xiao SHI Ke | 2020 | Acta Geologica Sinica(English Edition)2020，94，6： | 0 |
| 3 | Finite element modeling and analysis of planetary gear transmission based on transient meshing properties显示文摘Planetary gear trains are widely applied in various transmission units.Whether strengths of all gears are accurately calculated or not can affect reliability of the entire system significantly.Strength calculation method for planetary gear trains usually follows the method for cylindrical gears,in which the worst meshing positions for both contact stress and bending stress cannot be determined precisely,and calculation results tend to be conservative.To overcome these shortcomings,a kinematics analysis for a planetary gear train is firstly performed,in which the influence of relative speed is investigated.Then the finite element strength analysis of a planetary gear train based on its transient meshing properties is carried out in ANSYS.Time–history curves of contact and bending stresses of sun gear,planetary gears and ring gear are respectively obtained.Also the accurate moment and its corresponding position of the maximum stress are precisely determined.Finally,calculation results of finite element method(FEM)and traditional method are compared in order to verify the effectiveness.Simulation and comparison show the stability of the proposed method in this paper.Researches in this paper establish the foundations for fatigue analysis and optimization for a planetary gear train. | Qingliang Zeng Shoubo Jiang Lirong Wan Xueyi Li | 2015 | International Journal of Modeling, Simulation, and Scientific Computing2015，6，3： | 0 |
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