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| 1 | Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones显示文摘 | Zongming Zhang Zhuo Liu Limin Liu Mengmeng Song Chong Zhang Hongwei Yu Baijiang Wan Mingwen Zhu Zixu Liu Hai Deng Haiming Yuan Haiyan Yang Wenping Wei Yue Zhao | 2017 | Frontiers of Medicine2017，11，4： | 37 |
| 2 | Land-atmosphere-ocean coupling associated with the Tibetan Plateau and its climate impacts显示文摘This paper reviews recent advances regarding land-atmosphere-ocean coupling associated with the Tibetan Plateau(TP)and its climatic impacts.Thermal forcing over the TP interacts strongly with that over the Iranian Plateau,forming a coupled heating system that elevates the tropopause,generates a monsoonal meridional circulation over South Asia and creates conditions of large-scale ascent favorable for Asian summer monsoon development.TP heating leads to intensification and westward extension(northward movement)of the South Asian High(Atlantic Intertropical Convergence Zone),and exerts strong impacts on upstream climate variations from North Atlantic to West Asia.It also affects oceanic circulation and buoyancy fields via atmospheric stationary wave trains and air-sea interaction processes,contributing to formation of the Atlantic Meridional Overturning Circulation.The TP thermal state and atmospheric-oceanic conditions are highly interactive and Asian summer monsoon variability is controlled synergistically by internal TP variability and external forcing factors. | Yimin Liu Mengmeng Lu Haijun Yang Anmin Duan Bian He Song Yang Guoxiong Wu | 2020 | National Science Review2020，7，3： | 21 |
| 3 | Qingnaoyizhi decoction suppresses the formation of glial fibrillary acidic protein-positive cells in cultured neural stem cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway显示文摘OBJECTIVE: Inactivation of the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3) signaling axis plays a crucial role in determining the fate of neural stem cells(NSCs).Qingnaoyizhi decoction(QNYZD) has been used for the treatment of vascular dementia and has shown to improve synaptic remodeling. The aim of this study was to evaluate the effect of cerebrospinal fluid(CSF) containing QNYZD(CSF-QNYZD) on the differentiation of cultured NSCs and the involvement of the JAK2/STAT3 pathway.METHODS: The protein expression levels of glial fibrillary acidic protein(GFAP), tubulin, drosophila mothers against decapentaplegic protein(SMAD-1), STAT3, and phosphorylated-STAT3 were detected by western immunoblot analysis in the groups: control, CSF, JAK/STAT inhibitor(AG490),CSF-QNYZD, and CSF-XDZ(CSF-Xidezhen). The differentiation of NSCs was determined by immunofluorescence staining. The proliferation of NSCs was measured using the Cell Counting Kit-8 proliferation assay.RESULTS: Compared with the control group,CSF-QNYZD and AG490 significantly increased the number and expression of tubulin-positive cells, reduced the number and expression of GFAP-positive cells, and down-regulated the expression of p-STAT3. However, CSF-QNYZD also decreased the expression of SMAD-1 and STAT3.CONCLUSION: Enhanced neuronal differentiation may be associated with the down-regulation of glial differentiation instead of promoting proliferationin treated NSCs. Furthermore, QNYZD may play a direct role in suppressing the formation of GFAP-positive cells and enhancing neuronal differentiation by inhibiting JAK2/STAT3 activation. Overall, these results provide insights into the possible mechanism underlying QNYZD-mediated neurogenesis. | Wu Yanqing Jing Zhiwei Qin Xiude Zhou Zhen Wang Kai Song Wanshan Wang Xueyan Hou Mengmeng Zhang Yulian Kang Liyuan | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 11 |
| 4 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 5 | A transition prediction method for flow over airfoils based on high-order dynamic mode decomposition显示文摘This article presents a novel approach for predicting transition locations over airfoils,which are used to activate turbulence model in a Reynolds-averaged Navier-Stokes flow solver.This approach combines Dynamic Mode Decomposition(DMD)with e^Ncriterion.The core idea is to use a spatial DMD analysis to extract the modes of unstable perturbations from a steady flowfield and substitute the local Linear Stability Theory(LST)analysis to quantify the spatial growth of Tollmien–Schlichting(TS)waves.Transition is assumed to take place at the stream-wise location where the most amplified mode’s N-factor reaches a prescribed threshold and a turbulence model is activated thereafter.To improve robustness,the high-order version of DMD technique(known as HODMD)is employed.A theoretical derivation is conducted to interpret how a spatial highorder DMD analysis can extract the growth rate of the unsteady perturbations.The new method is validated by transition predictions of flows over a low-speed Natural-Laminar-Flow(NLF)airfoil NLF0416 at various angles of attack and a transonic NLF airfoil NPU-LSC-72613.The transition locations predicted by our HODMD/e^Nmethod agree well with experimental data and compare favorably to those obtained by some existing methods■.It is shown that the proposed method is able to predict transition locations for flows over different types of airfoils and offers the potential for application to 3D wings as well as more complex configurations. | Mengmeng WU Zhonghua HAN Han NIE Wenping SONG Soledad Le CLAINCHE Esteban FERRER | 2019 | Chinese Journal of Aeronautics2019，32，11： | 7 |
| 6 | Bimetallic nano-mushrooms with DNA-mediated interior nanogaps for high-efficiency SERS signal amplification显示文摘有为散布的提高表面的拉曼(重量的单位) 分析的 ultrasensitive 的明确的 nanogaps 抓住伟人诺言的一致包含银的金属 nanostructures。不过,有强壮、稳定的重量的单位的如此的 nanostructures 的直接合成表明极其质问的遗体。这里,我们与内部 nanogaps 为金银的 nano 蘑菇的直接合成报导一条调停 DNA 的途径。这些 nano 蘑菇的重量的单位紧张极其依赖于在金头和银帽子之间的 nanogap 的区域。我们发现 nanogaps 的形成由控制在金 nanoparticles 上标记搁浅单人赛的 DNA (ssDNA ) 的 6-carboxy-X-rhodamine (ROX ) 的表面密度是细微地悦耳的。我们与 1.0 的一个高重量的单位信号改进因素在高产量获得了 nano 蘑菇我们作为一项 retrofit 措施在 CHS 在用阶段变化材料(脉冲编码调制) 的热存储的采纳以后。结果显示那与融化 23 的温度使用脉冲编码调制 ? 訄吗?? | Jianlei Shen Jing Su Juan Yan Bin Zhao Dongfang Wang Siyi Wang Kun Li Mengmeng Liu Yao He Sanjay Mathur Chunhai Fan Shiping Song | 2015 | Nano Research2015，8，3： | 4 |
| 7 | Settling behavior of spherical particles in vertical annulus:Experimental study and model development显示文摘Coiled tubing(CT)drilling technology offers significant advantages in terms of cost and efficiency for exploitations of unconventional oil and gas resources.However,the development of CT drilling technol-ogy is restricted by cuttings accumulation in the wellbore due to non-rotation of the drill string and limited circulating capacity.Cuttings cleaning becomes more difficult with the wall resistance of pipe-wellbore annulus on the cutting transport.Accurate description of particle transport process in the pipe-wellbore annulus is,therefore,important for improving the wellbore cleanliness.In this study,high-speed cam-era is used to record and analyze the settling process of particles in the transparent annulus filled with power-law fluids.A total of 540 tests were carried out,involving dimensionless diameters of 0.10-0.95 and particle Reynolds Numbers of 0.01-12.97,revealing the effect of the dimensionless diameter and particle Reynolds number on the annulus wall effect,and the wall factor model with an average relative error of2.75%was established.In addition,a dimensionless parameter,Archimedes number,independent of the settling velocity,was introduced to establish an explicit model of the settling velocity of spherical particles in the vertical annulus,with the average relative error of 7.89%.Finally,a calculation example was provided to show how to use the explicit model of settling velocity in annulus.The results of this study are expected to provide guidance for field engineers to improve the wellbore cleanliness of coiled tubing drilling. | Zhaopeng Zhu Mengmeng Zhou Xianzhi Song Shuo Zhu Gensheng Li Zhengming Xu Xuezhe Yao Buwen Yu | 2022 | Particuology2022，20，9： | 2 |
| 8 | Strength criterion effect of the translator and destabilization model of gas-bearing coal seam显示文摘Coal seam destabilization inflicts damage to equipment, causes property loss and personnel casualties,and severely threatens mining safety and efficient production. To further understand this destabilization based on the basic theory of Lippmann seam destabilization, a mathematical model was introduced for gas pressure distribution by considering intermediate principal stress and support resistance.Subsequently, we established a translation model suitable for the entire roadway coal seam with rocky roof and floor by applying the unified form of yield criterion in the state of plane strain. We also obtained the analytic expressions of coal seam stress distribution on both sides of the roadway and the widths of plastic and disturbance zones. Afterward, we analyzed several typical cases with different material yield criteria, obtained the plastic zone widths of the coal seam under different gas pressures, and assessed the effects of support resistance, roadway size, and coal strength on coal seam destabilization. Results showed that: the results obtained on the basis of Wilson and Mohr–Coulomb criteria are considerably conservative, and the use of Druker–Prager criteria to evaluate the rockburst-induced coal seam destabilization is safer than the use of the two other criteria; coal seam stability is correlated with gas pressure;and high-pressure gas accelerates the coal seam destabilization. | Gang Wang Rui Wang Mengmeng Wu Cheng Fan Xiang Song | 2019 | International Journal of Mining Science and Technology2019，29，2： | 2 |
| 9 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 10 | Effect of strawberry vein banding virus and strawberry mottle virus co-infection on the growth and development of strawberry显示文摘Strawberry mottle virus(SMoV)and strawberry vein banding virus(SVBV)cause diseases on strawberry plants,but the effect of coinfection of SMoV and SVBV on the growth,development,and defense system of strawberry(Fragaria×ananassa Duchesne)remains unknown.We investigated the effect of SMoV and SVBV coinfection on strawberry cultivar‘Benihope’.The results showed that stem diameter,leaf size,leaf number,relative chlorophyll content,total chlorophyll content,photosynthetic parameters,and stomatal aperture of SMoV and SVBV co-infected strawberry(VIS)plants were in a weaker level than uninfected control plants,indicating that viruses inhibited the growth and photosynthesis of strawberry plants.Furthermore,the initiation of flowering and fruiting stages of VIS plants were delayed by about three weeks compared with the controls,and the fruiting period was shortened,demonstrating that the reproduction of VIS plants was inhibited.Fruit quality was damaged in VIS plants due to a significant increase in fruit firmness and titratable acidity and decrease in total soluble solid content than control fruits.More dead cells and H_(2)O_(2) accumulated along the veins of VIS leaves,and the content of abscisic acid and catalase activity significantly increased,whereas anthocyanin content was lower than that of control plants.The results demonstrate that SVBV and SMoV coinfection inhibits the growth and development of‘Benihope’strawberry plants,and the plants respond to viruses by regulating stomatal aperture,the accumulation of ABA and antioxidants.To our knowledge,this study contributes information to understand how both viruses impair the strawberry growth and development for the first time. | LINGJIAO FAN DAN SONG YINGWEI KHOO MENGMENG WU TENGFEI XU XIAOLI ZHAO HONGQING WANG | 2022 | BIOCELL2022，46，1： | 1 |
| 11 | Development and Validation of a Nomogram for Prediction of the Risk of MAFLD in an Overweight and Obese Population显示文摘Background and Aims:Metabolic associated fatty liver disease(MAFLD)is a serious condition,and a simple meth-od is needed for practitioners to identify patients with the disease and have a high risk of disease progression.Meth-ods:We developed and validated a nomogram for fatty liver disease and reclassified the risk factors for MAFLD.The development cohort had 335 patients who received bioel-ectrical impedance analysis and liver ultrasound attenua-tion measurements at Shenzhen People’s Hospital between September 2020 and June 2021.The validation cohort had 200 patients from other hospitals who received the same evaluation.A random forest procedure and binary logistic analysis were used to screen for risk factors,establish a fatty liver disease predictive model,and forecast the risk of MAFLD.The performance of the nomogram was evaluated by measurement of discrimination,calibration,and clinical usefulness.Results:The nomogram provided good predic-tions in a model that included body mass index(BMI)and waist circumference.The areas under the curve of the nom-ogram were 0.793 in the development cohort and 0.774 in the validation cohort.The nomogram performed well for calibration,category-free net reclassification improvement,and integrated discrimination improvement.Decision curve analysis indicated the nomogram performed better than BMI for predicting net outcome.Conclusions:The nomo-gram was an effective screening tool for fatty liver disease,and for those overweight individuals,may help physicians make appropriate decisions regarding treatment of MAFLD. | Di Song Qian Ge Ming Chen Song Bai Xiaoshu Lai Gege Huang Mengmeng Liu Miaofang Lin Jinfeng Xu Fajin Dong | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 1 |
| 12 | Xylo-Oligosaccharide Preparation through Enzyme Hydrolysis of Hemicelluloses Isolated from Press Lye显示文摘The emerging food additive, xylo-oligosaccharide(XOSs), was prepared through enzymatic hydrolysis of hemicelluloses isolated from press lye. Two of the three experimental enzyme preparations presented favourable effects, while the other one consisting of the nominal enzyme preparations with high enzyme activity was found to have poor catalytic effects. The conversion of xylan exceeded 40% and the selectivity for XOSs reached 90% when the temperature, hemicellulose concentration, dosage of enzymes, and hydrolysis time were 40?C, 100 g/L, 1 ku/g, and 4 h, respectively. Xylo-oligosaccharide preparation through enzymatic hydrolysis of hemicelluloses isolated from press lye was proved to be a feasible process to utilize the by-product of the lye regeneration, which will substantially improve the economy of the lye regeneration and recycling. | WANG Tiangui LI Chuang FAN Rongrong SONG Mengmeng | 2018 | Grain & Oil Science and Technology2018，1，4： | 1 |
| 13 | Porous fixed-bed photoreactor for boosting C-C coupling in photocatalytic CO_(2)reduction显示文摘Solar-driven CO_(2)conversion to chemical fuels in an aqueous solution is restricted not only by photocatalysts but also by mass transfer.Here,a regulatable three-phase interface on a porous fixed-bed is constructed for efficient C-C coupling in photocatalytic CO_(2)reduction.The photocatalytic results show that∼90%selectivity towards C^(2+)products is obtained by a Cu/Cd_(0.5)Zn_(0.5)S photocatalyst,with a yield of 6.54μmol/h(an irradiation area of 0.785 cm^(2)),while only 0.94μmol/h(an irradiation area of 19.625 cm^(2))is achieved with a commonly used suspension photocatalytic reactor.We find that under the same CO_(2)feed rate,the local CO_(2)concentration in this porous fixed-bed photoreactor is obviously higher than in the suspension photoreactor.The larger local CO_(2)coverage derived from a higher CO_(2)supply and aggregation enhances the C-C coupling,thereby generating more C^(2+).Even an observable three-phase interface on the porous fixed-bed can be regulated by adjusting the CO_(2)supply,for which the optimal gas inlet rate is 5-10 sccm. | Shengjie Bai Haoran Qiu Mengmeng Song Guiwei He Feng Wang Liejin Guo | 2022 | eScience2022，2，4： | 1 |
| 14 | MiR-495 functions as an adjuvant to radiation therapy by reducing the radiation-induced bystander effect显示文摘 | Jie Fu Mengmeng Jiang Meng Zhang Jing Zhang Yu Wang Shensi Xiang Xiaojie Xu Qinong Ye Haifeng Song | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 1 |
| 15 | Immunogenicity of different recombinant rabbit hemorrhagic disease virus-like particles carrying CD8+ T cell epitope from chicken ovalbumin (OVA)显示文摘 | Mengmeng Chen Yanhua Song Zhiyu Fan Ping Jiang Bo Hu Jiabin Xue Houjun Wei Fang Wang | 2014 | Virus Research2014，，： | 1 |
| 16 | A high-resolution ammonia emission inventory in China显示文摘 | Huang Xin Song Yu Li Mengmeng Li Jianfeng Huo Qing Cai Xuhui Zhu Tong Hu Min Zhang Hongsheng | 2012 | EN2012，，1： | 1 |
| 17 | A high-resolution emission inventory of crop burning in fields in China based on MODIS Thermal Anomalies/Fire products显示文摘 | Xin Huang Mengmeng Li Jianfeng Li Yu Song | 2012 | Atmospheric Environment2012，，： | 1 |
| 18 | A high-resolutionammonia emission inventory in China 显示文摘 | HUANG Xin SONG Yu LI Mengmeng | 2012 | Global BiogeochemicalCycles2012，26，1： | 1 |
| 19 | A biomimetic antitumor nanovaccine based on biocompatible calcium pyrophosphate and tumor cell membrane antigens显示文摘Currently,the cancer immunotherapy has made great progress while antitumor vaccine attracts substantial attention.Still,the selection of adjuvants as well as antigens are always the most crucial issues for better vaccination.In this study,we proposed a biomimetic antitumor nanovaccine based on biocompatible nanocarriers and tumor cell membrane antigens.Briefly,endogenous calcium pyrophosphate nanogranules with possible immune potentiating effect are designed and engineered,both as delivery vehicles and adjuvants.Then,these nanocarriers are coated with lipids and B16-OVA tumor cell membranes,so the biomembrane proteins can serve as tumor-specific antigens.It was found that calcium pyrophosphate nanogranules themselves were compatible and possessed adjuvant effect,while membrane proteins including tumor associated antigen were transferred onto the nanocarriers.It was demonstrated that such a biomimetic nanovaccine could be well endocytosed by dendritic cells,promote their maturation and antigen-presentation,facilitate lymph retention,and trigger obvious immune response.It was confirmed that the biomimetic vaccine could induce strong T-cell response,exhibit excellent tumor therapy and prophylactic effects,and simultaneously possess nice biocompatibility.In general,the present investigation might provide insights for the further design and application of antitumor vaccines. | Minghui Li Mengmeng Qin Ge Song Hailiang Deng Dakuan Wang Xueqing Wang Wenbing Dai Bing He Hua Zhang Qiang Zhang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，1： | 1 |
| 20 | Numerical si- mulation on hydro-mechanical coupling in porous media adopting three-dimensional pore-scale model显示文摘 | Liu Jianjun Song Rui Cui Mengmeng | 2014 | The Sci- entific World Journal2014，，： | 1 |
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