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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones显示文摘 | Zongming Zhang Zhuo Liu Limin Liu Mengmeng Song Chong Zhang Hongwei Yu Baijiang Wan Mingwen Zhu Zixu Liu Hai Deng Haiming Yuan Haiyan Yang Wenping Wei Yue Zhao | 2017 | Frontiers of Medicine2017，11，4： | 37 |
| 3 | Analyses on the tectonic thermal evolution and influence factors in the deep-water Qiongdongnan Basin显示文摘To reveal the tectonic thermal evolution and influence factors on the present heat flow distribution, based on 154 heat flow data, the present heat flow distribution features of the main tectonic units are first analyzed in detail, then the tectonic thermal evolution histories of 20 profiles are reestablished crossing the main deep-water sags with a structural, thermal and sedimentary coupled numerical model. On the basis of the present geothermal features, the Qiongdongnan Basin could be divided into three regions: the northern shelf and upper slope region with a heat flow of 50–70 m W/m2, most of the central depression zone of 70–85 m W/m2, and a NE trending high heat flow zone of 85–105 m W/m2 lying in the eastern basin. Numerical modeling shows that during the syn-rift phase, the heat flow increases generally with time, and is higher in basement high area than in its adjacent sags. At the end of the syn-rift phase, the heat flow in the deepwater sags was in a range of 60–85 m W/m2, while in the basement high area, it was in a range of 75–100 m W/m2. During the post-rift phase, the heat flow decreased gradually, and tended to be more uniform in the basement highs and sags. However, an extensive magmatism, which equivalently happened at around 5 Ma, has greatly increased the heat flow values, and the relict heat still contributes about 10–25 m W/m2 to the present surface heat flow in the central depression zone and the southern uplift zone. Further analyses suggested that the present high heat flow in the deep-water Qiongdongnan Basin is a combined result of the thermal anomaly in the upper mantle, highly thinning of the lithosphere, and the recent extensive magmatism. Other secondary factors might have affected the heat flow distribution features in some local regions. These factors include basement and seafloor topography, sediment heat generation, thermal blanketing, local magmatic injecting and hydrothermal activities related to faulting and overpressure. | WANG Zhenfeng SHI Xiaobin YANG Jun HUANG Baojia SUN Zhen WANG Yahui JIANG Haiyan YU Chuanhai YANG Xiaoqiu | 2014 | Acta Oceanologica Sinica2014，33，12： | 22 |
| 4 | The chromosome-level quality genome provides insights into the evolution of the biosynthesis genes for aroma compounds of Osmanthus fragrans显示文摘Sweet osmanthus(Osmanthus fragrans)is a very popular ornamental tree species throughout Southeast Asia and USA particularly for its extremely fragrant aroma.We constructed a chromosome-level reference genome of O.fragrans to assist in studies of the evolution,genetic diversity,and molecular mechanism of aroma development.A total of over 118 Gb of polished reads was produced from HiSeq(45.1 Gb)and PacBio Sequel(73.35 Gb),giving 100×depth coverage for long reads.The combination of Illumina-short reads,PacBio-long reads,and Hi-C data produced the final chromosome quality genome of O.fragrans with a genome size of 727 Mb and a heterozygosity of 1.45%.The genome was annotated using de novo and homology comparison and further refined with transcriptome data.The genome of O.fragrans was predicted to have 45,542 genes,of which 95.68%were functionally annotated.Genome annotation found 49.35%as the repetitive sequences,with long terminal repeats(LTR)being the richest(28.94%).Genome evolution analysis indicated the evidence of whole-genome duplication 15 million years ago,which contributed to the current content of 45,242 genes.Metabolic analysis revealed that linalool,a monoterpene is the main aroma compound.Based on the genome and transcriptome,we further demonstrated the direct connection between terpene synthases(TPSs)and the rich aromatic molecules in O.fragrans.We identified three new flower-specific TPS genes,of which the expression coincided with the production of linalool.Our results suggest that the high number of TPS genes and the flower tissue-and stage-specific TPS genes expressions might drive the strong unique aroma production of O.fragrans. | Xiulian Yang Yuanzheng Yue Haiyan Li Wenjie Ding Gongwei Chen Tingting Shi Junhao Chen Min S.Park Fei Chen Lianggui Wang | 2018 | Horticulture Research2018，5，1： | 16 |
| 5 | Effects of Slope Aspects on Soil Bacterial and Arbuscular Fungal Communities in a Boreal Forest in China显示文摘在 forested 环境的土壤 biogeochemical 性质和植物社区上的斜坡方面的效果广泛地被学习了;然而,倾斜对的方面影响大部分玷污微生物引起的社区遗体 unexamined,尽管有在生态系统工作的土壤生物区系的中央角色。在这研究,土壤细菌和 arbuscular mycorrhizal 真菌(AMF ) 的社区在更大的 Khingan 山的一个北方的森林里为斜坡方面(面对南方的方面,面对北方的方面和扁平的区域) 的三种类型用标注 pyrosequencing 被调查,中国。细菌并且 AMF 社区作文与斜坡方面不同。细菌的差异在面对北方的方面上是最低的,并且 AMF 差异在扁平的区域上是最低的。方面也在土壤 pH 和可得到的磷(P) 和灌木状的生物资源上有重要影响。土壤 pH 和 understory 灌木生物资源显著地与细菌的社区被相关,并且玷污可得到的 P 和灌木生物资源与 AMF 社区的显示出的重要关联。我们的结果建议了那个斜坡细菌的影响的方面和 AMF 社区,在植物社区和土壤化学药品性质由导致方面的变化调停了(例如, pH 和可得到的 P ) ,它在森林斜坡方面的效果上改进了知识在上未葬、地下社区。 | CHU Haiyan XIANG Xingjia YANG Jian Jonathan M. ADAMS ZHANG Kaoping LI Yuntao SHI Yu | 2016 | Pedosphere2016，26，2： | 15 |
| 6 | Association of miR-502-binding site single nucleotide polymorphism in the 3'-untranslated region of SET8 and TP53 codon 72 polymorphism with non-small cell lung cancer in Chinese population显示文摘这研究的目的是识别是否在 3-untranslated 区域( 3-UTR )的 miR-502-binding 地点单身者核苷酸多型性( SNP )使蛋白质 8 包含域( SET8 )并且肿瘤蛋白质 p53 ( TP53 ) codon 72 多型性为非小的房间肺癌症与风险被联系( NSCLC ),独立地或联合,在从南部的汉的中国人民之中。SET8 和 TP53 codon 的遗传型外部血 DNA 的 72 多型性用在 164 个 NSCLC 盒子和 199 控制上在 casecontrol 研究定序的聚合酶链反应限制碎片长度多型性和直接 DNA 被检测。SET8 TT (机会比率,或 = 2.173, 95% 信心间隔, CI = 1.0454.517 ) 或 TP53 GG (或 = 2.579, 95% CI = 1.3664.870 ) 遗传型被分别地与 SET8 CC 或 TP53 CC 遗传型作比较与 NSCLC 的增加的风险联系。类似的结果在 SET8 后退的模型被获得(或 = 2.074, 95% CI = 1.0194.221, P < 0.05 ) ,并且 TP53 codon 的主导、后退的模型 72 被执行,分别地(或 = 1.809, 95% CI = 1.1592.825, P < 0.05;或 = 1.933, 95% CI = 1.0963.409, P < 0.05 ) 。另外,在 SET8 和 TP53 多型性之间的相互作用增加了 NSCLC 的风险在一多样地举止,与 OR 是 3.032 (95%CI = 1.5805.816 ) 为带 SET8 TT 和 TP53 GG 遗传型的题目。因此,在 SET8 和 TP53 codon 的 3-UTR 的 miR-502-binding 地点 SNP 72 多型性可以是到在中国人口的 NSCLC 的基因危险性的标记,并且在 NSCLC 的发生有一个可能的 genegene 相互作用。 | Shaodi Yang Haiyan Guo Benjie Wei Shengcui Zhu Yanlin Cai Pei Jiang Jianxin Tang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 12 |
| 7 | β-diversity Patterns of Plant Community in Fragmented Habitat in a Degenerated Meadow in Songnen Plain,China显示文摘A number of isolated islands of Leymus chinensis + herbosa community were investigated in fragmented habitat islands,by Braun-Blanquet field survey approach,in a degenerated meadow in the Songnen Plain,China in 2007.These islands were classified as large,medium,and small scales on the basis of the island area(100-1000m2,large island;50-100m2,middle island;10-50m2,small island).Each scale of the investigation involved eight islands.The responses of β-diversity patterns of plant taxon to the habitat fragmentation at local community and metacommunity levels were analyzed on different scales of 24 isolated islands.The results indicated that at the local community level,there were 57 species belonging to 20 families and 49 genera in large islands,49 species belonging to 16 families and 40 genera in middle islands,and 27 species belonging to eight families and 23 genera in small islands.β-diversity indexes for species,genus and family in large,middle,and small islands varied greatly,and the highest value of the indexes was not noted in the largest island.However,the average of the data obtained at the three scales showed that across large islands,Whittaker indexes were low and Bray-Curtis similarity indexes were high,while across small islands,Whittaker indexes were high and Bray-Curtis similarity indexes were low.At the metacommunity level,Whittaker indexes for species and genus showed a great significantly negative double logarithmic correlation(p<0.01) with the island area,whereas the Bray-Curtis indexes for species,genus and family showed a great significantly positive double logarithmic correlation(p<0.01) with the island area.At both local community and metacommunity levels,turnovers of species and genus could respond more sensitively to spatial changes of plant diversity patterns than that of family.Hence,the species and the genus could be used for the analysis of β-diversity patterns of plant community. | HAN Dayong LI Haiyan YANG Yunfei | 2009 | Chinese Geographical Science2009，19，4： | 11 |
| 8 | Multi-drug Resistance and Characteristic of Integrons in Shigella spp.Isolated from China显示文摘Objective To investigate the characteristic of integrons and the relationship between integrons and antimicrobial resistance in Shigella spp. Methods Ninety Shigella strains (83 S. flexneri and 7 S. sonnei) were isolated from the stools of patients in China. Susceptibility to 8 antimicrobials was tested for all isolated strains. PCR, RFLP and sequencing analysis of integrons were applied to all of them. Results High prevalence of multi‐drug resistance (95.6%) was identified. Of the isolates 79 (87.8%) carried integrase genes of class 1 integron (3.3%), class 2 integron (10.0%) or both (74.4%). No intI3 was detected in the tested isolates. The prevalence of intI2 was significantly higher in isolates with multi‐drug resistance to at least 3 antibiotics than that in isolates with resistance to 2 and less antibiotics (P<0.05). Gene cassettes dfrA17‐aadA5, dfrA12‐orfF‐aadA2 of class 1 integron and dfrA1‐sat1‐aadA1 of class 2 integron were identified. Conclusion The class 2 integron may play a role in the emergence of multi‐drug resistance in Shigella spp. | ZHU JingYuan DUAN GuangCai YANG HaiYan FAN QingTang XI YuanLin | 2011 | Biomedical and Environmental Sciences2011，24，1： | 11 |
| 9 | Spatial variability of soil organic carbon in the forestlands of northeast China显示文摘Soil organic carbon(SOC) is an effective indicator of soil fertility and productivity, and it varies spatially and temporally in relation to other soil properties. Spatial variability of SOC in the forestlands of northeast China was characterized using geostatistics. Soil samples at the depths of 0?20 cm, 20?40 cm and 40?60 cm were collected from sixty-three temporary plots to evaluate SOC concentration and density(SOCD) and other soil properties. We analyzed correlations between SOC and soil properties. Soil organic carbon concentrations were high. The total amount of C stored in soil(0?60 cm) was 16.23 kg·m-2 with the highest SOCD of 7.98 kg?m-2 in topsoil. Soil properties in most cases differed by horizon, suggesting different processes and effects in each horizon. Soil organic carbon had positive relationships with total N, P and K as well as readily available K, but did not show a significant positive correlation with available P. Spatial factors including elevation, slope and aspect affected SOC distribution. Soil organic carbon at 0?60 cm had strong spatial autocorrelation with nugget/sill ratio of 5.7%, and moderate structured dependence was found at 0?20 cm, which indicated the existence of a highly developed spatial structure. Spatial distributionsof SOC concentration and SOCD were estimated using regression-kriging, with higher prediction accuracy than ordinary kriging. The fractal dimension of SOC indicated the preferential pattern of SOC distribution, with the greatest spatial heterogeneity and strongest spatial dependence in the northeast-southwest direction. | Ling Liu Haiyan Wang Wei Dai Xiangdong Lei Xiaojuan Yang Xu Li | 2014 | Journal of Forestry Research2014，25，4： | 11 |
| 10 | Biological soil crust distribution in Artemisia ordosica communities along a grazing pressure gradient in Mu Us Sandy Land, Northern China显示文摘This study investigated the distribution pattern of biological soil crust (BSC) in Artemisia ordosica communities in Mu Us Sandy Land. Three experimental sites were selected according to grazing pressure gradient. In each experimental site, the total vegetation cover, A. ordosica cover, BSC cover, litter-fall cover, BSC degree of fragmentation, BSC thickness and soil properties were investigated in both fixed and semi-fixed sand dunes and simultaneously analyzed in the laboratory. The results showed that at the same grazing pressure, BSC cover and composition were significantly affected by the fixation degree of sand dunes. In addition, BSC cover in the fixed sand dunes was 83.74% on average, whereas it is proportionally dominated by 28% mosses, 21% lichens, and 51% algae. Meanwhile, BSC cover in the semi-fixed sand dunes was 23.54% on average, which is proportionally dominated by 6.3% mosses, 2.5% lichens, and 91.2% algae. Fine sand, organic matter, and total nitrogen (N) contents in the fixed sand dunes were all significantly higher than those in the semi-fixed sand dunes. Litter-fall cover decreased along the grazing pressure gradient, whereas BSC fragmentation degree increased. Fine sand content decreased along with the increase of grazing pressure, whereas medium sand content increased in both fixed and semi-fixed dunes. The organic matter and total N contents in the no grazing site were significantly higher than those in light and normal grazing sites. However, there were no significant differences between the light and normal grazing sites. In addition, there were also no significant differences in BSC thickness between the light and normal grazing sites in the fixed sand dunes. However, a significant decrease was observed in both BSC cover and thickness in the normal grazing site. The BSC in the semi-fixed dunes was more sensitive to disturbance. | JunHong ZHANG Bo WU YongHua LI WenBin YANG YaKai LEI HaiYan HAN Ji HE | 2013 | Journal of Arid Land2013，5，2： | 10 |
| 11 | Comparison study of phosphorus adsorption on different waste solids:Fly ash,red mud and ferric–alum water treatment residues显示文摘The adsorption of phosphorus(P) onto three industrial solid wastes(fly ash, red mud and ferric–alum water treatment residual(FAR)) and their modified materials was studied systematically via batch experiments. Compared with two natural adsorbents(zeolite and diatomite), three solid wastes possessed a higher adsorption capacity for P because of the higher Fe, Al and Ca contents. After modification(i.e., the fly ash and red mud modified by FeCl_3 and FARs modified by HCl), the adsorption capacity increased, especially for the modified red mud, where more Fe bonded P was observed. The P adsorption kinetics can be satisfactorily fitted using the pseudo-second-order model. The Langmuir model can describe well the P adsorption on all of the samples in our study. p H and dissolved organic matter(DOM) are two important factors for P adsorption. Under neutral conditions, the maximum adsorption amount on the modified materials was observed. With the deviation from pH 7, the adsorption amount decreased, which resulted from the change of P species in water and surface charges of the adsorbents. The DOM in water can promote P adsorption, which may be due to the promotion effects of humic-Fe(Al) complexes and the pH buffer function exceeds the depression of competitive adsorption. | Ying Wang Yange Yu Haiyan Li Chanchan Shen | 2016 | Journal of Environmental Sciences2016，28，12： | 10 |
| 12 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 13 | The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4+CD25+ regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment显示文摘 | Jiezuan Yang Guoping Sheng Dangsheng Xiao Haiyan Shi Wei Wu Haifeng Lu Ping Yi Hongcui Cao Lanjuan Li | 2016 | Cellular & Molecular Immunology2016，13，5： | 9 |
| 14 | In-situ lunar dust deposition amount induced by lander landing in Chang’E-3 mission显示文摘China first in-situ lunar dust experiment is performed by a lunar dust detector in Chang’E-3 mission. The existed dust(less than 20 μm in diameter) properties, such as levitation, transportation and adhesion, are critical constraints for future lunar exploration program and even manned lunar exploration. Based on the problems discussed above, the in-situ lunar dust detector is originally designed to characterize dust deposition properties induced by lander landing as a function of environmental temperature, solar incident angle and orbit short circuit current on the northern Mare Imbrium, aiming to study lunar dust deposition properties induced by lander landing in depth. This paper begins with a brief of introduction of Chang’E-3 lunar dust detector design,followed by a series of experimental analysis of this instrument under different influencing factors, and concludes with lunar dust mass density deposition amount observed on the first lunar day is about 0.83 mg/cm^2, which is less than that observed in Apollo 11 mission because the landing site of Chang’E-3 has the youngest mare basalts comparing with previous Apollo and lunar landing sites. The young geologic environment is less weathered and thus it has thinner layer of lunar dust than Apollo missions’;hence, the amount of kicked-up lunar dust in Chang’E-3 mission is less than that in Apollo 11 mission. | ZHANG HaiYan WANG Yi CHEN LiPing ZHANG He LI CunHui ZHUANG JianHong LI DeTian WANG YongJun YANG ShengSheng LI XiongYao WANG WeiDong | 2020 | Science China(Technological Sciences)2020，63，3： | 9 |
| 15 | Study of the minerogenetic mechanism and origin of Qinghai nephrite from Golmud, Qinghai, Northwest China显示文摘Electronic microprobe analysis showed that all QN samples are mainly composed of tremolite and minor accessory minerals, such as diopside, calcite, serpentinite, and magnetite. According to the cation coefficients, the crystallo-chemistrygenesis illustration demonstrates that all QN deposits are contact metasomatic. Depending on the mole percent of Fe^(2+(3+))/(Mg^(2+)+Fe^(2+(3+)) and the content of Cr, Co, and Ni in all QN samples measured by X-ray fluorescence spectroscopy(XRF) and inductively coupled plasma-mass spectrometry(ICP-MS), green and azure-green QNs are characterized as serpentinite-related contact metasomatic deposit(S-type), whereas white, green-white, brown, blue-violet, yellow, and viridis QNs are dolomite-related contact metasomatic deposit(D-type). The assemblages and chemical composition of accessory minerals of the eight-color QN samples show evident characteristics, which reveal four possible ore-forming processes. We also measured trace and rare earth elements(REEs) in these samples through ICP-MS to deduce the origin of and the changes in metallogenic conditions. The chondrite-normalized REE patterns of D-type QN exhibit moderately negative Eu anomalies with moderate light REE enrichment, flat heavy REE(HREE), and low(50)REE concentrations, similar to dolomitic marble. Green QN samples of S-type show enrichment in HREE and moderately negative Eu anomalies, which is consistent with characteristics of dunite. Whereas azure-green QN samples of S-type exhibit a right-dipping V-type curve with severe depletion in Eu(δEu=0.36–0.47), in accordance with the characteristics of gabbro from Yushigou ophiolite in North Qilian mountains. Furthermore, this finding is consistent with the content of trace elements and the petrographic analysis results. On the basis of several significant differences in the characteristic elements, which may have been affected by the metallogenic environment, we inferred the differences in oxygen fugacity and basicity of mineralization environments in different-colored QNs. | YU HaiYan WANG RuCheng GUO JiChun LI JiaGui YANG XiaoWen | 2016 | Science China Earth Sciences2016，59，8： | 8 |
| 16 | The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands显示文摘电压门钾(Kv ) 隧道在电压传感器领域(VSD ) 从 gating 费用的运动导出他们的电压敏感。gating 在 VSD 通过一条物理小径控告 translocate 打开或关门隧道。以前的研究证明 gating 控告 Shaker 的小径, Kv1.2-2.1 妄想的隧道被堵塞,形成集中的电场和 gating 费用转移中心的结构的基础。这里,我们证明 gating 控告电压门 KCNQ2 钾隧道的小径,哪个引起癫痫的活动减小,能提供各种各样的小分子 ligands。记录的联合 mutagenesis,分子的模拟和 electrophysiological,为探查使活跃之物的一个有约束力的模型, ztz240,在 gating 费用,小径被定义。这个信息被用来建立指向定义 ligand 有约束力的衣袋的基于船坞的虚拟屏蔽试金。有五新 chemotypes 的九使活跃之物被识别,并且在 vivo,实验显示出那三 ligands 绑定到 gating 费用小径展览重要反癫痫活动。由指向衣袋的虚拟屏蔽的各种各样的新奇使活跃之物的鉴定在 gating 费用小径支持一个 ligand 有约束力的地点的存在。gating 费用小径的能力提供新卓见提供小分子 ligands 进治疗学地相关的 KCNQ2 隧道的 gating 费用小径。 | Ping Li Zhuxi Chen Haiyan Xu Haifeng Sun Hao Li Hong Liu Huaiyu Yang Zhaobing Gao Hualiang Jiang Min Li | 2013 | Cell Research2013，23，9： | 8 |
| 17 | Improved genetic algorithm for nonlinear programming problems显示文摘An improved genetic algorithm(IGA) based on a novel selection strategy to handle nonlinear programming problems is proposed.Each individual in selection process is represented as a three-dimensional feature vector which is composed of objective function value,the degree of constraints violations and the number of constraints violations.It is easy to distinguish excellent individuals from general individuals by using an individuals' feature vector.Additionally,a local search(LS) process is incorporated into selection operation so as to find feasible solutions located in the neighboring areas of some infeasible solutions.The combination of IGA and LS should offer the advantage of both the quality of solutions and diversity of solutions.Experimental results over a set of benchmark problems demonstrate that IGA has better performance than other algorithms. | Kezong Tang Jingyu Yang Haiyan Chen Shang Gao | 2011 | Journal of Systems Engineering and Electronics2011，22，3： | 8 |
| 18 | Genomic insights into the fast growth of paulownias and the formation of Paulownia witches' broom显示文摘Paulownias are among the fastest growing trees in the world,but they often suffer tremendous loss of wood production due to infection by Paulownia witches'broom(PaWB)phytoplasmas.In this study,we have sequenced and assembled a high-quality nuclear genome of Paulownia fortunei,a commonly cultivated paulownia species.The assembled genome of P.fortunei is 511.6 Mb in size,with 93.2%of its sequences anchored to 20 pseudo-chromosomes,and it contains 31985 protein-coding genes.Phylogenomic analyses show that the family Paulowniaceae is sister to a clade composed of Phrymaceae and Orobanchaceae.Higher photosynthetic efficiency is achieved by integrating C3 photosynthesis and the crassulacean acid metabolism pathway,which may contribute to the extremely fast growth habit of paulownia trees.Comparative transcriptome analyses reveal modules related to cambial growth and development,photosynthesis,and defense responses.Additional genome sequencing of PaWB phytoplasma,combined with functional analyses,indicates that the effector PaWB-SAP54 interacts directly with Paulownia PfSPLa,which in turn causes the degradation of PfSPLa by the ubiquitin-mediated pathway and leads to the formation of witches'broom.Taken together,these results provide significant insights into the biology of paulownias and the regulatory mechanism for the formation of PaWB. | Yabing Cao Guiling Sun Xiaoqiao Zhai Pingluo Xu Liming Ma Minjie Deng Zhenli Zhao Haibo Yang Yanpeng Dong Zhonghai Shang Yujie Lv Lijun Yan Haifang Liu Xibing Cao Bingbing Li Zhe Wang Xiaogai Zhao Haiyan Yu Fan Wang Wen Ma Jinling Huang Guoqiang Fan | 2021 | Molecular Plant2021，14，10： | 7 |
| 19 | Approach to WTA in air combat using IAFSA-IHS algorithm显示文摘In this paper, a static weapon target assignment(WTA)problem is studied. As a critical problem in cooperative air combat,outcome of WTA directly influences the battle. Along with the cost of weapons rising rapidly, it is indispensable to design a target assignment model that can ensure minimizing targets survivability and weapons consumption simultaneously. Afterwards an algorithm named as improved artificial fish swarm algorithm-improved harmony search algorithm(IAFSA-IHS) is proposed to solve the problem. The effect of the proposed algorithm is demonstrated in numerical simulations, and results show that it performs positively in searching the optimal solution and solving the WTA problem. | LI Zhanwu CHANG Yizhe KOU Yingxin YANG Haiyan XU An LI You | 2018 | Journal of Systems Engineering and Electronics2018，29，3： | 7 |
| 20 | Method of Modulation Recognition Based on Combination Algorithm of K-Means Clustering and Grading Training SVM显示文摘For the existing support vector machine, when recognizing more questions, the shortcomings of high computational complexity and low recognition rate under the low SNR are emerged. The characteristic parameter of the signal is extracted and optimized by using a clustering algorithm, support vector machine is trained by grading algorithm so as to enhance the rate of convergence, improve the performance of recognition under the low SNR and realize modulation recognition of the signal based on the modulation system of the constellation diagram in this paper. Simulation results show that the average recognition rate based on this algorithm is enhanced over 30% compared with methods that adopting clustering algorithm or support vector machine respectively under the low SNR. The average recognition rate can reach 90% when the SNR is 5 dB, and the method is easy to be achieved so that it has broad application prospect in the modulating recognition. | Faquan Yang Ling Yang Dong Wang Peihan Qi Haiyan Wang 无 | 2018 | China Communications2018，15，12： | 7 |
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