|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | Surface Active Sites on Co_(3)O_(4) Nanobelt and Nanocube Model Catalysts for CO Oxidation显示文摘CO oxidation has been performed on Co_(3)O_(4) nanobelts and nanocubes as model catalysts.The Co_(3)O_(4) nanobelts which have a predominance of exposed{011}planes are more active than Co_(3)O_(4) nanocubes with exposed{001}planes.Temperature programmed reduction of CO shows that Co_(3)O_(4) nanobelts have stronger reducing properties than Co_(3)O_(4) nanocubes.The essence of shape and crystal plane effect is revealed by the fact that turnover frequency of Co3+sites of{011}planes on Co_(3)O_(4) nanobelts is far higher than that of{001}planes on Co_(3)O_(4) nanocubes. | Linhua Hu Keqiang Sun Qing Peng Boqing Xu Yadong Li | 2010 | Nano Research2010，3，5： | 21 |
| 3 | Inside-out Ostwald ripening: A facile process towards synthesizing anatase TiO2 microspheres for high- efficiency dye-sensitized solar cells显示文摘一灵巧在内外面,到 TiO 2 microspheres 的控制形态学的准备的 Ostwald 成熟线路被开发。这里, TiO 2 空 microspheres (HM ) 和稳固的 microspheres (SM ) 被在 solvothermal 过程以 acetylacetone (Acac ) 调整 isopropanol (国际语音学协会) 的体积比率准备。在 HM,稳固的核心的降水,核心的表面上的外部壳的随后的免职,和同时的核心的形成过程期间,溶解和壳再结晶被观察,它验证在内外面 Ostwald 成熟机制。TiO 2 microspheres 的性质(毛孔尺寸,表面区域,和陷井状态) 的设计和优化对 dyesensitized 太阳能电池(DSSC ) 的高效重要。优化 TiO 2 microspheres (rHM 和 rSM ) 在再结晶上由 processing 以后获得了,拥有大毛孔尺寸,高表面区域和减少的陷井状态(Ti 3+ 和氧空缺) ,并且因此是为光电的设备的理想的材料。用 rHM photoanode 制作的 DSSC 的力量变换效率是 11.22% ,它显著地与基于 rSM 的 DSSC 的 10.54% 效率相比被改进。我们的工作为综合提供策略 TiO 2 microspheres 同时提供不同物理性质以表面区域, crystallinity,形态学,和 mesoporosity。 | Yong Ding Xin Xia Wangchao Chen Linhua Hu Li'e Mo Yang Huang Songyuan Dai | 2016 | Nano Research2016，9，7： | 7 |
| 4 | Metal chalcogenide complex-mediated fabrication of Cu_2S film as counter electrode in quantum dot sensitized solar cells显示文摘Cu2S film onto FTO glass substrate was obtained to function as counter electrode for polysulfide redox reactions in CdS/CdSe co-sensitized solar cells by sintering after spraying a metal chalcogenide complex, N4H9Cu7S4 solution. Relative to Pt counter electrode, the Cu2S counter electrode provides greater electrocatalytic activity and lower charge transfer resistance. The prepared Cu2S counter electrode represented nanoflower-like porous film which was composed of Cu2S nanosheets on FTO and had a higher surface area and lower sheet resistance than that of sulfided brass Cu2S counter electrode. An energy conversion efficiency of 3.62% was achieved using the metal chalcogenide complex-mediated fabricated Cu2S counter electrode for CdS/CdSe co-sensitized solar cells under 1 sun, AM 1.5 illumination. | YU XueChao ZHU Jun LIU Feng WEI JunFeng HU LinHua DAI SongYuan | 2013 | Science China Chemistry2013，56，7： | 6 |
| 5 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 6 | Micelle or polymersome formation by PCL-PEG-PCL copolymers as drug delivery systems显示文摘Polye-caprolactone)-b-poly(ethylene glycol)-b-poly(e-caprolactone)(PCL-b-PEG-b-PCL,PCEC) triblock copolymers have been widely investigated in last several decades.Here,by altering the weight ratio of monomers in ring-opening polymerization,a series of PCEC triblock copolymers with varying hydrophobicity were synthesized,which were characterized by FTIR,1 H NMR,GPC and DSC.When PCEC copolymers with different weight ratios of PCL/PEG were dispersed in different aqueous solutions,they could self-assemble and form two distinctive nanoparticular structures:micelles or polymersomes.We then chose paclitaxel(PTX) as the model drug and encapsulate PTX into PCEC polymeric micelles and polymersomes.The physicochemical characterizations of the nanoparticles such as morphology,the size and distribution,zeta potential,drug loading content,and encapsulation efficiency were also performed.Our results showed that polymeric micelles or polymersomes from PCEC both displayed narrow size distributions and could achieve high drug loading efficiencies.In vitro cellular uptake results suggested that Nile Red loaded polymeric micelles or polymersomes displayed more internalization after 24 h incubation than those after 4 h incubation.These findings suggest that polymeric micelles and polymersomes based on PCL-b-PEG-b-PCL copolymers have great potential to effectively delivery hydrophobic drugs. | Chunyan Hu Zhuo Chen Shengjie Wu Yanfeng Han Hai Wang Hongfan Sun Deling Kong Xigang Leng Chun Wang Linhua Zhang Dunwan Zhu | 2017 | Chinese Chemical Letters2017，28，9： | 4 |
| 7 | Surface states in TiO2 submicrosphere films and their effect on electron transport显示文摘 | Li'e Mo Wangchao Chen Ling Jiang Yong Ding Zhaoqian Li Linhua Hu Songyuan Dai | 2017 | Nano Research2017，10，11： | 3 |
| 8 | Electroluminescence performances of 1,1-bis(4-(N,N-dimethylamino)phenyl)-2,3,4,5-tetraphenylsilole based polymers in three cathode architectures显示文摘A new silole monomer with two 4-(N,N-dimethylamino)phenyl substitutions on silicon atom as designed and synthesized.Three copolymers PF-N-HPS1,PF-N-HPS10 and PF-N-HPS20 were then obtained by copolymerizations of 2,7-fluorene derivatives with the silole monomer at feed ratios of 1%,10%,and 20%.Their UV-vis absorption,electrochemical,photoluminescent,and electroluminescent (EL) properties were investigated.PF-N-HPS possessed HOMO levels of 5.25-5.58 eV,and showed green emissions.Using PF-N-HPS as the emissive layer,three different polymer light-emitting diodes were fabricated as device A with ITO/PEDOT/PF-N-HPS/Al,device B with ITO/PEDOT/PF-N-HPS/Ba/Al,and device C with ITO/PEDOT/PF-N-HPS/TPBI/Ba/Al.For the device A,PF-N-HPS only showed very low EL efficiency of 0.06-0.33 cd/A,indicating that the Al cathode could not inject electron efficiently to the emissive polymers containing the 4-(N,N-dimethylamino)phenyl groups.For the device B,low work function Ba supplied better electron injections,and the EL efficiency could be improved to 0.85-1.44 cd/A.TPBI with a deep HOMO level of 6.2 eV could enhance electron transport and hole blocking.Thus modified recombinations and largely elevated EL efficiency of 4.56-7.96 cd/A were achieved for the device C.The separation of the emissive layer and metal cathode with the TPBI layer may also suppress exciton quenching at the cathode interface. | LIU ZhiTian HU SuJun ZHANG LinHua CHEN JunWu PENG JunBiao CAO Yong | 2013 | Science China Chemistry2013，56，8： | 2 |
| 9 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5h66k0bvvfbwn56vbf.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 10 | A multistep attachment process:Transformation of titanate nanotubes into nanoribbons显示文摘The mechanism of the conversion of titanate nanotubes into nanoribbons is of considerable interest.The details of the transformation processes involved when nanoribbons are produced from a P25 TiO 2 powder precursor by alkaline hydrothermal treatment have been investigated systematically by transmission electron microscopy.A multistep attachment model is proposed for the growth at the early stage of coarsening.The treatment duration has a strong effect on the change in product morphology from hollow nanotubes into nanoribbons,since the nanotubes cannot retain their morphology in the strong alkaline solution for extended periods of time.Most of the nanotubes were etched and dissolved,providing the nutrients for subsequent nanoribbon growth.Some stable nanotubes grew spirally internally to form nanowires or became connected together to form rafts which acted as the grains for nanoribbon growth.With increasing hydrothermal time,a large number of nanotubes and other fragments became attached to the grains which began to grow larger and eventually formed the nanoribbons,in a process in which the stepped faces and kinked faces became fused and were eliminated while the flat faces were retained in the nanoribbon morphology. | SHENG Jiang HU LinHua MO Li'E LI WenXin TIAN HuaJun DAI SongYuan | 2012 | Science China Chemistry2012，55，3： | 2 |
| 11 | Microstructure Design of Nanoporous TiO2 Photoelectrodes for Dye-Sensitized Solar Cell显示文摘 | Linhua Hu Songyuan Dai | 2007 | Modules J Phys Chem B2007，111，： | 1 |
| 12 | Pretreatment with probiotics Enterococcus faecium NCIMB 11181 attenuated Salmonella Typhimurium-induced gut injury through modulating intestinal microbiome and immune responses with barrier function in broiler chickens显示文摘Background:Preventing Salmonella infection and colonization in young birds is key to improving poultry gut health and reducing Salmonella contamination of poultry products and decreasing salmonellosis for human consumption(poultry meat and eggs).Probiotics can improve poultry health.The present study was conducted to investigate the impact of a probiotics,Enterococcus faecium NCIMB 11181(E.faecium NCIMB 11181)on the intestinal mucosal immune responses,microbiome and barrier function in the presence or absence of Salmonella Typhimurium(S.Typh-imurium,ST)infection.Methods:Two hundred and forty 1-day-old Salmonella-free male broiler chickens(Arbor Acres AA+)were randomly allocated to four groups with 6 replicate cages of 10 birds each.The four experimental groups were follows:(1)nega-tive control(NC),(2)S.Typhimurium,challenged positive control(PC),(3)the E.faecium NCIMB 11181-treated group(EF),(4)the E.faecium NCIMB 11181-treated and S.Typhimurium-challenged group(PEF).Results:Results indicated that,although continuous feeding E.faecium NCIMB 11181 did not obviously alleviate growth depression caused by S.Typhimurium challenge(P>0.05),E.faecium NCIMB 11181 addition significantly blocked Salmonella intestinal colonization and translocation(P<0.05).Moreover,supplemental E.faecium NCIMB 11181 to the infected chickens remarkably attenuated gut morphological structure damage and intestinal cell apoptosis induced by S.Typhimurium infection,as evidenced by increasing gut villous height and reducing intes-tinal TUNEL-positive cell numbers(P<0.05).Also,E.faecium NCIMB 11181 administration notably promoting the production of anti-Salmonella antibodies in intestinal mucosa and serum of the infected birds(P<0.05).Addition-ally,16S rRNA sequencing analysis revealed that E.faecium NCIMB 11181 supplementation ameliorated S.Typhimu-rium infection-induced gut microbial dysbiosis by enriching Lachnospiracease and Alistipes levels,and suppressing Barnesiella abundance.Predicted function analysis indicated that the functional genes of cecal microbiome involved in C5-branched dibasic acid metabolism;valine,leucine and isoleucine biosynthesis;glycerolipid metabolism and lysine biosynthesis were enriched in the infected chickens given E.faecium NCIMB 11181.While alanine,asparate and glutamate metabolism;MAPK signal pathway-yeast;ubiquine and other terpenoid-quinore biosynthesis,protein processing in endoplasmic reticulum;as well as glutathione metabolism were suppressed by E.faecium NCIMB 11181 addition.Conclusion:Collectively,our data suggested that dietary E.faecium NCIBM 11181 supplementation could ameliorate S.Typhimurium infection-induced gut injury in broiler chickens.Our findings also suggest that E.faecium NCIMB 11181 may serve as an effective non-antibiotic feed additive for improving gut health and controlling Salmonella infection in broiler chickens. | Yujing Shao Wenrui Zhen Fangshen Guo Zeqiong Hu Kaichen Zhang Linhua Kong Yuming Guo Zhong Wang | 2023 | Journal of Animal Science and Biotechnology2023，14，2： | 1 |
| 13 | Preparation and char- acterization of tungsten carbide confined in the channels of SBA-15 显示文摘 | Hu Linhua Ji Shengfu Xiao Tiancun | 2007 | J Phys Chem B2007，111，： | 1 |
| 14 | Direct synthesis and structural characteristics of ordered SBA-15 mesoporous silica显示文摘 | Hu Linhua Ji Shengfu Jiang Zheng | 2007 | J Phys Chem C2007，111，15： | 1 |
| 15 | Microstructure design of nanoporous TiO2 photoeleetrodes for dye-sensitized solar cell modules 显示文摘 | Hu Linhua Dai Songyuan Weng Jian | 2007 | The Journal of Physical Chemistry B2007，111，2： | 1 |
| 16 | Microstructure design of nanoporous TiO2 photoelectrodes for dye-sensitized solar cell modules 显示文摘 | Hu Linhua Dai Songyuan Weng Jian | 2007 | Journal of Physical Chemistry B2007，111，2： | 1 |
| 17 | Retarded charge recombination in dye-sensitized nitrogen-doped TiO2 solar cells显示文摘 | Tian Huajun Hu Linhua Zhang Changneng | 2010 | J Phys Chem C2010，114，： | 1 |
| 18 | Improved crystallinity and self-healing effects in perovskite solar cells via functional incorporation of polyvinylpyrrolidone显示文摘Air moisture is the key issue for perovskites which invades the films and accelerates the damage of devices. Here, polyvinylpyrrolidone(PVP) is introduced to the methylammonium lead iodide(MAPbI_(3)) perovskite precursor to control crystal growth and endow the devices with self-healing ability in a moisture environment. The strong C=O...ΗAΝ hydrogen bonding interactions between PVP and MAPbI_(3) was confirmed by nuclear magnetic resonance measurements. By introducing hydrogen bonding in the MAPbI_(3)-based PSCs, we form a compact perovskite film of excellent electronic quality with a power conversion efficiency(PCE) of up to 20.32%. Furthermore, the O...ΗAΝ hydrogen bonding interactions at the grain boundaries suppress the decomposition of methylammonium cations and improve the recyclable dissolution–recrystallization of perovskite. As a result, the MAPbI_(3)-PVP based cells exhibited striking moisture stability and self-healing behavior, with negligible decay in efficiency after 500 h of operation in high humidity(65% ± 5% relative humidity) and rapid recovering ability after their removal from the humid environment. | Yunjuan Niu Dingchao He Zhengguo Zhang Jun Zhu Tulloch Gavin Polycarpos Falaras Linhua Hu | 2022 | Journal of Energy Chemistry2022，31，5： | 1 |
| 19 | Research progress of dye-sensitized solar cells 显示文摘 | Li Wenxin Hu Linhua Dai Songyuan | 2009 | China Material Progress2009，28，78： | 1 |
| 20 | Superior energy band structure and retarded charge recombination for ana-tase N, B codoped nano-crystalline Ti02 anodes solar cells 显示文摘 | TIAN Huajun HU Linhua ZHANG Changneng | 2012 | Journal of Materials Chemistry2012，22，18： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员