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| 1 | Bio-reduction of nitrate from groundwater using a hydrogen-based membrane biofilm reactor显示文摘A hydrogen-based membrane biofilm reactor(MBfR) using H2 as electron donor was investigated to remove nitrate from groundwater.When nitrate was first introduced to the MBfR,denitrification took place on the shell side of the membranes immediately,and the effluent concentration of nitrate continuously decreased with 100% removal rate on day 45 under the influent nitrate concentration of 5 mg NO3--N/L,which described the acclimating and enriching process of autohydrogenotrophic denitrification bacteria.A series of short-term experiments were applied to investigate the effects of hydrogen pressures and nitrate loadings on denitrification.The results showed that nitrate reduction rate improved as H2 pressure increasing,and over 97% of total nitrogen removal rate was achieved when the nitrate loading increased from 0.17 to 0.34 g NO3--N/(m2 ·day) without nitrite accumulation.The maximum denitrification rate was 384 g N/(m3 ·day).Partial sulfate reduction,which occurred in parallel to nitrate reduction,was inhibited by denitrififcation due to the competition for H2 .This research showed that MBfR is effective for removing nitrate from the contaminated groundwater. | Siqing Xia Fohua Zhong Yanhao Zhang Haixiang Li Xin Yang | 2010 | Journal of Environmental Sciences2010，22，2： | 23 |
| 2 | Suppressing unsteady motion of shock wave by high-frequency plasma synthetic jet显示文摘Three Plasma Synthetic Jet Actuators(PSJA)under the high-frequency actuation are used to control the Shock Wave Boundary Layer Interaction(SWBLI),a high-speed schlieren image processing method based on spatial Fourier transform as well as snapshot proper orthogonal decomposition were used to study the control effect of high-frequency plasma synthetic jet on lowfrequency unsteadiness of SWBLI.The analysis of the base flow shows that the separated shock wave actually has both large-and small-amplitude vibrations at low frequency.And the results revealed that the PSJA with an operating frequency of 2 k Hz has the ability to reduce the energy of low-frequency component of shock wave motion,indicating that the 2 k Hz actuation can effectively suppress low-frequency unsteadiness of the separated wave.Compared with the actuation frequency of 2 k Hz,the energy of low-frequency component of the shock wave is enhanced under the8 k Hz actuation,which aggravates the low-frequency unsteady motion of the shock wave.It is likely that the actuation frequency is too high,thus the intensity of the precursor shock wave induced by PSJA becomes weaker.Additionally,as the 4 k Hz actuation is applied,the pulsation of the separation region was enhanced,it is speculated that the actuation frequency is coupled with the oscillation frequency of the separation region. | Yanhao LUO Jun LI Hua LIANG Shanguang GUO Mengxiao TANG Hongyu WANG | 2021 | Chinese Journal of Aeronautics2021，34，9： | 4 |
| 3 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 4 | Transcatheter Arterial Embolization of Hepatic Arteriovenous Shunts in Patients with Hepatocellular Carcinoma显示文摘 | Quelin Mei Yanhao Li | 2012 | Semin intervent Radiol2012，，03： | 1 |
| 5 | Whole-genome Duplication Reshaped Adaptive Evolution in A Relict Plant Species,Cyclocarya paliurus显示文摘Cyclocarya paliurus is a relict plant species that survived the last glacial period and shows a population expansion recently.Its leaves have been traditionally used to treat obesity and diabetes with the well-known active ingredient cyclocaric acid B.Here,we presented three C.paliurus genomes from two diploids with different flower morphs and one haplotype-resolved tetraploid assembly.Comparative genomic analysis revealed two rounds of recent whole-genome duplication events and identified 691 genes with dosage effects that likely contribute to adaptive evolution through enhanced photosynthesis and increased accumulation of triterpenoids.Resequencing analysis of 45 C.paliurus individuals uncovered two bottlenecks,consistent with the known events of environmental changes,and many selectively swept genes involved in critical biological functions,including plant defense and secondary metabolite biosynthesis.We also proposed the biosynthesis pathway of cyclocaric acid B based on multi-omics data and identified key genes,in particular gibberellinrelated genes,associated with the heterodichogamy in C.paliurus species.Our study sheds light on evolutionary history of C.paliurus and provides genomic resources to study the medicinal herbs. | Yinquan Qu Xulan Shang Ziyan Zeng Yanhao Yu Guoliang Bian Wenling Wang Li Liu Li Tian Shengcheng Zhang Qian Wang Dejin Xie Xuequn Chen Zhenyang Liao Yibin Wang Jian Qin Wanxia Yang Caowen Sun Xiangxiang Fu Xingtan Zhang Shengzuo Fang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 1 |
| 6 | Pressureless two-step sintering of ultrafine-grained refractory metals:Tungsten-rhenium and molybdenum显示文摘The challenge of sintering ultrafine-grained refractory metals and alloys to full density is hereby addressed by pressureless two-step sintering in tungsten-rhenium alloy and pure molybdenum. Using properly processed nano powders(~50 nm average particle size), we are able to sinter W-10Re alloy to 98.4% density below 1200 ℃ while maintaining a fine grain size of 260 nm, and sinter molybdenum to 98.3% density below 1120 ℃ while maintaining a fine grain size of 290 nm. Compared to normal sintering,two-step sintering offers record-fine grain sizes and better microstructural uniformity, which translates to better mechanical properties with higher hardness(6.3 GPa for tungsten-rhenium and 4.0 GPa for molybdenum, both being the highest in all pressurelessly sintered samples of the respective material system)and larger Weibull modulus. Together with our previous demonstration in tungsten, we believe that twostep sintering is a general effective method to produce high-quality fine-grained refractory metals and alloys, and the lessons learned here are transferable to other materials for powder metallurgy. | Zhongyou Que Zichen Wei Xingyu Li Lin Zhang Yanhao Dong Mingli Qin Junjun Yang Xuanhui Qu Ju Li | 2022 | Journal of Materials Science & Technology2022，，31： | 1 |
| 7 | Maximizing the yield of nanocrystal- line cellulose from cotton pulp fiber显示文摘 | Fan Jinshi Li Yanhao | 2012 | Carbohydr Polym2012，88，： | 1 |
| 8 | Gigantic Cavernous Hemangioma of the Liver Treated by Intra-Arterial Embolization with Pingyangmycin-Lipiodol Emulsion: A Multi-Center Study显示文摘 | Qingle Zeng Yanhao Li Yong Chen Yong Ouyang Xiang He Heping Zhang | 2004 | CardioVascular and Interventional Radiology2004，，5： | 1 |
| 9 | Gigantic Cavernous Hemangioma of the Liver Treated by Intra-Arterial Embolization with Pingyangmycin-Lipiodol Emulsion: A Multi-Center Study显示文摘 | Qingle Zeng Yanhao Li Yong Chen Yong Ouyang Xiang He Heping Zhang | 2004 | CardioVascular and Interventional Radiology2004，，5： | 1 |
| 10 | Building a Scalable Bipartite P2P Overlay Network显示文摘 | Li Xiao | 2007 | IEEE Transactions on Parallel and Distributed Systems2007，18，9： | 1 |
| 11 | Gigantic Cavernous Hemangioma of the Liver Treated by Intra-Arterial Embolization with Pingyangmycin-Lipiodol Emulsion: A Multi-Center Study显示文摘 | Qingle Zeng Yanhao Li Yong Chen Yong Ouyang Xiang He Heping Zhang | 2004 | CardioVascular and Interventional Radiology2004，，5： | 1 |
| 12 | 显示文摘 | Fan jinshi Li Yanhao | 2012 | Carbohydrate Polymers2012，88，4： | 1 |
| 13 | Applications of 2D-Layered Palladium Diselenide and Its van der Waals Heterostructures in Electronics and Optoelectronics显示文摘The rapid development of two-dimensional(2D)transition-metal dichalcogenides has been possible owing to their special structures and remarkable properties.In particular,palladium diselenide(PdSe_(2))with a novel pentagonal structure and unique physical characteristics have recently attracted extensive research inter-est.Consequently,tremendous research progress has been achieved regarding the physics,chemistry,and electronics of PdSe_(2).Accordingly,in this review,we recapitulate and summarize the most recent research on PdSe_(2),including its structure,properties,synthesis,and appli-cations.First,a mechanical exfoliation method to obtain PdSe_(2) nanosheets is introduced,and large-area synthesis strate-gies are explained with respect to chemical vapor deposition and metal selenization.Next,the electronic and optoelectronic properties of PdSe_(2) and related hetero-structures,such as field-effect transistors,photodetectors,sensors,and thermoelec-tric devices,are discussed.Subsequently,the integration of systems into infrared image sensors on the basis of PdSe_(2) van der Waals heterostructures is explored.Finally,future opportunities are highlighted to serve as a general guide for physicists,chemists,materials scientists,and engineers.Therefore,this com-prehensive review may shed light on the research conducted by the 2D material community. | Yanhao Wang Jinbo Pang Qilin Cheng Lin Han Yufen Li Xue Meng Bergoi Ibarlucea Hongbin Zhao Feng Yang Haiyun Liu Hong Liu Weijia Zhou Xiao Wang Mark HRummeli Yu Zhang Gianaurelio Cuniberti | 2021 | Nano-Micro Letters2021，13，9： | 1 |
| 14 | Gigantic cavernous hemangioma of the liver treated by intra--arterial embolization with pingyangmycin- lipiodol emulsion: a multi-- center study 显示文摘 | Qingle Zeng Yanhao Li Yong Chen | 2004 | CVIR2004，27，5： | 1 |
| 15 | Carbon dioxide-digi-tal subtrac tion angiography features of hepatocellular carcinoma显示文摘 | Wei Lu Yanhao Li Yong Chen | 1999 | J Vasc Interv Rad iol1999，10，22： | 1 |
| 16 | Application of a real-ambient fine particulate matter exposure system on different animal models显示文摘Simulation of fine particulate matter(PM_(2.5))exposure is essential for evaluating adverse health effects.In this work,an ambient exposure system that mimicked real atmospheric conditions was installed in Taiyuan,China to study impacts of chronic PM_(2.5) exposure on adult and aged mice as well as Sirtuin3 knockout(Sirt3 KO)mice and wild-type(WT)mice.The real-ambient exposure system eliminated the possible artificial effects caused from exposure experiments and maintained the physiochemical characteristics of PM_(2.5).The case studies indicated that aged mice exhibited apparent heart dysfunction involving in-creased heart rate and decreased blood pressure after 17-week of real-ambient PM_(2.5) exposure.Meanwhile,15-week of real-ambient PM_(2.5) exposure decreased the heart rate and amounts of associated catecholamines to induce heart failure in Sirt3 KO mice.Additionally,the increased pro-inflammatory cytokines and decreased platelet related indices suggested that inflammation occurred.The changes of biomarkers detected by targeted metabolomics confirmed metabolic disorder in WT and Sirt3 KO mice after exposed to real-ambient PM_(2.5).These results indicated that the real-ambient PM_(2.5) exposure system could evaluate the risks of certain diseases associated with air pollution and have great potential for support-ing the investigations of PM_(2.5) effects on other types of rodent models. | Yuanyuan Song Lifang Zhao Zenghua Qi Yanhao Zhang Guodong Cao Ruijin Li Lin Zhu Zhu Yang Chuan Dong Zongwei Cai | 2021 | Journal of Environmental Sciences2021，33，7： | 1 |
| 17 | Gigantic cavernous hemangioma of the liver treated by intra-arterial embolization with pingyangmycin-lipiodol emulsion: a multi-center study显示文摘 | Zeng Qingle Li Yanhao Chen Yong | 2004 | CVIR2004，27，： | 1 |
| 18 | Multi-omics analysis of attenuated variant reveals potential evaluation marker of host damaging for SARS-CoV-2 variants显示文摘SARS-CoV-2 continues to threaten human society by generating novel variants via mutation and recombination.The high number of mutations that appeared in emerging variants not only enhanced their immune-escaping ability but also made it difficult to predict the pathogenicity and virulence based on viral nucleotide sequences.Molecular markers for evaluating the pathogenicity of new variants are therefore needed.By comparing host responses to wild-type and variants with attenuated pathogenicity at proteome and metabolome levels,six key molecules on the polyamine biosynthesis pathway including putrescine,SAM,dc-SAM,ODC1,SAMS,and SAMDC were found to be differentially upregulated and associated with pathogenicity of variants.To validate our discovery,human airway organoids were subsequently used which recapitulates SARS-CoV-2 replication in the airway epithelial cells of COVID-19 patients.Using ODC1 as a proof-ofconcept,differential activation of polyamine biosynthesis was found to be modulated by the renin-angiotensin system(RAS)and positively associated with ACE2 activity.Further experiments demonstrated that ODC1 expression could be differentially activated upon a panel of SARS-CoV-2 variants of concern(VOCs)and was found to be correlated with each VOCs’pathogenic properties.Particularly,the presented study revealed the discriminative ability of key molecules on polyamine biosynthesis as a predictive marker for virulence evaluation and assessment of SARS-CoV-2 variants in cell or organoid models.Our work,therefore,presented a practical strategy that could be potentially applied as an evaluation tool for the pathogenicity of current and emerging SARS-CoV-2 variants. | Guangshan Xie Lin Zhu Siwen Liu Cun Li Xin Diao Yanhao Zhang Xiuli Su Yuanyuan Song Guodong Cao Li Zhong Pui Wang Xiaojuan Liu Bobo Wing-Yee Mok Shusheng Zhang Dong-Yan Jin Jie Zhou Honglin Chen Zongwei Cai | 2024 | Science China(Life Sciences)2024，67，1： | 0 |
| 19 | Unveiling exceptional sinterability of ultrafine a-Al2O_(3) nanopowders显示文摘Scalable pressureless sintering of nanocrystalline alumina(Al2O_(3))ceramics is a challenging problem with great scientific and technological interest.This challenge was addressed in our recent works utilizing ultrafine a-Al2O_(3) nanopowders with exceptional sinterability combined with two-step sintering technique.Here the sintering mechanism and kinetic parameters(grain boundary diffusivity and its activation energy)were analyzed from constant heating-rate sintering experiments by three different sintering models and compared with existing sintering data in the literature.We found that the lowtemperature sintering of 4.7 nm a-Al2O_(3) nanopowders can be well explained by conventional sintering mechanism via grain boundary diffusion,with reasonable activation energy of 4e5 eV that is smaller than that of coarse Al2O_(3) powders and enhanced diffusivity.However,unphysically small activation energy could be obtained if an inappropriate model was used.Lastly,successful two-step sintering was demonstrated under different heating rates.Our work illustrates that the exceptional sinterability of ultrafine a-Al2O_(3) nanopowders are most likely contributed by small size(short diffusion distance),large surface area(large sintering driving force)and good dispersity rather than new sintering mechanism,and highlights the importance of fast firing and the non-equilibrium nature for the low-temperature sintering of such nanopowders. | Hongbing Yang Lu Li Yuanyuan Li Bing Shen Yueming Kang Libin Zhao Jiajie Li Yanhao Dong Jiangong Li | 2021 | Journal of Materiomics2021，7，4： | 0 |
| 20 | Hypercompact CRISPR–Cas12j2 (CasF) enables genome editing, gene activation, and epigenome editing in plants显示文摘CRISPR-Cas9,-Cas12a,-Cas12b,and-Cas13 have been harnessed for genome engineering in human and plant cells(Liu et al.,2022).However,the large size of these Cas proteins(e.g.190 kDa for SpCas9)makes them difficult to deliver into cells via a viral vector.The development of smaller Cas proteins will lead to reduced viral vector sizes that can be more widely adopted in versatile genome engineering systems.Recently,a CRISPR-Cas12j2(CasF)system was discovered in huge phages and developed into a hypercompact genome editor due to the small size of Cas12j2(80 kDa)(Pausch et al.,2020).Unfortunately,the gene editing efficiency of Cas12j2 in Arabidopsis protoplasts using ribonucleoprotein delivery was less than one percent(Pausch et al.,2020).Further optimization of this system is clearly required if CRISPR-Cas12j2-mediated editing in plant genomes is to be adopted by the plant sciences community. | Shishi Liu Simon Sretenovic Tingting Fan Yanhao Cheng Gen Li Aileen Qi Xu Tang Yang Xu Weijun Guo Zhaohui Zhong Yao He Yanling Liang Qinqin Han Xuelian Zheng Xiaofeng Gu Yiping Qi Yong Zhang | 2022 | Plant Communications2022，3，6： | 0 |
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