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| 1 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
| 2 | Earthquake-related Tectonic Deformation of Soft-sediments and Its Constraints on Basin Tectonic Evolution显示文摘The authors introduced two kinds of newly found soft-sediment deformation-syn-sedimentary extension structure and syn-sedimentary compression structure,and discuss their origins and constraints on basin tectonic evolution.One representative of the syn-sedimentary extension structure is syn-sedimentary boudinage structure,while the typical example of the syn-sedimentary compression structure is compression sand pillows or compression wrinkles.The former shows NW-SE-trending contemporaneous extension events related to earthquakes in the rift basin near a famous Fe-Nb-REE deposit in northern China during the Early Paleozoic(or Mesoproterozoic as proposed by some researches),while the latter indicates NE-SW-trending contemporaneous compression activities related to earthquakes in the Middle Triassic in the Nanpanjiang remnant basin covering south Guizhou,northwestern Guangxi and eastern Yunnan in southwestern China.The syn-sedimentary boudinage structure was found in an earthquake slump block in the lower part of the Early Paleozoic Sailinhudong Group,20 km to the southeast of Bayan Obo,Inner Mongolia,north of China.The slump block is composed of two kinds of very thin layers—pale-gray micrite(microcrystalline limestone)of 1?2 cm thick interbedded with gray muddy micrite layers with the similar thickness.Almost every thin muddy micrite layer was cut into imbricate blocks or boudins by abundant tiny contemporaneous faults,while the interbedded micrite remain in continuity.Boudins form as a response to layer-parallel extension(and/or layer-perpendicular flattening)of stiff layers enveloped top and bottom by mechanically soft layers.In this case,the imbricate blocks cut by the tiny contemporaneous faults are the result of abrupt horizontal extension of the crust in the SE-NW direction accompanied with earthquakes.Thus,the rock block is,in fact,a kind of seismites.The syn-sedimentary boudins indicate that there was at least a strong earthquake belt on the southeast side of the basin during the early stage of the Sailinhudong Group.This may be a good constraint on the tectonic evolution of the Bayan Obo area during the Early Paleozoic time.The syn-sedimentary compression structure was found in the Middle Triassic flysch in the Nanpanjiang Basin.The typical structures are compression sand pillows and compression wrinkles.Both of them were found on the bottoms of sand units and the top surface of the underlying mud units.In other words,the structures were found only in the interfaces between the graded sand layer and the underlying mud layer of the flysch.A deformation experiment with dough was conducted,showing that the tectonic deformation must have been instantaneous one accompanied by earthquakes.The compression sand pillows or wrinkles showed uniform directions along the bottoms of the sand layer in the flysch,revealing contemporaneous horizontal compression during the time between deposition and diagenesis of the related beds.The Nanpanjiang Basin was affected,in general,with SSW-NNE compression during the Middle Triassic,according to the syn-sedimentary compression structure.The two kinds of syn-sedimentary tectonic deformation also indicate that the related basins belong to a rift basin and a remnant basin,respectively,in the model of Wilson Cycle. | LU Hongbo ZHANG Yuxu ZHANG Qiling XIAO Jiafei | 2006 | Acta Geologica Sinica(English Edition)2006，80，5： | 13 |
| 3 | Flow characteristics of hypersonic inlets with different cowl-lip blunting methods显示文摘Under hypersonic flight conditions,the sharp cowl-lip leading edges have to be blunted because of the severe aerodynamic heating.This paper proposes four cowl-lip blunting methods and studies the corresponding flow characteristics and performances of the generic hypersonic inlets by numerical simulation under the design conditions of a flight Mach number of 6 and an altitude of 26 km.The results show that the local shock interference patterns in the vicinity of the blunted cowl-lips have a substantial influence on the flow characteristics of the hypersonic inlets even though the blunting radius is very small,which contribute to a pronounced degradation of the inlet performance.The Equal Length blunting Manner(ELM)is the most optimal in that a nearly even reflection of the ramp shock produces an approximately straight and weak cowl reflection shock.The minimal total pressure loss,the lowest cowl drag,maximum mass-capture and the minimal aeroheating are achieved for the hypersonic inlet.For the other blunting manners,the ramp shock cannot reflect evenly and produces more curved cowl reflection shock.The Type V shock interference pattern occurs for the Cross Section Cutting blunting Manner(CSCM)and the strongest cowl reflection shock gives rise to the largest flow loss and drag.The cowl-lip blunted by the other two blunting manners is subjected to the shock interference pattern that transits with an increase in the blunting radius.Accordingly,the peak heat flux does not fall monotonously with the blunting radius increasing.Moreover,the cowl-lip surface suffers from severe aerothermal load when the shear layer or the supersonic jet impinges on the wall. | LU HongBo YUE LianJie CHANG XinYu | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 13 |
| 4 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 5 | Velocity and pressure distributions in discharge tunnel of rotary-obstruction composite inner energy dissipation显示文摘On the basis of model test and theoretical analysis of velocity and pressure distributions,an hypothesis is presented that the distribution of tangential velocity in radial direction seems to be a combinational distribution of a quasi-free vortex and a quasi-forced vortex for the discharge tunnel of rotary-obstruction composite inner energy dissipation.The variations of corresponding parameters about the hypothesis are obtained under test conditions in this paper.The formula of pressure distribution in radial direction is deduced theoretically,and the theoretical values of pressure distribution computed by the formula are well consistent with the measured ones,showing that the formula is correct and can be applied to the computation and analysis of pressure distribution of this discharge tunnel. | CAO ShuangLi 1,NIU ZhengMing 1,YANG Jian 2 & LU HongBo 1 1 Xi’an University of Technology,Xi’an 710048,China 2 China Water Resources Pearl River Planning,Surveying & Designing Co.Ltd,Guangzhou 510610,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 10 |
| 6 | Biomimetic Corrugated Silicon Nanocone Arrays for Self-Cleaning Antireflection Coatings显示文摘Corrugated silicon nanocone(SiNC)arrays have been fabricated on a silicon wafer by two polystyrene-sphere-monolayer-masked etching steps in order to create high-performance antireflective coatings.The reflectance was reduced from above 35%to less than 0.7%in the range 400-1050 nm,and it remained below 0.5%at incidence angles up to 70°at 632.8 nm for both s-and p-polarized light.The fluorinated corrugated SiNC array surface exhibits superhydrophobic properties with a water contact angle of 164°. | Yandong Wang Nan Lu Hongbo Xu Gang Shi Miaojun Xu Xiaowen Lin Haibo Li Wentao Wang Dianpeng Qi Yanqing Lu Lifeng Chi | 2010 | Nano Research2010，3，7： | 8 |
| 7 | First-principles study of carbon effects in a tungsten grain boundary:site preference, segregation and strengthening显示文摘First-principles calculations have been performed to investigate energetics and site preference of carbon (C) in a tungsten (W) 5(310)/[001] grain boundary (GB). We calculate the solution energies of the C atom in the GB, which show that the interstitial C is energetically favored over the substitutional C. The segregation energy is calculated to be 3.95 eV for the energetically favorable GB interstitial site, indicating that C energetically prefers to segregate into the W GB. Based on the Rice-Wang model, our total energy calculations show that C has a significant beneficial effect on the W GB cohesion. | ZHOU HongBo JIN Shuo ZHANG Ying LU GuangHong | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，12： | 7 |
| 8 | Degradation of EB-PVD thermal barrier coatings caused by CMAS deposits | Hui Peng Lu Wang Lei Guo Wenhui Miao Hongbo Guo Shengkai Gong | 2012 | Progress in Natural Science:Materials International2012，22，5： | 7 |
| 9 | Data Analysis of Chang'E-1 Gamma-Ray Spectrometer and Global Distribution of U,K,and Th Elemental Abundances显示文摘Gamma 光线分光计(GRS ) 是 Chang'E-1 (CE-1 ) 上的主要收费载重之一月亮的探查,主要试图在月亮的表面上检测元素的丰富和分布。在 03:58 在 2007 年 11 月 28 日,它执行了月亮的 gamma 光线的第一观察。2008 年 10 月 24 日,有效 gamma 光线系列的 2105 h 被 CE-1 GRS 获得了,它盖住月亮的整个表面。这份报纸主要描述处理由使用导出元素的丰富的过程和 CE-1 GRS 时间系列改正了系列的方法的数据:首先,到进为印射的象素的箱数据;然后,执行累积系列的背景扣除并且获得元素的一个山峰区域;并且最后,当模特儿使用元素的丰富倒置生产元素的丰富。在这些上基于比 EPR 在 5s 处理方法, U 的全球丰富地图, K,和 Th。在在 near-EPR 海底山下面的岩浆结晶化压力和融化的条件之间的关联暗示来源吗? | ZOU Yongliao ZHANG Liyan LIU Jianzhong MU Lingli REN Xin ZHANG Guangliang CHANG Jin YAN Jun ZHANG Nan ZHANG Hongbo LU Chang LIU Jianjun ZUO Wei SU Yan WEN Weibin BIAN Wei WANG Min XU Chun LI Chunlai OUYANG Ziyuan | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 6 |
| 10 | FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis显示文摘Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been extensively studied in a variety of organs and diseases.However,the effect of FABP4 on RA remains unclear.Here,we found that FABP4 expression was upregulated in synovial M1-polarized macrophages in RA.The increase in FABP4 promoted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas BMS309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum and synovial M1-polarized macrophages in mice to alleviate RA progression.Further studies showed that constitutive activation of mammalian target of rapamycin complex 1(mTORC1)by TSC1 deletion specifically in the myeloid lineage regulated FABP4 expression in macrophages to exacerbate RA progression in mice.In contrast,inhibition of mTORC1 by ras homolog enriched in brain(Rheb1)disruption specifically in the myeloid lineage reduced FABP4 expression in macrophages to attenuate RA development in mice.Our findings established an essential role of FABP4 that is secreted by M1-polarized macrophages in synovitis,angiogenesis,and cartilage degradation in RA.BMS309403 and anagliptin inhibited FABP4 expression in synovial M1-polarized macrophages to alleviate RA development.Hence,FABP4 may represent a potential target for RA therapy. | Dong Guo Chuangxin Lin Yuheng Lu Hong Guan Weizhong Qi Hongbo Zhang Yan Shao Chun Zeng Rongkai Zhang Haiyan Zhang Xiaochun Bai Daozhang Cai | 2022 | Bone Research2022，10，4： | 5 |
| 11 | Locating Parent Lightning Strokes of Sprites Observed over a Mesoscale Convective System in Shandong Province,China显示文摘In this paper, we report the location results for the parent lightning strokes of more than 30 red sprites observed over an asymmetric mesoscale convective system(MCS) on 30 July 2015 in Shandong Province, China, with a long-baseline lightning location network of very-low-frequency/low-frequency magnetic field sensors. The results show that almost all of these cloud-to-ground(CG) strokes are produced during the mature stage of the MCS, and are predominantly located in the trailing stratiform region, which is similar to analyses of sprite-productive MCSs in North America and Europe. Comparison between the location results for the sprite-producing CG strokes and those provided by the World Wide Lightning Location Network(WWLLN) indicates that the location accuracy of WWLLN for intense CG strokes in Shandong Province is typically within 10 km, which is consistent with the result based on analysis of 2838 sprite-producing CG strokes in the continental United States. Also, we analyze two cases where some minor lightning discharges in the parent flash of sprites can also be located, providing an approach to confine the thundercloud region tapped by the sprite-producing CG strokes. | Anjing HUANG Gaopeng LU Hongbo ZHANG Feifan LIU Yanfeng FAN Baoyou ZHU Jing YANG Zhichao WANG | 2018 | Advances in Atmospheric Sciences2018，35，11： | 5 |
| 12 | In situ synthesis of CNTs/Fe-Ni/TiO_2 nanocomposite by fluidized bed chemical vapor deposition and the synergistic effect in photocatalysis显示文摘Carbon nanotube(CNTs)/Fe-Ni/TiO_2 nanocomposite photocatalysts have been synthesized by an in situ fluidized bed chemical vapor deposition(FBCVD) method.The composite photocatalysts were characterized by XRD,Raman spectroscopy,BET,FESEM,TEM,UV-vis spectroscopy,and XPS.The results showed that the CNTs were grown in situ on the surface of TiO_2.Fe(lll) in TiO_2 showed no chemical changes in the growth of CNTs.Ni(Ⅱ) was partly reduced to metal Ni in the FBCVD process,and the metal Ni acted as a catalyst for the growth of CNTs.The photocatalytic activities of CNTs/Fe-Ni/TiO_2 decreased with the rise of the FBCVD reaction temperature.For the sample synthesized at low FBCVD temperature(500℃),more than 90% and nearly 50% of methylene blue were removed under UV irradiation in 180 min and under visible light irradiation in 300 min,respectively.The probable mechanism of synergistic enhancement of photocatalysis on the CNTs/Fe-Ni/TiO_2 nanocomposite is proposed. | Lei Ma Aiping Chen Jindong Lu Zhe Zhang Hongbo He Chunzhong Li | 2014 | Particuology2014，12，3： | 5 |
| 13 | Effects of urban street trees on human thermal comfort and physiological indices: a case study in Changchun city, China显示文摘Planting trees along urban streets is one of the most important strategies to improve the urban thermal environment.However,the net impacts of urban street trees on human thermal comfort and physiological parameters are still less clear.On three similar east-west orientated streets with different degrees of tree cover-low(13%),medium(35%),and high(75%),urban microclimatic parameters and human physiological indices for six male students were simultaneously measured on three cloudless days in summer 2018.The results show that the differences in tree cover were predominant in influencing urban thermal environment and comfort.The street with the highest tree cover had significantly lower physiological equivalent temperature(PET) and more comfortable than the other two streets.The frequency of strong heat stress(PET> 35℃) was 64%,11 %,and 0%,respectively,for streets with low,medium,and high tree cover.For the six male university students,human physiological indices varied greatly across the three streets with different tree cover.Systolic blood pressure,diastolic blood pressure,and pulse rate increased with decreasing tree cover.The results also suggest that urban thermal environment and comfort had considerable impact on human physiological parameters.Our study provides reasons for urban planners to plant trees along streets to improve the thermal environment and promote urban sustainability. | Zhibin Ren Hongbo Zhao Yao Fu Lu Xiao Yulin Dong | 2022 | Journal of Forestry Research2022，33，3： | 4 |
| 14 | Additive manufacturing frontier: 3D printing electronics显示文摘3D printing is disrupting the design and manufacture of electronic products. 3D printing electronics offers great potentialto build complex object with multiple functionalities. Particularly, it has shown the unique ability to make embedded electronics,3D structural electronics, conformal electronics, stretchable electronics, etc. 3D printing electronics has beenconsidered as the next frontier in additive manufacturing and printed electronics. Over the past five years, a large numberof studies and efforts regarding 3D printing electronics have been carried out by both academia and industries. In thispaper, a comprehensive review of recent advances and significant achievements in 3D printing electronics is provided.Furthermore, the prospects, challenges and trends of 3D printing electronics are discussed. Finally, some promising solutionsfor producing electronics with 3D printing are presented. | Bingheng Lu Hongbo Lan Hongzhong Liu | 2018 | Opto-Electronic Advances2018，1，1： | 3 |
| 15 | Earle's balanced salts solution and rapamycin differentially regulate the Bacillus Calmette-Guerin-induced maturation of human dendritic cells显示文摘Autophagy 被显示了提高杆菌 Calmette-Gu 的功效吗? | Yan Min Wenxi Xu Dan Liu Hongbo Shen Ying Xu Shulin Zhang Lu Zhang Honghai Wang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 3 |
| 16 | Stability and diffusion properties of self-interstitial atoms in tungsten:a first-principles investigation显示文摘基于密度功能理论采用一个第一原则的方法,我们系统地在钨(W) 调查自我空隙的原子(SIA ) 的结构,稳定性和散开。The111 哑铃被显示是有 9.43 eV 的形成精力的最稳定的 SIA 缺点配置。所在地的旋转模式罐头被相当软的漂浮机制和一个下坡的飘移散开过程分别地从 110 哑铃描述到 111 哑铃并且从 001 哑铃到 110 哑铃。在跳接近附近的地点的不同 SIA 配置之中, 111 哑铃更更好与 0.004 eV 的一个低得多的精力障碍直接移居到 first-nearest-neighboring 地点。这些结果作为在熔化 Tokamak 面对材料的候选人血浆为 W 提供一本有用参考书。 | CHEN Long LIU YueLin ZHOU HongBo JIN Shuo ZHANG Ying LU GuangHong | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，4： | 2 |
| 17 | Emission Enhancement of Fluorescent Molecules by Antireflective Arrays显示文摘Traditional fluorescence enhancement based on a match of the maximum excitation or emission of fluorescence molecule with the spectra of the nanostructure can hardly enhance blue and red fluorescent molecules.Here,an enhanced method which is a new strategy based on the antireflective array has been developed to enhance the emission of blue and red fluorescent molecules.The fluorescence emission is enhanced by increasing the absorption at excitation wavelengths of the fluorescent molecules and reducing the fluorescent energy dissipation with an antireflective array.By introducing the antireflective arrays,the emission enhancement of blue and red fluorescent molecules is,respectively,up to 14 and 18 fold.It is a universal and effective strategy for enhancing fluorescence emission,which could be applied to enhance the intensity of organic LED and imaging. | Hongbo Xu Lingxiao Liu Fei Teng Nan Lu | 2019 | Research2019，，1： | 2 |
| 18 | A Improved Shunt-hybrid-type Active Power Filter and Its Control Method显示文摘 | ZHOU Ke WANG Kai LIU Lu TAN Qi CHU Hongbo | 2012 | 中国电机工程学报2012，32，30： | 2 |
| 19 | Aerothermal characteristics of bleed slot in hypersonic flows显示文摘Two types of flow configurations with bleed in two-dimensional hypersonic flows are numerically examined to investigate their aerodynamic thermal loads and related flow structures at choked conditions. One is a turbulent boundary layer flow without shock impingement where the effects of the slot angle are discussed, and the other is shock wave boundary layer interactions where the effects of slot angle and slot location relative to shock impingement point are surveyed. A key separation is induced by bleed barrier shock on the upstream slot wall, resulting in a localized maximum heat flux at the reattachment point. For slanted slots, the dominating flow patterns are not much affected by the change in slot angle, but vary dramatically with slot location relative to the shock impingement point. Different flow structures are found in the case of normal slot, such as a flow pattern similar to typical Laval nozzle flow, the largest separation bubble which is almost independent of the shock position. Its larger detached distance results in 20% lower stagnation heat flux on the downstream slot corner, but with much wider area suffering from severe thermal loads. In spite of the complexity of the flow patterns, it is clearly revealed that the heat flux generally rises with the slot location moving downstream, and an increase in slot angle from 20° to 40° reduces 50% the heat flux peak at the reattachment point in the slot passage. The results further indicate that the bleed does not raise the heat flux around the slot for all cases except for the area around the downstream slot corner. Among all bleed configurations, the slot angle of 40° located slightly upstream of the incident shock is regarded as the best. | YUE LianJie LU HongBo XU Xiao CHANG XinYu | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，10： | 2 |
| 20 | Cell-like-carbon-micro-spheres for robust potassium anode显示文摘Large-scale low-cost synthesis methods for potassium ion battery(PIB)anodes with long cycle life and high capacity have remained challenging.Here,inspired by the structure of a biological cell,biomimetic carbon cells(BCCs)were synthesized and used as PIB anodes.The protruding carbon nanotubes across the BCC wall mimicked the ion-transporting channels present in the cell membrane,and enhanced the rate performance of PIBs.In addition,the robust carbon shell of the BCC could protect its overall structure,and the open space inside the BCC could accommodate the volume changes caused by K+insertion,which greatly improved the stability of PIBs.For the first time,a stable solid electrolyte interphase layer is formed on the surface of amorphous carbon.Collectively,the unique structural characteristics of the BCCs resulted in PIBs that showed a high reversible capacity(302 m Ah g^(-1)at 100 m A g^(-1)and 248 mAh g^(-1)at500 m A g^(-1)),excellent cycle stability(reversible capacity of 226 m Ah g^(-1)after 2100 cycles and a continuous running time of more than 15 months at a current density of 100 m A g^(-1)),and an excellent rate performance(160 mAh g^(-1)at 1 A g^(-1)).This study represents a new strategy for boosting battery performance,and could pave the way for the next generation of battery-powered applications. | Hongbo Ding Jiang Zhou Apparao M.Rao Bingan Lu | 2021 | National Science Review2021，8，9： | 2 |
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