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| 1 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
| 2 | Design and experimental study of seed precise delivery mechanism for high-speed maize planter显示文摘Aiming at improving the seed spacing uniformity of maize planter at high forward speed,a seed precise delivery mechanism driven by electric motor has been developed and evaluated in laboratory.The mechanism was designed to deliver single seed from seed meter to furrow.Seed’s movement from the seed release point in a seed meter to the seed delivery cavity in the belt was analyzed,the mathematical model of seed movement in the seed precise delivery mechanism was established based on seed delivery time analysis.A mechanical prototype was designed and associated control system was developed.The performance contrast experiment was conducted between a traditional seed tube and newly developed seed precise delivery mechanism,and test results indicated that the qualities of feed index of the seed precise delivery mechanism were higher than those of the traditional seed tube delivery mechanism,and the coefficients of variation of the seed precise delivery mechanism were lower than those of the traditional seed tube delivery mechanism when the forward speed of planter was set at 10 km/h,12 km/h and 14 km/h,respectively.It indicated the seed precise delivery mechanism significantly improved seed spacing uniformity of maize planter compared with the traditional seed tube delivery mechanism. | Quanwei Liu Tao Cui Dongxing Zhang Li Yang Yunxia Wang Xiantao He Mantao Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，4： | 4 |
| 3 | Effects on Growth Performance and Feed Digestibility of Hainan Black Pigs by Adding Lysine in Low Protein Diet显示文摘[Objective] The paper was to study the effects on growth performance and feed digestibility of Hainan black pigs by adding lysine in low protein diet.[Method] A total of 36 Hainan black pigs with the body weight of(46.34 ±3.06) kg were randomly divided into three groups:control group(protein level 15%,lysine level 0.83%),experimental group I(protein level 13%,0.83%),and experimental group II(protein level 13%,lysine level 1.03),each group had three replicates of four pigs.The trial lasted 35 d.[Result] The growth performance of Hainan black pig in group II had no significant difference with that in control group(P>0.05).The apparent digestibility of crude protein and phosphorus of Hainan black pigs in Group II increased significantly(P<0.05),which were increased by 10.08% and 11.85% respectively compared to the control group;the apparent digestibility of calcium was increased,but the difference was not significant(P>0.05).[Conclusion] It will not reduce the growth performance of Hainan black pig when the protein level of diet is reduced by 2% and the lysine level is increased to 1.03%.It is recommended that the diet can be used in the production of Hainan black pig. | Wei Limin Liu Quanwei Sun Ruiping Zheng Xinli Wang Feng Tan Shuyi Huang Lili Xing Manping | 2018 | Animal Husbandry and Feed Science2018，10，2： | 4 |
| 4 | Effect of Pelleted Total Mixed Ration on Production Performance and Serum Biochemical Index of Growing Hainan Black Goats显示文摘[Objective] The paper was to investigate effects of pelleted total mixed ration on production performance and serum biochemical index of growing Hainan black goats.[Method] Twenty-four growing Hainan black goats with the same genetic backgrounds and similar initial weight of(10.05±0.049) kg were randomly assigned into two treatments, and supplied with Juncao + concentrate(control group), pelleted total mixed ration(experimental group), respectively. The trial lasted 50 d.[Result] The final weight, daily gain and feed intake of experimental group were significantly higher than those of control group(P<0.05), but the feed/gain ratio of experimental group was markedly lower than that of control group(P<0.05). Compared with the control group, the gross profit of experimental group significantly increased( P <0.05).[Conclusion] Pelleted total mixed ration led to better production performance of growing Hainan black goat. | Liu Quanwei Wang Feng Wei Limin Huang Lili Sun Ruiping Xing Manping Zheng Xinli | 2019 | Animal Husbandry and Feed Science2019，11，1： | 4 |
| 5 | Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists显示文摘Coronavirus disease 2019(COVID‐19)has become a pandemic disease globally.Although COVID-19 directly invades lungs,it also involves the nervous system.Therefore,patients with nervous system involvement as the presenting symptoms in the early stage of infection may easily be misdiagnosed and their treatment delayed.They become silent contagious sources or‘virus spreaders’.In order to help neurologists to better understand the occurrence,development and prognosis,we have developed this consensus of prevention and management of COVID‐19.It can also assist other healthcare providers to be familiar with and recognise COVID-19 in their evaluation of patients in the clinic and hospital environment. | Huijuan Jin Candong Hong Shengcai Chen Yifan Zhou Yong Wang Ling Mao Yanan Li Quanwei He Man Li Ying Su David Wang Longde Wang Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，2： | 3 |
| 6 | Effects of Dietary Crude Fiber Levels on Growth Performance and Serum Biochemical Index of Dingan Geese Aged from 35 to 70 Days显示文摘[Objective] The study was carried out to investigate the effects of dietary crude fiber on growth performance and serum biochemical in-dex of Dingan geese aged from 35 to 70 days.[Method] A total of 120 Dingan geese on day 28 with the same genetic background and similar initial weight(1 384.83.73±0.76 g) were randomly assigned into 3 groups, with 4 replicates per group and 10 geese per replicate. Geese were fed the diets containing 4.29%, 5.29% and 6.29 % crude fiber, respectively. The experiment lasted 35 d.[Result] Final weight and daily gain of 5.29 %CF group were significantly higher than those of 6.29 % CF group(P<0.05);Feed intake was markedly higher than those of 4.29% and 6.29 % CF groups(P<0.05);Feed gain ratio was significantly lower than that of 6.29 % CF group(P<0.05). Compared with 4.29% and 6.29 % CF groups, serum albumin concentrations of 5.29 % CF group increased significantly(P<0.05), while serum total protein and globin contents were higher(P>0.05), but serum uric acid level was lower(P>0.05).[Conclusion] 5.29 % crude fiber could lead to higher growth performance of Dingan geese. | Liu Quanwei Wang Feng Wei Limin Lin Dajie Xing Manping Yang Shaoxiong Sun Ruiping Ye Baoguo | 2019 | Animal Husbandry and Feed Science2019，11，1： | 3 |
| 7 | Effects of Dietary Concentrate to Forage Ratios on Production Performance and Serum Biochemical Indicators in Post-fattening Hainan Yellow Cattle显示文摘[Objective]The paper was to investigate the effects of dietary concentrate to forage ratios on production performance and serum bio-chemical indicators of post-fattening Hainan Yellow Cattle.[Method]Sixteen Hainan Yellow Cattles with the same genetic backgrounds and similar initial weight of(242.22 ±0.71 kg) were randomly divided into four treatments.Cattles were fed with diets of different concentrate to forage ratios(20:80, group Ⅰ;30:70, Group Ⅱ;40:60, group Ⅲ;50:50, group Ⅳ).The trial lasted 62 d.[Result]The daily gain in experimental group Ⅳ was significantly higher than that in experimental group Ⅱ(P<0.05), but the feed gain ratio in experimental group Ⅳ was lower than those in other ex-perimental groups(P>0.05).The feed intake in experimental group Ⅳ was also markedly higher than those in experimental groups Ⅰ and Ⅱ(P<0.05).Compared with the experimental group Ⅱ, the gross profit of experimental group Ⅳ was significantly promoted(P<0.05).The alanine aminotransferase and aspartate aminotransferase activities in experimental group Ⅱ were markedly higher than those in experimental groups Ⅰ, Ⅲ and Ⅳ.[Conclusion]When the dietary concentrate to forage ratios was 50∶50, the production performance of post-fattening Hainan Yellow Cattle was better. | Wang Feng Wei Limin Zheng Xinli Liu Hailong Sun Ruiping Chao Zhe Huang Lili Fu Liang Liu Quanwei | 2020 | Animal Husbandry and Feed Science2020，12，1： | 3 |
| 8 | Effects of Chromium on the Microstructures and Mechanical Properties of AlCoCrxFeNi2.1 Eutectic High Entropy Alloys显示文摘In the present study,a series of AlCoCrxFeNi2.1(x=0,0.25,0.5,0.75,1.0)eutectic high entropy alloys(EHEAs)have been designed and prepared.And the effect of Cr content on the microstructures and mechanical properties of the AlCoCrxFeNi2.1 alloys was systematically investigated.The results indicate that the AlCoCrxFeNi2.1(x>0)alloys exhibit almost complete lamellar eutectic microstructures with a mixture structure of FCC and B2 phases.And the AlCoFeNi2.1 alloy without Cr element exhibited a hypoeutectic microstructure with a primary B2 phase.In addition,the eutectic microstructures for AlCoCrxFeNi2.1 eutectic alloys do not change significantly.The room temperature compressive tests results show that with an increase in Cr content(from x=0 to x=1.0),the yield strength will first decrease,and thereafter increase.The trend is the opposite with the fracture strength and plastic strain.They show an increase trend at first,and then decrease.The AlCoCr0.5 FeNi2.1(Cr0.5)alloy shows the best comprehensive mechanical properties.The tensile yield strength,fracture strength,and elongation are 536.5 MPa,1062 MPa,and 13.8%,respectively.Furthermore,the Cr0.5 alloy also displays a high strength with a yield strength of 362 MPa at 700℃.In summary,by changing the Cr content,AlCoCrxFeNi2.1 eutectic high entropy alloys with excellent comprehensive mechanical properties were obtained and prepared. | Hui Jiang Li Li Rui Wang Kaiming Han Quanwei Wang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，11： | 2 |
| 9 | Ladinian radiolarian fauna, siliceous rock from the Xianshuihe Belt, West Sichuan and their tectonic significance显示文摘Ladinian radiolarian fauna, including Muelleritortis, Baumgartneria, Oertlispongus,Paroertlispongus, Pseudoertlispongus, etc., was discovered from the siliceous rock of the Runiange Formation in the Xianshuihe belt, West Sichuan Province. Geochemical test on five samples from the siliceous rock indicates that SiO2 content varies in 71.16%-90.06% and Si/Al ratio, in 49-71, which shows that the siliceous rock contains more terrigenous mud sediments.The siliceous rock is characterized by the large ratios of Al203/(Al203+Fe203) (0.63-0.81) and TiN (>26), the low ratio of V/Y (<2.8), and low vanadium content (<23 μg/g), which are similar to the geochemical characteristics of continental margin siliceous rock. The Ce/Ce* ratios of the four samples vary in 1.02-1.47 and the LaN/CeN ratio, in 0.75-1.07, which imply that the siliceous rock was deposited in the continental margin basin. But only one sample is similar to the oceanic siliceous rock in REE. Turbidite-siliceous rock bearing radiolarian-basalt assemblage and the geochemical characteristics of the siliceous rock indicate that the Xianshuihe belt is in the strong rift stage in the Ladinian age. | LIANG Bin, FENG Qinglai, WANG Quanwei, GUO Jianqiu, ZHONG Changhong & LI Zhenjiang Faculty of Earth Science, China University of Geosciences, Wuhan 430074, China Sichuan Geological Survey, Chengdu 610000, China | 2005 | Science China Earth Sciences2005，48，1： | 2 |
| 10 | Effect of Pelleted Total Mixed Ration of Different Particle Sizes on Production Performance and Serum Biochemical Index of Fattening Hainan Black Goats显示文摘[Objective] The paper to investigate the effects of pelleted total mixed ration of different particle size on production performance and serum biochemical index of fattening Hainan black goats.[Method] Thirty-six fattening Hainan black goats with the same genetic backgrounds and similar initial weight of(19.02±0.22) kg were randomly divided into three treatments. Goats were fed with Juncao+concentrate(control group), pel-leted total mixed ration I(particle size 6 mm, experimental group I) and II(particle size 5 mm, experimental group II), respectively. The trial lasted 45 d.[Result](1) The final weight and daily gain of experimental group II were significantly higher than those of control group( P<0.05), and the daily gain of experimental group II was also higher than that of experimental group I(P<0.05);the feed intake of experimental group II was markedly higher than that of control group(P<0.05), but was significantly lower than that of experimental group I(P<0.05). The feed/gain ratio of experimental group II was significantly lower than those of control group and experimental group I(P<0.05).(2) The feed gain cost of experimental group II was markedly lower than that of control group(P<0.05), but the gross profit was significantly higher than those of control group and experimental group I(P<0.05).(3) Compared with the control group, the serum total protein content of experimental group II increased markedly( P<0.05) while the urea nitrogen level decreased(P>0.05).[Conclusion] The pelleted total mixed ration with the particle size of 5 mm obtained better fattening ef-fect, and obviously improved the serum total protein level. | Liu Quanwei Wei Limin Wang Feng Tan Shuyi Sun Ruiping Huang Lili Zheng Xinli | 2019 | Animal Husbandry and Feed Science2019，11，1： | 2 |
| 11 | Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management显示文摘Coronavirus disease-2019(COVID‐19)has become a global pandemic.COVID-19 runs its course in two phases,the initial incubation phase and later clinical symptomatic phase.Patients in the initial incubation phase often have insidious clinical symptoms,but they are still highly contagious.At the later clinical symptomatic phase,the immune system is fully activated and the disease may enter the severe infection stage in this phase.Although many patients are known for their respiratory symptoms,they had neurological symptoms in their first 1-2 days of clinical symptomatic phase,and ischaemic stroke occurred 2 weeks after the onset of the clinical symptomatic phase.The key is to prevent a patient from progressing to this severe infection from mild infection.We are sharing our experience on prevention and management of COVID-19. | Yifan Zhou Wei Li David Wang Ling Mao Huijuan Jin Yanan Li Candong Hong Shengcai Chen Jiang Chang Quanwei He Mengdie Wang Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，2： | 2 |
| 12 | Comparability in geomorphic evolution of the three rivers in the northern Longitudinal Range-Gorge Region: Evidence of statistic relationships between geomorphic parameters and analyses of cause of formation显示文摘 | WANG Suiji WU Shaohong HE Daming DAI Erfu ZHOU Changhai WEI Quanwei | 2006 | Chinese Science Bulletin2006，51，B11： | 2 |
| 13 | Slaughtering Performance and Meat Quality of Hainan Black Goat and Its Hybrid Offsprings with Nubian Black Goat显示文摘In order to compare the slaughter performance and meat quality of Hainan black goats and hybrid offsprings of Nubian Black Goat and Hainan Black Goat, six 7-month-old Hainan black goats and six hybrid offsprings were selected to determine slaughter performance and muscle quality. The results showed that hybridization of Nubian black goat and Hainan black goat significantly improved the production performance and slaughter performance of hybrid offsprings (P>0.05). The meat quality of F1 hybrid black goat had no significant difference with that of Hainan black goat except for the hardness and elasticity (P<0.05). Therefore, the crossbred progenies of Nubian black goat and Hainan black goat have advantages in meat yield and meat performance, and the main meat quality indexes are not significantly different, which meets the market requirements for high-yield and high-quality hybrid combinations, and can be used for cross promotion. | Wei Limin Sun Ruiping Liu Yan Liu Ruina Liu Quanwei Zheng Xinli Wang Feng Huang Lili Xing Manping | 2019 | Animal Husbandry and Feed Science2019，11，2： | 2 |
| 14 | TEMPERATURE SENSITIVITY AND PREDICTION OF THE MECHANICAL BEHAVIORS OF ULTRAFINE GRAINED ALUMINUM UNDER UNIAXIAL COMPRESSION显示文摘In the present work, we explore the strain hardening behaviors as well as the effect of temperature on the plastic deformation of ultrafine grained aluminum. The temperature sensitivity is determined and compared with that of coarse grained material. The results indicate that the flow stress of ultrafine grained aluminum displays enhanced sensitivity to temperature. The reduction in activation volume is suggested to be the major reason for the enhanced temperature sensitivity as grain size is refined into the sub-micrometer regime. Finally, a phenomenological constitutive model is proposed to describe the post-yield response of ultrafine grained aluminum. | Quanwei Zhan Tao Suo Cunxian Wang Kui Xie Zhongbin Tang | 2014 | Acta Mechanica Solida Sinica2014，27，4： | 2 |
| 15 | Effect of travel speed on seed spacing uniformity of corn seed meter显示文摘Both seeding performance of seed metering unit and travel speed of seed planter have significant effects on seeding quality,thereby affecting crop growth and yields.In order to determine the effects of different travel speeds on seed spacing uniformity,four different types of seed meters were evaluated at five different travel speeds on seed meter test bench and in field.The tested seed meters included a finger pickup seed meter,a scoop-wheel seed meter,an air-pressure type seed meter and an air-blowing type seed meter.The seeding performance of the horizontal distribution of seeds within a row was described by using the coefficient of variation,the quality of feed index,the multiple index and the miss-seeding index.Experiments were performed in laboratory and field,respectively.Results indicated that different travel speeds have statistically significant effects on seed spacing uniformity.The four types of seed meters performed better on the seed meter test bench than in the field.Coefficient of variation increases and quality of feed index decreases as the travel speed of seed planter increases.The best seed spacing uniformity was obtained with the air-pressure type seed meter,followed with the air-blowing type seed meter,the finger pickup seed meter and the scoop-wheel seed meter.There were considerable differences between the performances of the scoop-wheel seed meter in the bench test and field test;the seeding qualities were much better in the bench test than in the field test.The scoop-wheel seed meter is more sensitive to vibration than the other types of seed meters. | Liu Quanwei He Xiantao Yang Li Zhang Dongxing Cui Tao Qu Zhe Yan Bingxin Wang Mantao Zhang Tianliang | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 2 |
| 16 | Analysis on the Super-winding Accident of Casting Crane and Con- figuration of the Safeguard 显示文摘 | Wen Hao Wang Quanwei Zheng Guang | 2011 | Advanced Materials Re- search2011，396，： | 1 |
| 17 | Effects of Crude Fiber Levels on Production Performance, Organ Index and Serum Biochemical Parameters of Dingan Geese Aged from 1 to 28 Days显示文摘[Objective]The paper was to investigate the effects of dietary crude fiber level on production performance,organ index and serum biochemical parameters of Dingan geese aged from 1 to 28 days.[Method]A total of 144 1-day-old Dingan geese with the same genetic background and similar initial weight(88.75±0.21g)were randomly assigned into 3 groups with 4 replicates per group and 12 geese per replicate,and fed with the diets containing 2.56%,3.52% and 4.48% crude fiber,respectively.The trial lasted 28 d.[Result]1)The final weight and daily gain of 3.52% CF group were significantly higher than those of 2.56% CF group(P<0.05);the feed/gain ratio was markedly lower than that of 2.56% CF group(P<0.05).2)The slaughter rate,semi-eviscerated rate and leg muscle rate of 3.52% CF group were higher than those of 2.56% and 4.48% CF groups(P>0.05).3)As the dietary crude fiber levels rose,the abdominal fat rate showed a downward trend(P>0.05).4)The liver index of 3.52% CF group was significantly higher than that of 2.56% CF group(P<0.05).4)Compared with 2.5%and 4.48% CF groups,the serum albumin concentrations of 3.52% CF group markedly increased(P<0.05),the serum total protein and globin contents were higher(P>0.05),but the serum uric acid level was lower(P>0.05).[Conclusion]When the crude fiber level was 3.52%,the production performances of Dingan geese aged from 1 to 28 days were better,and the liver index and serum albumin level could be obviously improved. | Liu Quanwei Wei Limin Wang Feng Lin Dajie Xing Manping Yang Shaoxiong Sun Ruiping Ye Baoguo | 2019 | Animal Husbandry and Feed Science2019，11，3： | 1 |
| 18 | Effects of Three Major Immunization Interventions on Measles Control—China,1952–2021显示文摘Measles,an acute respiratory infectious disease caused by the measles virus,was responsible for millions of deaths annually before the introduction of the measles vaccine(MV)(1).Widespread availability of measles vaccines and the initiation of the Expanded Program on Immunization,approved at the 27th World Health Assembly in 1974(2),have significantly improved global measles control.In China,measles has been a statutorily notifiable disease since the establishment of the National Notifiable Diseases Reporting System(NNDRS)in 1950(3). | Quanwei Song Chao Ma Lixin Hao Fuzhen Wang Zhijie An Zundong Yin Huaqing Wang | 2023 | China CDC weekly2023，5，17： | 1 |
| 19 | The role of calpain in the regulation of ADAM17-dependent GPIbα ectodomain shedding显示文摘 | Zhicheng Wang Quanwei Shi Rong Yan Guanglei Liu Weilin Zhang Kesheng Dai | 2010 | Archives of Biochemistry and Biophysics2010，，2： | 1 |
| 20 | Simulation and optimization of a double THGEM detector显示文摘A double thick GEM (THGEM) detector with thin THGEM foils and small holes was constructed. In order to optimize the operation parameters of the detector, a simulation study of the detector was carried out using ANSYS and Garfield program. Some important characteristics, including primary electron transparency, avalanche development and the secondary electron loss were calculated. Parameters, such as electric field and gas choice were optimized. | WANG Xiaohu WEI Tao LONG Jidong LI Quanwei ZHANG Linwen | 2013 | Nuclear Science and Techniques2013，24，1： | 1 |
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