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| 1 | Effect of Liuweibuqi capsule, a Chinese patent medicine, on the JAK1/STAT3 pathway and MMP9/TIMP1 in a chronic obstructive pulmonary disease rat model显示文摘OBJECTIVE: To observe effect of Liuweibuqi Capsule, a Traditional Chinese Medicine(TCM), on the janus kinase(JAK)/signal transducer and activator of transcription(STAT) pathway and matrix metalloproteinases(MMPs) in a chronic obstructive pulmonary disease(COPD) rat model with lung deficiency in terms of TCM's pattern differentiation.METHODS: Rats were randomly divided into a normal group, model group, Liuweibuqi group, Jinshuibao group, and spleen aminopeptidase group(n=10). Aside from the normal group, all rats were ex-posed to smoke plus lipopolysaccharide tracheal instillation to establish the COPD model with lung deficiency. Models were established after 28 days and then the normal and model groups were given normal saline(0.09 g/kg), Liuweibuqi group was given Liuweibuqi capsule(0.35 g/kg), Jinshuibao group was given Jinshuibao capsules(0.495 g/kg), and the spleen group was given spleen aminopeptidase(0.33 mg/kg), once a day for 30 days. Changes in symptoms, signs, and lung histology were observed. Lung function was measured with a spirometer. Serum cytokines were detected using enzyme-linked immunosorbent assay, and changes in the JAK/STAT pathway, MMP-9, and MMPs inhibitor1(TIMP1) were detected by immunohistochemistry, RT-PCR, and western blotting, respectively.RESULTS: Compared with the normal group, lung tissue was damaged, and lung function was reduced in the model control group. Additionally, the levels of interleukin(IL)-1β, γ interferon(IFN-γ), and IL-6 were higher, while IL-4 and IL-10 were lower in the model control group than those in the normal group. The expressions of JAK1, STAT3, p-STAT3,and MMP-9 m RNA and protein in lung tissue were higher, and TIMP1 m RNA and protein was lower in the model group compared with the normal group.After treatment, compared with the model group,the expression of inflammatory cytokines was lower in each treatment group, and expressions of JAK/STAT pathway, MMPs were lower. Compared with the positive control groups, the Jinshuibao and spleen aminopeptidase groups, lung function was better, and JAK1, STAT3, and p-STAT3 protein were lower and TIMP1 was higher in the Liuweibuqi group.CONCLUSION: Liuweibuqi capsules can improve the symptoms of COPD possibly by regulating the expression of the JAK1/STAT3 pathway and MMP9/TIMP1. | Wang Chengyang Li Zegen Liu Xiangguo Peng Qinghe Li Fang Li Da Wang Chuanbo | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 23 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | Modification of NiCoCrAlY with Pt: Part Ⅱ. Application in TBC with pure metastable tetragonal(t’) phase YSZ and thermal cycling behavior显示文摘A thermal barrier coating system comprising Pt-modified NiCoCrAlY bond coating and nanostructured 4mol.% yttria stabilized zirconia(4YSZ, hereafter) top coat was fabricated on a second generation Ni-base superalloy. Thermal cycling behavior of NiCoCrAlY-4 YSZ thermal barrier coatings(TBCs) with and without Pt modification was evaluated in ambient air at 1100?C up to 1000 cycles, aiming to investigate the effect of Pt on formation of thermally grown oxide(TGO) and oxidation resistance. Results indicated that a dual layered TGO, which consisted of top(Ni,Co)(Cr,Al)_2O_4 spinel and underlying α-Al_2O_3, was formed at the NiCoCrAlY/4 YSZ interface with thickness of 8.4μm, accompanying with visible cracks at the interface. In contrast, a single-layer and adherent α-Al_2O_3 scale with thickness of 5.6μm was formed at the interface of Pt-modified NiCoCrAlY and 4 YSZ top coating. The modification of Pt on NiCoCrAlY favored the exclusive formation of α-Al_2O_3 and the reduction of TGO growth rate, and thus could effectively improve overall oxidation performance and extend service life of TBCs. Oxidation and degradation mechanisms of the TBCs with/without Pt-modification were discussed. | Chuntang Yu He Liu Chengyang Jiang Zebin Bao Shenglong Zhu Fuhui Wang | 2019 | Journal of Materials Science & Technology2019，35，3： | 4 |
| 4 | Effects of design parameters on rooftop photovoltaic economics in the urban environment:A case study in Melbourne,Australia显示文摘Many researchers found high potential of adopting building photovoltaic(PV)systems in urban areas,especially on building rooftop,to improve the sustainability of urban environment.However,the optimal energy output performance and economic benefit of the PV system are affected by the usable roof area,PV array layout,and shading effect considering high city density.This study aims to understand the effects of these design parameters in the urban environment of rooftop PV's economic performance.This study carries out a case study in the urban area of Melbourne with 90 PV designs under three shading conditions to generate 270 scenarios.Through a lifecycle cost-benefit analysis,including net present value(NPV),NPV per kW,internal return rate(IRR),and payback year,the results can help in developing a comprehensive understanding of the economic performance of rooftop PV designs that cover most of the urban areas of Melbourne.The optimal PV design scenarios for the urban environment are identified,thereby providing investors and industry professionals with useful information on value-for-money PV design.Meanwhile,the maximum shading loss that makes the PV systems financially unfeasible is investigated,and design scenarios with greatest ability to sustain the shading effect are identified.This research can also support the policy makers'decision on the development and deployment of the roof PV systems in urban planning. | Hongying ZHAO Chaohong YANG W.M·Pabasara U.WIJERATNE Chengyang LIU Xiaolong XUE Nishara ABDEEN | 2019 | Frontiers of Engineering Management2019，6，3： | 2 |
| 5 | Preparation of mesoporous MgO-templated carbons from phenolic resin and their applications for electric double-layer capacitors显示文摘Mesoporous carbons were synthesized using thermoplastic phenolic resin(PF) as carbonaceous precursor and magnesium citrate as template precursor.Pore structure was determined as ink-bottle-like geometry through TEM,N2 adsorption analysis combined with TG curves.The porous carbons prepared were then applied as electrode material for electric double-layer capacitors.The capacitor performance was examined in 30 wt% KOH aqueous solution by cyclic voltammetry and galvanostatic charge/discharge measurements.The carbon prepared with MgO/PF mass ratio of 8/2 had a BET surface area of 1920 m2 g-1 and exhibited a capacitance of 220 F g-1 at a current density of 50 mA g-1.Besides,the carbon with the ratio of 4/6 had the optimize proportion of mesopores,which ensures its good rate performance that up to 98.3%,expressed as the ratio of the capacitance measured at 1000 mA g-1 against that at 50 mA g-1. | LIU WenJie WANG ChengYang WANG JiuZhou JIA Fan ZHENG JiaMing CHEN MingMing | 2013 | Chinese Science Bulletin2013，58，9： | 2 |
| 6 | A quasi-maximum like- lihood approach for integrated covariance matrix esti- mation with high-frequency data 显示文摘 | Liu Cheng Tang Chengyang | 2014 | Journal of Econo- metrics2014，180，2： | 1 |
| 7 | Benefits of Zr addition to oxidation resistance of a single-phase (Ni,Pt)Al coating at 1373 K显示文摘A single-phase (Ni,Pt)Al coating with lean addition of Zr was prepared by co-electroplating of Pt-Zr com posite plating and subsequent gaseous alum inization treatm ents. Isotherm al and cyclic oxidation behavior of the Zr-doped (Ni,Pt)Al coating sam ples was assessed at 1373K in static air in comparison with plain nickel alum inide (NiAl) and norm al (Ni,Pt)Al coatings. Results indicated th at Zr-doped (Ni,Pt)Al coating dem onstrated a lower oxidation rate constant and reduced tendency of oxide scale spallation as well as surface rumpling, in which the enhanced oxidation perform ance was m ainly attributed to the segregation of Zr at oxide scale grain boundaries and the im proved Young's modulus of the coating. Besides, the addition of Zr effectively delayed oxide phase transform ation of Al2O3 from θ phase to α phase in the early oxidation stage and coating degradation of β-NiAl to γ'-Ni3Al in the stable oxidation stage. | Chengyang jiang Lingyi Qian Min Feng He Liu Zebin Bao Minghui Chen Shenglong Zhu Fuhui Wang | 2019 | Journal of Materials Science & Technology2019，35，7： | 1 |
| 8 | Epigenomic plasticity enables human pancreatic [alpha] to [Beta] cell reprogramming显示文摘 | Bramswig Nuria C Everett Logan J Schug Jonathan Dorrell Craig Liu Chengyang Luo Yanping Streeter Philip R Naji Ali Grompe Markus Kaestner Klaus H | 2013 | Journal of Clinical Investigation2013，，3： | 1 |
| 9 | Tunable band gap in a photonic crystal modulated by a nematic liquid crystal显示文摘 | Liu Chengyang Chen lienwen | 2005 | Physical Review B2005，72，45： | 1 |
| 10 | Structural Characteristics of Mesophase Spheres Prepared ftom Coal Tar Pitch Modified by Phenolic Resin显示文摘 | LI Tongqi LIU Xiujun WANG Chengyang | 2006 | Chinese Journal Chemical Engineering2006，14，5： | 1 |
| 11 | CoB and BN composites enabling integrated adsorption/catalysis to polysulfides for inhibiting shuttle-effect in Li-S batteries显示文摘Lithium-sulfur(Li-S)batteries are hampered by the infamous shuttle effect and slow redox kinetics,resulting in rapid capacity decay.Herein,a bifunctional catalysis CoB/BN@rGO with integrated structure and synergy effect between adsorption and catalysis is proposed to solve the above problems.The integrated CoB and BN are simultaneously and uniformly introduced on the rGO substrate through a one-step calcination strategy,applied to modify the cathode side of PP separator.The transition metal borides can catalyze the conversion of lithium polysulfides(Li_(2)Sn,n≥4),whereas the bond of B-S is too weak to absorb LPS.Thus BN introduced can effectively restrict the diffusion of polysulfides via strong chemisorption with LiSnLi+…N,while the rGO substrate ensures smooth electron transfer for redox reaction.Therefore,through the integrated adsorption/catalysis,the shuttle effect is suppressed,the kinetics of redox reaction is enhanced,and the capacity decay is reduced.Using CoB/BN@rGO modified PP separator,the Li-S batteries with high initial capacity(1450 mAh g^(-1)at 0.35 mA cm^(-2))and long-cycle stability(700 cycles at 1.74 mA cm^(-2)with a decay rate of 0.032%per cycle)are achieved.This work provides a novel insight for the preparation of bifunctional catalysis with integrated structure for long-life Li-S batteries. | Tianli Wu Ting Yang Jizong Zhang Xuewen Zheng Kunlin Liu Chengyang Wang Mingming Chen | 2021 | Journal of Energy Chemistry2021，30，8： | 1 |
| 12 | Characteristics of mesocarbon microbeads generated from a coal tar pitch with addition of micro-alumina powder显示文摘 | Li Tongqi Wang Chengyang Liu Xiujun | 2005 | Fuel Processing Technology2005，87，1： | 1 |
| 13 | The involvement of integrin β1 signaling in the migration and myofibroblastie differentiation of skin Fthroblasts on anisotmpic collagen-containing nanofibers 显示文摘 | Huang Chengyang Fu Xiaoling Liu Jie | 2012 | Biomatefials2012，33，6： | 1 |
| 14 | Application of SEM to detect the structure of mesocarbon microbeads显示文摘 | Li Tongqi Wang Chengyang Liu Xiujun | 2005 | Journal of Materials Science2005，40，8： | 1 |
| 15 | Optimal design of vertical natural circulation steam generator显示文摘 | LIU Chengyang YAN Changqi WANG Jianjun | 2012 | Nuclear Engineering and Design2012，252，： | 1 |
| 16 | Overexpression of Hepatocyte Nuclear Factor-4α Initiates Cell Cycle Entry, but Is not Sufficient to Promote β-Cell Expansion in Human Islets显示文摘 | Sebastian Rieck Jia Zhang Zhaoyu Li Chengyang Liu Ali Naji Karen K. Takane Nathalie M. Fiaschi-Taesch Andrew F. Stewart Jake A. Kushner Klaus H. Kaestner | 2012 | Molecular Endocrinology2012，，9： | 1 |
| 17 | On the use of [ 18 F]DOPA as an imaging biomarker for transplanted islet mass显示文摘 | Olof Eriksson Akiva Mintz Chengyang Liu Ming Yu Ali Naji Abass Alavi | 2014 | Annals of Nuclear Medicine2014，，1： | 1 |
| 18 | Distributed Robust Optimal Dispatch for the Microgrid Considering Output Correlation between Wind and Photovoltaic显示文摘As an effective carrier of integrated clean energy,the microgrid has attracted wide attention.The randomness of renewable energies such as wind and solar power output brings a significant cost and impact on the economics and reliability of microgrids.This paper proposes an optimization scheme based on the distributionally robust optimization(DRO)model for a microgrid considering solar-wind correlation.Firstly,scenarios of wind and solar power output scenarios are generated based on non-parametric kernel density estimation and the Frank-Copula function;then the generated scenario results are reduced by K-means clustering;finally,the probability confidence interval of scenario distribution is constrained by 1-norm and∞-norm.The model is solved by a column-and-constraint generation algorithm.Experimental studies are conducted on a microgrid system in Jiangsu,China and the obtained scheduling solution turned out to be superior under wind and solar power uncertainties,which verifies the effectiveness of the proposed DRO model. | Ming Li Cairen Furifu Chengyang Ge Yunping Zheng Shunfu Lin Ronghui Liu | 2023 | Energy Engineering2023，120，8： | 0 |
| 19 | Screening of Bacillus subtilis HAAS01 and Its Biocontrol Effect on Fusarium wilt in Sweet Potato显示文摘Fusarium wilt,a disease caused by Fusarium oxysporum f.sp batatas(Fob)is an important disease in sweet potato production.Using endophytic bacteria for biological control of sweet potato diseases is one of the important ways.A Bacillus subtilis with antagonistic effect on Fusarium wilt of sweet potato was isolated from soil by confrontation culture.According to the biological characteristics,16S rDNA sequence analysis,and physiological and biochemical analysis,the Bacillus subtilis HAAS01 was named.A pot experiment was conducted for the biological control experiment of strain HAAS01,and the endogenous hormone content,antioxidant enzyme activity,soluble protein content,and related gene expressions of sweet potato plants were detected.The results showed that the HAAS01 strain could promote the production of endogenous hormones and resist the infection of plant diseases together with defensive enzymes and upregulation of related gene expressions.In summary,Bacillus subtilis HAAS01 was effective in controlling Fusarium wilt of sweet potato and has potential for application and development. | Chengyang Li Lianjun Wang Shasha Chai Yinghua Xu Chong Wang Yi Liu Jian Lei Xiaojie Jin Xianliang Cheng Yuanyuan Yang Xinsun Yang Wenying Zhang | 2022 | Phyton-International Journal of Experimental Botany2022，91，8： | 0 |
| 20 | Spatio-temporal Changes in Water Conservation Ecosystem Service During 1990–2019 in the Tumen River Basin, Northeast China显示文摘The water conservation(WC) function of ecosystems is related to regional ecological security and the sustainable development of water resources, and the assessment of WC and its influencing factors is crucial for ecological and water resource management.The Tumen River Basin(TRB) is located in the core of the Northeast Asian ecological network and has been experiencing severe ecological crises and water shortages in recent years due to climate change and human activities. However, these crises have not been fully revealed to the extent that corresponding scientific measures are lacking. This study analyzed the spatial and temporal evolution characteristics and drivers of WC in the TRB from 1990 to 2019 based on the water yield module of the Integrated Valuation of Ecosystem Services and Tradeoffs(InVEST) model. The results showed that: 1) under the combined effect of nature and socioeconomics, the WC depth of the TRB has slowly increased at a rate of 0.11 mm/yr in the past 30 years, with an average WC depth of 36.14 mm. 2) The main driving factor of the spatial variation in WC is precipitation, there is a significant interaction between precipitation and velocity, the interaction between each factor is higher than the contribution of a single factor, and the interactions between factors all have nonlinear enhancement and two-factor enhancement. 3) Among the seven counties and municipalities in the study area, the southern part of Helong City and the southeastern part of Longjing City are extremely important areas for WC(> 75 mm), and they should be regarded as regional water resources and ecological priority protection areas. It is foreseen that under extreme climate conditions in the future, the WC of the watershed is under great potential threat, and protection measures such as afforestation and forestation should begin immediately. Furthermore, the great interannual fluctuations in WC depth may place more stringent requirements on the choice of time scales in the ecosystem service assessment process. | ZHANG Peng LIU Xiaoping ZHU Weihong LI Chunjing JIN Ri YAN Hengqi GU Chengyang WANG Jingzhi | 2023 | Chinese Geographical Science2023，33，1： | 0 |
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