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| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients显示文摘Glioma 是有有限治疗选择的复杂疾病。最近的进展在多达 80% 更低的等级 gliomas (LGG ) 并且在 76% 第二等的 glioblastomas (GBM ) 识别了 isocitrate 脱氢酶(IDH ) 变化。IDH 变化也在尖锐 myeloid 白血病(AML ) 的 10%-20% 被看见。在 AML,包含 epigenetic 规定的 IDH 和另外的基因的变化是早事件,这被决定,出现在 pre 白血病的干细胞(最低有效字符前) 上演,而在宣传 oncogenic 信号的基因的变化是在白血病的迟了的事件。IDH 变化也是在 glioma 的早事件,发生在 TP53 变化前, 1p/19q 删除,等等。尽管有在 glioma 研究的这些进展,进另外的分子的改变的研究更加落后。在这研究,我们分析了当前可得到的数据库。我们除了已知的基因 IDH1/2 在 glioma 识别了 EZH2, KMT2C,和 CHD4 同样重要的基因。我们也证明 PIK3CA, CDKN2A, CDK4, FIP1L1,或 FUBP1 的 genomic 改变与 IDH 变化协作否定地在 LGG 影响病人幸存。在有 TP53 变化或 IDH1/2 变化的 LGG 病人,没有如此的改变, EZH2, KMC2C,和 CHD4 的另外的 genomic 改变个别地或在联合比病人与显著地减少的没有疾病的幸存被联系。在基因水平或蛋白质水平的 EZH2, KMT2C,和 CHD4 的改变能使不安 epigenetic 节目,在 glioma 导致恶意的转变。由在可得到的数据集上在 AML 和 glioma 和表现生物信息学分析上考察当前的文学,我们从 premalignant 干细胞在 tumorigenesis 上开发了一个假想模型到 glioma。 | Le Zhang Ying Liu Mengning Wang Zhenhai Wu Na Li Jinsong Zhang Chuanwei Yang | 2017 | Journal of Molecular Cell Biology2017，9，6： | 11 |
| 3 | In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine显示文摘Berberrubine (BRB ) 是在 vivo 比 BBR 显示出更强壮的葡萄糖阴沉的效果的 berberine (BBR ) 的主要代谢物。在另一方面, BRB 快速并且广泛地被使产生代射变化进 berberrubine-9-O -- 在在口头的管理以后的老鼠的 D-glucuronide (BRBG ) 。在这研究,我们在老鼠比较了 BRB 和 BRBG 的 pharmacokinetic 性质,并且探索了位于他们的葡萄糖阴沉的活动下面的机制。有导致 HFD 的多糖症的 C57BL/6 老鼠被管理 BRB (50 mg 吗?? | Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 9 |
| 4 | MicroRNA-125b regulates Th17/Treg cell differentiation and is associated with juvenile idiopathic arthritis显示文摘Background Juvenile idiopathic arthritis(JIA)is the most common rheumatic disease in childhood driven by aberrant pathways of T-cell activation.T helper 17(Th17)/regulatory T cell(Treg)imbalance plays critical roles in the pathogenesis of arthritis.MicroRNA-125b(miR-125b)was upregulated after the activation of the initial CD4^+T cells,and could regulate the differentiation of CD4^+T cells.However,the effects of miR-125b on Th17/Treg imbalance and differentiation of Th 17/Treg cells remain unknown.Methods In this study,we evaluated the expression of miR-125b in the peripheral blood mononuclear cells(PBMCs)of children with JIA,and the relationship of miR-125b with Th17/Treg imbalance.Then,we used lentivirus vector-mediated overexpression technology to investigate the regulatory function of miR-125b in CD4^+T cells or dendritic cell/CD4^+T co-culture system.Results Decreased miR-125b expression in PBMCs and CD4^+T cells of JIA patients was negatively correlated with the ratio of Th17/Treg cells.It also correlated negatively with retinoic acid receptor-related orphan receptorγt but positively with Forkhead box protein 3 at transcriptional levels.Furthermore,we found that miR-125b overexpression inhibited Th17 cell differentiation,whereas facilitated the differentiation of Treg cells.MiR-125b upregulation led to the decrease of Th 17-secreting cytokines but the increase of the Treg-secreting cytokines.Conclusions Our results demonstrate that miR-125b participated in regulating Thl7/Treg cell differentiation and imbalance in JIA patients.These findings provide novel insight into the critical role of miR-125b in the Th17/Treg imbalance of JIA,and raise the distinct possibility that miR-125b may prove to be a potential therapeutic target for JIA. | Zhi-Dan Fan Qian Cao Na Huang Le Ma Hui-Hui Ma Ya-Yuan Zhang Hai-Guo Yu Guo-Ping Zhou | 2020 | World Journal of Pediatrics2020，16，1： | 7 |
| 5 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 6 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 7 | Internal field study of 21700 battery based on long-life embedded wireless temperature sensor显示文摘The safety of lithium-ion batteries is an essential concern where instant and accurate temperature sensing is critical.It is generally desired to put sensors inside batteries for instant sensing.However,the transmission of internal measurement outside batteries without interfering their normal state is a non-trivial task due to the harsh electrochemical environment,the particular packaging structures and the intrinsic electromagnetic shielding problems of batteries.In this work,a novel in-situ temperature sensing framework is proposed by incorporating temperature sensors with a novel signal transmission solution.The signal transmission solution uses a self-designed integrated-circuit which modulates the internal measurements outside battery via its positive pole without package breaking.Extensive experimental results validate the noninterference properties of the proposed framework.Our proposed in-situ temperature measurement by the self-designed signal modulation solution has a promising potential for in-situ battery health monitoring and thus promoting the development of smart batteries. | Le Yang Na Li Likun Hu Shaoqi Wang Lin Wang Jiang Zhou Wei-Li Song Lei Sun Tai-Song Pan Hao-Sen Chen Daining Fang | 2021 | Acta Mechanica Sinica2021，37，6： | 3 |
| 8 | Two new terpenes from Tripterygium wilfordii显示文摘Two new terpenes,wilfornine H(1) and triptobenzene Q(2) were isolated from Tripterygium wilfordii,as well as 11 terpenes. Their structures were elucidated by spectroscopic methods.Compounds 5,9-13 showed significant immunosuppressive activities. | Bo Le Li Qian Shen Mei Na Jin Hong Quan Duan | 2010 | Chinese Chemical Letters2010，21，7： | 2 |
| 9 | Understanding the role of rumen epithelial host-microbe interactions in cattle feed efficiency显示文摘Feed efficiency is one of the economically important traits for the cattle industry that affects profit(feed costs)and the environment(production of manure and methane).Due to that feed efficiency is driven by multi-factors,mechanisms contributing to the animal to animal variation in this trait have not been well defined,limiting the development of precision feeding strategies to improve the herd production efficiency.Rumen microbial fermentation and volatile fatty acids(VFA)production have been recently reported to be associated with cattle feed efficiency,however the roles of rumen epithelial function in feed efficiency are less studied although the rumen epithelium has an important function in VFA absorption and metabolism which can affect host feed efficiency.Rumen epithelium is colonized with a diverse microbial population,termed epimural microbiota,which has proposed functions in tissue development,barrier and inflammation,urea transport,and oxygen scavenging,suggesting that they can affect rumen epithelial functions and subsequently cattle feed efficiency.Especially,prospective functions of epimural microbiota,enhanced rumen immunity and increased rumen epithelial thickness,might contribute to less nutritional requirement for tissue recuperation.Thus,the understanding of the functions of rumen epithelium,epimural microbiota,and rumen epithelial host-microbe interactions is essential to identify their roles in contributing to feed efficiency.In this review,we will focus on to date research findings on the structure of rumen epithelium,epimural microbiota,and epithelial host-microbe interactions together with their functions and how these are associated with feed efficiency,aiming to provide insights on future directions to study rumen epithelial host-microbe interactions and improve the rumen functions in cattle. | Sang Weon Na Le Luo Guan | 2022 | Animal Nutrition2022，，3： | 2 |
| 10 | AoATG5 plays pleiotropic roles in vegetative growth,cell nucleus development,conidiation,and virulence in the nematode-trapping fungus Arthrobotrys oligospora显示文摘Autophagy is an evolutionarily conserved process in eukaryotes,which is regulated by autophagy-related genes(ATGs).Arthrobotrys oligospora is a representative species of nematode-trapping(NT)fungi that can produce special traps for nematode predation.To elucidate the biological roles of autophagy in NT fungi,we characterized an orthologous Atg protein,AoAtg5,in A.oligospora.We found that AoATG5 deletion causes a significant reduction in vegetative growth and conidiation,and that the transcript levels of several sporulation-related genes were significantly downregulated during sporulation stage.In addition,the cell nuclei were significantly reduced in theΔAoATG5 mutant,and the transcripts of several genes involved in DNA bio-synthesis,repair,and ligation were significantly upregulated.InΔAoATG5 mutants,the autophagic process was significantly impaired,and trap formation and nematocidal activity were significantly decreased.Comparative transcriptome analysis results showed that AoAtg5 is involved in the regulation of multiple cellular processes,such as autophagy,nitrogen metabolism,DNA biosynthesis and repair,and vesicular transport.In summary,our results suggest that AoAtg5 is essential for autophagy and significantly contributes to vegetative growth,cell nucleus development,sporulation,trap formation,and pathogenicity in A.oligospora,thus providing a basis for future studies focusing on related mechanisms of autophagy in NT fungi. | Duanxu Zhou Yingmei Zhu Na Bai Le Yang Meihua Xie Jiangliu Yang Meichen Zhu Ke-Qin Zhang Jinkui Yang | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
| 11 | Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo显示文摘Objective: To determine the in vitro and in vivo absorption properties of active ingredients of the Chinese medicine, baicalein, to enrich mechanistic understanding of oral drug absorption.Methods: The Biopharmaceutic Classification System(BCS) category was determined using equilibrium solubility, intrinsic dissolution rate, and intestinal permeability to evaluate intestinal absorption mechanisms of baicalein in rats in vitro. Physiologically based pharmacokinetic(PBPK) model commercial software GastroPlus~(TM) was used to predict oral absorption of baicalein in vivo.Results: Based on equilibrium solubility, intrinsic dissolution rate, and permeability values of main absorptive segments in the duodenum, jejunum, and ileum, baicalein was classified as a drug with low solubility and high permeability. Intestinal perfusion with venous sampling(IPVS) revealed that baicalein was extensively metabolized in the body, which corresponded to the low bioavailability predicted by the PBPK model. Further, the PBPK model predicted the key indicators of BCS, leading to reclassification as BCS-II. Predicted values of peak plasma concentration of the drug(C_(max)) and area under the curve(AUC)fell within two times of the error of the measured results, highlighting the superior prediction of absorption of baicalein in rats, beagles, and humans. The PBPK model supported in vitro and in vivo evidence and provided excellent prediction for this BCS class II drug.Conclusion: BCS and PBPK are complementary methods that enable comprehensive research of BCS parameters, intestinal absorption rate, metabolism, prediction of human absorption fraction and bioavailability, simulation of PK, and drug absorption in various intestinal segments across species. This combined approach may facilitate a more comprehensive and accurate analysis of the absorption characteristics of active ingredients of Chinese medicine from in vitro and in vivo perspectives. | Yang Liu Jing Sun Linying Zhong Yu Li A Na Er Tong Li Le Yang Ling Dong | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，3： | 2 |
| 12 | Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV-10-2 or pneumonic F1-V vaccines 显示文摘 | Quenee LE Ciletti NA Elli D et d | 2011 | Vaccine2011，38，29： | 1 |
| 13 | Yersinia pestis cafl variants and the limits of plague vaccine protection 显示文摘 | Quenec LE Cornelius CA Ciletti NA | 2008 | Infect Immun2008，76，5： | 1 |
| 14 | Immunosuppressive regulatory T ceils are abundant in the reactive lymphocytes of Hodgkin lymphoma显示文摘 | Marshall NA Christie LE Munro LR | 2004 | Blood2004，103，5： | 1 |
| 15 | Chromosome abnormalities in advanced stage lymphoblastic lymphoma of children and adolescents:a report from CCG-E08显示文摘 | Lones MA Heerema NA Le Beau MM | | 0，，01： | 1 |
| 16 | Efficient microwave-assisted synthesis of 1-(1 H -indol-1-yl)-2-phenyl-3-(1 H -1,2,4-triazol-1-yl)propan-2-ols as antifungal agents显示文摘 | Nicolas Lebouvier Francis Giraud Typhanie Corbin Young Min Na Guillaume Le Baut Pascal Marchand Marc Le Borgne | 2006 | Tetrahedron Letters2006，，36： | 1 |
| 17 | What is the true nature of the osteoblastic hematopoietic stem cell niche显示文摘 | Askmyr M Sims NA Martin TJ Purton LE | | 0，，： | 1 |
| 18 | PKC-SWI6 signaling regulates asexual development,cell wall integrity,stress response,and lifestyle transition in the nematode-trapping fungus Arthrobotrys oligospora显示文摘Predatory fungi possess intricate signal transduction systems that regulate their development and support successful infection of the host.Herein,we characterized three components of the cell wall integrity-controlling pathway,namely protein kinase C(Ao PKC),SLT2-MAPK(Ao SLT2),and SWI6(Ao SWI6),in a representative nematode-trapping fungus Arthrobotrys oligospora,using gene disruption and multi-omics approaches.The phenotypic traits(such as mycelia development,conidiation,stress response,and trap morphogenesis) and metabolic profiles of ΔAopkc and ΔAoswi6 mutants were similar but differed from those of the ΔAoslt2 mutants.Transcriptomic analysis indicated that the genes differentially expressed in the absence of Aoswi6 were involved in DNA replication,repair,and recombination during trap formation.Moreover,the yeast two-hybrid assay showed that Ao PKC interacted with Ao SWI6,suggesting that in A.oligospora,PKC can directly regulate SWI6,bypassing the SLT2signaling cascade.Conclusively,our findings deepen our understanding of the regulatory mechanism of asexual development and lifestyle switching in nematode-trapping fungi. | Meihua Xie Ni Ma Na Bai Le Yang Xuewei Yang Ke-Qin Zhang Jinkui Yang | 2022 | Science China(Life Sciences)2022，65，12： | 1 |
| 19 | Itchy mice : the identifica- tion of a new pathway for the development of autoimmunity 显示文摘 | Matesic LE Copeland NG Jenkins NA | 2008 | Curt Top Microbiol Immuno12008，321，： | 1 |
| 20 | Immunosuppressive regu-latory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma显示文摘 | Marshall NA Christie LE Munro LR | 2004 | Blood2004，103，5： | 1 |
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