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| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | 在男吸烟者之中的白血球 DNA methylation 和 colorectal 癌症显示文摘 AIM: To explore the association between methylation in leukocyte DNA and colorectal cancer (CRC) risk in male smokers using the α-tocopherol, β-carotene cancer prevention study. METHODS: About 221 incident CRC cases, and 219controls, frequency-matched on age and smoking intensity were included. DNA methylation of 1505 CpG sites selected from 807 genes were evaluated using Il-lumina GoldenGate Methylation Cancer Panel I in prediagnostic blood leukocytes of study subjects. Tertiles of methylation level classified according to the distribution in controls for each CpG site were used to analyze the association between methylation level and CRC risk with logistic regression. The time between blood draw to cancer diagnosis (classifying cases according to latency) was incorporated in further analyses using proportional odds regression. RESULTS: We found that methylation changes of 31 CpG sites were associated with CRC risk at P<0.01 level. Though none of these 31 sites remained statistically significant after Bonferroni correction, the most statistically significant CpG site associated with CRC risk achieved a Pvalue of 1.0×10-4 . The CpG site is located in DSP gene, and the risk estimate was 1.52 (95% CI: 0.91-2.53) and 2.62 (95% CI: 1.65-4.17) for the second and third tertile comparing with the lowest tertile respectively. Taking the latency information into account strengthened some associations, suggesting that the methylation levels of corresponding sites might change over time with tumor progression. CONCLUSION: The results suggest that the methylation level of some genes were associated with cancer susceptibility and some were related to tumor development over time. Further studies are warranted to confirm and refine our results. | Keith Killian Stephanie Weinstein Jarmo Virtamo Margaret Tucker Philip Taylor Demetrius Albanes Paul Meltzer Neil Caporaso | 2012 | World Journal of Gastrointestinal Oncology2012，4，8： | 2 |
| 3 | Effects of alpha-tocopherol and beta-carotene supplementation on gastric cancer incidence in male smokers (ATBC Study, Finland)显示文摘 | Nea Malila Philip R. Taylor Mikko J. Virtanen Pasi Korhonen Jussi K. Huttunen Demetrius Albanes Jarmo Virtamo | 2002 | Cancer Causes and Control2002，，7： | 1 |
| 4 | Atrophic gastritis and the risk of incident colorectal cancer显示文摘 | Adeyinka O. Laiyemo Farin Kamangar Pamela M. Marcus Philip R. Taylor Jarmo Virtamo Demetrius Albanes Rachael Z. Stolzenberg-Solomon | 2009 | Cancer Causes & Control2009，，1： | 1 |
| 5 | Polymorphisms in Inflammation-related Genes and Risk of Gastric Cancer (Finland)显示文摘 | Farin Kamangar Christian C. Abnet Amy A. Hutchinson Craig J. Newschaffer Kathy Helzlsouer Yin Yao Shugart Pirjo Pietinen Sanford M. Dawsey Demetrius Albanes Jarmo Virtamo Philip R. Taylor | 2006 | Cancer Causes & Control2006，，1： | 1 |
| 6 | A prospective study of medical conditions, anthropometry, physical activity, and pancreatic cancer in male smokers (Finland)显示文摘 | Rachael Z. Stolzenberg-Solomon Pirjo Pietinen Philip R. Taylor Jarmo Virtamo Demetrius Albanes | 2002 | Cancer Causes and Control2002，，5： | 1 |
| 7 | Polymorphisms in Inflammation-related Genes and Risk of Gastric Cancer (Finland)显示文摘 | Farin Kamangar Christian C. Abnet Amy A. Hutchinson Craig J. Newschaffer Kathy Helzlsouer Yin Yao Shugart Pirjo Pietinen Sanford M. Dawsey Demetrius Albanes Jarmo Virtamo Philip R. Taylor | 2006 | Cancer Causes & Control2006，，1： | 1 |
| 8 | Leisure-time physical activity and lung cancer: a meta-analysis显示文摘 | Adonina Tardon Won Jin Lee Miguel Delgado-Rodriguez Mustafa Dosemeci Demetrius Albanes Robert Hoover Aaron Blair | 2005 | Cancer Causes & Control2005，，： | 1 |
| 9 | Manganese superoxide dismutase (MnSOD) polymorphism, α-tocopherol supplementation and prostate cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (Finland)显示文摘 | Karen Woodson Joseph A. Tangrea Teresa A. Lehman Ramakrishna Modali Kristin M. Taylor Kirk Snyder Philip R. Taylor Jarmo Virtamo Demetrius Albanes | 2003 | Cancer Causes and Control2003，，6： | 1 |
| 10 | Flavonol and flavone intake and the risk of cancer in male smokers (Finland)显示文摘 | Tero Hirvonen Jarmo Virtamo Pasi Korhonen Demetrius Albanes Pirjo Pietinen | 2001 | Cancer Causes and Control2001，，9： | 1 |
| 11 | A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer显示文摘 | Min Shen Richard Cawthon Nathaniel Rothman Stephanie J. Weinstein Jarmo Virtamo H. Dean Hosgood Wei Hu Unhee Lim Demetrius Albanes Qing Lan | 2011 | Lung Cancer2011，，： | 1 |
| 12 | A Large Study of Androgen Receptor Germline Variants and Their Relation to Sex Hormone Levels and Prostate Cancer Risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium显示文摘 | Sara Lindstr?m Jing Ma David Altshuler Edward Giovannucci Elio Riboli Demetrius Albanes Naomi E. Allen Sonja I. Berndt Heiner Boeing H. Bas Bueno-de-Mesquita Stephen J. Chanock Alison M. Dunning Heather Spencer Feigelson J. Michael Gaziano Christopher A. | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，9： | 1 |
| 13 | Short-term weight change and fluctuation as risk factors for type 2 diabetes in Finnish male smokers显示文摘 | Merja Kataja-Tuomola Jari Sundell Satu M?nnist? Mikko J. Virtanen Jukka Kontto Demetrius Albanes Jarmo Virtamo | 2010 | European Journal of Epidemiology2010，，5： | 1 |
| 14 | Polymorphisms in Inflammation-related Genes and Risk of Gastric Cancer (Finland)显示文摘 | Farin Kamangar Christian C. Abnet Amy A. Hutchinson Craig J. Newschaffer Kathy Helzlsouer Yin Yao Shugart Pirjo Pietinen Sanford M. Dawsey Demetrius Albanes Jarmo Virtamo Philip R. Taylor | 2006 | Cancer Causes & Control2006，，1： | 1 |
| 15 | Nut and peanut butter consumption and risk of prostate cancer in the NIH-AARP diet and health study显示文摘Dear Editor,Prostate cancer is the second most common cancer among men worldwide and leading cancer in incidence among men in the United States(US).In 2018,the US had over 190,000 new prostate cancer cases,accounting for almost 1 in 5 new male cancer diagnoses[1].A recent review of dietary factors in relation to prostate cancer risk did not find evidence regarding nut consumption as neither a risk nor protective factor,though it has been hypothesized to be associated with a decreased cancer risk through multi-ple mechanisms[2]. | Mimi Ton Leah M.Ferrucci Stephanie J.Weinstein Maryam Hashemian Demetrius Albanes Jiaqi Huang | 2022 | Cancer Communications2022，42，1： | 0 |
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