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| 1 | Systematic review of laparoscopic vs open surgery for colorectal cancer in elderly patients显示文摘AIM: To verify the safety and validity of laparoscopic surgery for the treatment of colorectal cancer in elderly patients.METHODS: A meta-analysis was performed of a systematic search of studies on an electronic database. Studies that compared laparoscopic colectomy(LAC) in elderly colorectal cancer patients with open colectomy(OC) were retrieved, and their short and long-term outcomes compared. Elderly people were defined as 65 years old or more. Inclusion criteria were set at: Resection of colorectal cancer, comparison between laparoscopic and OC and no significant difference in backgrounds between groups.RESULTS: Fifteen studies were identified for analysis. LAC was performed on 1436 patients, and OC performed on 1810 patients. In analyses of short-term outcomes, operation time for LAC was longer than for OC(mean difference = 34.4162, 95%CI: 17.8473-50.9851, P < 0.0001). The following clinical parameters were lower in LAC than in OC: Amount of estimated blood loss(mean difference =-93.3738, 95%CI:-132.3437 to-54.4039, P < 0.0001), overall morbidity(OR = 0.5427, 95%CI: 0.4425-0.6655, P < 0.0001), incisional surgical site infection(OR = 0.6262, 95%CI: 0.4310-0.9097, P = 0.0140), bowel obstruction and ileus(OR = 0.6248, 95%CI: 0.4519-0.8638, P = 0.0044) and cardiovascular complications(OR = 0.4767, 95%CI: 0.2805-0.8101, P = 0.0062). In analyses of long-term outcomes(median follow-up period: 36.4 mo in LAC, 34.3 mo in OC), there was no significant difference in overall survival(mean difference = 0.8321, 95%CI: 0.5331-1.2990, P = 0.4187) and disease specific survival(mean difference = 1.0254, 95%CI: 0.6707-1.5675, P = 0.9209). There was also no significant difference in the number of dissected lymph nodes(mean difference =-0.1360, 95%CI:-4.0553-3.7833, P = 0.9458).CONCLUSION: LAC in elderly colorectal cancer patients had benefits in short-term outcomes compared with OC except operation time. The long-term outcomes and oncological clearance of LAC were similar to that of OC. These results support the assertion that LAC is an effective procedure for elderly patients with colorectal cancer. | Shoichi Fujii Mitsuo Tsukamoto Yoshihisa Fukushima Ryu Shimada Koichi Okamoto Takeshi Tsuchiya Keijiro Nozawa Keiji Matsuda Yojiro Hashiguchi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 10 |
| 2 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 3 | Neoadjuvant chemotherapy with gemcitabine for pancreatic cancer increasesin situ expression of the apoptosis marker M30 and stem cell marker CD44显示文摘 | Hidehiro Tajima Tetsuo Ohta Hirohisa Kitagawa Koichi Okamoto Seisho Sakai Jun Kinoshita Isamu Makino Hiroyuki Furukawa Hironori Hayashi Keishi Nakamura Katsunobu Oyama Masafumi Inokuchi Hisatoshi Nakagawara Hideto Fujita Hiroyuki Takamura Itasu Ninomiya S | 2012 | Oncology Letters2012，，： | 2 |
| 4 | Requirement of Protocol Biopsy Before and After Complete Cessation of Immunosuppression After Liver Transplantation显示文摘 | Mami Yoshitomi Takaaki Koshiba Hironori Haga Ying Li Xiangdong Zhao Donghua Cheng Aya Miyagawa Hiromi Sakashita Tatsuaki Tsuruyama Hidenori Ohe Mikiko Ueda Shinya Okamoto Hiroto Egawa Kathryn Wood Shimon Sakaguchi Toshiaki Manabe Koichi Tanaka Shinji Uemo | 2009 | Transplantation2009，，4： | 2 |
| 5 | Certified sediment reference materials for trace element analysis from the National Metrology Institute of Japan (NMIJ)显示文摘 | Kazumi Inagaki Akiko Takatsu Takayoshi Kuroiwa Atsuko Nakama Sakae Eyama Koichi Chiba Kensaku Okamoto | 2004 | Analytical and Bioanalytical Chemistry2004，，5： | 1 |
| 6 | Expansion and characterization of cancer stem- like cells in squamous cell carcinoma of the head and neck 显示文摘 | Atsushi Okamoto Kazuaki Chikamatsu Koichi Sakakura | 2008 | Oral On- cology2008，，： | 1 |
| 7 | A male patient with severe acute hepatitis who was domestically infected with a genotype H hepatitis B virus in Iwate, Japan显示文摘 | Ichiro Kumagai Koichi Abe Takayoshi Oikawa Akihiro Sato Shinichiro Sato Ryujin Endo Yasuhiro Takikawa Kazuyuki Suzuki Tomoyuki Masuda Shigehiko Sainokami Kazunori Endo Masaharu Takahashi Hiroaki Okamoto | 2007 | Journal of Gastroenterology2007，，2： | 1 |
| 8 | Surface plasmon enhanced light emitters based on InGaN quantum wells 显示文摘 | Okamoto Koichi Niki Isamu Shvaxtser Alexander | 2004 | Nature Materials2004，3，： | 1 |
| 9 | Surface plasmon enhanced emission from dye doped polymer layers 显示文摘 | Neal Terrell D Okamoto Koichi Scherer Axel | 2005 | Optics Express2005，13，14： | 1 |
| 10 | Low?dose paclitaxel inhibits the induction of epidermal?mesenchymaltransition in the human cholangiocarcinoma CCKS?1 cell line显示文摘 | Atsushi Hirose Hidehiro Tajima Tetsuo Ohta Tomoya Tsukada Koichi Okamoto Shinichi Nakanuma Seisho Sakai Jun Kinoshita Isamu Makino Hiroyuki Furukawa Hironori Hayashi Keishi Nakamura Katsunobu Oyama Masafumi Inokuchi Hisatoshi Nakagawara Tomoharu Miyashita | 2013 | Oncology Letters2013，，4： | 1 |
| 11 | Application of magnetic field to the control of grain boundary segregation in iron显示文摘 | Sadahiro Tsurekawa Koichi Kawahara Kousuke Okamoto Tadao Watanabe Roy Faulkner | 2004 | Materials Science & Engineering A2004，，： | 1 |
| 12 | Epidemiological and clinical study of sporadic acute hepatitis E caused by indigenous strains of hepatitis E virus in Japan compared with acute hepatitis A显示文摘 | Shigehiko Sainokami Koichi Abe Ichiro Kumagai Akio Miyasaka Ryujin Endo Yasuhiro Takikawa Kazuyuki Suzuki Hitoshi Mizuo Yoshiki Sugai Yoshihiro Akahane Yoichi Koizumi Yoshiaki Yajima Hiroaki Okamoto | 2004 | Journal of Gastroenterology2004，，7： | 1 |
| 13 | Argon plasma coagulation treatment of hemorrhagic radiation proctopathy: the optimal settings for application and long-term outcome显示文摘 | Yasushi Sato Tetsuji Takayama Tamotsu Sagawa Masahiro Hirakawa Hiroyuki Ohnuma Koji Miyanishi Tsutomu Sato Rishu Takimoto Masayoshi Kobune Koichi Okamoto Hisashi Takeuchi Junji Kato | 2011 | Gastrointestinal Endoscopy2011，，： | 1 |
| 14 | Endoscopic submucosal dissection for early gastric cancer using a cross-counter technique显示文摘 | Koichi Okamoto Seisuke Okamura Naoki Muguruma Shinji Kitamura Tetsuo Kimura Yoshitaka Imoto Hiroshi Miyamoto Toshiya Okahisa Tetsuji Takayama | 2012 | Surgical Endoscopy2012，，12： | 1 |
| 15 | A Phase I/II study of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL显示文摘 | Arinobu Tojo Kensuke Usuki Akio Urabe Yasuhiro Maeda Yukio Kobayashi Itsuro Jinnai Kazuma Ohyashiki Miki Nishimura Tatsuya Kawaguchi Hideo Tanaka Koichi Miyamura Yasushi Miyazaki Timothy Hughes Susan Branford Shinichiro Okamoto Jun Ishikawa Masaya Okada N | 2009 | International Journal of Hematology2009，，5： | 1 |
| 16 | Protective Effect of High-Mobility Group Box 1 Blockade on Acute Liver Failure in Rats显示文摘 | Kiminori Takano Masahiro Shinoda Minoru Tanabe Taku Miyasho Shingo Yamada Shigeshi Ono Yohei Masugi Koichi Suda Koichi Fukunaga Tetsu Hayashida Taizo Hibi Hideaki Obara Hiroya Takeuchi Shigeyuki Kawachi Kazufumi Kawasako Minoru Okamoto Hiroshi Yokota Ikur | 2010 | Shock2010，，6： | 1 |
| 17 | Fragmentation of Golgi apparatus of nigral neurons with α-synuclein-positive inclusions in patients with Parkinson’s disease显示文摘 | Yukio Fujita Eisaku Ohama Masamitsu Takatama Safa Al-Sarraj Koichi Okamoto | 2006 | Acta Neuropathologica2006，，3： | 1 |
| 18 | TLymphocyte Numbers in Human Gut Associated Lymphoid Tissue Are Reduced Without Enteral Nutrition显示文摘 | Koichi okamoto MD kazuhiko fukatsu MD | 2005 | JPEN2005，29，1： | 1 |
| 19 | Confocal microphotoluminescence of InGaN-based light-emitting diodes显示文摘 | Koichi Okamoto Akio Kaneta Yoichi Kawakami | 2005 | Journal of Applied Physics2005，98，06： | 1 |
| 20 | Novel des‐γ‐carboxy prothrombin in serum for the diagnosis of hepatocellular carcinoma显示文摘 | Takahiro Tanaka Tatsuya Taniguchi Katsutaka Sannomiya Hidetaka Takenaka Tetsu Tomonari Koichi Okamoto Shinji Kitamura Toshiya Okahisa Katsuyoshi Tamaki Hiroaki Mikasa Sadao Suzuki Tetsuji Takayama | 2013 | J Gastroenterol Hepatol2013，，8： | 1 |
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