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| 1 | Systematic review of laparoscopic vs open surgery for colorectal cancer in elderly patients显示文摘AIM: To verify the safety and validity of laparoscopic surgery for the treatment of colorectal cancer in elderly patients.METHODS: A meta-analysis was performed of a systematic search of studies on an electronic database. Studies that compared laparoscopic colectomy(LAC) in elderly colorectal cancer patients with open colectomy(OC) were retrieved, and their short and long-term outcomes compared. Elderly people were defined as 65 years old or more. Inclusion criteria were set at: Resection of colorectal cancer, comparison between laparoscopic and OC and no significant difference in backgrounds between groups.RESULTS: Fifteen studies were identified for analysis. LAC was performed on 1436 patients, and OC performed on 1810 patients. In analyses of short-term outcomes, operation time for LAC was longer than for OC(mean difference = 34.4162, 95%CI: 17.8473-50.9851, P < 0.0001). The following clinical parameters were lower in LAC than in OC: Amount of estimated blood loss(mean difference =-93.3738, 95%CI:-132.3437 to-54.4039, P < 0.0001), overall morbidity(OR = 0.5427, 95%CI: 0.4425-0.6655, P < 0.0001), incisional surgical site infection(OR = 0.6262, 95%CI: 0.4310-0.9097, P = 0.0140), bowel obstruction and ileus(OR = 0.6248, 95%CI: 0.4519-0.8638, P = 0.0044) and cardiovascular complications(OR = 0.4767, 95%CI: 0.2805-0.8101, P = 0.0062). In analyses of long-term outcomes(median follow-up period: 36.4 mo in LAC, 34.3 mo in OC), there was no significant difference in overall survival(mean difference = 0.8321, 95%CI: 0.5331-1.2990, P = 0.4187) and disease specific survival(mean difference = 1.0254, 95%CI: 0.6707-1.5675, P = 0.9209). There was also no significant difference in the number of dissected lymph nodes(mean difference =-0.1360, 95%CI:-4.0553-3.7833, P = 0.9458).CONCLUSION: LAC in elderly colorectal cancer patients had benefits in short-term outcomes compared with OC except operation time. The long-term outcomes and oncological clearance of LAC were similar to that of OC. These results support the assertion that LAC is an effective procedure for elderly patients with colorectal cancer. | Shoichi Fujii Mitsuo Tsukamoto Yoshihisa Fukushima Ryu Shimada Koichi Okamoto Takeshi Tsuchiya Keijiro Nozawa Keiji Matsuda Yojiro Hashiguchi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 10 |
| 2 | Omentum-preserving gastrectomy for advanced gastric cancer: a propensity-matched retrospective cohort study显示文摘 | Shinichi Hasegawa Chikara Kunisaki Hidetaka Ono Takashi Oshima Shoichi Fujii Masataka Taguri Satoshi Morita Tsutomu Sato Roppei Yamada Norio Yukawa Yasushi Rino Munetaka Masuda | 2013 | Gastric Cancer2013，，3： | 2 |
| 3 | Short-term results of a randomized study between laparoscopic and open surgery in elderly colorectal cancer patients显示文摘 | Shoichi Fujii Atsushi Ishibe Mitsuyoshi Ota Shigeru Yamagishi Kazuteru Watanabe Jun Watanabe Amane Kanazawa Yasushi Ichikawa Mari Oba Satoshi Morita Yojiro Hashiguchi Chikara Kunisaki Itaru Endo | 2014 | Surgical Endoscopy2014，，2： | 2 |
| 4 | Short-term outcomes of laparoscopic intersphincteric resection from a phase II trial to evaluate laparoscopic surgery for stage 0/I rectal cancer: Japan Society of Laparoscopic Colorectal Surgery Lap RC显示文摘 | Shoichi Fujii Seiichiro Yamamoto Masaaki Ito Shigeki Yamaguchi Kazuhiro Sakamoto Yusuke Kinugasa Yukihito Kokuba Junji Okuda Kenichi Yoshimura Masahiko Watanabe | 2012 | Surgical Endoscopy2012，，11： | 1 |
| 5 | Impact of body mass index and visceral adiposity on outcomes in colorectal cancer显示文摘 | Naoto YAMAMOTO Shoichi FUJII Tsutomu SATO Takashi OSHIMA Yasushi RINO Chikara KUNISAKI Munetaka MASUDA Toshio IMADA | 2012 | Asia‐Pacific Journal of Clinical Oncology2012，，4： | 1 |
| 6 | Evaluation of intraperitoneal lavage cytology before colorectal cancer resection显示文摘 | Shoichi Fujii Hiroshi Shimada Shigeru Yamagishi Mitsuyoshi Ota Chikara Kunisaki Hideyuki Ike Yasushi Ichikawa | 2009 | International Journal of Colorectal Disease2009，，8： | 1 |
| 7 | Postoperative morbidity and mortality after mesorectal excision with and without lateral lymph node dissection for clinical stage II or stage III lower rectal cancer (JCOG0212): results from a multicentre, randomised controlled, non-inferiority trial显示文摘 | Shin Fujita Takayuki Akasu Junki Mizusawa Norio Saito Yusuke Kinugasa Yukihide Kanemitsu Masayuki Ohue Shoichi Fujii Manabu Shiozawa Takashi Yamaguchi Yoshihiro Moriya | 2012 | Lancet Oncology2012，，6： | 1 |
| 8 | Surgery for spontaneous intracerebral hemorrhage has greater remedial value than conservative therapy显示文摘 | Jun Morioka Masami Fujii Shoichi Kato | 2006 | Surgical Neurology2006，65，： | 1 |
| 9 | Comparison of short, long-term surgical outcomes and mid-term health-related quality of life after laparoscopic and open resection for colorectal cancer: a case-matched control study显示文摘 | Shoichi Fujii Mitsuyoshi Ota Yasushi Ichikawa Shigeru Yamagishi Kazuteru Watanabe Kenji Tatsumi Jun Watanabe Hirokazu Suwa Takashi Oshima Chikara Kunisaki Shigeo Ohki Itaru Endo Hiroshi Shimada | 2010 | International Journal of Colorectal Disease2010，，11： | 1 |
| 10 | Predictive factors for surgical complications of laparoscopy-assisted distal gastrectomy for gastric cancer显示文摘 | Chikara Kunisaki Hirochika Makino Ryo Takagawa Kei Sato Mayumi Kawamata Amane Kanazawa Naoto Yamamoto Yasuhiko Nagano Shoichi Fujii Hidetaka A. Ono Hirotoshi Akiyama Hiroshi Shimada | 2009 | Surgical Endoscopy2009，，9： | 1 |
| 11 | Surgery for spontaneous intracerebral hemorrhage has greater remedial value than conservative therapy显示文摘 | Jun Morioka Masami Fujii Shoichi Kato | 2006 | Surgical Neurology2006，67，1： | 1 |
| 12 | A prospective randomized controlled trial of subcutaneous passive drainage for the prevention of superficial surgical site infections in open and laparoscopic colorectal surgery显示文摘 | Masakatsu Numata Teni Godai Junya Shirai Kazuteru Watanabe Daisuke Inagaki Shinichi Hasegawa Tsutomu Sato Takashi Oshima Shoichi Fujii Chikara Kunisaki Norio Yukawa Yasushi Rino Masataka Taguri Satoshi Morita Munetaka Masuda | 2014 | International Journal of Colorectal Disease2014，，3： | 1 |
| 13 | Prospective Randomized Trial Comparing Billroth I and Roux-en-Y Procedures after Distal Gastrectomy for Gastric Carcinoma显示文摘 | Makoto Ishikawa M.D. Joji Kitayama M.D. Ph.D. Shoichi Kaizaki M.D. Hiroshi Nakayama M.D. Ph.D. Hironori Ishigami M.D. Shin Fujii M.D. Ph.D. Hiroyuki Suzuki M.D. Tomomi Inoue M.D. Ph.D. Akihiro Sako M.D. Ph.D. Masahiro Asakage M.D. Hiroharu Yamashita | 2005 | World Journal of Surgery2005，，11： | 1 |
| 14 | Postoperative morbidity and mortality after mesorectal excision with and without lateral lymph node dissection for clinical stage II or stage III lower rectal cancer (JCOG0212): results from a multicentre, randomised controlled, non-inferiority trial显示文摘 | Shin Fujita Takayuki Akasu Junki Mizusawa Norio Saito Yusuke Kinugasa Yukihide Kanemitsu Masayuki Ohue Shoichi Fujii Manabu Shiozawa Takashi Yamaguchi Yoshihiro Moriya | 2012 | Lancet Oncology2012，，6： | 1 |
| 15 | Surgical outcomes of laparoscopy-assisted gastrectomy versus open gastrectomy for gastric cancer: a case-control study显示文摘 | Chikara Kunisaki Hirochika Makino Takashi Kosaka Takashi Oshima Shoichi Fujii Ryo Takagawa Jun Kimura Hidetaka A. Ono Hirotoshi Akiyama Masataka Taguri Satoshi Morita Itaru Endo | 2012 | Surgical Endoscopy2012，，3： | 1 |
| 16 | Postoperative morbidity and mortality after mesorectal excision with and without lateral lymph node dissection for clinical stage II or stage III lower rectal cancer (JCOG0212): results from a multicentre, randomised controlled, non-inferiority trial显示文摘 | Shin Fujita Takayuki Akasu Junki Mizusawa Norio Saito Yusuke Kinugasa Yukihide Kanemitsu Masayuki Ohue Shoichi Fujii Manabu Shiozawa Takashi Yamaguchi Yoshihiro Moriya | 2012 | Lancet Oncology2012，，6： | 1 |
| 17 | Surgical outcomes of laparoscopy-assisted gastrectomy versus open gastrectomy for gastric cancer: a case-control study显示文摘 | Chikara Kunisaki Hirochika Makino Takashi Kosaka Takashi Oshima Shoichi Fujii Ryo Takagawa Jun Kimura Hidetaka A. Ono Hirotoshi Akiyama Masataka Taguri Satoshi Morita Itaru Endo | 2012 | Surgical Endoscopy2012，，3： | 1 |
| 18 | Surgery for spontaneous intracerebral hemorrhage has greater remedial value than conservative therapy显示文摘 | Jun Morioka Masami Fujii Shoichi Kato etal | 2006 | Sugical Neurology2006，65，1： | 1 |
| 19 | Repetitive administration of cultured human CD34+cells improve adenine-induced kidney injury in mice显示文摘BACKGROUND There is no established treatment to impede the progression or restore kidney function in human chronic kidney disease(CKD).AIM To examine the efficacy of cultured human CD34+cells with enhanced proliferating potential in kidney injury in mice.METHODS Human umbilical cord blood(UCB)-derived CD34+cells were incubated for one week in vasculogenic conditioning medium.Vasculogenic culture significantly increased the number of CD34+cells and their ability to form endothelial progenitor cell colony-forming units.Adenineinduced tubulointerstitial injury of the kidney was induced in immunodeficient non-obese diabetic/severe combined immunodeficiency mice,and cultured human UCB-CD34+cells were administered at a dose of 1×106/mouse on days 7,14,and 21 after the start of adenine diet.RESULTS Repetitive administration of cultured UCB-CD34+cells significantly improved the time-course of kidney dysfunction in the cell therapy group compared with that in the control group.Both interstitial fibrosis and tubular damage were significantly reduced in the cell therapy group compared with those in the control group(P<0.01).Microvasculature integrity was significantly preserved(P<0.01)and macrophage infiltration into kidney tissue was dramatically decreased in the cell therapy group compared with those in the control group(P<0.001).CONCLUSION Early intervention using human cultured CD34+cells significantly improved the progression of tubulointerstitial kidney injury.Repetitive administration of cultured human UCB-CD34+cells significantly improved tubulointerstitial damage in adenine-induced kidney injury in mice via vasculoprotective and anti-inflammatory effects. | Takayasu Ohtake Shoichi Itaba Amankeldi A Salybekov Yin Sheng Tsutomu Sato Mitsuru Yanai Makoto Imagawa Shigeo Fujii Hiroki Kumagai Masamitsu Harata Takayuki Asahara Shuzo Kobayashi | 2023 | World Journal of Stem Cells2023，15，4： | 0 |
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