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| 1 | Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis显示文摘AIM:To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis(NASH).METHODS:In total 26 patients,23 NASHs and 3 normal controls were enrolled in this study.NASH was staged based on Brunt criterion.At a region of interest(ROI),a shear wave was evoked by implementing an acoustic radiation force impulse(ARFI),and the propagation velocity was quantif ied.RESULTS:Shear wave velocity(SWV) could be reproducibly quantified at all ROIs in all subjects except for 4 NASH cases,in which a reliable SWV value was not calculated at several ROIs.An average SWV of 1.34 ± 0.26 m/s in fibrous stage 0-1 was significantly slower than 2.20 ± 0.74 m/s and 2.90 ± 1.01 m/s in stages 3 and 4,respectively,but was not significantly different from 1.79 ± 0.78 m/s in stage 2.When a cutoff value was set at 1.47 m/s,receiver operating characteristic analysis showed significance to dissociate stages 3 and 4 from stage 0-1(P=0.0092) with sensitivity,specificity and area under curve of 100%,75% and 94.2%,respectively.In addition,the correlation between SWV and hyaluronic acid was significant(P<0.0001),while a tendency toward negative correlation was observed with serum albumin(P=0.053).CONCLUSION:The clinical implementation of ARFI provides noninvasive repeated evaluations of liver stiffness at an arbitrary position,which has the potential to shed new light on NASH management. | Akihiko Osaki Tomoyuki Kubota Takeshi Suda Masato Igarashi Keisuke Nagasaki Atsunori Tsuchiya Masahiko Yano Yasushi Tamura Masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa Toru Kikuchi Minoru Nomoto Yutaka Aoyagi | 2010 | World Journal of Gastroenterology2010，16，23： | 30 |
| 2 | Autoantibodies in primary biliary cirrhosis:Recent progress in research on the pathogenetic and clinical significance显示文摘Primary biliary cirrhosis(PBC)is a chronic progressive cholestatic liver disease characterized by immunemediated destruction of the small-and medium-sized intrahepatic bile ducts and the presence of antimitochondrial antibodies(AMA)in the serum.AMA are detected in over 90%of patients with PBC,whereas their prevalence in the general population is extremely low,varying from 0.16%to 1%.Previous studies have shown that the unique characteristics of biliary epithelial cells undergoing apoptosis may result in a highly direct and very specific immune response to mitochondrial autoantigens.Moreover,recent studies have demonstrated that serum from AMA-positive PBC patients is reactive with a number of xenobiotic modified E2 subunits of the pyruvate dehydrogenase complex,which is not observed in the serum of normal individuals.These findings indicate that chemicals originating from the environment may be associated with a breakdown in the tolerance to mitochondrial autoantigens.While it is currently generally accepted that AMA are the most specific serological markers of PBC,more than 60 au-toantibodies have been investigated in patients with PBC,and some have previously been considered specific to other autoimmune diseases.This review covers the recent progress in research on the pathogenetic and clinical significance of important autoantibodies in PBC.Determining the pathogenic role of those autoantibodies in PBC remains a priority of basic and clinical research. | Satoshi Yamagiwa Hiroteru Kamimura Masaaki Takamura Yutaka Aoyagi | 2014 | World Journal of Gastroenterology2014，20，10： | 19 |
| 3 | Considerations of elderly factors to manage the complication of liver cirrhosis in elderly patients显示文摘The aging of the organ function causes sensitivity to the disease progression and need careful consideration for the medical treatment. With the increase of aging population, the opportunity to provide medical treatment for people in very old age is rapidly increasing therefore, the understanding of the various physiological changes of cellular function, size and function of organs are essential for the decision of therapeutic options. Among the various chronic conditions seen in elderly people, we have focused on liver cirrhosis, since despite specific therapeutic options for many of liver diseases including direct acting antivirals for hepatitis C virus, nucleoside analogs for hepatitis B, and corticosteroids for autoimmune hepatitis, there is currently no standard therapy to treat liver cirrhosis, which is the final stage of these liver diseases. Therefore,management of the various symptoms of liver cirrhosis is essential, and agingrelated parameters must be considered in the decision making for therapeutic strategies and dosage of the available medicine. In this mini-review, we have summarized the therapeutic options to manage various symptoms of liver cirrhosis, carefully considering the physiological changes of various organs associated with aging. | Kenya Kamimura Akira Sakamaki Hiroteru Kamimura Toru Setsu Takeshi Yokoo Masaaki Takamura Shuji Terai | 2019 | World Journal of Gastroenterology2019，25，15： | 9 |
| 4 | Detrital zircon geochronology of the Lutzow-Holm Complex,East Antarctica:Implications for Antarctica-Sri Lanka correlation显示文摘The Lützow-Holm Complex(LHC) of East Antarctica has been regarded as a collage of Neoarchean(ca.2.5 Ga), Paleoproterozoic(ca. 1.8 Ga), and Neoproterozoic(ca. 1.0 Ga) magmatic arcs which were amalgamated through the latest Neoproterozoic collisional events during the assembly of Gondwana supercontinent. Here, we report new geochronological data on detrital zircons in metasediments associated with the magmatic rocks from the LHC, and compare the age spectra with those in the adjacent terranes for evaluating the tectonic correlation of East Antarctica and Sri Lanka. Cores of detrital zircon grains with high Th/U ratio in eight metasediment samples can be subdivided into two dominant groups:(1) late Meso-to Neoproterozoic(1.1-0.63 Ga) zircons from the northeastern part of the LHC in Prince Olav Coast and northern Soya Coast areas, and(2) dominantly Neoarchean to Paleoproterozoic(2.8-2.4 Ga) zircons from the southwestern part of the LHC in southern Lutzow-Holm Bay area. The ca.1.0 Ga and ca. 2.5 Ga magmatic suites in the LHC could be proximal provenances of the detrital zircons in the northeastern and southwestern LHC, respectively. Subordinate middle to late Mesoproterozoic(1.3-1.2 Ga) detrital zircons obtained from Akarui Point and Langhovde could have been derived from adjacent Gondwana fragments(e.g., Rayner Complex, Eastern Ghats Belt). Meso-to Neoproterozoic domains such as Vijayan and Wanni Complexes of Sri Lanka, the southern Madurai Block of southern India, and the central-western Madagascar could be alternative distal sources of the late Meso-to Neoproterozoic zircons. Paleo-to Mesoarchean domains in India, Africa, and Antarctica might also be distal sources for the minor ~2.8 Ga detrital zircons from Skallevikshalsen. The detrital zircons from the Highland Complex of Sri Lanka show similar Neoarchean to Paleoproterozoic(ca. 2.5 Ga) and Neoproterozoic(ca. 1.0 Ga) ages, which are comparable with those of the LHC, suggesting that the two complexes might have formed under similar tectonic regimes. We consider that the Highland Complex and metasedimentary unit of the LHC formed a unified latest Neoproterozoic suture zone with a large block of northern LH-Vijayan Complex caught up as remnant of the ca. 1.0 Ga magmatic arc. | Yusuke Takamura Toshiaki Tsunogae M.Santosh Yukiyasu Tsutsumi | 2018 | Geoscience Frontiers2018，9，2： | 6 |
| 5 | Life prognosis of sentinel node navigation surgery for early-stage gastric cancer:Outcome of lymphatic basin dissection显示文摘BACKGROUND Lymphatic basin dissection is a sentinel node biopsy method that is specific for gastric cancer.In this method,the dyed lymphatic system is dissected en bloc,and sentinel nodes are identified at the back table(ex vivo).Even with lymphatic basin dissection,blood flow to the residual stomach can be preserved,and functionpreserving curative gastrectomy can be performed.The oncological safety of function-preserving curative gastrectomy combined with lymphatic basin dissection has not yet been fully investigated.We hypothesized that the oncological safety of sentinel node navigation surgery(SNNS)is not inferior to that of the guidelines.AIM To investigate the life prognosis of SNNS for gastric cancer in comparison with guidelines surgery.METHODS This was a retrospective cohort study.Patients were selected from gastric cancer patients who underwent sentinel node biopsy from April 1999 to March 2016.Patients from April 1999 to August 2008 were from the Department of Surgery II,Kanazawa University Hospital,and patients from August 2009 to March 2016 were from the Department of Surgical Oncology,Kanazawa Medical University Hospital.Patients who were diagnosed with gastric cancer,which was preoperatively diagnosed as superficial type(type 0),5 cm or less in length,clinical T1-2 and node negative,and underwent various gastrectomies guided by sentinel node navigation were retrospectively collected.The overall survival(OS)and relapsefree survival(RFS)of these patients(SNNS group)were investigated.Patients with gastric cancer of the same stage and who underwent guidelines gastrectomy with standard nodal dissection were also selected as the control group.RESULTS A total of 239 patients in the SNNS group and 423 patients in the control group were included.Pathological nodal metastasis was observed in 10.5%and 10.4%of the SNNS and control groups,respectively.The diagnostic abilities of sentinel node biopsy were 84%and 98.6%for sensitivity and accuracy,respectively.In the SNNS group,81.6%of patients underwent modified gastrectomy or functionpreserving curative gastrectomy with lymphatic basin dissection,in which the extent of nodal dissection was further reduced compared to the guidelines.The OS rate in the SNNS group was 96.8%at 5 years and was significantly better than 91.3%in the control group(P=0.0014).The RFS rates were equal in both groups.After propensity score matching,there were 231 patients in both groups,and the cumulative recurrence rate was 0.43%at 5 years in the SNNS group and 1.30%in the control group,which was not statistically different.CONCLUSION The oncological safety of patients who undergo gastrectomy guided by sentinel node navigation is not inferior to that of the guidelines surgery. | Shinichi Kinami Naohiko Nakamura Tomoharu Miyashita Hidekazu Kitakata Sachio Fushida Takashi Fujimura Yasuo Iida Noriyuki Inaki Toru Ito Hiroyuki Takamura | 2021 | World Journal of Gastroenterology2021，27，46： | 5 |
| 6 | Diagnostic ability of multi-detector spiral computed tomography for pathological lymph node metastasis of advanced gastric cancer显示文摘BACKGROUND The reliability of preoperative nodal diagnosis of advanced gastric cancer by multi-detector spiral computed tomography(MDCT)is still unclear.AIM To examine the diagnostic ability of MDCT more precisely by using data on intranodal pathological metastatic patterns.METHODS A total of 108 patients with advanced gastric cancer who underwent MDCT and curative gastrectomy at Kanazawa Medical University Hospital were enrolled in this study.The nodal sizes measured on computed tomography(CT)images were compared with the pathology results.A receiver-operating characteristic curve was constructed,from which the critical value(CV)was calculated by using the data of the first 69 patients retrospectively.By using the CV,sensitivity and specificity were calculated with prospectively collected data from 39 consecutive patients.This enabled a more precise one-to-one correspondence of lymph nodes between CT and pathological examination by using the size data of lymph node mapping.The intranodal pathological metastatic patterns were classified into the following four types:Small nodular,peripheral,large nodular,and diffuse.RESULTS Although all the cases were clinically suspected as having metastasis,81 had lymph node metastasis and 27 had no metastasis.The number of dissected,detected on CT,and metastatic nodes were,4241,897,and 801,respectively.The CV obtained from the receiver-operating characteristic was 7.6 mm for the long axis.The sensitivity was 91.4%and the specificity was 47.3%in the prospective phase.The large nodular and diffuse metastases were easy to diagnose becausemetastatic nodes with a large axis often exhibit these forms.CONCLUSION The ability of MDCT to contribute to a nodal diagnosis of advanced gastric cancer was examined prospectively with precise size data from node mapping,using a CV of 7.6 mm for the long axis that was calculated from the retrospectively collected data.The sensitivity was as high as 91%,and would be improved when referring to the enhanced patterns.However,its specificity was as low as 47%,because most of metastatic nodes in gastric cancer being small in size.The small nodular or peripheral type metastatic nodes were often small and considered difficult to diagnose. | Zhi-Yong Jiang Shinichi Kinami Naohiko Nakamura Takashi Miyata Hideto Fujita Hiroyuki Takamura Nobuhiko Ueda Takeo Kosaka | 2020 | World Journal of Gastrointestinal Oncology2020，12，4： | 5 |
| 7 | 合肥地区无云晴天地表太阳短波辐射特征显示文摘利用SKYNET合肥站1999年9月至2005年8月期间285个无云晴天地面辐射收支观测资料,计算分析了合肥地区地表太阳短波辐射特征。结果表明,地表太阳短波辐射各个分量的日变化均呈上下午近似对称的倒“U”型分布,中午变化较平缓并出现最大值;漫射辐射与总辐射之比KDF呈“U”型日分布。太阳短波辐射各个分量的年最小值均出现在12月份,6月份总辐射、地表太阳短波净辐射和漫射辐射最强,7月份太阳直接辐射和地面反射的短波辐射最强但漫射辐射出现相对低谷。漫射辐射春季最强、夏季次之;太阳短波辐射其它各分量的季节变化均为夏季最强、春季次之、冬季最弱,而且冬夏差异较大。在1月份最大, 7月份值最小并有明显的突变现象;其季节变化特征为夏季最小,冬季最大;其七年平均值为38.4%。 | 李超 刘东 范爱媛 周军 Takamura T | 2007 | 大气与环境光学学报2007，2，1： | 4 |
| 8 | Active treatments are a rational approach for hepatocellular carcinoma in elderly patients显示文摘AIM: To determine whether an active intervention is beneficial for the survival of elderly patients with hepa-tocellular carcinoma (HCC). METHODS: The survival of 740 patients who received various treatments for HCC between 1983 and 2011 was compared among different age groups using Cox regression analysis. Therapeutic options were principal-ly selected according to the clinical practice guidelines for HCC from the Japanese Society of Hepatology. The treatment most likely to achieve regional control capa-bility was chosen, as far as possible, in the following order: resection, radiofrequency ablation, percutaneous ethanol injection, transcatheter arterial chemoembo-lization, transarterial oily chemoembolization, hepatic arterial infusion chemotherapy, systemic chemotherapy including molecular targeting, or best supportive care.Each treatment was used alone, or in combination, with a clinical goal of striking the best balance be-tween functional hepatic reserve and the volume of the targeted area, irrespective of their age. The percent survival to life expectancy was calculated based on a Japanese national population survey. RESULTS: The median ages of the subjects during each 5-year period from 1986 were 61, 64, 67, 68 and 71 years and increased significantly with time (P<0.0001). The Child-Pugh score was comparable among younger (59 years of age or younger), middle-aged (60-79 years of age), and older (80 years of age or older) groups (P=0.34), whereas the tumor-node-metastasis stage tended to be more advanced in the younger group (P=0.060). Advanced disease was significantly more frequent in the younger group compared with the middle-aged group (P=0.010), whereas there was no difference between the middle-aged and elderly groups (P=0.75). The median sur-vival times were 2593, 2011, 1643, 1278 and 1195 d for 49 years of age or younger, 50-59 years of age, 60-69 years of age, 70-79 years of age, or 80 years of age or older age groups, respectively, whereas the me-dian percent survival to life expectancy were 13.9%, 21.9%, 24.7%, 25.7% and 37.6% for each group, respectively. The impact of age on actual survival time was significant (P=0.020) with a hazard ratio of 1.021, suggesting that a 10-year-older patient has a 1.23-fold higher risk for death, and the overall survival was the worst in the oldest group. On the other hand, when the survival benefit was evaluated on the basis of per-cent survival to life expectancy, age was again found to be a significant explanatory factor (P=0.022); how-ever, the oldest group showed the best survival among the five different age groups. The youngest group revealed the worst outcomes in this analysis, and the hazard ratio of the oldest against the youngest was 0.35 for death. The survival trends did not differ substan-tially between the survival time and percent survival tolife expectancy, when survival was compared overall or among various therapeutic interventions. CONCLUSION: These results suggest that a thera-peutic approach for HCC should not be restricted due to patient age. | Takeshi Suda Aiko Nagashima Shyunsaku Takahash Tsutomu Kanefuji Kenya Kamimura Yasushi Tamura Ma-saaki Takamura Masato Igarashi Hirokazu Kawai Satoshi Yamagiwa Minoru Nomoto Yutaka Aoyagi | 2013 | World Journal of Gastroenterology2013，19，24： | 4 |
| 9 | Spontaneous regression of hepatocellular carcinoma: A mini-review显示文摘Spontaneous tumor regression is an extremely rare phenomenon in the oncology field. However, there are several case reports resulted in the regression of hepatocellular carcinoma(HCC) and the accumulation of clinical information and analyses of the mechanism can contribute to the development of a novel therapy. For this purpose, we have carefully reviewed 23 cases of spontaneously regressed HCC published in recent 5 years and our case. The information regarding the tumor size, tumor marker, treatments, etc., have been summarized. The mechanism of spontaneous regression has been discussed to date and presumed to be due to many factors, including hypoxia and immunological reactions. In this careful review of the 24 cases based on the clinical information, hypoxia, systemic inflammation, and both upon spontaneous regression were seen in 3, 8, and 4 cases, respectively amo ng t he 15 c as e s f or w hic h t he inf o r mat io n regarding the proposed mechanisms are available. Recent development of immunotherapeutic approaches in oncology shows promising results, therefore, accumulation of additional cases and analysis of mechanisms underlying the spontaneous regression of HCC are essential and could lead to the development of a new generation of immunotherapies including antibodies directed against immune reactions. | Akira Sakamaki Kenya Kamimura Satoshi Abe Atsunori Tsuchiya Masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa Shuji Terai | 2017 | World Journal of Gastroenterology2017，23，21： | 4 |
| 10 | Body mass index correlated with forced expiratory volume in 1 second/forced vital capacity in a population with a relatively low prevalence of obesity显示文摘背景肥胖是在世界上的最普通的新陈代谢的疾病。然而,在肥胖之间的关系和肺功能充分没被理解。尽管几纵的研究证明了那在身体增加,重量能在肺的功能导致减小,这是否并且是否高是有日本人口的盒子身体团索引( BMI )地位独自代表现在的学习的 unclear.The 目的是在日本病人的呼吸量测定法在一般诊所测量的肺功能上估计 BMI 的效果的妨碍的肺机能障碍遗体的一个适当预言者。我们屏蔽请教了一般 clinics.Methods 题目的病人上的测量 BMI 和执行呼吸量测定法包括了 1231 个病人 40 岁(吝啬的年龄(65. | Susumu Fukahori Hiroto Matsuse Nobom Takamura Tomoko Tsuchida Tetsuya Kawano Chizu Fukushima Senjyu Hideaki Shigeru Kohno | 2010 | Chinese Medical Journal2010，，20： | 3 |
| 11 | Rational arrangement of measuring shear wave speed in the liver显示文摘BACKGROUND Shear wave speed has been widely applied to quantify a degree of liver fibrosis. However, there is no standardized procedure, which makes it difficult to utilize the speed universally. AIM To provide procedural standardization of shear wave speed measurement. METHODS Point shear wave elastography (pSWE) was measured in 781 patients, and twodimensional shear wave elastography (2dSWE) was measured on the same day in 18 cases. Regions-of-interest were placed at 12 sites, and the median and robust coefficient-of-variation (CVR) were calculated. A residual sum-of-square (Σdi2) was computed for bootstrap values of 1000 iterations in 18 cases with each assumption of 1 to 12 measurements. The proportion of the Σdi2 (%Σdi2) was calculated as the ratio of Σdi2 to pSWE after converting it based on the correlation between pSWE and 2dSWE. RESULTS The CVR showed a significantly broader distribution in the left lobe (P < 0.0001),and the smallest CVR in the right anterior segment that covered 95% cases was 40.4%. pSWE was significantly higher in the left lobe than in the right lobe (1.63 ± 0.78 m/s vs 1.61 ± 0.78 m/s, P = 0.0004), and the difference between the lobes became further discrete when the subjects were limited to the cases with a CVR less than 40.4% in any segment (1.76 ± 0.80 m/s vs 1.70 ± 0.82 m/s, P < 0.0001). The highest values of the CVR in every 0.1 m/s interval were plotted in convex upward along pSWE and peaked at 1.93 m/s. pSWE and 2dSWE were significantly correlated (P < 0.0001, r = 0.95). In 216000 resamples from 18 cases, the %Σdi2 of 12 sites was 8.0% and gradually increased as the acquisition sites decreased to reach a significant difference with a %Σdi2 of 7 sites (P = 0.027). CONCLUSION These data suggest that shear wave speed should be measured at 8 or more sites of spreading in both lobes. | Takeshi Yokoo Tsutomu Kanefuji Takeshi Suda Itsuo Nagayama Takahiro Hoshi Satoshi Abe Shinichi Morita Hiroteru Kamimura Kenya Kamimura Atsunori Tsuchiya Masaaki Takamura Kazuyoshi Yagi Shuji Terai | 2019 | World Journal of Gastroenterology2019，25，20： | 3 |
| 12 | 合肥地区大气水汽标高变化特征的统计研究显示文摘根据合肥站四年整层大气水汽含量和地面水汽密度p_0的晴天观测资料,统计分析了该地区大气水汽标高H的变化特征。结果表明:H的年变化特征为夏季最大,冬季最小,春、秋季节相差很小;季节平均水汽标高值和季节平均地面气温呈高度正相关;各个季节水汽标高的日变化特征均为双谷型,最大值出现在下午16:00左右,两个低谷分别出现在上午08:00和夜间20:00左右;上午06:00至下午16:00,H的时平均值与对应p_0的时平均值呈高度负相关。 | 李超 魏合理 王珍珠 陈秀红 周军 Takamura T | 2008 | 大气与环境光学学报2008，3，2： | 3 |
| 13 | LUCC and Accompanied Soil Degradation in China from 1960's to 1990's显示文摘This paper tries to qualitatively analyze land use and cover changes (LUCC) and accompanied soil degradation in China, the data of World Atlas of Agriculture in 1969, Land Cover Data of Asia in 1992 and Global Assessment of Human Induced Soil Degradation in 1992, etc. have been used. From 1960' s to 1990's, the area of forestland had increased, arable land and paddy as well as grassland had significantly decreased in China. The major type of soil degradation is due to water erosion, which is widely distributed especially in Loess Plateau and in Southeast and Southwest China, this happened in forestland, grassland and arable land and mainly resulted from deforestation. The secondary type is wind erosion, which is mainly distributed in Northwest China, it happened in arable land and grassland and was caused by overgrazing. Chemical deterioration is distributed in North and Northwest China, which happened in paddy, arable land and grassland. Physical deterioration only concentrated in local area in North China, it happened in arable and paddy. Chemical and physical deteriora-tion mainly resulted from unreasonable activity. Because of different human activities, different LUCC and different natural conditions, the types and strength of soil degradation can be different. | JIANG Qigang(College of Earth Sciences, Jilin University, Changchun 130026, P. R. China) Shintaro GOTO and Hiroki TAKAMURA(Faculty of Geoenvironmental Science, Rissho University, Saitama, 360-0194, Japan) | 2002 | Global Geology2002，7，1： | 3 |
| 14 | SEASONAL CHANGES OF DISSOLVED AND PARTICULATE ORGANIC CARBON IN DONGHU LAKE,CHINA显示文摘Concentrations of dissolved and particulate organic carbon (DOC and POC) were documented in 1996-1997 at 4 different trophic state stations in Donghu Lake, a typical shallow eutrophic lake along the Changjiang River’s middle reaches. The mean concentrations of DOC were 15.11±3.26, 15.19±4.24, 14.27±3.43, and 13.31±3.30 mg/L in Station I, II, III, and IV, respectively. The DOC concentrations of the studied area were very similar to that in other lakes along the Changjiang River’s middle reaches. The POC mean of the whole lake was 5.01 mg/L due to the large amount of organic detritus of both allochthonous and autochthonous origin. Significant linear relationship was found between POC and chlorophyll a at all 4 stations, which presumably reflect that phytoplankton, its exudates and its metabolic products were the main contributors to the POC pool in the water column. The slope of such linear relationship at Station IV was significantly steeper than that at Station I, II and III. In addition, the DOC/POC ratios (mean value: 4.40) indicated that the organic detritus was the most important component of the particulate organic matter; in other words, next to organic detritus, phytoplankton dominated the particulate organic matter in Donghu Lake. | 刘学君 徐小清 谢平 Noriko Takamura | 2000 | Chinese Journal of Oceanology and Limnology2000，18，4： | 3 |
| 15 | Hypervascular hepatocellular carcinoma: detection with double arterial phase multi-detector row helical CT显示文摘 | Murakami T Kim T Takamura M | 2001 | Radiology2001，218，3： | 2 |
| 16 | Thick vacuum deposited silicon films suitable for the anode of Li-ion battery显示文摘 | Makiko Uehara Junji Suzuki Kohki Tamura Kyoichi Sekine Tsutomu Takamura | 2005 | Journal of Power Sources2005，，1： | 2 |
| 17 | A case report of anaplastic carcinoma of the pancreas with remarkable intraductal tumor growth into the main pancreatic duct显示文摘We herein report a case of anaplastic carcinoma of the pancreas with remarkable intraductal tumor growth into the main pancreatic duct.A 76-year-old male was referred to our hospital for treatment of a pancreatic tumor.Preoperative examinations revealed a poorly defined tumor in the main pancreatic duct in the body of the pancreas,accompanied with severe dilatation of the main pancreatic duct,which was diagnosed as an intraductal papillary-mucinous neoplasm.We performed distal pancreatectomy and splenectomy.The pathological examination revealed that the tumor consisted of a mixture of anaplastic carcinoma(giant cell type)and adenocarcinoma in the pancreas.There was a papillary projecting tumor composed of anaplastic carcinoma in the dilated main pancreatic duct.The patient is now receiving chemotherapy because liver metastasis was detected 12 mo after surgery.In this case,we could observe a remarkable intraductal tumor growth into the main pancreatic duct.We also discuss the pathogenesis and characteristics of this rare tumor with specific tumor growth. | Mitsuyoshi Okazaki Isamu Makino Hirohisa Kitagawa Shinichi Nakanuma Hironori Hayashi Hisatoshi Nakagawara Tomoharu Miyashita Hidehiro Tajima Hiroyuki Takamura Tetsuo Ohta | 2014 | World Journal of Gastroenterology2014，20，3： | 2 |
| 18 | Intraductal papillary neoplasm of the bile duct accompanying biliary mixed adenoneuroendocrine carcinoma显示文摘We present the first case of an intraductal papillary neoplasm of the bile duct(IPNB) accompanying a mixed adenoneuroendocrine carcinoma(MANEC).A 74-yearold woman presented with fever of unknown cause.Laboratory data revealed jaundice and liver injury.Contrast-enhanced computed tomography revealed a 20 mm polypoid tumor in the dilated distal bile duct,which exhibited early enhancement and papillary growth.Upper gastrointestinal endoscopy revealed mucus production from the papilla of Vater,characterized by its protruding and dilated orifice.Endoscopic ultrasonography visualized the polypoid tumor in the distal bile duct,but no invasive region was suggested by diagnostic imaging.Therefore,the initial diagnosis was IPNB.After endoscopic nasobiliary drainage,a pylorus-preserving pancreaticoduodenectomy was performed.Pathological examination of the resected bile duct revealed papillary proliferation of biliary-type cells with nuclear atypia,indicating pancreaticobiliary-type IPNB.In addition,solid portions comprised of tumor cells with characteristic salt-and-pepper nuclei were evident.Immunohistochemistry revealed expression of the neuroendocrine marker synaptophysin in this solid component,diagnosing it as a neuroendocrine tumor(NET).Furthermore,the MIB-1 proliferation index of NET was higher than that of IPNB,and microinvasion of the NET component was found,indicating neuroendocrine carcinoma(NET G3).This unique case of MANEC,comprising IPNB and NET,provides insight into the pathogenesis of biliary NET. | Ichiro Onishi Hirohisa Kitagawa Kenichi Harada Syogo Maruzen Seisyo Sakai Isamu Makino Hironori Hayashi Hisatoshi Nakagawara Hidehiro Tajima Hiroyuki Takamura Takashi Tani Masato Kayahara Hiroko Ikeda Tetsuo Ohta Yasuni Nakanuma | 2013 | World Journal of Gastroenterology2013，19，20： | 2 |
| 19 | The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial显示文摘 | Yumie Takeshita Toshinari Takamura Masao Honda Yuki Kita Yoh Zen Ken-ichiro Kato Hirofumi Misu Tsuguhito Ota Mikiko Nakamura Kazutoshi Yamada Hajime Sunagozaka Kuniaki Arai Tatsuya Yamashita Eishiro Mizukoshi Shuichi Kaneko | 2014 | Diabetologia2014，，5： | 2 |
| 20 | Performances of glaucoma operations with Kahook Dual Blade or iStent combined with phacoemulsification in Japanese open angle glaucoma patients显示文摘AIM:To compare surgical outcomes of phacoemulsification combined with glaucoma surgical techniques performed with either Kahook Dual Blade(KDB)or iStent for Japanese patients with either primary open angle glaucoma or exfoliation glaucoma.METHODS:We retrospectively evaluated the surgical outcomes of 129 eyes of 84 Japanese patients with glaucoma who underwent KDB or 44 eyes of 34 patients who underwent phacoemulsification with iStent procedures combined with cataract surgery.The primary outcome was surgical success or failure[with surgical failure being indicated by<20%reduction from preoperative intraocular pressure(IOP)or IOP>18 mm Hg as criterion A;IOP>14 mm Hg as criterion B on two consecutive study visits;or reoperation requirement].In addition,we assessed the number of postoperative glaucoma medications and the resulting complications.RESULTS:The probability of success was significantly higher in the KDB group than in the iStent group for criterion A(60.2%vs 46.4%,P=0.019).In the KDB group,the mean preoperative IOP of 19.8±7.3 mm Hg decreased significantly to 13.0±3.1 mm Hg(P<0.01),and the mean number of glaucoma medications at 2.5±1.4 decreased significantly to 1.6±1.6(P<0.01)12 mo postoperatively.In the iStent group,the mean preoperative IOP of 17.8±2.9 mm Hg significantly decreased to 14.3±2.3 mm Hg(P<0.01),and the mean number of glaucoma medications at 2.2±1.1 decreased significantly to 0.9±1.4(P<0.01)12 mo postoperatively.The overall IOP reduction percentage was higher in the KDB group(26.2%)than in the iStent group(19.0%)12 mo postoperatively(P=0.03).Hyphema occurred significantly more frequently in the KDB group(16.3%)than in the iStent group(2.3%,P=0.017).CONCLUSION:KDB and iStent procedures combined with cataract surgery both result in significant IOP and glaucoma medication reductions after the 12-month followup.The patients in the KDB group have a higher success rate for the target IOP of less than 18 mm Hg and a higher complication rate than those in the iStent group. | Kentaro Iwasaki Yoshihiro Takamura Yusuke Orii Shogo Arimura Masaru Inatani | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
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