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| 1 | Efficient InGaN-based yellow-light-emitting diodes显示文摘Realization of efficient yellow-light-emitting diodes(LEDs) has always been a challenge in solid-state lighting.Great effort has been made, but only slight advancements have occurred in the past few decades. After comprehensive work on InGaN-based yellow LEDs on Si substrate, we successfully made a breakthrough and pushed the wall-plug efficiency of 565-nm-yellow LEDs to 24.3% at 20 A∕cm^2 and 33.7% at 3 A∕cm^2. The success of yellow LEDs can be credited to the improved material quality and reduced compressive strain of InGaN quantum wells by a prestrained layer and substrate, as well as enhanced hole injection by a 3 D pn junction with V-pits. | FENGYI JIANG JIANLI ZHANG LONGQUAN XU JIE DING GUANGXU WANG XIAOMING WU XIAOLAN WANG CHUNLAN MO ZHIJUE QUAN XING GUO CHANGDA ZHENG SHUAN PAN JUNLIN LIU | 2019 | Photonics Research2019，7，2： | 13 |
| 2 | A high-quality Actinidia chinensis(kiwifruit)genome显示文摘Actinidia chinensis(kiwifruit)is a perennial horticultural crop species of the Actinidiaceae family with high nutritional and economic value.Two versions of the A.chinensis genomes have been previously assembled,based mainly on relatively short reads.Here,we report an improved chromosome-level reference genome of A.chinensis(v3.0),based mainly on PacBio long reads and Hi-C data.The high-quality assembled genome is 653 Mb long,with 0.76%heterozygosity.At least 43%of the genome consists of repetitive sequences,and the most abundant long terminal repeats were further identified and account for 23.38%of our novel genome.It has clear improvements in contiguity,accuracy,and gene annotation over the two previous versions and contains 40,464 annotated protein-coding genes,of which 94.41%are functionally annotated.Moreover,further analyses of genetic collinearity revealed that the kiwifruit genome has undergone two whole-genome duplications:one affecting all Ericales families near the K-T extinction event and a recent genus-specific duplication.The reference genome presented here will be highly useful for further molecular elucidation of diverse traits and for the breeding of this horticultural crop,as well as evolutionary studies with related taxa. | Haolin Wu Tao Ma Minghui Kang Fandi Ai Junlin Zhang Guanyong Dong Jianquan Liu | 2019 | Horticulture Research2019，6，1： | 10 |
| 3 | DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling显示文摘endoplasmic 蜂窝胃(嗯) 由原子信封, perinuclear 表和一个外部管状的网络组成。外设嗯并且线粒体形式在特定的子域的紧密的接触,它协调二个细胞器的函数并且为象 Ca 2+ 转移和 apoptosis 那样的多重细胞的进程被要求。然而,它大部分是未知的怎么嗯形态学并且嗯线粒体发信号动态地在象 DNA 那样的不同生理或病理学的条件下面被调整损坏。这里,我们证明外设,管状嗯响应 DNA 经历重要扩展损坏,和那这个过程依赖于嗯塑造蛋白质 REEP1, REEP2 和 EI24 (别名 PIG8 ) 的调停 p53 的 transcriptional 激活。这通过 EI24 和 mitochondrial 支持嗯线粒体接触的形成外部膜蛋白质 VDAC2,便于 Ca 2+ 转移从嗯到线粒体并且支持 DNA 导致损坏的 apoptosis。因此,我们识别包含改变在的一条唯一的 DNA 损坏反应小径嗯形态学,发信号的嗯线粒体,和 apoptosis。 | Pengli Zheng Qingzhou Chen Xiaoyu Tian Nannan Qian Peiyuan Chai Bing Liu Junjie Hu Craig Blackstone Desheng Zhu Junlin Teng Jianguo Chen | 2018 | Cell Research2018，28，8： | 9 |
| 4 | Common-anode LED on a Si substrate for beyond 15 Gbit/s underwater visible light communication显示文摘Visible light communication based on light-emitting diodes(LEDs) has become a promising candidate by providing high data rates, low latency, and secure communication for underwater environments. In this paper,a self-designed common-anode GaN-based five-primary-color LED(RGBYC LED) on a Si substrate is proposed and fabricated. The design of a common anode is used to mitigate the saturation effect for a low-frequency component. Additionally, compared with commercially available LEDs that suffer from nonlinearity distortion,applying the designed LED can provide much better and broader linearity according to the measurement results.Therefore, the modulation depth and system performance can be further improved to implement a high-speed underwater visible light communication(UVLC) system. There is no nonlinearity compensation algorithm applied due to the good linearity of the proposed LED;thus, the offline digital signal processing is simplified. We experimentally demonstrate 14.81 Gbit/s 64 quadrature amplitude modulation(QAM)-discrete multitone(DMT)and 15.17 Gbit/s bit-loading-DMT transmissions through a 1.2-m-long underwater channel based on the proposed RGBYC LED with an intrasymbol frequency-domain averaging channel estimation and zero-forcing equalization.As far as we know, this is the highest data rate for an LED-based UVLC system. | YINGJUN ZHOU XIN ZHU FANGCHEN HU JIANYANG SHI FUMIN WANG PENG ZOU JUNLIN LIU FENGYI JIANG NAN CHI | 2019 | Photonics Research2019，7，9： | 7 |
| 5 | Development of Genomic Microsatellite Multiplex PCR Using Dye-Labeled Universal Primer and Its Validation in Pedigree Analysis of Pacific Oyster(Crassostrea gigas)显示文摘There is an increasing requirement for traceability of aquaculture products, both for consumer protection and for food safety. There are high error rates in the conventional traceability systems depending on physical labels. Genetic traceability technique depending on DNA-based tracking system can overcome this problem. Genealogy information is essential for genetic traceability, and microsatellite DNA marker is a good choice for pedigree analysis. As increasing genotyping throughput of microsatellites, microsatellite multiplex PCR has become a fast and cost-effective technique. As a commercially important cultured aquatic species, Pacific oyster Crassostrea gigas has the highest global production. The objective of this study was to develop microsatellite multiplex PCR panels with dye-labeled universal primer for pedigree analysis in C. gigas, and these multiplex PCRs were validated using 12 full-sib families with known pedigrees. Here we developed six informative multiplex PCRs using 18 genomic microsatellites in C. gigas. Each multiplex panel contained a single universal primer M13(-21) used as a tail on each locus-specific forward primer and a single universal primer M13(-21) labeled with fluorophores. The polymorphisms of the markers were moderate, with an average of 10.3 alleles per locus and average polymorphic information content of 0.740. The observed heterozygosity per locus ranged from 0.492 to 0.822. Cervus simulations revealed that the six panels would still be of great value when massive families were analysed. Pedigree analysis of real offspring demonstrated that 100% of the offspring were unambiguously allocated to their parents when two multiplex PCRs were used. The six sets of multiplex PCRs can be an important tool for tracing cultured individuals, population genetic analysis, and selective breeding program in C. gigas. | LIU Ting LI Qi SONG Junlin YU Hong | 2017 | Journal of Ocean University of China2017，16，1： | 5 |
| 6 | CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage显示文摘Circular RNAs(circRNAs)are a novel class of endogenous noncoding RNAs that play important roles in gene expression regulation.This study aimed to evaluate the potential role of circRNAs in decidual tissue of patients with early recurrent miscarriage(RM).We constructed circRNA expression profiles in decidual tissue using microarray data.A total of 123 differentially expressed circRNAs,including 78 upregulated and 45 downregulated circRNAs were detected in the early RM group compared with the control group(P<0.05).Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis also revealed the enrichment of specific circRNAs.The verified circRNA-targeted miRNA-mRNA network was constructed,most of the circRNAs harbored miRNA binding sites.The network involved 3 circRNAs,27 microRNAs and 82 mRNAs.Hsa_circRNA_103092-miR-224-PRLR network was selected to verify by qRT-PCR.These results showed that circRNAs are aberrantly expressed in the decidual tissue in early RM patients and play potential roles in the development of early RM.It gives new insights into the mechanism of recurrent miscarriage. | Chunli Li Xuemei Chen Xueqing Liu Xiaoli Liu Junlin He Yubin Ding Chao Tong Chuan Peng Yingxiong Wang Rufei Gao | 2020 | Genes & Diseases2020，7，3： | 3 |
| 7 | Characteristics of black carbon aerosol in Jiaxing,China during autumn 2013显示文摘We conducted measurements of black carbon(BC) aerosol in Jiaxing,China during autumn from September 26 to November 30,2013.We investigated temporal and diurnal variations of BC,and its correlations with meteorological parameters and other major pollutants.Results showed that hourly mass concentrations of BC ranged from 0.2 to 22.0 μg/m^3,with an average of 5.1 μg/m^3.The diurnai variation of BC exhibited a bimodal distribution,with peaks at 07:00 and 18:00.The morning peak was larger than the evening peak.The mass percentages of BC in PM_(2.5) and PM_(10) were 7.1%and 4.8%,respectively.The absorption coefficient of BC was calculated to be 44.4 Mm^(-1),which accounted for 11.1%of the total aerosol extinction.BC was mainly emitted from local sources in southwestern Jiaxing where BC concentrations were generally greater than 11 μg/m^3 during the measurement period.Correlation analysis indicated that the main sources of BC were motor vehicle exhaust,and domestic and industrial combustion. | Lijuan Shen Li Li Sheng Lu Xiaohan Zhang Jie Liu Junlin An Guojun Zhang Bo Wu Fei Wang | 2015 | Particuology2015，13，3： | 2 |
| 8 | Mechanism for the formation and microphysical characteristics of submicron aerosol during heavy haze pollution episode in the Yangtze River Delta, China显示文摘 | Honglei Wang Junlin An Lijuan Shen Bin Zhu Chen Pan Zirui Liu Xiaohui Liu Qing Duan Xuan Liu Yuesi Wang | 2014 | Science of the Total Environment2014，，： | 2 |
| 9 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 10 | An organometallic super-gelator with multiple-stimulus responsive properties 显示文摘 | Liu Jing He Panli Yan Junlin | 2008 | Advanced Materials2008，20，： | 1 |
| 11 | A non-viral vector for potential DMD gene therapy study by targeting a minidystrophin-GFP fusion gene into the hrDNA locus显示文摘基因治疗为 Duchenne 肌肉发达的营养障碍(DMD ) 的致命的混乱作为一条有希望的途径出现了。用一个新奇非病毒的交货系统,指向向量的人的 ribosomal DNA (hrDNA ) ,我们与 10 的高地点特定的综合效率指向了 minidystrophin-GFP 熔化基因进 HT1080 房间的 hrDNA 地点 ? 5,在里面 transgene 能高效地并且连续地表示它。minidystrophin-GFP 熔化蛋白质容易被发现在 HT1080 房间的血浆膜上本地化,显示它的可能的生理的表演。我们的调查结果证明指向 hrDNA 向量可能为 DMD 基因治疗学习是高度有用的。 | Junlin Yang Xionghao Liu Jiaoling Yu Liang Sheng Yan Shi Zhuo Li Youjin Hu Jinfeng Xu Lingqian Wu Yu Liang Jiahui Xia Desheng Liang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，12： | 1 |
| 12 | Radiological thera py with low enery He Nelaser显示文摘 | WEI XINGCHANG LIU KAIXIANG FENG JUNLIN | 1995 | Chinese Physical Therapy Journal1995，18，2： | 1 |
| 13 | Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery显示文摘Due to better penetrating abilities of near-infrared (NIR) light and lower autofluorescence of biological tissue at NIR region, the combination of NIR fluorescent imaging with therapeutic abilities has gradually emerged as a promising strategy for cancer therapy. Herein, tumor microenvironment (TME) sensitive nanocarriers based on doxorubicin hydrochloride (DOX), NIR emitting carbon dots (C-dots), hollow mesoporous silica nanoparticles (HMSN) and anionic polymer citraconic anhydride-modified polylysine (PLL(cit)) are fabricated for imaging guided drug delivery. The NIR emitting C-dots were conjugated onto the surface of HMSN via disulfide bonds which can be reduced by intracellular glutathione (GSH) and result in the release of DOX into cells. And then the PLL(cit) was grafted on the surface of the nanocarriers to endow the nanocarriers with charge convertible property in mildly acidic TME (pH = 6.50) which results in prolonged blood circulation time and enhanced cellular internalization. The in vitro and in vivo experiments confirmed that the dual pH/GSH responsive features of nanocarriers can eliminate the tumor tissues effectively and elicit much slighter side effects. Moreover, since the fluorescence of C-dots can be recovered after the reduction of disulfide bonds and selectively accumulation of nanocarriers around tumor tissue, the DOX@HMSN-SS-C-dots-PLL(cit) can be served as a promising NIR fluorescence probe for targeted imaging of tumor tissue. As a kind of multifunctional nanocarrier with NIR fluorescent imaging and therapeutic functions, the theranostic nanocarriers hold great potential for tumor therapy and in vivo imaging of tumor tissue. | Zhongyin Chen Tao Liao Lihui Wan Ying Kuang Chang Liu Junlin Duan Xiangyu Xu Ziqiang Xu Bingbing Jiang Cao Li | 2021 | Nano Research2021，14，11： | 1 |
| 14 | The role of reproductive phenology, seedling emergence and establish- ment of perennial Salix gordejevii in active sand dune fields 显示文摘 | YAN Qiaoling LIU Zhimin MA Junlin | 2007 | Annals of Botany2007，99，1： | 1 |
| 15 | Catalytic cleavage activities of 10–23 DNAzyme analogs functionalized with an amino group in its catalytic core显示文摘Functionalization of the catalytic loop of 10–23 DNAzyme with an amino group was performed by incorporation of 7-(3-aminopropyl)-8-aza-7-deaza-20-deoxyadenosine in different single positions.Among the nine modified positions in the catalytic loop,A9 is the unique position with positive contribution by such modification.These results indicated that more efficient deoxyribozymes remain to be explored by introduction of exogenous functional groups in an appropriate position in the catalytic loop of 10–23 DNAzyme,such as the combination of 7-functional group substituted 8-aza-7-deaza-20-deoxyadenosine analogs and A9 position. | Qi Wang Di Zhang Maosheng Cheng Junlin He Keliang Liu | 2012 | Acta Pharmaceutica Sinica B2012，2，1： | 1 |
| 16 | A Preliminary Study on Silver Isotopic Composition in Polymetallic Ore Deposits in Eastern China显示文摘A preliminary survey of silver isotopic composition in four polymetallic ores in eastern China shows a larger variation inδ^(109)Ag from-0.014‰to+0.983‰,which is within the total ranges for the entire respective ore deposit types worldwide.The diversity of silver isotopic compositions in oredeposits reported here and previous studies seemed to preclude simple isotopic links to particular sources,but reflected the silver isotope fractionation in transport-and deposit-related processes instead.Theδ^(109)Ag values in supergene samples from the Qixiashan Pb-Zn-Ag polymetallic deposit are more positive,in consistent with the statistical δ^(109)Ag distribution from-0.4‰to+2.2‰in 36 pieces of supergene ore samples around the World,which reflects the diverse controls on silver isotope fractionation from the first-order thermodynamic effect,reduction-mediated reaction,remobilization of silver with surficial low-temperature weathering processes.The hypogene samples in Dazhuangzi orogenic Au-Ag ore deposit,have δ^(109)Ag values close to 0,which implies that equilibrium partitioning associated with metal sources at the high-temperature does not result in a resolvable difference in silver isotopic compositions.By contrast,the hypogene samples which are dominated by pyrite without visible silver minerals (i.e.,skarn iron ore deposit in Edongnan) have shown the largest variation range of δ^(109)Ag,followed by that from the porphyry copper ore in Zijinshan.It could be concluded that the surface adsorption and/or lattice substitution are important factors to control Ag isotope fractionation in oreforming processes,especially for skarn deposits with only pyrite.The perspective of silver isotope shows great potentials to understand the processes that lead to the concentrations of metals to economic levels and to constrain the physicochemical conditions during ore-mineralization in metallic ore-deposits. | Ge Dong Hai-Zhen Wei Yuanfeng Zhu Xi Liu Qi Guo Wei Pu Yibo Lin Junlin Wang | 2022 | Journal of Earth Science2022，33，1： | 1 |
| 17 | Spatial patterns of Picea crassifolia driven by environmental heterogeneity and intraspecifi c interactions显示文摘Research on the spatial patterns of tree populations is critical for understanding the structure and dynamic processes of forests.However,little is known about how the underlying drivers shape these patterns and species interactions in forest systems.In this study,spatial point pattern analysis investigated the combined eff ects of intraspecifi c interactions and environmental heterogeneity on the spatial structure and internal maintenance mechanisms of Picea crassifolia in the Qilian Mountain National Nature Reserve,China.Data were obtained from a 10.2-ha dynamic monitoring plot(DMP)and sixteen 0.04-ha elevation gradient plots(EGPs).Under complete spatial randomness,both mature trees and saplings in the DMP demonstratedlarge-scale aggregation with negative correlations.In EGPs,saplings were clustered in small mesoscales,mature trees were randomly distributed,and the interactions of saplingstrees at all elevations were not correlated.By eliminating the interference of environmental heterogeneity through the inhomogeneous Poisson process,saplings in the DMP and EGPs were clustered in small scales and trees randomly distributed.Intraspecifi c associations were negatively correlated,in the DMP and at low elevations,and no correlations in high elevations of EGPs.In the vertical scale,saplings showed a small-scale aggregation pattern with increase in elevation,and the aggregation degree fi rst decreased and then increased.The interactions of saplings-trees and saplings–saplings showed inhibitions at small scales,with the degree of inhibition gradually decreasing.Spatial patterns and associations of adults–adults did not change signifi-cantly.The results revealed that intraspecifi c interactions and environmental heterogeneity regulated the spatial patterns of P.crassifolia at small and large scales,respectively.Environmental heterogeneity might be the most decisive factor aff ecting the spatial patterns of saplings,while trees were more aff ected by intraspecifi c interactions.Moreover,competition between trees in this area could be more common than facilitation for the growth and development of individuals. | Changxing Zhao Weijun Zhao Ming Jin Jiqiang Zhou Feng Ta Lei Wang Wenbo Mou Longju Lei Jinrong Liu Junlin Du Xinglin Zhang | 2023 | Journal of Forestry Research2023，34，4： | 1 |
| 18 | Corrosion inhibiting performance and mechanism of protic ionic liquids as green brass inhibitors in nitric acid显示文摘Four protic ionic liquids(ILs)were synthesized via a one-step method by using benzotriazole(BTA)and benzimidazole as cations,and benzenesulfonic acid and 2-naphthalenesulfonic acid(NSA)as anions.These ILs were used as green corrosion inhibitors for brass specimens in a nitric acid solution.The structure of the protic ILs was characterized by 1H-NMR,13C-NMR,and FT-IR spectroscopy.The effects of the IL structure,IL concentration,acid concentration,and corrosion time on the surface morphology of brass specimens and the inhibition efficiency(η%)of ILs were investigated by the weight loss method combined with SEM and EDS spectroscopy.Polarization curves and impedance spectroscopy were used to analyze the electrochemical corrosion inhibition mechanism of ILs.Results showed that IL synthesis was a proton transfer process,and the proton of the–SO3H group on NSA was deprived by BTA.IL[BTA][NSA],which had a high charge density and large conjugateπband,was the most effective inhibitor for brass corrosion.Theη%of[BTA][NSA]decreased with the increase in acid concentration and corrosion time,which showed an increment with the increase in[BTA][NSA]concentration.The higher theη%of[BTA][NSA]is,the smoother the surface of the brass specimens is,and the smaller the undistributed area of Cu element will be.Corrosion inhibiting mechanism from electrochemical analysis indicated that the addition of[BTA][NSA]increased the polarization resistance of the brass electrode significantly and suppressed both anodic and cathodic reactions. | Pengcheng Hu Zhitao Wu Junlin Wang Yuqing Huang Quanyou Liu Shu-Feng Zhou | 2020 | Green Energy & Environment2020，5，2： | 1 |
| 19 | Calixarene-based supra-molecular gels with unprecedented rheological properties 显示文摘 | Cai Xiuqin Liu Kaiqiang Yan Junlin | 2012 | Soft Matter2012，8，14： | 1 |
| 20 | A quality by design (QbD) case study on entericcoated pellets: Screening of critical variables and establishment of design space at laboratory scale显示文摘The study aims to prepare naproxen enteric-coated pellets(NAP-ECPs)by fluid-bed coating using QbD principle.Risk assessment was firstly performed by using failure mode and effect analysis(FMEA)methodology.A PlacketteBurman design was then used for assessment of the most important variables affecting enteric-coated pellets characteristics.A BoxeBehnken design was subsequently used for investigating the main,interactive,and quadratic effects of these variables on the response.By FMEA we discovered that eight factors should be considered to be high/important risk variables as compared with others.The responses of acid resistance and cumulative drug release were taken as critical quality attributes(CQAs).Pareto ranking analyses indicated that the coating weight gain(X_(7)),triethyl citrate percentage(X_(1))and glycerol monostearate percentage(X_(2))were the most significant factors affecting the selected responses out of the eight high-risk variables.Optimization with response surface method(RSM)further fully clarified the relationship between X_(7),X_(1),X_(2) and CQAs,and design space was established based on the constraints set on the responses.Due to the extreme coincidence of the predicted value generated by model with the observed value,the accuracy and robustness of the model were confirmed.It could be concluded that a promising NAP-ECPs was successfully designed using QbD approach in a laboratory scale. | Shuling Kan Jing Lu Jianping Liu Junlin Wang Yi Zhao | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，5： | 1 |
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