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| 1 | LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer显示文摘Altered metabolism is a hallmark of cancer,and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors.It is well recognized that long noncoding RNAs(lncRNAs)regulate energy metabolism in cancer.However,lncRNA-mediated posttranslational modifications and metabolic reprogramming are unclear at present.In this review,we summarized the current understanding of the interactions between the alterations in cancer-associated energy metabolism and the lncRNA-mediated posttranslational modifications of metabolic enzymes,transcription factors,and other proteins involved in metabolic pathways.In addition,we discuss the mechanisms through which these interactions contribute to tumor initiation and progression,and the key roles and clinical significance of functional lncRNAs.We believe that an in-depth understanding of lncRNA-mediated cancer metabolic reprogramming can help to identify cellular vulnerabilities that can be exploited for cancer diagnosis and therapy. | Yue-Tao Tan Jin-Fei Lin Ting Li Jia-Jun Li Rui-Hua Xu Huai-Qiang Ju | 2021 | Cancer Communications2021，41，2： | 92 |
| 2 | Behavior and mechanism of the adsorption/desorption of tectonically deformed coals显示文摘The physical and chemical texture of tectonically deformed coals produced by various formational mechanisms are different from those of primary coals,thus resulting in major differences among the physical properties of the reservoirs of these coals. We have studied the adsorption/desorption be-havior of tectonically deformed coals by the use of isothermal adsorption/desorption experiments un-der equilibrium moisture condition. Experiments of isothermal adsorption/desorption of methane or multi-component gases have indicated that,the adsorption curves of coals with a low degree of tec-tonic deformation conform to the type of isothermal adsorption curve described by the Langmuir equation; the methane adsorption curves of coals with strong tectonic deformation cannot be de-scribed by the Langmuir equation. The adsorption/desorption process of methane and multi-compo-nent gases in the deformed coals is not consistent with primary coals,which form an effect of hys-teresis in different kinds of tectonically deformed coals. With the change of pore structure of tectoni-cally deformed coals at reservoir condition,the added adsorbed CH4 in the experiments is desorbed on the pore surface of coals during the pressure reduction process. Thus,the result shows that the ad-sorption volume in the process of desorbing is greater than that in adsorbing. Because of the defor-mation,structural change,and transformation of the adsorption potential field of coals,it is essential to form a new kind of isothermal adsorption curve and the hysteresis effect of the desorption process. | JU YiWen JIANG BO HOU QuanLin TAN YongJie WANG GuiLiang XIAO WenJiao | 2009 | Chinese Science Bulletin2009，54，1： | 26 |
| 3 | Serum cystatin C levels are negatively correlated with post-stroke cognitive dysfunction显示文摘Stroke is the leading cause of death and long-term disability worldwide,and cognitive impairment and dementia are major complications of ischemic stroke.Cystatin C (CysC) has been found to be a neuroprotective factor in animal studies.However,the relationship between CysC levels and cognitive dysfunction in previous studies has revealed different results.This prospective observational study investigated the correlation between serum CysC levels and post-stroke cognitive dysfunction at 3 months.Data from 638 patients were obtained from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS).Cognitive dysfunction was assessed using the Mini-Mental State Examination (MMSE) at 3 months after stroke.According to the MMSE score,308 patients (52.9%) had post-stroke cognitive dysfunction.After adjusting for potential confounding factors,the odds ratio (95% CI) of post-stroke cognitive dysfunction for the highest quartile of serum CysC levels was 0.54 (0.30–0.98),compared with the lowest quartile.The correlation between serum CysC and cognitive dysfunction was modified by renal function status.We observed a negative linear dose-response correlation between CysC and cognitive dysfunction in patients with normal renal function (Plinearity = 0.044),but not in those with abnormal renal function.Elevated serum CysC levels were correlated with a low risk of 3-month cognitive dysfunction in patients with acute ischemic stroke,especially in those with normal renal function.The current results suggest that CysC is a protective factor for post-stroke cognitive dysfunction,and could be used to treat post-stroke cognitive dysfunction.The CATIS study was approved by the Institutional Review Boards at Soochow University from China (approval No.2012-02) on December 30,2012,and was registered at ClinicalTrials.gov (identifier No.NCT01840072) on April 25,2013. | Dao-Xia Guo Zheng-Bao Zhu Chong-Ke Zhong Xiao-Qing Bu Li-Hua Chen Tan Xu Li-Bing Guo Jin-Tao Zhang Dong Li Jian-Hui Zhang Zhong Ju Chung-Shiuan Chen Jing Chen Yong-Hong Zhang Jiang He | 2020 | Neural Regeneration Research2020，15，5： | 14 |
| 4 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 5 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 6 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 7 | Heat flow and its coalbed gas effects in the central-south area of the Huaibei coalfield, eastern China显示文摘Based on an analysis of the present geo-temperature field and the thermal conductivity (K) of 62 samples from the central-south area of the Huaibei coalfield in eastern China, we calculated the heat flow and plotted its distribution map. The results show that the average heat flow in the research area is about 60 mW/m2. It is different from other major energy basins in the North China Plate, but has close relationship with the regional geology and the deep geological setting. The heat flow is comparatively higher in the southeastern, central, and northwestern areas than in the northeastern and southwestern areas. The geo-temperature distribution map of the bottom interface of the Permian coal measure was drawn by calculating its embedding depth and geo-temperature gradients. Finally, the present gas generation condition of the Permian coal measure is discussed by associating with the temperature condition, the vitrinite reflectance (Ro), the metamorphism of coal and tectonic-burial evolution. The study indicates all present characters of the Permian coal measure, such as lower present temperature, higher Ro value, middle-high rank coals, and uplift and extension events after the coal measure sediment, are favorable for the generation of secondary biogenic gas, but not thermogenic gas or primary biogenic gas. | TAN JingQiang JU YiWen ZHANG WenYong HOU QuanLin TAN YongJie | 2010 | Science China Earth Sciences2010，53，5： | 9 |
| 8 | Spraying printing of liquid metal electronics on various clothes to compose wearable functional device显示文摘Liquid metal printing is emerging as an important tool for making wearable electronics. However, very limited academic efforts were made to fulfill such an increasing need. This paper is dedicated to present relatively complete theoretical and experimental characterizations for liquid metal spraying printing towards developing wearable electronic textile. The practical conditions of liquid metal droplets in the spraying printing process such as the jet velocity, the size distribution of droplets and their evenness degree, the morphology of droplets and their unrolling areas after impacting the substrate are quantified. The dominating factors, including the oxidation of liquid metal and the pressure force on cloth substrate during the impacting process, which ensure liquid metal firmly adhere to the cloth, are clarified. Further, various clothes are comparatively investigated to test their capabilities in printing liquid metal conductors, where the resistance difference can be over thousand-fold. In addition to interpreting the basic mechanisms and performances of the spraying printing, two programmable flexible circuits with specifically designed functions such as blinking LED lighting and wireless infrared temperature measurement via current manufacture technology were also demonstrated and evaluated for their washable ability. With the realization of wearable modules via liquid metal printing technology, it can be expected that flexible functional devices on cloth fabricated quickly and directly would witness more broad applications in the coming time. | GUI Han TAN SiCong WANG Qian YU Yang LIU FuJun LIN Ju LIU Jing | 2017 | Science China(Technological Sciences)2017，60，2： | 8 |
| 9 | Room temperature phosphorescence from natural products: Crystallization matters显示文摘Efficient room temperature phosphorescence is observed in natural compounds and polymers such as starch, cellulose, bovine serum albumin (BSA), and some other carbohydrates. Whereas being practically nonluminescent in solutions and TLC plates, they emit bright phosphorescence in the crystalline states with lifetime up to microseconds, exhibiting crystallization-induced phosphorescence (CIP) characteristics. The CIP of these natural products without any conventional chromophores offers a new platform for the exploration of conceptually novel luminogens. | GONG YongYang TAN YeQiang MEI Ju ZHANG YiRen YUAN WangZhang ZHANG YongMing SUN JingZhi TANG Ben Zhong | 2013 | Science China Chemistry2013，56，9： | 8 |
| 10 | Oxyphyllones A and B,novel sesquiterpenes with an unusual 4,5-secoeudesmane skeleton from Alpinia oxyphylla显示文摘二新奇 4,5-secoeudesmane sesquiterpenoids, oxyphyllones A (1 ) 和 B (2 ) 从 Alpinia oxyphylla 的水果被孤立。他们的结构被包括 1D 和 2D NMR 系列的分光镜的方法建立。这二混合物是有在 Zingiberaceae 的家庭的一架 4,5-secoeudesmane 骨骼的自然地发生的 sesquiterpenoids 的第一个例子, oxyphyllone A (1 ) 是 13-norsesquiterpenoid 的第一种 4,5-secoeudesmane 类型。1 和 2 展出了的混合物对三个癌症房间的 cytotoxicities 都不在 10 μ 排队; g/mL。 | Jun Ju Xu Ning Hua Tan Jiang Xiong Abiodun Humphrey Adebayo Hong Jin Han Guang Zhi Zeng Chang Jiu Ji Yu Mei Zhang Mei Ju Zhu | 2009 | Chinese Chemical Letters2009，20，8： | 7 |
| 11 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 12 | The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite显示文摘The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components.The energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME. | XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu Liang Sun XiaoJing Liu JiaWei Yang Xian Li Ying Tan ShaoZhen Liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei Li ChengMo Zhang XiangYang Wen JinLu Qu LiMing Song XiaoBo Li MingYu Ge YuPeng Zhou ShaoLin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang MaoShun Li XiaoHua Liang Min Gao EnBo Yang XiaoHang Liu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 5 |
| 13 | Construction of a small-caliber tissue-engineered blood vessel using icariin-loaded β-cyclodextrin sulfate for in situ anticoagulation and endothelialization显示文摘The rapid endothelialization of tissue-engineered blood vessels(TEBVs) can effectively prevent thrombosis and inhibit intimal hyperplasia. The traditional Chinese medicine ingredient icariin is highly promising for the treatment of cardiovascular diseases.β-cyclodextrin sulfate is a type of hollow molecule that has good biocompatibility and anticoagulation properties and exhibits a sustained release of icariin. We studied whether icariin-loaded β-cyclodextrin sulfate can promote the endothelialization of TEBVs. The experimental results showed that icariin could significantly promote the proliferation and migration of endothelial progenitor cells; at the same time, icariin could promote the migration of rat vascular endothelial cells(RAVECs). Subsequently,we used an electrostatic force to modify the surface of the TEBVs with icariin-loaded β-cyclodextrin sulfate, and these vessels were implanted into the rat common carotid artery. After 3 months, micro-CT results showed that the TEBVs modified using icariin-loaded β-cyclodextrin sulfate had a greater patency rate. Scanning electron microscopy(SEM) and CD31 immunofluorescence results showed a better degree of endothelialization. Taken together, icariin-loaded β-cyclodextrin sulfate can achieve anticoagulation and rapid endothelialization of TEBVs to ensure their long-term patency. | Jingyuan Yang Keyu Wei Yeqin Wang Yanzhao Li Ning Ding Da Huo Tianran Wang Guanyuan Yang Mingcan Yang Tan Ju Wen Zeng Chuhong Zhu | 2018 | Science China(Life Sciences)2018，61，10： | 5 |
| 14 | Present Situation and Technical Developing Tendency of Shale Gas Development in China显示文摘1 Introduction American shale gas production in 2005 year is 194×108m3 and it rapidly growth to 2600×108m3 in 2014 year,the successful development of shale gas change American energy supply pattern and make important influence to global energy supply and geopolitics(Daniel et al.,2007).At present China is a country with rich coal,lack oil | TAN Fengqi JU Yiwen XU Houwei | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 4 |
| 15 | CSF Brain-Reactive Autoantibodies are Elevated in Patients with Viral Encephalitis显示文摘Dear Editor,Brain-reactive autoantibodies are thought to play an important role in mediating disorders of the central nervous system(CNS).These antibodies direct the processes underlying several diseases,such as multiple sclerosis(MS),neuromyelitis optica(NMO),and neuropsychiatric systemic lupus erythematosus[1-3].In infectious diseases of the CNS,the pathogen itself is regarded to play a major role in the pathogenesis[4]. | Zhong-Yuan Yu Jian-Hong Wang Wei-Wei Li Ye-Ran Wang Noralyn B.Manucat-Tan Jun Wang Ju Wang Gao-Yu Cui Jie-Xiang Pan Shui-Xian Zhang Zu-Juan Liu Liang Tan Yu-Hui Liu | 2020 | Neuroscience Bulletin2020，36，8： | 3 |
| 16 | Detection of Variants of B.1.617 Lineage from Five Returning Chinese Nationals at a Guangxi-Vietnam Border Port——Guangxi Zhuang Autonomous Region,China,April 2021显示文摘A 47-year-old male(Patient A)passenger from Vietnam whose nucleic acid results for coronavirus disease 2019(COVID-19),also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were positive at Pingxiang Customs on April 29,2021,and subsequently confirmed by Guangxi CDC laboratories on April 30. | Ning Kang Yinpin Liu Fuyin Bi Jing Wang Huafeng Chen Jing Wang Zhenli Liang Min Chen Guangwu Wei Aiming Li Yonghong Li Bao Lu Zhenling Jiang Yi Tan Ge Zhong Mei Lin Yu Ju | 2021 | China CDC weekly2021，3，30： | 3 |
| 17 | Neuroprotection by cattle encephalon glycoside and ignotin beyond the time window of thrombolysis in ischemic stroke显示文摘Cattle encephalon glycoside and ignotin(CEGI)injection is known as a multi-target neuroprotective drug that contains numerous liposoluble molecules,such as polypeptides,monosialotetrahexosyl ganglioside(GM-1),free amino acids,hypoxanthine and carnosine.CEGI has been approved by the Chinese State Food and Drug Administration and widely used in the treatments of various diseases,such as stroke and Alzheimer's disease.However,the neuroprotective effects of CEGI beyond the time window of thrombolysis(within 4.5 hours)on acute ischemic stroke remain unclear.This study constructed a rat middle cerebral artery occlusion model by suture-occluded method to simulate ischemic stroke.The first daily dose was intraperitoneally injected at 8 hours post-surgery and the CEGI treatments continued for 14 days.Results of the modified five-point Bederson scale,beam balance test and rotameric test showed the neurological function of ischemic stroke rats treated with 4 m L/kg/d CEGI improved significantly,but the mortality within 14 days did not change significantly.Brain MRI and 2,3,5-triphenyltetrazolium chloride staining confirmed that the infarct size in the 4 m L/kg/d CEGI-treated rats was significantly reduced compared with ischemic insult only.The results of transmission electron microscopy and double immunofluorescence staining showed that the hippocampal neuronal necrosis in the ischemic penumbra decreased whereas the immunopositivity of new neuronal-specific protein doublecortin and the percentage of Ki67/doublecortin positive cells increased in CEGI-treated rats compared with untreated rats.Our results suggest that CEGI has an effective neuroprotective effect on ischemic stroke when administered after the time window of thrombolysis.The study was approved by the Animal Ethics Committee of The Third Military Medical University,China. | Jun Zhong Rong-Wei Li Ju Wang Ying Wang Hong-Fei Ge Ji-Shu Xian Hua Feng Liang Tan | 2021 | Neural Regeneration Research2021，16，2： | 2 |
| 18 | The change of magnetic inclination angles associated with the X3.4 flare on December 13,2006显示文摘Recent studies showed a consistent pattern of changes in the sunspot structure associated with major flares: part of the peripheral penumbral regions vanishes during flares, and meanwhile, the umbral cores and/or inner penumbral regions are darkened. To understand the underlying physics of these observations, we compare the magnetic inclination angle in the decayed peripheral and the enhanced inner penumbral regions before and after the 4B/X3.4 flare of 2006 December 13 by using the high-resolution vector magnetograms from Hinode. We find that the mean inclination angle in the decayed penumbra increases after the flare while that in the enhanced penumbra near flaring neutral line decreases. The result confirms the previous idea that two components of a δ sunspot become connected after flares. As a result of new connection, peripheral penumbral fields change from a more inclined to a more vertical configuration and transverse fields in umbral core and inner penumbral regions increase substantially (Liu et al. 2005). The flare-associated changes of Doppler width as well as other parameters (the transverse field strength, continuum intensity and filling factor) are also presented. | LI YiXuan JING Ju TAN ChangYi WANG HaiMin | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，11： | 2 |
| 19 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 20 | Genetic Characterization of Two Human Cases Infected with the Avian Influenza A(H5N6)Viruses—Guangxi Zhuang Autonomous Region,China,2021显示文摘Summary What is known about this topic?H5N6 has replaced H5N1 as a dominant avian influenza virus(AIV)subtype in southern China.The increasing genetic diversity and geographical distribution of H5N6 pose a serious threat to the poultry industry and human health.What is added by this report?A total of 2 cases of H5N6 that occurred from February 2021 to July 2021 in Guangxi. | Fuyin Bi Lili Jiang Lihua Huang Jingguang Wei Xiaowen Pan Yu Ju Jianjun Mo Minmei Chen Ning Kang Yi Tan Yonghong Li Jing Wang | 2021 | China CDC weekly2021，3，44： | 2 |
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