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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 3 | Soft error reliability in advanced CMOS technologies—trends and challenges显示文摘With the decrease of the device size,soft error induced by various particles becomes a serious problem for advanced CMOS technologies.In this paper,we review the evolution of two main aspects of soft error-SEU and SET,including the new mechanisms to induced SEUs,the advances of the MCUs and some newly observed phenomena of the SETs.The mechanisms and the trends with downscaling of these issues are briefly discussed.We also review the hardening strategies for different types of soft errors from different perspective and present the challenges in testing,modeling and hardening assurance of soft error issues we have to address in the future. | TANG Du HE ChaoHui LI YongHong ZANG Hang XIONG Cen ZHANG JinXin | 2014 | Science China(Technological Sciences)2014，57，9： | 3 |
| 4 | SwordDTA: A Dynamic Taint Analysis Tool for Software Vulnerability Detection显示文摘Software vulnerabilities are the root cause of various information security incidents while dynamic taint analysis is an emerging program analysis technique. In this paper, to maximize the use of the technique to detect software vulnerabilities, we present Sword DTA, a tool that can perform dynamic taint analysis for binaries. This tool is flexible and extensible that it can work with commodity software and hardware. It can be used to detect software vulnerabilities with vulnerability modeling and taint check. We evaluate it with a number of commonly used real-world applications. The experimental results show that Sword DTA is capable of detecting at least four kinds of software vulnerabilities including buffer overflow, integer overflow, division by zero and use-after-free, and is applicable for a wide range of software. | CAI Jun ZOU Peng MA Jinxin HE Jun | 2016 | Wuhan University Journal of Natural Sciences2016，21，1： | 3 |
| 5 | Heavy ion micro-beam study of single-event transient(SET) in Si Ge heterjunction bipolar transistor显示文摘Silicon-germainum heterojunction bipolar transistor(Si Ge HBT)has been demonstrated to be suitable in extreme environment because of its superior temperature characteristics which can operate from 43 K to 400 K[1].In addition,outstanding hardness to both total ionizing dose(TID)radiation and displacement damage make Si Ge HBT technology particularly attractive for | Jinxin ZHANG Hongxia GUO Fengqi ZHANG Chaohui HE Pei LI Yunyi YAN Hui WANG Linxia ZHANG | 2017 | Science China(Information Sciences)2017，60，12： | 2 |
| 6 | Application of RgMap system on digital regional geological survey显示文摘Digital geological mapping fundamentally broke through the traditional working pattern,successfully carried out the geological mapping digitalization.By using the RGMAP system to field digital geological mapping,the authors summarized the method of work and the work flow of the RGMAPGIS during the field geological survey.First,we prepared material,set up the PRB gallery,then put the geographic base map under the background maplayer and organizing the field hand map,forming the field factual datum map.At last,the geological space database is formed. | Qingying ZHAO Jinxin HE Guoliang WANG Xiumei HAN | 2007 | Global Geology2007，10，1： | 2 |
| 7 | Scanning electron microscopy of Chinese (mainland) strain Schistosorna japonicum 显示文摘 | Ma Jinxin He Yixun | 1981 | Chin Med J1981，94，1： | 1 |
| 8 | Determination of membrane thicknessof microcapsule 显示文摘 | Zou Liming He Jinxin | 1997 | J China Textile University ( Eng Ed)1997，14，4： | 1 |
| 9 | Determination of membrane thickness of mierocapsule显示文摘 | Zou Liming He Jinxin | 1997 | Journal of China Textile University(Eng Ed)1997，14，4： | 1 |
| 10 | Modification of silk with aminated polyepichlorohydrin to improve dyeability with reactive dyes 显示文摘 | XIE Weibin HE Jinxin CHEN Shuilin | 2007 | Coloration Technology2007，123，2： | 1 |
| 11 | Synthesis and characterization of chitosan biguanidine hydrochloride under microwave irradiation显示文摘 | Zhao Xue He Jinxin Zhan Yizhen | 2009 | Polymer Journal2009，41，12： | 1 |
| 12 | The performances of carboxymethyl chitosan in wash-off reactive dyeings 显示文摘 | Xuting Xue Ling Li Jinxin He | 2009 | Carbohydrate Polymers2009，75，： | 1 |
| 13 | Scanning electron microscopy of Chinese (mainland) strain Schistosorna japonicum 显示文摘 | Ma Jinxin He Yixun | 1981 | Chin Med J1981，94，1： | 1 |
| 14 | Modification of silk with aminated polyepichlorohydrin to improve dyeability with reactive dyes显示文摘 | Xie Weibin He Jinxin Chen Shuilin | 2007 | Coloration Technology2007，123，2： | 1 |
| 15 | Synthesis and characterization of chitosan biguanidine hydrochloride under micro- wave irradiation显示文摘 | Zhao Xue He Jinxin Zhan Yizhen | 2009 | Polymer Journal2009，41，12： | 1 |
| 16 | Proton-induced current transient in SiGe HBT and charge collection model based on Monte Carlo simulation显示文摘The study presents an investigation into the proton-induced current transient in a silicon-germanium heterojunction bipolar transistor(SiGe HBT).The temporal information of the proton-induced current transients is first measured and then compared with results from heavy ion microbeam experiment.Additionally,a model for proton-induced charge collection based on Geant4 Monte Carlo simulation tools is constructed by using the information from heavy ion experiment and 3D TCAD simulation.The results obtained by the validated model exhibit good consistency with the proton experiment. | WEI JiaNan LI Yang YANG WeiTao HE ChaoHui LI YongHong ZANG Hang LI Pei ZHANG JinXin GUO Gang | 2020 | Science China(Technological Sciences)2020，63，5： | 1 |
| 17 | Evaluation of lithium - ion battery equivalent circuit models for state of charge estimation by an experimental approach显示文摘 | He Hongwen Xiong Rui Fan Jinxin | 2011 | Energies2011，，4： | 1 |
| 18 | Evaluation of lithium -ion battery equavalent circuit method for state of chargeestimation by an experimental approach显示文摘 | He Hongwen Xiong R u i Fan Jinxin | 2011 | Energies2011，4，4： | 1 |
| 19 | 显示文摘 | Zhao Xue He Jinxin Zhan Yizhen | 2009 | Polymer Journal2009，41，12： | 1 |
| 20 | Evaluation of lithium-ion battery equivalent circuit models for state of charge estimation by an experimental approach显示文摘 | Hongwen He Rui Xiong Jinxin Fan | 2011 | Energies2011，4，4： | 1 |
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