|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Oleic Acid and Eicosapentaenoic Acid Reverse Palmitic Acid-induced Insulin Resistance in Human HepG2 Cells via the Reactive Oxygen Species/JUN Pathway显示文摘Oleic acid(OA),a monounsaturated fatty acid(MUFA),has previously been shown to reverse saturated fatty acid palmitic acid(PA)-induced hepatic insulin resistance(IR).However,its underlying molecular mechanism is unclear.In addition,previous studies have shown that eicosapentaenoic acid(EPA),aω-3 polyunsaturated fatty acid(PUFA),reverses PA-induced muscle IR,but whether EPA plays the same role in hepatic IR and its possible mechanism involved need to be further clarified.Here,we confirmed that EPA reversed PA-induced IR in HepG2 cells and compared the proteomic changes in HepG2 cells after treatment with different free fatty acids(FFAs).A total of 234 proteins were determined to be differentially expressed after PA+OA treatment.Their functions were mainly related to responses to stress and endogenous stimuli,lipid metabolic process,and protein binding.For PA+EPA treatment,the PA-induced expression changes of 1326 proteins could be reversed by EPA,415 of which were mitochondrial proteins,with most of the functional proteins involved in oxidative phosphorylation(OXPHOS)and tricarboxylic acid(TCA)cycle.Mechanistic studies revealed that the protein encoded by JUN and reactive oxygen species(ROS)play a role in OA-and EPA-reversed PA-induced IR,respectively.EPA and OA alleviated PA-induced abnormal adenosine triphosphate(ATP)production,ROS generation,and calcium(Ca^(2+))content.Importantly,H_(2)O_(2)-activated production of ROS increased the protein expression of JUN,further resulting in IR in HepG2 cells.Taken together,we demonstrate that ROS/JUN is a common response pathway employed by HepG2 cells toward FFA-regulated IR. | Yaping Sun Jifeng Wang Xiaojing Guo Nali Zhu Lili Niu Xiang Ding Zhensheng Xie Xiulan Chen Fuquan Yang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 6 |
| 3 | Study on membrane fouling of submerged membrane bioreactor in treating bathing wastewater显示文摘A pilot-scale submerged membrane bioreactor (MBR) was used to treat the bathing wastewater for more than 90 d. Several factors affecting membrane fouling were studied, including the variation in transmembrane pressure (TMP), changes in extracellular polymeric substance (EPS), and distribution of membrane resistance (R). The relationships between R and EPS concentration were found to be R = 0.00008(EPSS)2.915 in the mixed liquor (EPSS) and R = 0.2853(EPSm) - 0.824 on the membrane surface (EPSm). The constant resistance of the clean membrane (Rm), the resistance due to concentration polarization (Rp), the cake layer resistance (Rc), and the resistance due to pore blocking (Ri), were 0.006%, 20.15%, 54.13%, and 25.72% of R, respectively. The results indicated that Rc had the greatest contribution to the total membrane resistance. The obtained membrane resistance model was R(t) = 4.609 × 108(1 + 0.01t)0.5. Molecular-based methods (polymerase chain reaction-denaturing gel gradient electrophoresis (PCR-DGGE) and ?uorescent in situ hybridization (FISH)) were used to study the bacteria attached on the membrane. The 16S rDNA gene sequence analysis suggested that certain phylogenetic group of bacteria, for example, Pseudomonas sp. and Nitrobacter sp., might have contributed to the formation of membrane on biofilms. | Jifeng GUO Jianfu ZHAO | 2008 | Journal of Environmental Sciences2008，20，10： | 6 |
| 4 | Correlation and analysis of well-log sequence with Milankovitch cycles as rulers: A case study of coal-bearing strata of late Permian in western Guizhou显示文摘Based on the well-logging data of typical wells of Zhijin,Panxian and Weining areas in western Guizhou,the well-logging data GR of late Permian coal-bearing strata were processed and wavelet transform technique was used to carry out the sequence stratigraphy division and correlation.The study mainly focuses on the controlling effects which Milankovitch had on high frequency sequence,Milankovitch cycle can be used as a ruler of sequence stratigraphy division and correlation to ensure the scientifcity and the unity of sequence stratigraphy division.According to well-logging signal of the ideal Milankovitch cycle,the corresponding relation between the wavelet scales and the cycles is determined by wavelet analysis.Through analyzing analog signals of subsequence sets to search the corresponding relation between various system tracts and the features of time-frequency,the internal features of wavelet transform scalogram could be made clearly.According to ideal model research,features of Milankovitch curves and wavelet spectrum can be seen clearly and each well can be classifed into four third-order sequences and two system tracts.At the same time Milankovitch cycle can realize the division and correlation of stratigraphic sequence in a quick and convenient way. | Yuan Xuexu Guo Yinghai Yu Jifeng Shen Yulin Shao Yubao | 2013 | International Journal of Mining Science and Technology2013，23，4： | 6 |
| 5 | A brief review of forensically important flesh flies (Diptera: Sarcophagidae)显示文摘Forensic entomology could provide valuable data for the minimum postmortem interval (PMImin) estimation and other relevant information,such as causes and circumstances of death.Some representatives of flesh flies are one of the dominant necrophagous insects during early stages of decomposition,demonstrating unique biological characteristics compared with other necrophagous flies.Moreover,they lead to global health concerns as carriers of various pathogenic micro-organisms,and dominantly result in the traumatic myiasis.Thus,sarcophagid flies are considered important in decomposition processes for PMImin estimation.However,the utility of sarcophagid flies has been seriously hampered by limited ecological,biological and taxonomic knowledge of them.The aim of this paper is to provide a brief review on the species,distribution and biological habit of forensically important sarcophagid flies.In addition,the relation between traumatic myiasis and flesh flies,molecular identification methods and developmental pattern of flesh flies are summarized. | Lipin Ren Yanjie Shang Wei Chen Fanming Meng Jifeng Cai Guanghui Zhu Lushi Chen Yong Wang Jianqiang Deng Yadong Guo | 2018 | Forensic Sciences Research2018，3，1： | 3 |
| 6 | PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis显示文摘In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson's disease(PD).However,difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous investigation of the in vivo role of PINK1.Here we report that PINK1 kinase form is selectively expressed in the human and monkey brains.CRISPR/Cas9-mediated deficiency of PINK1 causes similar neurodegeneration in the brains of fetal and adult monkeys as well as cultured monkey neurons without affecting mitochondrial protein expression and morphology.Importantly,PINK1 mutations in the primate brain and human cells reduce protein phosphorylation that is important for neuronal function and survival.Our findings suggest that PINK1 kinase activity rather than its mitochondrial function is essential for the neuronal survival in the primate brains and that its kinase dysfunction could be involved in the pathogenesis of PD. | Weili Yang Xiangyu Guo Zhuchi Tu Xiusheng Chen Rui Han Yanting Liu Sen Yan Qi Wang Zhifu Wang Xianxian Zhao Yunpeng Zhang Xin Xiong Huiming Yang Peng Yin Huida Wan Xingxing Chen Jifeng Guo Xiao-Xin Yan Lujian Liao Shihua Li Xiao-Jiang Li | 2022 | Protein & Cell2022，13，1： | 3 |
| 7 | An ethnobotanical study of forage plants in Zhuxi County in the Qinba mountainous area of central China显示文摘In the Qinba mountainous area of Central China,pig farming has a significant impact on the growth of the rural economy and has substantially increased farmer incomes.Traditional knowledge plays an important role in the selection of forage plant species for pig farming by local people.This study aimed to identify the forage plants used for pig feeding and to catalog indigenous knowledge regarding their use.During 2016 and 2017,ethnobotanical surveys and inventories were conducted in Zhuxi County,Hubei Province,China.Data were collected using semi-structured interviews,key informant reports,free listings,guided field walks,and participatory observations with 77 households in 16 villages in 13 towns/townships.The obtained data were analyzed using a relative frequency citation(RFC)index.Overall,145 wild forage plants from 91 genera and 31 families were recorded.The most cited families were Asteraceae,Polygonaceae,Urticaceae,Amaranthaceae,Fabaceae,Cruciferae,Caryophyllaceae,and Lamiaceae.Whole plants(75.9%)and tender leaves(12.4%)were the most frequently used parts of the plants.Most of the forage plants were herbaceous(88.9%).Almost all forage plants could be collected throughout the year(62.7%).Raw and cooked were the two main preparation methods.The most frequently cited species were Taraxacum mongolicum,Bidens pilosa,Sonchus oleraceus,Pilea verrucosa,and Pilea pumila var.obtusifolia.A total of 14 species were identified as the top forage plants in Zhuxi County based on their RFC values(RFC value greater than 0.5).Local people possess rich traditional knowledge about the utilization and management of forage plants for pig feeding.However,the maintenance of this traditional knowledge may be seriously threatened by changes in pig feeding modes and the lack of successors.Appropriate strategies and action plans have been suggested for the conservation of traditional knowledge associated with biodiversity and the sustainable use of forage species resources.These include 1)taking targeted measures to protect forage resources and associated traditional knowledge;2)strengthening research on the forage plants with the highest RFC values for nutritional value,digestibility,other functions,and ecological status;and 3)enhancing the identification of poisonous forage plants. | Jun Yang Jifeng Luo Qiliang Gan Leiyu Ke Fengming Zhang Hairu Guo Fuwei Zhao Yuehu Wang | 2021 | Plant Diversity2021，43，3： | 3 |
| 8 | Changes in Soil Enzyme Activity and Nutrient Content in Different Years of Continuous Cropping Tobacco Fields显示文摘In order to find out changes in the main fertility indicators of continuous cropping tobacco fields in Henan Province with years of continuous cropping,5 typical tobacco fields( Jia County,Shaoling District,Fangcheng County,Xiangcheng County,and Song County) were studied. Indicators in question included activity of main enzymes( sucrase,urease,catalase,and acid phosphatase),p H value,organic matters,total nitrogen,available phosphorus and available potassium. The results indicate that in most tobacco fields,the activity of sucrase and urease increased in two years of continuous cropping,later,it showed a declining trend with increase in years of continuous cropping; in some fields,it directly declined with increase in years of continuous cropping; the activity of catalase increased in two years of continuous cropping,later,it showed a declining trend with increase in years of continuous cropping,and it became stable after three years of continuous cropping;generally,the activity of acid phosphatase declined with increase in the years of continuous cropping within 3 years continuous cropping,later,it became stable. Except Fangcheng County,the soil p H value of other districts( counties) generally declined with increase in years of continuous cropping,and it was in the range of 5. 6-6. 8. With the increase in continuous cropping,the soil organic matters( SOM) in tobacco fields of Jia County and Song County declined,changes of SOM in tobacco fields of Fangcheng County and Xiangcheng County were not obvious,and SOM showed the trend of first decline then rise in Shaoling District. In most tobacco fields( Jia County,Xiangcheng County,and Song County),the total nitrogen showed a declining trend; in Shaoling District,it showed a trend of first decline then rise; in Fangcheng County,it showed a rising trend. The available phosphorus firstly slightly declined then rose in tobacco fields of Shaoling District and Song County; it showed a trend of first rise then decline in Jia County; there were no obvious changes in Fangcheng County and Xiangcheng County. Changes in the available potassium were different in tobacco fields. In sum,there are certain rules for changes in soil enzyme activity and nutrient content in tobacco fields in Henan Province,but changes are not completely the same. It is concluded that the site conditions and farming activities exert a certain influence on soil enzyme activity,p H value,organic matters,and nitrogen,phosphorus and potassium content. Therefore,to solve obstacles in continuous cropping of tobacco fields,different regions should take different measures. | Jifeng CHEN Hui SUN Yang XIA Kaixuan CAI Hongyuan LIU Yuanyuan LI Ruiliang GUO Bei HOU Shuai FENG Xiaoxin JIANG | 2017 | Asian Agricultural Research2017，9，5： | 2 |
| 9 | mRNA expression of Rho GTPase-related signaling molecules during rat hippocampal development显示文摘BACKGROUND:Rho GTPase family members have been shown to participate in neurite growth by regulating the neuronal cytoskeleton.However,there are very few reports of developmental roles of signaling molecules related to Rho GTPases. OBJECTIVE:To investigate messenger ribonucleic acid mRNA expression of signaling molecules associated with Rho GTPases,including Rho-A,Rac-1,collapsin response mediator protein 1(CRMP-1),and tubulin(53(Tubβ3) during rat hippocampus development. DESIGN,TIME AND SETTING:A non-randomized,controlled,animal experiment,based on different developmental stages of the rat hippocampus,was performed at the Guangdong Key Laboratory of Tissue Construction and Detection,Institute of Clinical Anatomy,Southern Medical University between December 2005 and July 2007. MATERIALS:Trizol reagent was purchased from Invitrogen,USA.RNA PCR kit(AMV) Ver 3.0 and 150 bp DNA Ladder Marker were purchased from TaKaRa,Japan.Unless otherwise specified,all other reagents were purchased from Sigma-Aldrich,USA. METHODS:Twenty-five Sprague Dawley rats were assigned to five groups(n = 5) according to developmental stages:embryonic(embryonic 15 days),neonatal(postnatal 5 days),juvenile (postnatal 1 month),adult(postnatal 3 months),and senile(postnatal 18 months). MAIN OUTCOME MEASURES:Detection of mRNA expression of Rho-A,Rac-1,CRMP-1,and Tubβ3 during various hippocampal developmental stages by reverse-transcription polymerase chain reaction. RESULTS:Hippocampal mRNA expression of Rho-A,as well as Rac-1,reached peak levels at embryonic,juvenile,and senile stages,and was relatively less during neonatal and adult stages. mRNA expression of Rac-1 was greater than Rho-A during each hippocampal developmental stage. CRMP-1 mRNA expression levels were as follows:embryonic>neonatal>juvenile>adultneonatal>juvenile>adult = senile. CONCLUSION:Rho-A and Rac-1 shared similar expression profiles,which demonstrated similar variations during the entire rat hippocampus developmental process.However,Rac-1 mRNA expression remained greater than Rho-A.Both CRMP-1 and Tubβ3 mRNA expression profiles gradually declined during hippocampal development from embryonic to adult stages.Tubβ3 mRNA expression arrested during the adult stage,and CRMP-1 mRNA expression increased during the senile stage. | Guoqing Guo Jifeng Zhang Li Xin Jing Chen Weizai Shen Lin Yuan Shizhen Zhong | 2009 | Neural Regeneration Research2009，4，10： | 2 |
| 10 | Adaptive control with saturation-constrainted observations for drag-free satellites——a set-valued identification approach显示文摘The high-accuracy drag-free control is one of the key technologies for gravity gradient satellites.Since the range of the gravity gradiometer is limited,the measurement is subject to the saturation constraint.This paper introduces a design method of the adaptive drag-free control law by employing the set-valued identification approach.By inserting several thresholds in the constrained interval,the output observation is transformed into the set-valued information under different thresholds,based on which and the weighted optimization technique the identification algorithm for the unknown parameter is constructed.The adaptive drag-free control law is designed via the certainty equivalence principle.It is shown that the identification algorithm is strongly convergent and the convergence rate of the estimation error is obtained.The performance of the closed-loop system is analyzed,and the asymptotic optimality of the adaptive controller is proved.The numerical simulation is included to verify the effectiveness of the main results. | Shuping TAN Jin GUO Yanlong ZHAO Jifeng ZHANG | 2021 | Science China(Information Sciences)2021，64，10： | 2 |
| 11 | Facet-dependent electrochemiluminescence spectrum of nanostructured ZnO显示文摘A facet-dependent electrochemiluminescence (ECL) behavior was found for nanostructured ZnO with different dominant exposing planes.The ECL spectrum of nanostructured ZnO was recorded by the emission scan mode with a fluorescence spectrometer and applied to investigate the difference of surface state for different crystal planes.Electronic structure calculations based on density functional theory were used to study the effect of crystal plane on the band structure and density of states.It revealed that the ECL emission was originated primarily from the recombination of electrons from Zn 4s and the hole from O 2p,which could be utilized to study the physical and chemical properties of surface structures of as-prepared nanostructured ZnO.A physical model was suggested to elucidate the differences of ECL spectra.A concept was proposed that the energy released as photons during ECL process of nanocrystalline semiconductor materials will be correlated with the energy level of active sites located at different crystal planes. | WANG Lei YUE QiaoLi LI HaiBo XU ShuLing GUO LianShun ZHANG XianXi WANG HuaiSheng GAO XueXi WANG WenJun LIU JiFeng LIU Peng | 2013 | Science China Chemistry2013，56，1： | 2 |
| 12 | Force and characteristics of hybrid transducer type ultrasonic motors显示文摘 | Guo Jifeng Gong transfer model shujuan Guo Haixun | 2004 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2004，51，4： | 1 |
| 13 | RNA interference blocking the apoptosis in HEK293 cells induced by overexpression of alpha-synuclein显示文摘BACKGROUND:Overexpression ofα-synuclein can induce cell apoptosis.RNA interference(RNAi) may block specific gene function and cause gene silencing. OBJECTIVE:To construct a specific and effective RNAi plasmid for theα-synuclein gene and investigate if RNAi can block apoptosis in HEK293 cells,induced by overexpression of wild-typeα-synuclein. DESIGN,TIME AND SETTING:A contrast experiment based on genetically engineered cytobiology was performed at the State Key Lab of Medical Genetics of China,Xiangya Medical College of Central South University,between October 2004 and October 2008. MATERIALS:HEK293 cells and pBSHH1 plasmid were provided by the State Key Lab of Medical Genetics of China;OligDNA sequence by Sagon Bioengineering Company,Shanghai; Lipofectamine 2000 by Invitrogen,USA;α-synuclein monoclonal antibody,Hoechst 33258,and MTT; by Sigma,USA;Horseradish peroxidase-coupled goat anti-rat IgG by KPL,USA;FACSan flow cytometry by BD,USA. METHODS:Four target sites were used to construct hairpin RNA pBSHH1 vectors-pSYNi-1, pSYNi-2,pSYNi-3 and pSYNi-4-which were cloned in the pBSHH1 plasmid.HEK293 cells were transfected using Lipofectamine 2000.In addition,a non-transfect group and a negative plasmid transfect group were established.The cultured HEK293 cells were processed as follows: transfection of blank plasmid(blank control group),transfection ofα-synuclein-pEGFP and RNAi negative vector(negative control group),and transfection ofα-synuclein-pEGFP and pSYNi-1 (transfection group).Cells in all groups were transfected with Lipofectamine 2000 for 48 hours. MAIN OUTCOME MEASURES:Expression ofα-synuclein mRNA and protein were detected by RT-PCR and Western blot.Cell morphology was observed under an inverted fluorescence microscope;cell viability was measured using MTT method;and cell apoptosis was determined with Annexin V-PE flow cytometry. RESULTS:α-synuclein mRNA and protein expressions were significantly decreased in the pSYNi-1 group when compared with the non-transfect and negative plasmid transfect groups(P<0.05).The expressions were partially decreased in the pSYNi-2 group,but there was no significant difference in the pSYNi-3 and pSYNi-4 groups.Hoechst staining indicated that cell nuclei were enlarged in the negative control group,coloring was not uniform,and chromatin was accumulated and appeared spot-like.The nucleus coloring was uniform in the transfection group compared to negative control group.Cell viability in the negative control group was significantly lower than blank control group with cell apoptosis being significantly increased(P<0.05).In comparison with negative control group, cell viability was significantly increased in the transfection group and cell apoptosis was significantly decreased(P<0.05). CONCLUSION:pSYNi-1 can inhibitα-synuclein gene expression and block apoptosis of HEK293 cells induced by overexpression of wild-typeα-synuclein. | Tao Chen Beisha Tang Xiaoping Liao Guoqiang Wen Xinxiang Yan Jifeng Guo Yuhu Zhang Feng Ouyang Zhigang Long Li Cao Jing Li | 2009 | Neural Regeneration Research2009，4，7： | 1 |
| 14 | Rapid fabrication of bonded diamond composite using the spark plasma sintering reaction synthesis method显示文摘 | Ma Yunchao Guo Jifeng Liang Baoyan | 2010 | Int J Refractory Metals Hard Mater2010，29，3： | 1 |
| 15 | Force transfer model and characteristics of hybrid transducer type ultrasonic motor 显示文摘 | Guo Jifeng Gong Shunjuan Guo Haisun | 2004 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2004，51，4： | 1 |
| 16 | Membrane fouling of hybrid submerged membrane bioreactor (hMBR) in treating municipal wastewater显示文摘 | Jifeng Guo Weisheng Guan Siqing Xia | 2014 | Desalination and Water Treatment2014，52，： | 1 |
| 17 | Contact mode and force transferring model of cylindrical ultrasonic motor with bending vibration mode显示文摘圆柱的超声的马达( CUSM )能广泛地在许多地例如里被使用激增并且集中照相机的系统,电的窗帘并且工作专注于的 MEMS.This 微司机单个点并且在定子和 rotor.which 之间的双点接触模式被理论证明, experiment.There 是预先迫使在单个点的模型是的批评 point.the 下面的 pre-pressure.When 的一个批评的点合适;否则双点模型是 appropriate.Then | WANG Jian GUO Jifeng | 2008 | Chinese Journal of Acoustics2008，27，4： | 1 |
| 18 | Wavelet denoising of well logs and its geological performance 显示文摘 | Yu Jifeng Guo Kai Yuan Xuexu | 2010 | Energy Exploration & Ex- ploitation2010，28，2： | 1 |
| 19 | Efficacy and safety of obinutuzumab for the first-line treatment of follicular lymphoma:a subgroup analysis of Chinese patients enrolled in the phase III GALLIUM study显示文摘Backgrounds:GALLIUM is a global phase Ⅲ study that demonstrated significant improvements in progression-free survival(PFS)for obinutuzumab plus chemotherapy(G-chemo)vs.rituximab plus chemotherapy(R-chemo)in previously untreated patients with follicular lymphoma(FL).This study aimed to report the results of a subgroup of patients in China.Methods:Patients were randomized to G-chemo or R-chemo.Responders received maintenance therapy for 2 years or until disease progression.The primary endpoint was investigator(INV)-assessed PFS.Secondary endpoints included the overall response rate(ORR)and complete response rate(CRR)at the end of induction chemotherapy,overall survival(OS),and safety.Results:Overall,58 patients with FL were randomized to the G-chemo(n=25)and R-chemo arms(n=33).The INV-assessed PFS rate at 3 years was 81.8%in the G-chemo arm,vs.70.2%in the R-chemo arm(hazard ratio 0.35;95%confidence interval:0.09-1.34;P=0.1120).The INV-assessed CRRs(without positron emission tomography[PET])in these arms were 24.0%and 21.2%,respectively,whereas the ORRs were 80.0%and 90.9%,respectively.INV-assessed CRR-PET was 52.6%in the G-chemo,vs.60.9%in the R-chemo.Median OS was not reached in either arm.Grade 3 to 5 adverse events were more frequent in the R-chemo arm(97.0%vs.88.0%).Conclusions:The results of this subgroup analysis were consistent with those of the global population,and they suggest that G-chemo has a positive benefit-risk profile in patients from China with FL.Trial registration:ClinicalTrials.gov,No.NCT01332968. | Xiaonan Hong Yuqin Song Yuankai Shi Qingyuan Zhang Wei Guo Gang Wu Junmin Li Jifeng Feng Anastasiia Kinkolykh Andrea Knapp Tongyu Lin | 2022 | Chinese Medical Journal2022，，4： | 1 |
| 20 | Sliding mode variable structure control for time-invariant linear time-delay singular uncertain system显示文摘 | Gao Cunchen Guo Jifeng | 2005 | Impulsive Dynamical Systems and Applications2005，3，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员