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| 1 | Molecular Cloning and Expression Analysis of the ζ-Carotene Desaturase Gene in Chinese kale(Brassica oleracea var.alboglabra Bailey)显示文摘ζ-Carotene desaturase(ZDS)is an important enzyme in carotenoid biosynthesis.Here,the Brassica oleracea var.alboglabra ZDS(Boa ZDS)gene was cloned from Chinese kale via reverse transcription-polymerase chain reaction(RT-PCR)and deposited in Gen Bank(accession number KY662297).The Boa ZDS gene contains an open reading frame of 1 686 bp that encodes a 561-amino acid protein.Sequence analysis indicates that the ZDS protein is apparently conserved during plant evolution and is most closely related to B.oleracea var.capitata and B.rapa.The promoter sequence of the Boa ZDS gene was predicted to harbor several cis-acting elements that are related to light and phytohormone responses.Semiquantitative RT-PCR analysis showed that Boa ZDS expression varied among different developmental stages and organs.Relative ZDS expression remained stable during germination and seedling stages and rapidly increased at the mature leaf stage.The leaves showed the highest ZDS expression levels compared to the other organs.ZDS expression decreased in all flower tissues during blooming.The fused protein of Boa ZDS was obtained by prokaryotic expression.Heterologous expression of Boa ZDS in Escherichia coli confirmed that Boa ZDS encodes a functionalζ-carotene desaturase that increases β-carotene accumulation in E.coli cells harboring a β-carotene-producing plasmid.The findings of the present study provide a molecular basis for the elucidation of ZDS gene function in Chinese kale. | SUN Bo ZHANG Fen XUE Shengling CHANG Jiaqi ZHENG Aihong JIANG Min MIAO Huiying WANG Qiaomei TANG Haoru | 2018 | Horticultural Plant Journal2018，4，3： | 10 |
| 2 | CH4/N2 separation on methane molecules grade diameter channel molecular sieves with a CHA-type structure显示文摘Samples of methane molecules grade diameter channel CHA-type molecular sieves(Chabazite-K, SAPO-34 and SSZ-13) were investigated using the adsorption separation of CH4/N2 mixtures. The isotherms recorded for CH4 and N2 follow a typical type-Ι behavior, which were fitted well with the Sips model(R2>0.999) and the selectivity was calculated using IAST theory. The results reveal that Chabazite-K has the highest selectivity(SCH4/N= 5.5).2 SSZ-13 has the largest capacity, which can adsorb up to a maximum of 30.957 cm3·g-1(STP) of CH4, due to it having the largest pore volume and surface area, but the lowest selectivity(SCH4/N2= 2.5). From the breakthrough test, we can conclude that SSZ-13 may be a suitable candidate for the recovery of CH4 from low concentration methane(CH4<20%) based on its larger pore volume and higher CH4 capacity. Chabazite-K is more suited to the separation of high concentration methane(CH4>50%) due to its higher selectivity. | Hua Shang Yuping Li Jiaqi Liu Xuan Tang Jiangfeng Yang Jinping Li | 2019 | Chinese Journal of Chemical Engineering2019，27，5： | 8 |
| 3 | Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation显示文摘Severe acute pancreatitis-associated acute lung injury(SAP-ALI) is a serious disease associated with high mortality. Emodin has been applied to alleviate SAP-ALI;however, the mechanism remains unclear. We report that the therapeutic role of emodin in attenuating SAP-ALI is partly dependent on an exosomal mechanism. SAP rats had increased levels of plasma exosomes with altered protein contents compared to the sham rats. These infused plasma exosomes tended to accumulate in the lungs and promoted the hyper-activation of alveolar macrophages and inflammatory damage. Conversely,emodin treatment decreased the plasma/pancreatic exosome levels in the SAP rats. Emodin-primed exosomes showed less pro-inflammatory effects in alveolar macrophages and lung tissues than SAP exosomes. In detail, emodin-primed exosomes suppressed the NF-κB pathway to reduce the activation of alveolar macrophage and ameliorate lung inflammation by regulating PPARγ pathway, while these effects were amplified/abolished by PPARγ agonist/antagonist. Blockage of pancreatic acinar cell exosome biogenesis also exhibited suppression of alveolar macrophage activation and reduction of lung inflammation. This study suggests a vital role of exosomes in participating inflammation-associated organ-injury,and indicates emodin can attenuate SAP-ALI by reducing the pancreatic exosome-mediated alveolar macrophage activation. | Qian Hu Jiaqi Yao Xiajia Wu Juan Li Guixiang Li Wenfu Tang Jingping Liu Meihua Wan | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 7 |
| 4 | Effects of cerium incorporation on the catalytic oxidation of benzene over flame-made perovskite La_(1-x)Ce_xMnO_3 catalysts显示文摘Perovskite-type La_(1-x)Ce_xMnO_3(x = 0-10%) catalysts were prepared by flame spray pyrolysis and their activities during the catalytic oxidation of benzene were examined over the temperature range of100-450℃.The structural properties and reducibility of these materials were also characterized by X-ray diffraction(XRD),N_2 adsorption/desorption,H_2 temperature-programmed reduction(H_2-TPR) and X-ray photoelectron spectroscopy(XPS).The incorporation of Ce was found to improve the benzene oxidation activity,and the perovskite in which x was 0.1 exhibited the highest activity.Phase composition and surface elemental analyses indicated that non-stoichiometric compounds were present.The incorporation of Ce had a negligible effect on the specific surface area of the perovskites and hence this factor has little impact on the catalytic activity.Introduction of Ce4^(4+) resulted in modification of the chemical states of both B-site ions and oxygen species and facilitated the reducibility of the perovskite.The surface Mn^(4+)/Mn^(3+)ratio was increased as a result of Ce^(4+) substitution,while a decrease in the surface-adsorbed O/lattice O(O_(ads)/O_(latt)) ratio was observed.The relationship between the surface elemental ratios and catalytic activity was established to allow a better understanding of the process by which benzene is oxidized over perovskites. | Gang Liu Jiaqi Li Kun Yang Wenxiang Tang Haidi Liu Jun Yang Renliang Yue Yunfa Chen | 2015 | Particuology2015，13，2： | 6 |
| 5 | Study of real-time LWD data visual interpretation and geo-steering technology显示文摘LWD(logging while drilling) data has been used to explore complex subtle reservoirs by realtime visual interpretation and geo-steering.The method comprises of computer communication,well log data processing,formation recognition,reservoir modeling and model updating in real time.We studied the key technologies related to real-time LWD data visual interpretation and geo-steering and developed computer software with Chinese intellectual property rights covering the following important aspects: 1) real-time computer communication of well site LWD data;2) visualization of geological model and borehole information;3) real-time interpretation of LWD data;4) real-time geological model updating and geo-steering technology.We use field application examples to demonstrate the feasibility and validity of the proposed technologies. | Shao Cairui Zhang Fuming Chen Guoxing Ji Jiaqi Hou Qinggong Tang Jianhong Cao Xianjun | 2013 | Petroleum Science2013，10，4： | 6 |
| 6 | OsMKKK70 regulates grain size and leaf angle in rice through the OsMKK4-OsMAPK6-OsWRKY53 signaling pathway显示文摘Grain size and leaf angle are key agronomic traits that determine final yields in rice.However,the underlying molecular mechanisms are not well understood.Here we demonstrate that the Oryza sativa Mitogen Activated Protein Kinase Kinase Kinase OsMKKK70 regulates grain size and leaf angle in rice.Overexpressing OsMKKK70 caused plants to produce longer seeds.The osmkkk62/70 double mutant and the osmkkk55/62/70 triple mutant displayed significantly smaller seeds and a more erect leaf angle compared to the wild type,indicating that OsMKKK70 functions redundantly with its homologs Os MKKK62 and Os MKKK55.Biochemical analysis demonstrated that OsMKKK70 is an active kinase and that OsMKKK70 interacts with Os MKK4 and promotes Os MAPK6 phosphorylation.In addition,the osmkkk62/70 double mutant showed reduced sensitivity to Brassinosteroids(BRs).Finally,overexpressing constitutively active Os MKK4,Os MAPK6,and Os WRKY53 can partially complement the smaller seed size,erect leaf,and BR hyposensitivity of the osmkkk62/70 double mutant.Taken together,these findings suggest that OsMKKK70 might regulate grain size and leaf angle in rice by activating Os MAPK6 and that OsMKKK70,Os MKK4,Os MAPK6,and Os WRKY53 function in a common signaling pathway that controls grain shape and leaf angle. | Zhiqi Liu Enyang Mei Xiaojie Tian Mingliang He Jiaqi Tang Min Xu Jiali Liu Lu Song Xiufeng Li Zhenyu Wang Qingjie Guan Qijiang Xu Qingyun Bu | 2021 | Journal of Integrative Plant Biology2021，63，12： | 6 |
| 7 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 8 | Disproportionate Increase of New Diagnosis of HIV/AIDS Infection by Sex and Age--China, 2007−2018显示文摘What is already known about this topic?The annual rates of newly diagnosed HIV/AIDS among total population is increasing in China,yet HIV/AIDS in older adults has received little attention.What is added by this report?The overall rates of new diagnosis of HIV/AIDS per 100,000 populations increased 3.26 and 2.18 times among male and female in all ages from 2007 to 2018,respectively.Among adults aged≥60 years,the rate increased 10.41 times(1.35 to 14.06 per 100,000)from 2007 to 2018.Male adults aged 60–69 and 70–79 years and female aged 50–59 and 60–69 years had the highest increasing rates among all groups.What are the implications for public health practice?This study highlights the need to strengthen HIV/AIDS prevention among older adults.Health education and other effective measurements might be used to prevent HIV/AIDS among this group. | Yewu Zhang Chang Cai Xiaofeng Wang Yanfei Li Houlin Tang Jiaqi Ma | 2020 | China CDC weekly2020，2，5： | 5 |
| 9 | Enzyme-electrolytic degradation of dichloromethane: Efficiency, kinetics and mechanism显示文摘Enzymatic electrolysis cell(EEC)has advantages over microbial electrolysis cell(MEC)due to the needless of microbe inoculation and high-efficiency of enzymatic reaction.In this study,an EEC was first applied to achieve the effective degradation of halogenated organic pollutants and dichloromethane(CH2Cl2)was utilized as a model pollutant.The results indicate that the degradation efficiency of CH2Cl2 after 2 hr reaction in the EEC was almost100%,which was significantly higher than that with enzyme(51.1%)or current(19.0%).The current induced the continuous regeneration of reduced glutathione(GSH),thus CH2Cl2 was degraded under the catalysis of GSH-dependent dehalogenase through stepwise dechlorination,and successively formed monochloromethane(CH3Cl)and methane(CH4).The kinetic result shows that with a current of 15 mA,the maximum specific degradation rate of CH2Cl2(3.77×10-3 hr-1)was increased by 5.7 times.The optimum condition for CH2Cl2 dechlorination was also obtained with pH,current and temperature of 7.0,15 mA and 35°C,respectively.Importantly,this study helps to understand the behavior of enzymes and the fate of halogenated organic pollutants with EEC,providing a possible treatment technology for halogenated organic pollutants. | Jianming Yu Meng Wu Yuwei Tang Jiaqi Shi Jun Hu Zhiliang Yu Jianmeng Chen | 2019 | Journal of Environmental Sciences2019，31，12： | 3 |
| 10 | Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair显示文摘Over 300 billion of cells die every day in the human body,producing a large number of endogenous apoptotic extracellular vesicles(apoEVs).Also,allogenic stem cell transplantation,a commonly used therapeutic approach in current clinical practice,generates exogenous apoEVs.It is well known that phagocytic cells engulf and digest apoEVs to maintain the body’s homeostasis.In this study,we show that a fraction of exogenous apoEVs is metabolized in the integumentary skin and hair follicles.Mechanistically,apoEVs activate the Wnt/β-catenin pathway to facilitate their metabolism in a wave-like pattern.The migration of apoEVs is enhanced by treadmill exercise and inhibited by tail suspension,which is associated with the mechanical force-regulated expression of DKK1 in circulation.Furthermore,we show that exogenous apoEVs promote wound healing and hair growth via activation of Wnt/β-catenin pathway in skin and hair follicle mesenchymal stem cells.This study reveals a previously unrecognized metabolic pathway of apoEVs and opens a new avenue for exploring apoEV-based therapy for skin and hair disorders. | Lan Ma Chider Chen Dawei Liu Zhiqing Huang Jiaqi Li Haixiang Liu Ryan Tsz Kin Kwok Benzhong Tang Bingdong Sui Xiao Zhang Jianxia Tang Xueli Mao Weiying Huang Songtao Shi Xiaoxing Kou | 2023 | Bioactive Materials2023，，1： | 3 |
| 11 | Oryza sativa mediator subunit OsMED25 interacts with OsBZR1 to regulate brassinosteroid signaling and plant architecture in rice显示文摘Brassinosteroids(BRs)are plant-specific steroid hormones which regulate plant growth,development,and adaptation.Transcriptional regulation plays key roles in plant hormone signaling.A mediator can serve as a bridge between gene-specific transcription factors and the RNA polymerase machinery,functioning as an essential component in regulating the transcriptional process.However,whether a mediator is involved in BR signaling is unknown.Here,we discovered that Oryza sativa mediator subunit 25(Os MED25)is an important regulator of rice BR signaling.Phenotypic analyses showed that the Os MED25-RNAi and osmed25 mutant presented erect leaves,as observed in BR-deficient mutants.In addition,the Os MED25-RNAi and osmed25 mutant exhibited decreased BR sensitivity.Genetic analysis indicated that Os MED25-RNAi could suppress the enhanced BR signaling phenotype of Osbzr1-D.Further biochemical analysis showed that Os MED25 interacts with Os BZR1 in vivo,and Os MED25 is enriched on the promoter of Os BZR1 target genes.RNA sequencing analysis indicated that Os MED25 affects the expression of approximately 45%of Os BZR1-regulated genes and mainly functions as a corepressor of Os BZR1.Together,these findings revealed that Os MED25 regulates rice BR signaling by interacting with Os BZR1 and modulating the expression of Os BZR1 target genes,thus expanding our understanding of the roles of mediators in plant hormone signaling. | Yuekun Ren Xiaojie Tian Shuyu Li Enyang Mei Mingliang He Jiaqi Tang Min Xu Xiufeng Li Zhenyu Wang Chuanyou Li Qingyun Bu | 2020 | Journal of Integrative Plant Biology2020，62，6： | 3 |
| 12 | Quantitation of HBV covalently closed circular DNA in micro formalin fixed paraffin-embedded liver tissue using rolling circle amplification in combination with real-time PCR显示文摘 | Yanwei Zhong Jiaqi Han Zhengsheng Zou Shuhong Liu Bo Tang Xiaoqiang Ren Xiaodong Li Yulai Zhao Yan Liu Dongqing Zhou Weijie Li Jingmin Zhao Dongping Xu | 2011 | Clinica Chimica Acta2011，，21： | 2 |
| 13 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://gffzz4a3adbfa122d4a47hcfw06nubko5v6bfp.ffgz.tsg.suse.edu.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 14 | Flow reconstructions and aerodynamic shape optimization of turbomachinery blades by POD-based hybrid models显示文摘This study presented a hybrid model method based on proper orthogonal decomposition(POD) for flow field reconstructions and aerodynamic design optimization. The POD basis modes have better description performance in a system space compared to the widely used semi-empirical basis functions because they are obtained through singular value decomposition of the system.Instead of the widely used linear regression, nonlinear regression methods are used in the function response of the coefficients of POD basis modes. Moreover, an adaptive Latin hypercube design method with improved space filling and correlation based on a multi-objective optimization approach was employed to supply the necessary samples. Prior to design optimization, the response performance of POD-based hybrid models was first investigated and validated through flow reconstructions of both single-and multiple blade rows. Then, an inverse design was performed to approach a given spanwise flow turning distribution at the outlet of a turbine blade by changing the spanwise stagger angle, based on the hybrid model method. Finally, the span wise blade sweep of a transonic compressor rotor and the spanwise stagger angle of the stator blade of a single low-speed compressor stage were modified to reduce the flow losses with the constraints of mass flow rate, total pressure ratio, and outlet flow turning.The results are presented in detail, demonstrating the good response performance of POD-based hybrid models on missing data reconstructions and the effectiveness of POD-based hybrid model method in aerodynamic design optimization. | LUO JiaQi ZHU YaLu TANG Xiao LIU Feng | 2017 | Science China(Technological Sciences)2017，60，11： | 2 |
| 15 | bZIP71 delays flowering by suppressing Ehd1 expression in rice显示文摘Flowering time is a fundamental factor determining the global distribution and final yield of rice(Oryza sativa).Although diverse flowering time genes have been reported in this crop,the transcriptional regulation of its key flowering genes are poorly understood.Here,we report that a basic leucine zipper transcription factor,bZIP71,functions as a flowering repressor.The overexpression of bZIP71 delays flowering,while the bzip71 mutant flowers early in both long-day and short-day conditions.A genetic analysis showed that the regulation of flowering by bZIP71 might be independent of Heading date 2(Hd2),Hd4,and Hd5.Importantly,bZIP71 directly associates with the Early heading date 1(Ehd1)promoter and represses its transcription,and genetically the function of bZIP71 is impaired in the ehd1 mutant.Moreover,bZIP71 interacts with major components of polycomb repressive complex 2(PRC2),SET domain group protein 711(SDG711),and Fertilization independent endosperm 2(FIE2),through which bZIP71 regulates the H3K27me3 level of Ehd1.Taken together,we present a transcriptional regulatory mechanism in which bZIP71 enhances the H3K27me3 level of Ehd1 and transcriptionally represses its expression,which not only offers a novel insight into a flowering pathway,but also provides a valuable putative target for the genetic engineering and breeding of elite rice cultivars. | Xiufeng Li Xiaojie Tian Mingliang He Xinxin Liu Zhiyong Li Jiaqi Tang Enyang Mei Min Xu Yingxiang Liu Zhenyu Wang Qingjie Guan Wei Meng Jun Fang Jian Zhang Qingyun Bu | 2022 | Journal of Integrative Plant Biology2022，64，7： | 2 |
| 16 | Zeolite templated carbon nanodots for broadband ultrafast pulsed fiber laser generation显示文摘Carbon nanodots(C-dots) with a uniform size of about 2 nm are synthesized via in situ pyrolysis of n-propylamine that is confined in the nanochannels of zeolite Linde Type A(LTA). The as-synthesized C-dots@LTA composite shows nonlinear optical saturable absorption properties in a broad wavelength band and can be used as saturable absorber(SA) to generate ultrafast pulsed fiber lasers. By inserting a zeolite LTA single crystal hosting C-dots into the fiber laser cavity, mode-locked fiber lasers with long-term operation stability at 1.5 μm and 1 μm are achieved. These results show that the C-dots@LTA are a promising SA material for ultrafast pulsed fiber laser generation in a broad wavelength band. To the best of our knowledge, this is the first demonstration of a C-dots@LTA-based mode-locked fiber laser. | XINTONG XU JIAQI CHEN WENTAO SHI DALIN SUN SHAOWEN CHU LANG SUN WENFEI ZHANG YANPING CHEN JIANPANG ZHAI SHUANGCHEN RUAN ZIKANG TANG | 2019 | Photonics Research2019，7，10： | 2 |
| 17 | New Maikhanellid Shells and Siphogonuchitid Spicule Bundles from the Cambrian Fortunian Stage of South China显示文摘Maikhanellids are a distinct group of Cambrian Fortunian small shelly fossils by the capshaped profiles and scaly shell ornamentation.According to the individual shell shape and ornamentation feature types of 50 maikhanellids fossils which were collected from Xixiang botia,we confirmed the family Maikhanellidae content of six genera,which are Maikhanella,Ramenta,Purella,Ramentoides,Yunnannopleura and Mediata.Unlike the halkieriid animals whose shells and spicules are articulated on different body parts,maikhanellids were presumably yielded by siphogonuchitid spicules penetrating the intermediate matrix(the 'spicule shell' hypothesis),and this is the reason that some researchers treated maikhanellids and co-occurring siphogonuchitids as synonyms.The affinities of Maikhanellids and siphogonuchitids remain debatable.Here,we report three dimensionally phosphatized maikhanellid shells and siphogonuchitid spicule bundles from the Cambrian Fortunian small shell faunas of South China.They differ from all the previously reported maikhanellids and siphogonuchitids,and may represent new types.The intact and smooth surface underneath the partially preserved scales of the shells challenges the 'spicule-shell' hypothesis.The present siphogonuchitid spicules differ from the maikhanellid scales in size,morphology,and.arrangement pattern,thus the spicules might not be derived from the shells.Whether the shells and spicule bundles were articulated on different body parts of the same animals remains unknown. | LIU Yunhuan ZHANG Yanan SHAO Tiequan TANG Hanhua JIANG Kaituo WANG Qi CHEN Cheng DONG Junyan LIANG Yongchun DAI Jun XUE Jiaqi | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 2 |
| 18 | Streptococcal Toxic Shock Syndrome Caused by Streptococcus suis Serotype 2 显示文摘 | Jiaqi Tang Changjun Wang Youjun Feng | 2006 | PLoS Med2006，3，5： | 1 |
| 19 | Orally administered BZL-s RNA-20 oligonucleotide targeting TLR4 effectively ameliorates acute lung injury in mice显示文摘The global COVID-19 pandemic emerged at the end of December 2019.Acute respiratory distress syndrome(ARDS)and acute lung injury(ALI)are common lethal outcomes of bacterial lipopolysaccharide(LPS),avian influenza virus,and SARS-Co V-2.Toll-like receptor 4(TLR4)is a key target in the pathological pathway of ARDS and ALI.Previous studies have reported that herbal small RNAs(s RNAs)are a functional medical component.BZL-s RNA-20(Accession number:B59471456;Family ID:F2201.Q001979.B11)is a potent inhibitor of Toll-like receptor 4(TLR4)and pro-inflammatory cytokines.Furthermore,BZLs RNA-20 reduces intracellular levels of cytokines induced by lipoteichoic acid(LTA)and polyinosinic-polycytidylic acid(poly(I:C)).We found that BZL-s RNA-20 rescued the viability of cells infected with avian influenza H5N1,SARS-Co V-2,and several of its variants of concern(VOCs).Acute lung injury induced by LPS and SARS-Co V-2 in mice was significantly ameliorated by the oral medical decoctosome mimic(bencaosome;sphinganine(d22:0)+BZL-s RNA-20).Our findings suggest that BZLs RNA-20 could be a pan-anti-ARDS/ALI drug. | Dandan Zhao Yuhao Qin Jiaqi Liu Kegong Tang Shuaiyao Lu Zirui Liu Yexuan Lin Cong Zhang Fengming Huang Jiahui Chang Chang Li Mingyao Tian Yiming Ma Xiaoyun Li Congzhao Zhou Xiao Li Xiaozhong Peng Ningyi Jin Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 20 | Milk fat chemical composition of yak breeds in China显示文摘 | Shenghua He Ying Ma Jiaqi Wang Qiming Li Xin Yang Shanhu Tang Haimei Li | 2010 | Journal of Food Composition and Analysis2010，，2： | 1 |
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