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| 1 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis显示文摘 | Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang | 2015 | Cell Research2015，25，8： | 323 |
| 2 | Expansion of Rural Construction in Suburbs of Beijing:A Case Study on Nanjuan Village of Shunyi显示文摘1. Background Today the rural land use in China calls for major concerns. Villages in suburban areas, due to their special location, are experiencing dramatic changes on | ZHANG Yue,PhD,Associate Professor,School of Architecture,Tsinghua University,Beijing,P. R. China. CAO Wen,Undergraduate,School of Architecture,Tsinghua University,Beijing,P. R. China. ZHANG Lu,Undergraduate,School of Architecture,Tsinghua University,Beijing,P. R. China. LAN Weijie,Undergraduate,School of Architecture,Tsinghua University,Beijing,P. R. China. | 2007 | China City Planning Review2007，16，4： | 34 |
| 3 | Single-photon computational 3D imaging at 45 km显示文摘Single-photon light detection and ranging(lidar)offers single-photon sensitivity and picosecond timing resolution,which is desirable for high-precision three-dimensional(3 D)imaging over long distances.Despite important progress,further extending the imaging range presents enormous challenges because only a few echo photons return and are mixed with strong noise.Here,we tackled these challenges by constructing a high-efficiency,low-noise coaxial single-photon lidar system and developing a long-range-tailored computational algorithm that provides high photon efficiency and good noise tolerance.Using this technique,we experimentally demonstrated active single-photon 3 D imaging at a distance of up to 45 km in an urban environment,with a low return-signal level of^1 photon per pixel.Our system is feasible for imaging at a few hundreds of kilometers by refining the setup,and thus represents a step towards low-power and high-resolution lidar over extra-long ranges. | ZHENG-PING LI XIN HUANG YUAN CAO BIN WANG YU-HUAI LI WEIJIE JIN CHAO YU JUN ZHANG QIANG ZHANG CHENG-ZHI PENG FEIHU XU AND JIAN-WEI PAN | 2020 | Photonics Research2020，8，9： | 24 |
| 4 | Blockchain technology:development and prospects显示文摘It has been more than 10 years since Satoshi Nakamoto published his famous paper entitled 'Bitcoin: a peer-to-peer electronic cash system', which set the foundation of blockchain technology. Accompanied by the price volatility of bitcoins from 2017 to 2018, blockchain has been a hot word on the internet, and particularly hot in China. Blockchain offers a distributed and secure system for data storage and value transactions. Its applications are springing up in multiple fields.The Chinese government is considering these trends with great caution. Initial coin offering has been banned in China since September 2017. By contrast, an official white paper on China s blockchain technology, which was released in May 2018, said that blockchain technology will be widely applied in the real economy of China within 3 years. In a recent panel discussion held by National Science Review, experts talked about related topics. Their opinions may provide a quick view of the future development of blockchain in China and abroad. | Weijie Zhao | 2019 | National Science Review2019，6，2： | 13 |
| 5 | Recent developments in nanofiltration membranes based on nanomaterials显示文摘Nanofiltration membranes are the core elements for nanofiltration process. The chemical structures and physical properties of nanofiltration membranes determine water permeability, solute selectivity, mechanical/thermal stability, and antifouling properties, which greatly influence the separation efficiency and operation cost in nanofiltration applications. In recent years, a great progress has been made in the development of high performance nanofiltration membranes based on nanomaterials. Considering the increasing interest in this field, this paper reviews the recent studies on the nanofiltration membranes comprising various nanomaterials, including the metal and metal oxide nanoparticles, carbon-based nanomaterials, metal–organic frameworks(MOFs), water channel proteins, and organic micro/nanoparticles. Finally, a perspective is given on the further exploitation of advanced nanomaterials and novel strategy for fabricating nano-based nanofiltration membranes. Moreover,the development of precision instruments and simulation techniques is necessary for the characterization of membrane microstructure and investigation of the separation and antifouling mechanism of nanofiltration membranes prepared with nanomaterials. | Yanli Ji Weijie Qian Yawei Yu Quanfu An Lifen Liu Yong Zhou Congjie Gao | 2017 | Chinese Journal of Chemical Engineering2017，25，11： | 12 |
| 6 | Comprehensive analysis of NAC transcription factors in diploid Gossypium: sequence conservation and expression analysis uncover their roles during fiber development显示文摘Determining how function evolves following gene duplication is necessary for understanding gene expansion.Transcription factors(TFs)are a class of proteins that regulate gene expression by binding to specific cis-acting elements in the promoters of target genes,subsequently activating or repressing their transcription.In the present study,we systematically examined the functional diversification of the NAC transcription factor(NAC-TFs)family by analyzing their chromosomal location,structure,phylogeny,and expression pattern in Gossypium raimondii(Gr)and G.arboreum(Ga).The 145 and 141 NAC genes identified in the Gr and Ga genomes,respectively,were annotated and divided into 18 subfamilies,which showed distinct divergence in gene structure and expression patterns during fiber development.In addition,when the functional parameters were examined,clear divergence was observed within tandem clusters,which suggested that subfunctionalization had occurred among duplicate genes.The expression patterns of homologous gene pairs also changed,suggestive of the diversification of gene function during the evolution of diploid cotton.These findings provide insights into the mechanisms underlying the functional differentiation of duplicated NAC-TFs genes in two diploid cotton species. | Haihong Shang Zhongna Wang Changsong Zou Zhen Zhang Weijie Li Junwen Li Yuzhen Shi Wankui Gong Tingting Chen Aiying Liu Juwu Gong Qun Ge Youlu Yuan | 2016 | Science China(Life Sciences)2016，59，2： | 12 |
| 7 | Genetic diversity analysis of spawner and recaptured populations of Chinese shrimp(Fenneropenaeus chinensis)during stock enhancement in the Bohai Bay based on an SSR marker显示文摘Eight microsatellite markers were used to analyze genetic diversity, level of inbreeding, and effective population size of spawner and recaptured populations of Chinese shrimp(Fenneropenaeus chinensis) during stock enhancement in the Bohai Bay in 2013. A total of 254 and 238 alleles were identified in the spawner and recaptured populations, respectively, and the numbers of alleles(N_a) were 8–63 and 6–60, respectively. The numbers of effective alleles(N_e) were 2.52–21.60 and 2.67–20.72, respectively. The polymorphism information content ranged from 0.529 to 0.952. The observed heterozygosity(H_o) values(0.638–0.910 and 0.712–0.927) were lower than the expected heterozygosity(H_e) values(0.603–0.954 and 0.625–0.952), which indicated that the two populations possessed a rich genetic diversity. In 16 tests(2 populations×8 loci), 13 tests deviated from the HardyWeinberg equilibrium. F_(is) values were positive at seven loci and the inbreeding coefficients(F) of the two populations estimated by trio ML were 13.234% and 11.603%, suggesting that there was a relatively high degree of inbreeding. A certain level of inbreeding depression had occurred in the Chinese shrimp population. F_(st) values ranged from 0 to 0.059, with a mean of 0.028, displaying a low level of genetic differentiation in the two populations. Effective population sizes(3 060.2 and 3 842.8) were higher than the minimum number suggested for retaining the evolutionary potential to adapt to new environmental conditions. For enhancement activity in 2014,the ideal number of captured shrimp spawners should have ranged from 7 686 to 19 214 to maintain genetic diversity and effective population size. Further strategies to adjust the balance of economic cost, fishing effort and ideal number of shrimp spawners to maintain a satisfactory effective population size for ensuring the sustainability of Chinese shrimp are proposed. | WANG Mosang WANG Weiji XIAO Guangxia LIU Kefeng HU Yulong TIAN Tao KONG Jie JIN Xianshi | 2016 | Acta Oceanologica Sinica2016，35，8： | 11 |
| 8 | Prognostic Significance of Tumor-infiltrating CD8^+ or CD3^+ T Lymphocytes and Interleukin-2 Expression in Radically Resected Non-small Cell Lung Cancer显示文摘 | Chuntao Tian Shixin Lu Qingxia Fan Weijie Zhang Shunchang Jiao Xiao Zhao Zhiyong Wu Liang Sun Liuxing Wang | 2015 | Chinese Medical Journal2015，，1： | 11 |
| 9 | SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stabilityviathe PI3K/AKT/GSK3β signaling pathway显示文摘Objective:The tyrosine phosphatase SHP2 has a dual role in cancer initiation and progression in a tissue type-dependent manner.Several studies have linked SHP2 to the aggressive behavior of breast cancer cells and poorer outcomes in people with cancer.Nevertheless,the mechanistic details of how SHP2 promotes breast cancer progression remain largely undefined.Methods:The relationship between SHP2 expression and the prognosis of patients with breast cancer was investigated by using the TCGA and GEO databases.The expression of SHP2 in breast cancer tissues was analyzed by immunohistochemistry.CRISPR/Cas9 technology was used to generate SHP2-knockout breast cancer cells.Cell-counting kit-8,colony formation,cell cycle,and EdU incorporation assays,as well as a tumor xenograft model were used to examine the function of SHP2 in breast cancer proliferation.Quantitative RT-PCR,western blotting,immunofluorescence staining,and ubiquitination assays were used to explore the molecular mechanism through which SHP2 regulates breast cancer proliferation.Results:High SHP2 expression is correlated with poor prognosis in patients with breast cancer.SHP2 is required for the proliferation of breast cancer cellsin vitro and tumor growthin vivo through regulation of Cyclin D1 abundance,thereby accelerating cell cycle progression.Notably,SHP2 modulates the ubiquitin–proteasome-dependent degradation of Cyclin D1viathe PI3K/AKT/GSK3βsignaling pathway.SHP2 knockout attenuates the activation of PI3K/AKT signaling and causes the dephosphorylation and resultant activation of GSK3β.GSK3βthen mediates phosphorylation of Cyclin D1 at threonine 286,thereby promoting the translocation of Cyclin D1 from the nucleus to the cytoplasm and facilitating Cyclin D1 degradation through the ubiquitin–proteasome system.Conclusions:Our study uncovered the mechanism through which SHP2 regulates breast cancer proliferation.SHP2 may therefore potentially serve as a therapeutic target for breast cancer. | Yue Yuan Yanling Fan Zicong Gao Xuan Sun He Zhang Zhiyong Wang Yanfen Cui Weijie Song Zhaosong Wang Fei Zhang Ruifang Niu | 2020 | Cancer Biology & Medicine2020，17，3： | 11 |
| 10 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 11 | Principle and simulation of coherent interference suppression by a three-sensor array显示文摘The Principles of coherent interference suppression are presented by a three-sensor array. The formulae of extracting expected signals from strong interference are derived. The selection of sensor space is discussed and then relationships between the space and frequency point, at which the signals can be extracted, are given. When expected signals are band- limit, the conditions of the selected sensor space, which should be satisfied, are given. Lastly, Performance of interference suppression is analyzed when the amplitude of interference power spectra of signals Received by three sensors fluctuates, and the expressions of relative error of the extracted signals and processing gain are derived. The theoretical and simulation results show that signals can be extracted from strong background interference without any information about signals and interference expect for the arriving direction of signals, that the space between sensors should be smaller than half wavelength of upper limit freqency when the expected signals are band-limit, and that performance of extracting signals will decline with the increase of fluctuation of interference spectrum amplitude. | ZHU weijie, SUN Jincai, SUN Yiyuan (Institute of Acoustic Engineering, Northwestern Polytechnical University Xi’an 710072) | 2002 | Chinese Journal of Acoustics2002，21，2： | 10 |
| 12 | Efficient adiabatic silicon-on-insulator waveguide taper显示文摘A silicon-on-insulator-based adiabatic waveguide taper with a high coupling efficiency and small footprint is presented.The taper was designed to reduce the incidence of mode conversion to higher-order and radiation modes inside the waveguide.In connecting a 0.5-μm-wide output waveguide and a 12-μm-wide input waveguide of a grating coupler,a compact 120-μm-long taper was demonstrated,achieving a transmission of 98.3%.Previously,this transmission level could only be achieved using a conventional linear taper with a length of more than 300μm. | Yunfei Fu Tong Ye Weijie Tang Tao Chu | 2014 | Photonics Research2014，2，3： | 10 |
| 13 | Parameter estimation of sinusoidal signals by using principle of signal matched-phase显示文摘A method for estimating frequency, amplitude and phase of a sinusoidal signal is presented based on the principle of signal matched-phase. The formulae for estimating signal parameters are derived, and the algorithm of searching for signal parameters is also given in the case where the signal frequency is unknown. The algorithm is simple and time_saving. The simulation results show that this new method is valid. | ZHU Weijie , SUN Yiyuan, SUN Jincai and LI Zhishun(College of Marine Engineering, Northwestern Polytechnical University, Xi’an 710072, China) | 2002 | Progress in Natural Science:Materials International2002，12，4： | 10 |
| 14 | Grinding force and surface quality in creep feed profile grinding of turbine blade root of nickel-based superalloy with microcrystalline alumina abrasive wheels显示文摘Creep feed profile grinding of the fir-tree blade root forms of single crystal nickel-based superalloy was conducted using microcrystalline alumina abrasive wheels in the present study. The grinding force and the surface quality in terms of surface topography, subsurface microstructure,microhardness and residual stress obtained under different grinding conditions were evaluated comparatively. Experimental results indicated that the grinding force was influenced significantly by the competing predominance between the grinding parameters and the cross-sectional root workpiece profile. In addition, the root workpiece surface, including the root peak and valley regions, was produced with the large difference in surface quality due to the nonuniform grinding loads along the root workpiece profile in normal section. Detailed results showed that the surface roughness, subsurface plastic deformation and work hardening level of the root valley region were higher by up to25%, 20% and 7% in average than those obtained in the root peak region, respectively, in the current investigation. Finally, the superior parameters were recommended in the creep feed profile grinding of the fir-tree blade root forms. This study is helpful to provide industry guidance to optimize the machining process for the high-valued parts with complicated profiles. | Qing MIAO Wenfeng DING Weijie KUANG Changyong YANG | 2021 | Chinese Journal of Aeronautics2021，34，2： | 10 |
| 15 | MiR-33a suppresses breast cancer cell proliferation and metastasis by targeting ADAM9 and ROS1显示文摘MicroRNAs (miRNAs ) 是由指向多重 mRNAs 的定序明确地在基因表示的 post-transcriptional 规定有一个枢轴的角色的小 noncoding RNA。尽管 miR-33a 最近被报导在类脂化合物动态平衡,动脉粥样硬化,和肝的纤维变性起一个重要作用,在肿瘤前进和转移的 miR-33a 的功能大部分是未知的。这里,我们发现在乳癌纸巾的 downregulated miR-33a 与淋巴节点转移相关。MiR-33a 表示比 noncancerous 胸在高度变形的乳癌房间线是显著地更低的上皮的房间和非变形的乳癌房间。而且,在变形乳癌细胞的 miR-33a 的 overexpression 显著地减少在 vitro 并且显著地的细胞增长和侵略在 vivo 禁止肿瘤生长和肺转移,而它的在非变形的乳癌细胞击倒显著地在 vitro 提高细胞增长和侵略并且在 vivo 支持肿瘤生长和肺转移。联合生物信息学预言和生物化学的分析,我们证明 ADAM9 和 ROS1 是 miR-33a 的直接下游的目标。这些调查结果作为乳癌房间增长和转移的一个否定管理者识别了 miR-33a。 | Chuankai Zhang Yunda Zhang Weiji Ding Yancheng Lin Zhengjie Huang Qi Luo | 2015 | Protein & Cell2015，6，12： | 10 |
| 16 | High-speed flowing plasmas in the Earth’s plasma sheet显示文摘A research topic of great interest to the space physics community is the observation of plasmas flowing at hundreds of kilometers per second in the Earth’s plasma sheet. Although considerable effort has been made to understand the source of fast-flowing plasmas, many questions remain unanswered about the mechanisms that produce high-speed flows and the effects they have on magnetospheric disturbances, especially their contributions to magnetospheric convection and substorms. In this paper, we discuss briefly the history of high-speed flows and review the proposed mechanisms, signatures of high-speed flows in auroras and their interaction with the background plasma. We then summarize the relationships between high-speed flows and magnetic structures, discuss questions associated with substorms, and finally pose several important scientific questions that need to be addressed. | FU SuiYan SHI QuanQi WANG Chi PARKS George ZHENG Ling ZHENG Hao SUN WeiJie | 2011 | Chinese Science Bulletin2011，56，12： | 9 |
| 17 | On the Similarity Parameter Between Two Targets for the Case of Multi-Look Polarimetric SAR显示文摘 | AN Wentao ZHANG Weijie YANG Jian HONG Wen CAO Fang | 2009 | Chinese Journal of Electronics2009，18，3： | 9 |
| 18 | Superior mesenteric venous thrombosis after laparoscopic radical resection of rectal cancer: a report of a rare case and literature review显示文摘Mesenteric venous thrombosis(MVT) is rare, but life-threatening. MVT is often characterized by occult and nonspecific signs and symptoms. Diagnosis requires a high index of clinical suspicion, and emergency surgery is necessary to optimize patient survival, especially in people aged more than 70 years. MVT is a rare but fatal complication after laparoscopic radical surgery for rectal cancer. This study reports a case of extensive intestinal ischemic infarction caused by acute MVT after laparoscopic radical surgery for rectal cancer in a 70-year-old male. | Xinliang Jin Weijie Xue Yixiu Wang Qinkai Xue Zhiqi Gong Yongke Liu Zhaojian Niu Chengzhan Zhu | 2018 | Oncology and Translational Medicine2018，4，6： | 9 |
| 19 | Sirt1-ROS-TRAF6 Signaling-Induced Pyroptosis Contributes to Early Injury in Ischemic Mice显示文摘Stroke is an acute cerebro-vascular disease with high incidence and poor prognosis,most commonly ischemic in nature.In recent years,increasing attention has been paid to inflammatory reactions as symptoms of a stroke.However,the role of inflammation in stroke and its underlying mechanisms require exploration.In this study,we evaluated the inflammatory reactions induced by acute ischemia and found that pyroptosis occurred after acute ischemia both in vivo and in vitro,as determined by interleukin-1β,apoptosis-associated speck-like protein,and caspase-1.The early inflammation resulted in irreversible ischemic injury,indicating that it deserves thorough investigation.Meanwhile,acute ischemia decreased the Sirtuin 1(Sirtl)protein levels,and increased the TRAF6(TNF receptor associated factor 6)protein and reactive oxygen species(ROS)levels.In further exploration,both Sirtl suppression and TRAF6 activation were found to contribute to this pyroptosis.Reduced Sirtl levels were responsible for the production of ROS and increased TRAF6 protein levels after ischemic exposure.Moreover,N-acetyl-L-cysteine,an ROS scavenger,suppressed the TRAF6 accumulation induced by oxygen-glucose deprivation via suppression of ROS bursts.These phenomena indicate that Sirtl is upstream of ROS,and ROS bursts result in increased TRAF6 levels.Further,the activation of Sirtl during the period of ischemia reduced ischemiainduced injury after 72 h of reperfusion in mice with middle cerebral artery occlusion.In sum,these results indicate that pyroptosis-dependent machinery contributes to the neural injury during acute ischemia via the Sirt1-ROS-TRAF6 signaling pathway.We propose that inflammatory reactions occur soon after oxidative stress and are detrimental to neuronal survival;this provides a promising therapeutic target against ischemic injuries such as a stroke. | Weijie Yan Wei Sun Jiahui Fan Haiqing Wang Song Han Junfa Li Yanling Yin | 2020 | Neuroscience Bulletin2020，36，8： | 9 |
| 20 | Wavelength Dispersion Analysis on Fiber-Optic Raman Distributed Temperature Sensor System显示文摘 | Weijie WANG Jun CHANG Guangping LV Zongliang WANG Zhi LIU Sha LUO Shuo JIANG Xiangzhi LIU Xiaohui LIU Yongning LIU | 2013 | Photonic Sensors2013，3，3： | 9 |
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