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| 1 | Sensitivity analysis of glacier systems to climate warming in China显示文摘在在这篇论文使用的中国的 44 个冰河系统的数据从中国冰河库存被获得,气象学的数据从西方中国的高原的气象学的地图集被得到。基于统计分析和功能的模型 | WANG Xin XIE Zichu LI Qiaoyuan WANG Shuhong CHENG Lei | 2008 | Journal of Geographical Sciences2008，18，2： | 24 |
| 2 | Factors Affecting Sensory Quality of Cooked japonica Rice显示文摘The sensory quality of cooked rice is an important factor in determining its market price, as well as consumer acceptance and breeding efforts aimed at improvement of rice grain quality. In this study,the sensory quality and physicochemical properties of three japonica rice varieties harvested in two different growing locations(Xiangshui and Hangzhou of China) were compared to determine the most important factors affecting the sensory quality. All the three varieties had higher scores for overall sensory quality in Xiangshui than in Hangzhou, indicating that the growing location is a key factor in determining the sensory quality of cooked japonica rice. In addition to growing location, variety(genotype) also had an important effect. Longdao 18 scored the highest for overall sensory quality in the two locations, whereas Longdao 30 had the lowest score in Xiangshui, and both Longdao 20 and Longdao 30 had the lowest scores in Hangzhou. Many physicochemical properties, such as apparent amylose content, protein content, thermal properties and free amino acid contents, showed significant differences between the two locations. Correlation analysis showed that apparent amylose content and protein content had contrasting effects on all the sensory attributes. The overall sensory quality was negatively correlated with protein content(r =-0.89, P < 0.01) and positively correlated with gel hardness(r = 0.91, P < 0.01),indicating that the protein content and hardness are important physicochemical properties for predicting the sensory quality of japonica rice. These findings will provide guidance for selection from the diverse genotypes available to develop new varieties with the desired eating and cooking quality. | XU Yanjie YING Yining OUYANG Shuhong DUAN Xiaoliang SUN Hui JIANG Shukun SUN Shichen BAO Jinsong | 2018 | Rice science2018，25，6： | 23 |
| 3 | PIV measurement on internal instantaneous flows of a centrifugal pump显示文摘In this paper,the internal flow field in a centrifugal pump working at the design flow rate operating condition has been measured using the particle image velocimetry(PIV)technique with the fluorescent particles and the index-matched fluid technology.The index-marching fluid with the same refractive index as the transparent material has been prepared and applied in the present test of pump with geometrical complex walls.The comparison between velocity distributions of PIV results both with and without fluorescent particles,as well as with and without index-marching fluid are conducted to find the differences.The DES(Detached Eddy Simulation)has been employed to calculate the three-dimensional unsteady turbulent flow in the pump to examine and to certify the PIV measurement results.The DES results of instantaneous flow velocity fields agree with PIV test results with fluorescent particles and index-marching fluid.It is necessary to perform the PIV measurement of pumps with fluorescent seeds and index-marching fluid in order to get exact results.The experimental results show the distributions of velocity,steamlines,and the principal Reynolds normal stress(PRNS)and the principal Reynolds shear stress(PRSS). | WU YuLin LIU ShuHong YUAN HuiJing SHAO Jie | 2011 | Science China(Technological Sciences)2011，54，2： | 20 |
| 4 | An optimization method on runner blades in bulb turbine based on CFD analysis显示文摘In this paper an optimization method of the runner blades in a bulb turbine based on CFD analysis is proposed.In the method the main scales of the turbine including guide vane,runner and draft are maintained.Only the runner blades are modified based on the present method.In the optimization method the runner blade is expressed by spline surface with a gather of coordinate points.The B-spline curve is used to keep the modified blades smooth.In order to make the blade optimization simple and ef- ficient,one of the coordinates is fixed and only the angles of the points are changed according to different modification purposes.Three main optimization principles based on flow diagnosis are presented here.These three principles are all based on the CFD analysis of the internal flow in bulb turbine.For the purpose of method verification,the optimization method is used in a model bulb turbine.A three dimensional steady turbulent computation is carried out through the whole passage including the bulb body,guide vanes,runner and draft tube of the bulb turbine under seven different work conditions.An SST k-ωturbulence model is used during the CFD analysis and the performance of the turbine can be achieved.The runner blade is optimized according to the three optimization principles based on flow diagnosis.The CFD analysis is conducted again on the optimized turbine and another modification is needed if the new turbine can’t satisfy the required performance.Comparison of the computational results between the original turbine and an optimized one indicates that the optimization method is practical and does improve the performance of the bulb turbine. | YANG Wei WU YuLin LIU ShuHong | 2011 | Science China(Technological Sciences)2011，54，2： | 15 |
| 5 | Estimation of carbon sinks in chemical weathering in a humid subtropical mountainous basin显示文摘The fluvial geochemistry of the mainstream and tributaries of the Zengjiang River was investigated,and the mass balance approach and deduction methods were used to estimate the uptake of atmospheric CO2 through rock chemical weathering.The results showed that the chemical runoff mainly consisted of HCO3-,Ca2+,Na+,and dissolved Si,and that silicate mineral weathering was significant,but carbonate mineral weathering was a minor source of dissolved loads in the Zengjiang River basin because of the low amount of interlayered carbonate rock strata in the catchment.The ion composition indicated that atmospheric CO2 was the primary erosive agent for rock chemical weathering in the Zengjiang River basin.The CO2 consumption fluxes caused by rock chemical weathering were(3.50-3.81) × 105 mol km-2 a-1,which is just lower than that in tropical and subtropical basalt and carbonate regions,and is much higher than that in temperate and cold-temperate regions,indicating that surficial chemical weathering processes in the humid and hot monsoon current influencing the low-middle latitude zone of the Northern Hemisphere constitutes a significant carbon sink in the global biogeochemical cycle. | TAO Zhen GAO QuanZhou WANG ZhenGang ZHANG ShengHua XIE ChenJi LIN PeiSong RUAN XiaoBing LI ShuHong MAO HaiRuo | 2011 | Chinese Science Bulletin2011，56，35： | 15 |
| 6 | Machine learning in materials genome initiative:A review显示文摘Discovering new materials with excellent performance is a hot issue in the materials genome initiative.Traditional experiments and calculations often waste large amounts of time and money and are also limited by various conditions. Therefore, it is imperative to develop a new method to accelerate the discovery and design of new materials. In recent years, material discovery and design methods using machine learning have attracted much attention from material experts and have made some progress. This review first outlines available materials database and material data analytics tools and then elaborates on the machine learning algorithms used in materials science. Next, the field of application of machine learning in materials science is summarized, focusing on the aspects of structure determination, performance prediction, fingerprint prediction, and new material discovery. Finally, the review points out the problems of data and machine learning in materials science and points to future research. Using machine learning algorithms, the authors hope to achieve amazing results in material discovery and design. | Yingli Liu Chen Niu Zhuo Wang Yong Gan Yan Zhu Shuhong Sun Tao Shen | 2020 | Journal of Materials Science & Technology2020，54，22： | 15 |
| 7 | Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism显示文摘Periodontitis is caused by host immune-inflammatory response to bacterial insult.A high proportion of proinflammatory macrophages to anti-inflammatory macrophages leads to the pathogenesis of periodontitis.As stem cell-derived exosomes can modulate macrophage phenotype,dental pulp stem cell-derived exosomes(DPSC-Exo)can effectively treat periodontitis.In this study,we demonstrated that DPSC-Exo-incorporated chitosan hydrogel(DPSC-Exo/CS)can accelerate the healing of alveolar bone and the periodontal epithelium in mice with periodontitis.Gene Ontology(GO)term enrichment analysis showed that treatment with DPSC-Exo/CS ameliorated periodontal lesion by suppressing periodontal inflammation and modulating the immune response.Specifically,DPSC-Exo/CS facilitated macrophages to convert from a pro-inflammatory phenotype to an anti-inflammatory phenotype in the periodontium of mice with periodontitis,the mechanism of which could be associated with miR-1246 in DPSC-Exo.These results not only shed light on the therapeutic mechanism of DPSCExo/CS but also provide the basis for developing an effective therapeutic approach for periodontitis. | Zongshan Shen Shuhong Kuang Yong Zhang Mingmei Yang Wei Qin Xuetao Shi Zhengmei Lin | 2020 | Bioactive Materials2020，5，4： | 14 |
| 8 | Mild hypothermia combined with a scaffold of Ng Rsilenced neural stem cells/Schwann cells to treat spinal cord injury显示文摘Because the inhibition of Nogo proteins can promote neurite growth and nerve cell differentiation, a cell-scaffold complex seeded with Nogo receptor(Ng R)-silenced neural stem cells and Schwann cells may be able to improve the microenvironment for spinal cord injury repair. Previous studies have found that mild hypothermia helps to attenuate secondary damage in the spinal cord and exerts a neuroprotective effect. Here, we constructed a cell-scaffold complex consisting of a poly(D,L-lactide-co-glycolic acid)(PLGA) scaffold seeded with Ng R-silenced neural stem cells and Schwann cells, and determined the effects of mild hypothermia combined with the cell-scaffold complexes on the spinal cord hemi-transection injury in the T9 segment in rats. Compared with the PLGA group and the Ng R-silencing cells + PLGA group, hindlimb motor function and nerve electrophysiological function were clearly improved, pathological changes in the injured spinal cord were attenuated, and the number of surviving cells and nerve fibers were increased in the group treated with the Ng R-silenced cell scaffold + mild hypothermia at 34°C for 6 hours. Furthermore, fewer pathological changes to the injured spinal cord and more surviving cells and nerve fibers were found after mild hypothermia therapy than in injuries not treated with mild hypothermia. These experimental results indicate that mild hypothermia combined with Ng R gene-silenced cells in a PLGA scaffold may be an effective therapy for treating spinal cord injury. | Dong Wang Jinhua Liang Jianjun Zhang Shuhong Liu Wenwen Sun | 2014 | Neural Regeneration Research2014，9，24： | 12 |
| 9 | Neuroprotective effects of Ginkgo biloba extract and GinkgoUde B against oxygen-glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model显示文摘 | Xiaohan Yang Tiezheng Zheng Hao Hong Nan Cai Xiaofeng Zhou Changkai Sun Liying Wu Shuhong Liu Yongqi Zhao Lingling Zhu Ming Fan Xuezhong Zhou Fengxie Jin | 2018 | Frontiers of Medicine2018，12，3： | 12 |
| 10 | rMVP: A Memory-efficient, Visualization-enhanced, and Parallel-accelerated Tool for Genome-wide Association Study显示文摘Along with the develoipment of high-throughput sequencing technologies,both sample size and SNP number are increasing rapidly in genome-wide association studies(GWAS),and the associated computation is more challenging than ever.Here,we present a memory-efficient,visualization-enhanced,and parallel-accelerated R package called“r MVP”to address the need for improved GWAS computation.r MVP can 1)effectively process large GWAS data,2)rapidly evaluate population structure,3)efficiently estimate variance components by Efficient Mixed-Model Association e Xpedited(EMMAX),Factored Spectrally Transformed Linear Mixed Models(Fa ST-LMM),and Haseman-Elston(HE)regression algorithms,4)implement parallel-accelerated association tests of markers using general linear model(GLM),mixed linear model(MLM),and fixed and random model circulating probability unification(Farm CPU)methods,5)compute fast with a globally efficient design in the GWAS processes,and 6)generate various visualizations of GWASrelated information.Accelerated by block matrix multiplication strategy and multiple threads,the association test methods embedded in r MVP are significantly faster than PLINK,GEMMA,and Farm CPU_pkg.r MVP is freely available at http://gffzz188fe103f8f1460asnupx0fovbocw6bu5.ffgz.tsg.suse.edu.cn/xiaolei-lab/r MVP. | Lilin Yin Haohao Zhang Zhenshuang Tang Jingya Xu Dong Yin Zhiwu Zhang Xiaohui Yuan Mengjin Zhu Shuhong Zhao Xinyun Li Xiaolei Liu | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 12 |
| 11 | Multiscale carbon foam confining single iron atoms for efficient electrocatalytic CO2 reduction to CO显示文摘Electrocatalytic CO2 reduction to CO is a sustainable process for energy conversion.However,this process is still hindered by the diffusi limited mass transfer,low electrical conductivity and catalytic activity.Therefore,new strategies for catalyst design should be adopted to solve these problems and improve the electrocatalytic performa nee for CO production.Herein,we report a multiscale carb on foam confining〔single iron atoms prepared with the assistant of S1O2 template.The pore-enriched environment at the macro-scale facilitates the diffusion of reacta nts and products.The graphe ne nano sheets at the nano-scale promote the charge tran sfer duri ng the reaction.The single iron atoms con fined in carb on matrix at the atomic-scale provide the active sites for electrocatalytic CO2 reductio n to CO.The optimized catalyst achieves a CO Faradaic efficiency of 94.9%at a moderate potential of-0.5 V vs.RHE.Furthermore,the performance can be maintained over 60 hours due to the stable single iron atoms coordi nated with four n itroge n atoms in the carb on matrix.This work provides a promising strategy to improve both the activity and stability of single atom catalysts for electrocatalytic CO2 reduction to CO. | Zheng Zhang Chao Ma Yunchuan Tu Rui Si Jie Wei Shuhong Zhang Zhen Wang Jian-Feng Li Ye Wang Dehui Deng | 2019 | Nano Research2019，12，9： | 11 |
| 12 | Quantitative calculation for the dissipated energy of fault rock burst based on gradient-dependent plasticity显示文摘The capacity of energy absorption by fault bands after rock burst was calculated quantitatively according to shear stressshear deformation curves considering the interactions and interplaying among microstructures due to the heterogeneity of strain softening rock materials. The post-peak stiffness of rock specimens subjected to direct shear was derived strictly based on gradientdependent plasticity, which can not be obtained from the classical elastoplastic theory. Analytical solutions for the dissipated energy of rock burst were proposed whether the slope of the post-peak shear stress-shear deformation curve is positive or not. The analytical solutions show that shear stress level, confining pressure, shear strength, brittleness, strain rate and heterogeneity of rock materials have important influence on the dissipated energy. The larger value of the dissipated energy means that the capacity of energy dissipation in the form of shear bands is superior and a lower magnitude of rock burst is expected under the condition of the same work done by external shear force. The possibility of rock burst is reduced for a lower softening modulus or a larger thickness of shear bands. | Xuebin Wang Shuhong Dai Long Hai Department of Mechanics and Engineering Sciences, Liaoning Technical University, Fuxin 123000, China | 2004 | Journal of University of Science and Technology Beijing2004，11，3： | 11 |
| 13 | Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells显示文摘声音的刺猬(嘘) 小径在正常胚胎开始和 carcinogenesis 起一个关键作用,但是它在与 5 氟尿嘧啶(5-FU ) 对待的癌症房间的功能仍然保持未知。我们检验了表明小径基因的嘘的一个子集的表示,包括嘘, SMO, PTC1,苏(Fu ) 和在人的 hepatocellular 癌(HCC ) 的臀部房间线, Hep3BandHepG2,由反向的抄写聚合酶链反应与 5-FU 对待。用尝试平底锅蓝色分析, 3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyltetrazoliumbromide 试金和终端 deoxynucleotidyl 调停 transferase 的 digoxigenin-dUTP 刻痕结束标记试金,我们也检测了源于表示向量与 5-FU 治疗相结合的 pCS2-Glil 的 transfection 的 Hep3B 房间的 apoptosis。房间的活动性被擦伤创伤闭合试金检测。在 5-FU 对待的 Hep3B 房间的 PTC1 蛋白质的细胞的地点也是的表示和潜水艇由西方的污点分析和免疫调查了荧光灯的显微镜学。结果显示在送信人 RNA 和蛋白质层次的嘘小径目标分子的表示在与 5-FU 对待的 Hep3B 房间是显然下面调整的。过去图形用户界面的表示恢复房间生存能力并且到某程度,移植能力由 5-FU 禁止了。而且, 5-FU 处理影响潜水艇 PTC1 蛋白质的细胞的本地化,在嘘发信号的一个关键成员小径。我们的数据证明表明小径活动的嘘的下面规定在激活刺猬的 HCC 房间线涉及 5-FU-induced apoptosis 和活动性的抑制。这暗示表明小径禁止者和 5-FU-based 化疗的嘘的联合可能对 HCC 代表更有希望的策略。 | Qiyu Wang Shuhong Huang Ling Yang Ling Zhao Yuxia Yin Zhongzhen Liu Zheyu Chen Hongwei Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 10 |
| 14 | Cytocompatibility with osteogenic cells and enhanced in vivo anti-infection potential of quaternized chitosan-loaded titania nanotubes显示文摘Infection is one of the major causes of failure of orthopedic implants. Our previous study demonstrated that nanotube modification of the implant surface, together with nanotubes loaded with quaternized chitosan(hydroxypropyltrimethyl ammonium chloride chitosan, HACC), could effectively inhibit bacterial adherence and biofilm formation in vitro. Therefore, the aim of this study was to further investigate the in vitro cytocompatibility with osteogenic cells and the in vivo anti-infection activity of titanium implants with HACC-loaded nanotubes(NT-H). The titanium implant(Ti), nanotubes without polymer loading(NT), and nanotubes loaded with chitosan(NT-C) were fabricated and served as controls. Firstly, we evaluated the cytocompatibility of these specimens with human bone marrow-derived mesenchymal stem cells in vitro.The observation of cell attachment, proliferation, spreading, and viability in vitro showed that NT-H has improved osteogenic activity compared with Ti and NT-C. A prophylaxis rat model with implantation in the femoral medullary cavity and inoculation with methicillin-resistant Staphylococcus aureus was established and evaluated by radiographical, microbiological, and histopathological assessments. Our in vivo study demonstrated that NT-H coatings exhibited significant anti-infection capability compared with the Ti and NT-C groups. In conclusion, HACC-loaded nanotubes fabricated on a titanium substrate show good compatibility with osteogenic cells and enhanced anti-infection ability in vivo, providing a good foundation for clinical application to combat orthopedic implant-associated infections. | Ying Yang Haiyong Ao Yugang Wang Wentao Lin Shengbing Yang Shuhong Zhang Zhifeng Yu Tingting Tang | 2016 | Bone Research2016，4，3： | 9 |
| 15 | Numerical simulation of pressure fluctuation in Kaplan turbine显示文摘As it is almost impossible to carry out the prototype hydro-turbine experiment be- fore the power plant is built up, rational prediction of pressure fluctuations in the prototype turbine is very important at the design stage. From this viewpoint, we at first treated the unsteady turbulent flow computation based on the modified RNG k-ε turbulence model through the whole flow passage to simulate the pressure fluctuation in a model turbine. Since fair agreement was recognized between the numerical results and the experimental data, this numerical method was applied to simulate the pressure fluctuations in the prototype turbine. From the comparison of them with the model turbine results, it is seen that their qualitative trend of pres- sure fluctuations are similar, but an appreciable difference is observed between the amplitudes of pressure fluctuation of the prototype turbine and that of the model turbine. Though the present findings may be explained by the effect of Reynolds number, further studies are expected for quantitative interpretation. We paid atten- tion to the interaction between the fluid and turbine structure. Adopting a weak fluid-solid coupling method, we studied the pressure fluctuation in the prototype turbine to clarify how the elastic behavior of runner blades influenced the charac- teristics of pressure fluctuation. | LIU ShuHong SHAO Jie WU ShangFeng WU YuLin | 2008 | Science China(Technological Sciences)2008，51，8： | 9 |
| 16 | Catastrophe Model of Steam Flow Excitation Vibration in Steam Turbine Governing Stage显示文摘汽流激振是影响大型汽轮机组安全运行的主要故障之一。根据突变理论、非线性振动理论以及流体动力学,从机理分析的角度出发,对汽轮机调节级在部分进汽下导致的汽流激振突变性能进行了定量分析。建立了部分进汽情况下调节级气流激振力模型,以及考虑汽流激振力的调节级非线性动力学模型,通过基于突变理论的推导,得到了调节级汽流激振的尖点突变流形和分岔集,确定了系统汽流激振突变的影响因子,讨论了振幅突变与影响因子的相关性,划分了系统工作的突变区域。最后,利用数值计算方法对汽流激振的幅值响应进行了分析,分析结果验证了基于突变理论的汽流激振突变分析方法的正确性。研究成果为汽轮机汽流激振突变性能的研究提供了一条新的途径。 | LI Jianlan GUO Xuhong YU Chen HUANG Shuhong | 2013 | 中国电机工程学报2013，33，11： | 8 |
| 17 | Analytical Solutions of Cracks Emanating from an Elliptic Hole in an Infinite Plate under Tension显示文摘It is a common phenomenon that the cracks originating from a hole can cause structural damage in engineering.However,the fracture mechanics studies of hole edge crack problems are not sufficient.The problem of an elliptical hole with two collinear edge cracks of unequal length in an infinite plate under uniform tension at infinity is investigated.Based on the complex variable method,the analytical solutions of stress functions and stress intensity factors are provided.The stress distribution along the axes and the edge of the elliptical hole is given graphically.The numerical results show that there is obvious stress concentration near the hole and cracks,and the stresses tend to applied loads at distances far from the defect,which conform to Saint-Venant’s principle.Hence,the stress functions are proved to be right.Under special conditions,the present configuration becomes the Griffith crack,two symmetrical cracks emanating from an elliptical hole,two cracks of unequal length emanating from a circular hole,a crack at the edge of a circular hole,or a crack emanating from an elliptical hole.Compared with available results,stress intensity factors for these special shapes of ellipses and cracks show good coincidence.The stress intensity factor for two cracks of unequal length at the edge of an elliptical hole increases with the crack length and the major-to-minor axis ratio of the elliptical hole.The stress distribution in an infinite plate containing an elliptic hole with unsymmetrical cracks is given for the first time. | LIU Shuhong DUAN Shijie | 2014 | Chinese Journal of Mechanical Engineering2014，27，5： | 8 |
| 18 | Abundance and community of snow bacteria from three glaciers in the Tibetan Plateau显示文摘Bacterial abundance and diversity in snow of East Rongbuk,Laohugou and Hailuogou glaciers on the Tibetan Plateau were investigated through epifluorescence microscope and denaturing gradient gel electrophoresis.Cell abundance ranged from 4.0 × 10 3 to 290.2 × 10 3 cells/mL.The phylogenetic trees placed the 16S rRNA sequences in four major groups:Proteobacteria,Firmicutes,Actinobacteria and Bacteroidetes.Brevundimonas,Flavobacterium,Hymenobacter,Bacillus,Polaromonas,Rhodoferax and Streptomyces were widely distributed bacteria in glaciers from different cold regions.The remaining five genera of Hylemonella,Delftia,Zoogloea,Blastococcus and Rhodococcus were endemism,only recovered from our investigated glaciers.It is proposed that the three glaciers on the Tibetan Plateau provide a specific ecological niche for prolonging survival of diverse microbial lineages. | Shuhong Zhang Guangli Yang Yetang Wang Shugui Hou | 2010 | Journal of Environmental Sciences2010，22，9： | 7 |
| 19 | Exact Solutions for Piezoelectric Materials with an Elliptic Hole or a Crack under Uniform Internal Pressure显示文摘The existing investigations on piezoelectric materials containing an elliptic hole or a crack mainly focus on remote uniform tensile loads.In order to have a better understanding for the fracture behavior of piezoelectric materials under different loading conditions,theoretical and numerical solutions are presented for an elliptic hole or a crack in transversely isotropic piezoelectric materials subjected to uniform internal pressure and remote electro-mechanical loads.On the basis of the complex variable approach,analytical solutions of the elastic and electric fields inside and outside the defect are derived by satisfying permeable electric boundary condition at the surface of the elliptical hole.As an example of PZT-4 ceramics,numerical results of electro-elastic fields inside and outside the crack under various electric boundary conditions and electro-mechanical loads are given,and graphs of the electro-elastic fields in the vicinity of the crack tip are presented.The non-singular term is compared to the asymptotic one in the figures.It is shown that the dielectric constant of the air in the crack has no effect on the electric displacement component perpendicular to the crack,and the stresses in the piezoelectric material depend on the material properties and the mechanical loads on the crack surface and at infinity,but not on the electric loads at infinity.The figures obtained are strikingly similar to the available results.Unlike the existing work,the existence of electric fields inside an elliptic hole or a crack is considered,and the piezoelectric solid is subjected to complicated electro-mechanical loads. | LIU Shuhong SHEN Yingming LIU Jinxi | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 7 |
| 20 | Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties显示文摘Diabetes-associated periodontitis(DP)aggravates diabetic complications and increases mortality from diabetes.DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult.In this study,we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related to DP.Moreover,inhibition of CCL2 by oral administration of bindarit reduced alveolar bone loss and increased periodontal epithelial thickness by suppressing periodontal inflammation.Furthermore,bindarit suppressed the infiltration of proinflammatory monocytes and altered the inflammatory properties of macrophages in the diabetic periodontium.This finding provides a basis for the development of an effective therapeutic approach for treating DP. | Zongshan Shen Shuhong Kuang Min Zhang Xin Huang Jiayao Chen Meiliang Guan Wei Qin Hockin H.K.Xu Zhengmei Lin | 2021 | Cellular & Molecular Immunology2021，18，9： | 6 |
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