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| 1 | Deformation Forecasting of Huangtupo Riverside Landslide in the Case of Frequent Microseisms显示文摘Ever since the impoundment of Three Gorges Reservoir(TGR), the seismicity in head region of TGR has increased significantly. Coupled with wide fluctuation of water level each year, it becomes more important to study the deformation forecasting of landslides beside TGR. As a famous active landslide beside TGR, Huangtupo riverside landslide is selected for a case study. Based on long term water level fluctuation and seismic monitoring, three typical adverse conditions are determined. With the established 3D numerical landslide model, seepage-dynamic coupling calculation is conducted under the seismic intensity of V degree. Results are as follows: 1. the dynamic water pressure formed by water level fluctuation will intensify the deformation of landslide; 2. under seismic load, the dynamic hysteresis is significant in defective geological bodies, such as weak layer and slip zone soil, because of much higher damping ratios, the seismic accelerate would be amplified in these elements; 3. microseisms are not intense enough to cause the landslide instability suddenly, but long term deformation accumulation effect of landslide should be paid more attention; 4. in numerical simulation, the factors of unbalance force and excess pore pressure also can be used in forecasting deformation tendency of landslide. | Jiwei Jiang Wei Xiang Wei Zhang Jiajun Pan | 2016 | Journal of Earth Science2016，27，1： | 4 |
| 2 | Organic–inorganic hybrid perovskite scintillators for mixed field radiation detection显示文摘Sensitive and fast detection of neutrons and gamma rays is vital for homeland security,high-energy physics,and proton therapy.Fast-neutron detectors rely on light organic scintillators,andγ-ray detectors use heavy inorganic scintillators and semiconductors.Efficient mixed-field detection using a single material is highly challenging due to their contradictory requirements.Here we report hybrid perovskites(C_(8)H_(12)N)_(2)Pb(Br_(0.95)Cl_(0.05))_(4)that combine light organic cations and heavy inorganic skeletons at a molecular level to achieve unprecedented performance for mixed-field radiation detection.High neutron absorption due to a high density of hydrogen,strong radiative recombination within the highly confined[PbX_(6)]^(4-)layer,and sub-nanometer distance between absorption sites and radiative centers,enable a light yield of 41000 photons/MeV,detection pulse width of 2.97 ns and extraordinary linearity response toward both fast neutrons andγ-rays,outperforming commonly used fast-neutron scintillators.Neutron energy spectrum,time-of-flight based fast-neutron/γ-ray discrimination and neutron yield monitoring were all successfully achieved using(C_(8)H_(12)N)_(2)Pb(Br_(0.95)Cl_(0.05))_(4)detectors.We further demonstrate the monitoring of reaction kinetics and total power of a nuclear fusion reaction.We envision that molecular hybridized scintillators open a new avenue for mixed-field radiation detection and imaging. | Mengling Xia Guangda Niu Linyue Liu Runlong Gao Tong Jin Pengying Wan Weicheng Pan Xianpeng Zhang Zuoxiang Xie Sam Teale Zenghua Cai Jiajun Luo Shan Zhao Haodi Wu Shiyou Chen Zhiping Zheng Qingguo Xie Xiaoping Ouyang Edward HSargent Jiang Tang | 2022 | InfoMat2022，4，9： | 2 |
| 3 | In vivo evaluation of additively manufacturedmulti-layered scaffold for the repair of large osteochondral defects显示文摘The repair of osteochondral defects is one of the major clinical challenges in orthopaedics.Well-established osteochondral tissue engineering methods have shown promising results for the early treatment of small defects.However,less success has been achieved for the regeneration of large defects,which is mainly due to the mechanical environment of the joint and the heterogeneous nature of the tissue.In this study,we developed a multi-layered osteochondral scaffold to match the heterogeneous nature of osteochondral tissue by harnessing additive manufacturing technologies and combining the established art laser sintering and material extrusion techniques.The developed scaffold is based on a titanium and polylactic acid matrix-reinforced collagen“sandwich”composite system.The microstructure and mechanical properties of the scaffold were examined,and its safety and efficacy in the repair of large osteochondral defects were tested in an ovine condyle model.The 12-week in vivo evaluation period revealed extensive and significantly higher bone in-growth in the multi-layered scaffold compared with the collagen–HAp scaffold,and the achieved stable mechanical fixation provided strong support to the healing of the overlying cartilage,as demonstrated by hyaline-like cartilage formation.The histological examination showed that the regenerated cartilage in the multi-layer scaffold group was superior to that formed in the control group.Chondrogenic genes such as aggrecan and collagen-II were upregulated in the scaffold and were higher than those in the control group.The findings showed the safety and efficacy of the cell-free“translation-ready”osteochondral scaffold,which has the potential to be used in a one-step surgical procedure for the treatment of large osteochondral defects. | Maryam Tamaddon Gordon Blunn Rongwei Tan Pan Yang Xiaodan Sun Shen-Mao Chen Jiajun Luo Ziyu Liu Ling Wang Dichen Li Ricardo Donate Mario Monzón Chaozong Liu | 2022 | Bio-Design and Manufacturing2022，5，3： | 2 |
| 4 | Source attribution for mercury deposition with an updated atmospheric mercury emission inventory in the Pearl River Delta Region, China显示文摘We used CMAQ-Hg to simulate mercury pollution and identify main sources in the Pearl River Delta (PR.D) with updated local emission inventory and latest regional and global emissions. The total anthropogenic mercury emissions in the PRD for 2014 were 11,939.6 kg. Power plants and industrial boilers were dominant sectors, responsible for 29.4 and 22.7%. We first compared model predictions and observations and the results showed a good performance. Then five scenarios with power plants (PP), municipal solid waste incineration (MSWI), industrial point sources (IP), natural sources (NAT), and boundary conditions (BCs) zeroed out separately were simulated and compared with the base case. BCs was responsible for over 30% of annual average mercury concentration and total deposition while NAT contributed around 15%. Among the anthropogenic sources, IP (22.9%) was dominant with a contribution over 20.0% and PP (18.9%) and MSWI (11.2%) ranked second and third. Results also showed that power plants were the most important emission sources in the central PRD, where the ultra-low emission for thermal power units need to be strengthened. In the northern and western PRD, cement and metal productions were priorities for mercury control. The fast growth of municipal solid waste incineration were also a key factor in the core areas. In addition, a coordinated regional mercury emission control was important for effectively controlling pollution. In the future, mercury emissions will decrease as control measures are strengthened, more attention should be paid to mercury deposition around the large point sources as high levels of pollution are observed. | Jiajun Liu Long Wang Yun Zhu Che-Jen Lin Carey Jang Shuxiao Wang Jia Xing Bin Yu Hui Xu Yuzhou Pan | 2019 | Frontiers of Environmental Science & Engineering2019，13，1： | 2 |
| 5 | Peroxisome proliferator activated receptor-γ ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells显示文摘 | Jiajun Liu Huiling Lu Renwei Huang Dongjun Lin Xiangyuan Wu Qu Lin Xinyao Wu Jing Zheng Xianglin Pan Jun Peng Yuqin Song Maohong Zhang Ming Hou Feng Chen | 2005 | Cancer Chemotherapy and Pharmacology2005，，4： | 1 |
| 6 | Congruence rela- tions induced by weak-filters and FWLI-ideals in lattice impli- cation algebra显示文摘 | Jiajun Lai Yang Xu Jun Ma Xiaodong Pan | 2007 | International Journal of Modem Mathemat- ics2007，2，1： | 1 |
| 7 | Biocompatible Chemically Fueled Transient Polymer Nanoparticles for Temporally Programmable in Vivo Imaging显示文摘Chemically fueled dissipative self-assembly paves the way for innovative materials with lifelike properties and functions.Achievement of nonequilibrium systems with biocompatibility and biofunctions remains an important and challenging task.Here,we present biocompatible chemically fueled transient polymer nanoparticles and their applications in temporally programmable in vivo imaging.The lifetime of the transient polymer nanoparticles can be tuned by varying the concentration of polymer,adenosine triphosphate,and phosphatase.Moreover,the transient assembly of polymer nanoparticles can be paused for storage and then subsequently restored.The transient polymer nanoparticles exhibit good biocompatibility.Notably,we implement in vivo imaging in a temporally programmable fashion by using an autonomous fluorescence modulator of transient nanoparticles assembled from polymers with a fluorescence moiety.The results in this work provide a valuable way to achieve nonequilibrium self-assembly of synthetic systems with good biocompatibility and programmable biofunctions,accelerating innovative developments of nonequilibrium soft biomaterials. | Chunyu Pan Jiajun Xu Liang Wang Yiyang Jia Jiahui Li Guancheng Liu Shoujun Zhu Bai Yang Yunfeng Li | 2023 | CCS Chemistry2023，5，3： | 0 |
| 8 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 9 | Bionics-based Optimization of Step-climbing Gait in a Novel Mini-RHex Robot显示文摘RHex-style robots can perform manifold moving gaits in different applications,but they have always faced a challenge of climbing up high obstacles.In this paper,the bionics-based gait optimization in an RHex-style robot is proposed for climbing steps at different heights,which even enables the robot to climb up the step with 4.2 times of the leg length.First,a thoracic flexion is designed in the robot,and an algorithm of adjusting body inclination is proposed to perform the rising stage after placing front legs on top of step,which can be applied in different RHex-style robots with different sizes.Especially,when the thoracic flexion is implemented,the robot can climb the higher step with the proposed algorithm.Second,to climbing the higher steps,a claw-shape legs-based algorithm is proposed for robot reaching the higher step and climbing it up.During the vital rising stage,when the front legs of the robot have reached the top of the step,the robot can bend the front body downward with its thoracic flexion like a cockroach,and then lift the front and middle legs alternately to move COM up and forward onto the step.The simulation analysis is utilized to verify the feasibility of the proposed algorithms.Finally,the step-climbing experiments at different heights are performed in our robot to compare with the existing works.The results of simulations and experiments show the superiority of the proposed algorithms for the improved robot due to climbing up the higher steps. | Xingguo Song Jiajun Pan Xiaolong Zhang Chunjun Chen Danshan Huang | 2022 | Journal of Bionic Engineering2022，19，3： | 0 |
| 10 | NK cell depletion promotes liver metastasis of lung cancer cells显示文摘Lung cancer is the malignant tumor with the highest morbidity and mortality in the world[1].Metastasis is the main cause of death in lung cancer patients[2].Cancer cells that are shed from the primary tumor tissue and enter the peripheral circulation are called circulating tumor cells(CTCs)[3].Among them,tumor cells that reach and colonize distant target organs are named disseminated tumor cells(DTCs)[4].Influenced by the microenvironment,immune surveillance,angiogenesis and other factors,DTCs have a weak ability to proliferate or even enter a dormant state[5].Therefore,reducing proliferative activity or maintaining the dormancy of DTCs has emerged as a novel strategy to prevent lung cancer metastasis. | Pan Yu Long Zhang Jianhui Tian Jiajun Liu Zujun Que Ge Li Yiyang Zhou | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 11 | GATA2^(−/−) human ESCs undergo attenuatedendothelial to hematopoietic transition andthereafter granulocyte commitment显示文摘Background: Hematopoiesis is a progressive process collectively controlled by an elaborate network of transcriptionfactors (TFs). Among these TFs, GATA2 has been implicated to be critical for regulating multiple steps of hematopoiesisin mouse models. However, whether similar function of GATA2 is conserved in human hematopoiesis, especially duringearly embryonic development stage, is largely unknown.Results: To examine the role of GATA2 in human background, we generated homozygous GATA2 knockout humanembryonic stem cells (GATA2^(−/−) hESCs) and analyzed their blood differentiation potential. Our results demonstratedthat GATA2^(−/−) hESCs displayed attenuated generation of CD34^(+)CD43^(+) hematopoietic progenitor cells (HPCs), due tothe impairment of endothelial to hematopoietic transition (EHT). Interestingly, GATA2^(−/−) hESCs retained the potentialto generate erythroblasts and macrophages, but never granulocytes. We further identified that SPI1 downregulationwas partially responsible for the defects of GATA2^(−/−) hESCs in generation of CD34^(+)CD43^(+) HPCs and granulocytes.Furthermore, we found that GATA2^(−/−) hESCs restored the granulocyte potential in the presence of Notch signaling.Conclusion: Our findings revealed the essential roles of GATA2 in EHT and granulocyte development throughregulating SPI1, and uncovered a role of Notch signaling in granulocyte generation during hematopoiesis modeled byhuman ESCs. | Ke Huang Juan Du Ning Ma Jiajun Liu Pengfei Wu Xiaoya Dong Minghui Meng Wenqian Wang Xin Chen Xi Shi Qianyu Chen Zhongzhou Yang Shubin Chen Jian Zhang Yuhang Li Wei Li Yi Zheng Jinglei Cai Peng Li Xiaofang Sun Jinyong Wang Duanqing Pei Guangjin Pan | 2015 | Cell Regeneration2015，4，1： | 0 |
| 12 | Spatial Coupling Relationship and Driving Mechanism of Population and Economy in Rural Areas in Qinling-Daba Mountains,China显示文摘Addressing the issue of the healthy and coordinated development of the population and economic factors in rural areas will not only help consolidate and expand the achievements of poverty alleviation,but will also lay a foundation for comprehensive rural revitalization.In this paper,the spatial coupling relationship between the population and economic factors in rural areas in the QinlingDaba Mountains,China,is explored to provide a reference for rural revitalization and regional sustainable development in poverty areas.Sixty-eight county units in rural areas in the Qinling-Daba Mountains,as well as the population and economic factors in rural areas,are used to study the spatial coupling relationship between population and economy,as well as the driving mechanism,in rural areas in the Qinling-Daba Mountains from 2010 to 2020.The results show that a population contraction phenomenon occurred in the rural areas in the Qinling-Daba Mountains,and the spatial agglomeration trends of the population and economic factors were consistent.The agglomeration was mainly located in the suburban areas of the municipal area,and the agglomeration degree was significantly higher in these areas than in other areas.In terms of the spatial distribution,the economic development level of the rural areas in the northeastern part of the Qinling-Daba Mountains was generally higher than that in the central and western parts,and the unbalanced trends of the population and economic spatial differentiation in the eastern and western regions were significant.The spatial coupling relationship between the population and economy changed from coordinated development to economic advancement.This was mainly due to the mutual restriction and joint actions of the industrial structure,capital situation,natural environment,policies,and institutional regulations,among which the industrial structure and capital status had significant effects. | XIAO Jie QIAO Jiajun HAN Dong LIU Yang PAN Tao | 2023 | Chinese Geographical Science2023，33，5： | 0 |
| 13 | Application of Quicksort Algorithm in Information Retrieval显示文摘With the development and progress of today’s network information technology,a variety of large-scale network databases have emerged with the situation,such as Baidu Library and Weipu Database,the number of documents in the inventory has reached nearly one million.So how do you quickly and effectively retrieve the information you want in such a huge database?This requires finding efficient algorithms to reduce the computational complexity of the computer during Information Retrieval,improve retrieval efficiency,and adapt to the rapid expansion of document data.The Quicksort Algorithm gives different weights to each position of the document,and multiplies the weight of each position with the number of matches of that position,and then adds all the multiplied sums to set a feature value for Quicksort,which can achieve the full accuracy of Information Retrieval.Therefore,the purpose of this paper is to use the quick sort algorithm to increase the speed of Information Retrieval,and to use the position weighting algorithm to improve the matching quality of Information Retrieval,so as to achieve the overall effect of improving the efficiency of Information Retrieval. | Jiajun Xie Zuyan Li Han Wu Linhan Li Bin Pan Peng Guo Guang Sun | 2021 | Journal on Big Data2021，3，4： | 0 |
| 14 | Cockroach-inspired Traversing Narrow Obstacles for a Sprawled Hexapod Robot显示文摘Inspired by the cockroach’s use of a pitch-roll mode traverses through narrow obstacles,we improve the RHex-style robot by adding two sprawl joints to adjust the body posture,and propose a novel pitch-roll approach that enables an RHex-style robot to traverse through two cylindrical obstacles with a spacing of 90 mm,about 54%body width.First,the robot can pitch up against the obstacle on the one side by the cooperation of its rear and middle legs.Then,the robot rotates one side rear leg to kick the ground fast,meanwhile the sprawl joint on the other side rotates inward to make the robot roll and fall forward.Finally,the robot can rotate the legs on the ground to move the body forward until it crosses the obstacles.In this article,both cylinder and rectangular columns are considered as the narrow obstacles for traversing.The experiments are demonstrated by using the proposed approach,and the results show that the robot can smoothly traverse through different narrow spaces. | Xingguo Song Jiajun Pan Faming Lin Xiaolong Zhang Chunjun Chen Danshan Huang | 2022 | Journal of Bionic Engineering2022，19，5： | 0 |
| 15 | Jinfukang inhibits clustering and invasion of circulating lung tumor cells by regulating the EGFR signaling pathway显示文摘Lung cancer is the leading cause of cancer-related death in China and worldwide[1].Although the popularization and application of PET-CT have improved the detection rate of patients with early lung cancer,there is still a lack of effective drugs to prevent and treat lung cancer metastasis and prolong the survival of patients[2,3].Circulating tumor cells(CTCs),as seeds of tumor metastasis,play an important role in the metastasis of lung cancer. | Yun Yang Lihua Zhu Jiajun Liu Pan Yu Zujun Que Yan Li Hegen Li Jianhui Tian | 2023 | Acta Biochimica et Biophysica Sinica2023，55，11： | 0 |
| 16 | The cytotoxicity of oxidized multi-walled carbon nanotubes on macrophages显示文摘Carbon nanotubes(CNTs) have been developed for medical and biotechnological applications in the past decades. Their widespread applications make it important to understand their potential hazards to human and the environment. In this study, the possible toxicological effects of the oxidized multi-walled carbon nanotubes(O-MWCNTs) were assessed on RAW 264.7 macrophages in vitro. Several toxicological endpoints, such as cell viability, the release of LDH and IL-8, GSH/GSSG ratio, intracellular calcium concentration and ultrastructural changes in cell morphology, were carried out. The results showed that O-MWCNTs had very limited effects on oxidative stress, cellular toxicity and apoptosis. Transmission electron microscope clearly demonstrates RAW 264.7 macrophages engulfed plenty of O-MWCNTs, and some of them resided in the cytoplasm, while the morphology was not altered by O-MWCNTs. As the control, the pristine MWCNTs(p-MWCNTs) show higher cytotoxicity than O-MWCNTs, damaging cell viability and inducing cell apoptosis. All these toxicological data are of benefit to more wide applications of O-MWCNTs in the future. | Man Luo Pan Chen Jiajun Wang Xiaoyong Deng Ling Dong Minghong Wu Xizhong Shen | 2016 | Science China Chemistry2016，59，7： | 0 |
| 17 | The construction of pseudo-Janus silica/surfactant assembly and their application to stabilize Pickering emulsions and enhance oil recovery显示文摘Nanoparticles with high surface energy and chemical activity have drawn substantial attention in petroleum industry. Recently, Janus nanoparticles exhibited tremendous potential in enhanced oil recovery (EOR) due to their asymmetric structures and properties. In this study, a series of amphiphilic pseudo-Janus@OTAB (PJ@C18) nanoparticles with different concentrations of stearyltrimethylammoium bromide (OTAB) were successfully fabricated. The structures and properties of PJ@C18 were characterized by Fourier transform infrared spectroscopy and ζ-potential measurements. Based on the emulsification experimental results, the interaction models and the self-assembly behavior between hydrophilic nanoparticles (SiO_(2)@NH_(2)) and OTAB molecules at the oil/water interface were proposed, which was further confirmed via the measurements of the contact angle and dynamic interfacial tension. Interestingly, it was found that the change of pH value from 7.5 to 4.0 caused the type reversal of the PJ@C18-1000 stabilized Pickering emulsions. Furthermore, the PJ@C18-1000 stabilized Pickering emulsion system with excellent salt and temperature tolerances (10000 mg∙L^(–1), 90℃) significantly improved the oil recovery in the single-tube (more than 17%) and double-tube (more than 25%) sand pack model flooding tests. The findings of this study could help to better understand the construction mechanism of pseudo-Janus silica/surfactant assembly and the potential application of PJ@C18-1000 stabilized Pickering emulsions for EOR. | Han Jia Jiajun Dai Tingyi Wang Yingbiao Xu Lingyu Zhang Jianan Wang Lin Song Kaihe Lv Dexin Liu Pan Huang | 2022 | Frontiers of Chemical Science and Engineering2022，16，7： | 0 |
| 18 | Thermal perception method of virtual chemistry experiments显示文摘Background With the aim of addressing the difficulty in identifying temperatures in virtual chemistry experiments,we propose a temperature-sensing simulation method of virtual chemistry experiments.Methods We construct a virtual chemistry experiment temperature simulation platform,based on which a wearable temperature generation device is developed.The typical middle school virtual experiments of concentrated sulfuric acid dilution and ammonium nitrate dissolution are conducted to verify the actual effect of the device.Results The platform is capable to indicate near real-world experimental situations.The performance of the device not only meets the temperature sensing characteristics of human skin,but also matches the temperature change of virtual chemistry experiments in real-time.Conclusions It is demonstrated that this temperature-sensing simulation method can represent exothermic or endothermic chemistry experiments,which is beneficial for students to gain understanding of the principles of thermal energy transformation in chemical reactions,thus avoiding the danger that may be posed in the course of traditional teaching of chemistry experiments effectively.Although this method does not have a convenient enough operation for users,the immersion of virtual chemical experiments can be enhanced. | Hengwei XU Siru LI Wenpeng SONG Jiajun SUN Xinli WU Xiaoqi WANG Wenzhen YANG Zhigeng PAN Abdennour EI RHALIBI | 2020 | Virtual Reality & Intelligent Hardware2020，2，4： | 0 |
| 19 | Unraveling the advances of trace doping engineering for potassium ion battery anodes via tomography显示文摘Doping have been considered as a prominent strategy to stabilize crystal structure of battery materials during the insertion and removal of alkali ions.The instructive knowledge and experience acquired from doping strategies predominate in cathode materials,but doping principle in anodes remains unclear.Here,we demonstrate that trace element doping enables stable conversion-reaction and ensures structural integrity for potassium ion battery(PIB) anodes.With a synergistic combination of X-ray tomography,structural probes,and charge reconfiguration,we encode the physical origins and structural evolution of electro-chemo-mechanical degradation in PIB anodes.By the multiple ion transport pathways created by the orderly hierarchical pores from 'surface to bulk' and the homogeneous charge distribution governed in doped nanodomains,the anisotropic expansion can be significantly relieved with trace isoelectronic element doping into the host lattice,maintaining particle mechanical integrity.Our work presents a close relationship between doping chemistry and mechanical reliability,projecting a new pathway to reengineering electrode materials for next-generation energy storage. | Zhenjiang Yu Ruhong Li Kedi Cai Yudong Yao Junjing Deng Shuaifeng Lou Mi Lu Qinmin Pan Geping Yin Zaixing Jiang Jiajun Wang | 2021 | Journal of Energy Chemistry2021，30，7： | 0 |
| 20 | A Spark Scheduling Strategy for Heterogeneous Cluster显示文摘As a main distributed computing system,Spark has been used to solve problems with more and more complex tasks.However,the native scheduling strategy of Spark assumes it works on a homogenized cluster,which is not so effective when it comes to heterogeneous cluster.The aim of this study is looking for a more effective strategy to schedule tasks and adding it to the source code of Spark.After investigating Spark scheduling principles and mechanisms,we developed a stratifying algorithm and a node scheduling algorithm is proposed in this paper to optimize the native scheduling strategy of Spark.In this new strategy,the static level of nodes is calculated,the dynamic factors such as the length of running tasks,and CPU usage of work nodes are considered comprehensively.And through a series of comparative experiments in alienation cluster,the new strategy costs less running time and lower CPU usage rate than the original Spark strategy,which verifies that the new schedule strategy is more effective one. | Xuewen Zhang Zhonghao Li Gongshen Liu Jiajun Xu Tiankai Xie Jan Pan Nees | 2018 | Computers, Materials & Continua2018，，6： | 0 |
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