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| 1 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 2 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 3 | Improved Base Editor for Efficiently Inducing Genetic Variations in Rice with CRISPR/Cas9- Guided Hyperactive hAID Mutant显示文摘 | Bin Ren Fang Yan Yongjie Kuang Na Li Dawei Zhang Xueping Zhou Honghui Lin Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 46 |
| 4 | Limbic Encephalitis Associated with Anti-y-aminobutyric Acid B Receptor Antibodies: A Case Series from China显示文摘 | Hong-Zhi Guan Hai-Tao Ren Xun-Zhe Yang Qiang Lu Bin Peng Yi-Cheng Zhu Xiao-Qiu Shao Yong-Qiang Hu Dong Zhou Li-Ying Cui | 2015 | Chinese Medical Journal2015，，22： | 38 |
| 5 | Base-Editing-Mediated Artificial Evolution of OsALS1 In Planta to Develop Novel Herbicide-Tolerant Rice Germplasms显示文摘Recently developed CRISPR-mediated base editors,which enable the generation of num erous nucleotide changes in target genomic regions,have been widely adopted for gene correction and generation of crop germ plasms containing im portant gain-of-function genetic variations.How ever,to engineer target genes with unknown functional SNPs remains challenging.To address this issue,we present here abase-e diting-mediated gene evolution(BEMGE)m ethod,employing both Cas9n-based cytosine and adenine base editors as well as a single-guide RNA(sgRNA)library tiling the full-length coding region,for developing novel rice germ plasm swith mutations in any endogenous gene.To this end,OsALS1 was artificially evolved in rice cells using BEMGE through both Agrobacterium-mediated and particle-bom bardment-mediated transform ation.Four different types of amino acid substitutions in the evolved OsALS1,derived from two sites that have never been targeted by natural or human selection during rice dom estication,were identified,conferring varying levels of tolerance to the herbicide bispyribac-sodium.Furtherm ore,the P171F substitution identified in a strong OsALS1 allele was quickly introduced into the commercial rice cultivar Nangeng 46 through precise base editing w ith the corresponding base editor and sgRNA.Collectively,these data indicate great potential of BEMGE in creating important genetic variants of target genes for crop improvement. | Yongjie Kuang Shaofang Li Bin Ren Fang Yan Carl Spetz Xiangju Li Xueping Zhou Huanbin Zhou | 2020 | Molecular Plant2020，13，4： | 37 |
| 6 | Tumor gene mutations and messenger RNA expression: correlation with clinical response to icotinib hydrochloride in non-small cell lung cancer显示文摘背景分子的指向的药现在广泛地在临床的 treatment.lcotinib hydrochloride 是的非小的房间肺癌症(NSCLC ) 被使用口头的表皮的生长的一种新类型因素受体(EGFR ) tyresine kinase 禁止者(EGFR-TKIs ) 。在这研究,我们作为我们分析了的 icotinib hydrochlodde.Methods 的功效的 predicators 从先进 NSCLC 病人在肿瘤标本检验了 EGFR ,K地岬,B皇家空军体的变化和 EGFR mRNAexpression 的角色肿瘤嵌入石蜡的标本,它与先进 NSCLC 从 40 个病人中的 14 个被获得在阶段注册了 icotinib hydrochloride 的临床的试用。体的变化被充实异种的 liquidchip (MEL ) 评估技术,和 EGFR mRNA 表示被分叉的 DNA liquidchip (MBL ) 测量在 14 个标本的 technology.Results,七个病人显示出 EGFR 变化, exon 19 删除(3/7 ) 和 exon 21 点变化(4/7 ) ;并且二个病人显示出 K 地岬变化。在 EGFR exon 的没有变化 20。或 B 皇家空军被检测。在有 EGFR 变化的病人,一个病人得了进步疾病(PD ) ,三个病人有稳定的疾病(SD ) ,二个病人有部分回答(PR ) ,一个病人有完全的回答(CR ) 。在有野类型的 EGFR 的病人,四个病人有 PD,三个病人获得了 SD,并且任何一个都没有 PR/CR (P=0.0407 ) 。EGFR 变化与更好没有进步的幸存(PFS )(141 天对 61 天) ,但是没有统计上重要的差别(P=0.8597 ) 被联系,并且中部的全面幸存(OS )(449 天对 140 天) 。 EGFR mRNA 表示层次被评估(三高度,八中等,一个低,并且二那不能由于不够的肿瘤织物被测量)并且没有统计上重要的关系与 EGFR 变化率是的反应, PFS 或 OS.Conclusions 被观察与在亚洲人口报导了那一致, MEL 技术因此为与高产量和快测量 EGFR 变化是可靠的。EGFR exon 19 删除和 exon 21 点变化作为第二线治疗以上是为对 icotinib hydrochloride 的反应的预兆的 biomarkers。 | REN Guan-jun ZHAO Yuan-yua ZHU Yu-jia XIAO Yi XU Jia-sen SHAN Bin ZHANG Li | 2011 | Chinese Medical Journal2011，，1： | 30 |
| 7 | Morphological study on colonic pathology in ulcerative colitis treated by moxibustion显示文摘AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P<0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P<0.001).The goblet cells significantlyincreased(P<0.001);crypt paracrypt abscessor mucosal ulceration was seen(P<0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. | Huan Gan Wu Li Bin Zhou Da Ren Shi Shi Min Liu Hui Rong Liu Bi Meng Zhang Han Ping Chen Lin Shan Zhang | 2000 | World Journal of Gastroenterology2000，6，6： | 28 |
| 8 | A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice显示文摘Dear Editor,Gene-targeting technologies using sequence specific nucleases have been widely adopted to induce genetic modifications in both plant molecular biology research and crop improvement,of which generating targeted point mutation for gain-of-function phenotype is of great value.Although tremendous efforts have been made in developing geneinsertion or replacement approaches by | Bin Ren Fang Yan Yongjie Kuang Na Li Dawei Zhang Honghui Lin Huanbin Zhou | 2017 | Science China(Life Sciences)2017，60，5： | 28 |
| 9 | Highly Efficient A. T to G. C Base Editing by Cas9n- 3uided tRNA Adenosine Deaminase in Rice显示文摘 | Fang Yan Yongjie Kuang Bin Ren Jingwen Wang Dawei Zhang Honghui Lin Bing Yang Xueping Zhou Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 26 |
| 10 | Overexpression of P53 and its risk factors in esophageal cancer in urban areas of Xi′an显示文摘OverexpressionofP53anditsriskfactorsinesophagealcancerinurbanareasofXi′anQIAOGuiBin1,HANChengLong2,JIANGRenChao1,SUNChang?.. | QIAO GuiBin1, HAN ChengLong2, JIANG RenChao1, SUN ChangSheng3, WANG Yan3 and WANG YunJie3 | 1998 | World Journal of Gastroenterology1998，4，1： | 21 |
| 11 | Deep-learning-based information mining from ocean remote-sensing imagery显示文摘With the continuous development of space and sensor technologies during the last 40 years,ocean remote sensing has entered into the big-data era with typical five-V(volume,variety,value,velocity and veracity)characteristics.Ocean remote-sensing data archives reach several tens of petabytes and massive satellite data are acquired worldwide daily.To precisely,efficiently and intelligently mine the useful information submerged in such ocean remote-sensing data sets is a big challenge.Deep learning-a powerful technology recently emerging in the machine-learning field-has demonstrated its more significant superiority over traditional physical-or statistical-based algorithms for image-information extraction in many industrial-field applications and starts to draw interest in ocean remote-sensing applications.In this review paper,we first systematically reviewed two deep-learning frameworks that carry out ocean remote-sensing-image classifications and then presented eight typical applications in ocean internal-wave/eddy/oil-spill/coastal-inundation/sea-ice/green-algae/ship/coral-reef mapping from different types of ocean remote-sensing imagery to show how effective these deep-learning frameworks are.Researchers can also readily modify these existing frameworks for information mining of other kinds of remote-sensing imagery. | Xiaofeng Li Bin Liu Gang Zheng Yibin Ren Shuangshang Zhang Yingjie Liu Le Gao Yuhai Liu Bin Zhang Fan Wang | 2020 | National Science Review2020，7，10： | 19 |
| 12 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 13 | Cas9-NG Greatly Expands the Targeting Scope of the Genome-Editing Toolkit by Recognizing NG and Other Atypical PAMs in Rice显示文摘CRISPR technologies enabling precise genome manipulation are valuable for gene function studies and molecular crop breeding. However, the requirement of a protospacer adjacent motif (PAM)y such as NGG and TTN, for Cas protein recognition restricts the selection of targetable genomic loci in practical applications of CRISPR technologies. Recently Cas9-NG, which recognizes a minimal NG PAM, was reported to expand the targeting space of genome editing in human cells, but it remains unclear whether this Cas9 variant can be used in plants. In this study, we evaluated the nuclease activity of Cas9-NG toward various NGN PAMs by targeting endogenous genes in transgenic rice. We found that Cas9-NG edits all NGG, NGA, NGT, and NGC sites with impaired activity, while the gene-edited plants were dominated by monoallelic mutations. Cas9-NG-engineered base editors were then developed and used to generate O s B Z R I gainof- function plants that can not be created by other available Cas9-engineered base editors. Moreover, we showed that a Cas9-NG-based transcriptional activator efficiently upregulated the expression of endogenous target genes in rice. In addition, we discovered that Cas9-NG recognizes NAC, NTG, NTT, and NCG apart from NG PAM. Together, these findings demonstrate that Cas9-NG can greatly expand the targeting scope of genome-editing tools, showing great potential for targeted genome editing, base editing, and genome regulation in plants. | Bin Ren Lang Liu Shaofang Li Yongjie Kuang Jingwen Wang Dawei Zhang Xueping Zhou Honghui Lin Huanbin Zhou | 2019 | Molecular Plant2019，12，7： | 18 |
| 14 | Evaluation of high-resolution satellite precipitation products with surface rain gauge observations from Laohahe Basin in northern China显示文摘Three high-resolution satellite precipitation products,the Tropical Rainfall Measuring Mission (TRMM) standard precipitation products 3B42V6 and 3B42RT and the Climate Precipitation Center's (CPC) morphing technique precipitation product (CMORPH),were evaluated against surface rain gauge observations from the Laohahe Basin in northern China.Widely used statistical validation indices and categorical statistics were adopted.The evaluations were performed at multiple time scales,ranging from daily to yearly,for the years from 2003 to 2008.The results show that all three satellite precipitation products perform very well in detecting the occurrence of precipitation events,but there are some different biases in the amount of precipitation.3B42V6,which has a bias of 21%,fits best with the surface rain gauge observations at both daily and monthly scales,while the biases of 3B42RT and CMORPH,with values of 81% and 67%,respectively,are much higher than a normal receivable threshold.The quality of the satellite precipitation products also shows monthly and yearly variation:3B42RT has a large positive bias in the cold season from September to April,while CMORPH has a large positive bias in the warm season from May to August,and they all attained their best values in 2006 (with 10%,50%,and-5% biases for 3B42V6,3B42RT,and CMORPH,respectively).Our evaluation shows that,for the Laohahe Basin,3B42V6 has the best correspondence with the surface observations,and CMORPH performs much better than 3B42RT.The large errors of 3B42RT and CMORPH remind us of the need for new improvements to satellite precipitation retrieval algorithms or feasible bias adjusting methods. | Shan-hu JIANG Li-liang REN Bin YONG Xiao-li YANG Lin SHI | 2010 | Water Science and Engineering2010，3，4： | 17 |
| 15 | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade显示文摘The ubiquitin system is important for drug discovery,and the discovery of selective small-molecule inhibitors of deubiquitinating enzymes (DUBs) remains an active yet extremely challenging task. With a few exceptions,previously developed inhibitors have been found to bind the evolutionarily conserved catalytic centers of DUBs,resulting in poor selectivity. The small molecule IU1 was the first-ever specific inhibitor identified and exhibited surprisingly excellent selectivity for USP14 over other DUBs. However,the molecular mechanism for this selectivity was elusive. Herein,we report the high-resolution co-crystal structures of the catalytic domain of USP14 bound to IU1 and three IU1 derivatives. All the structures of these complexes indicate that IU1 and its analogs bind to a previously unknown steric binding site in USP14,thus blocking the access of the C-terminus of ubiquitin to the active site of USP14 and abrogating USP14 activity. Importantly,this steric site in USP14 is very unique,as suggested by structural alignments of USP14 with several known DUB X-ray structures. These results,in conjunction with biochemical characterization,Indicate a coherent steric blockade mechanism for U5P14 inhibition by compounds of the IU series. In light of the recent report of steric blockade of USP7 by FT671,this work suggests a potential generally applicable allosteric mechanism for the regulation of DUBs via steric blockade,as showcased by our discovery of IU1-248 which is 10-fold more potent than IU1. | Yiwei Wang Yuxuan Jiang Shan Ding Jiawang Li Ningjing Song Yujing Ren Danning Hong Cai Wu Bin Li Feng Wang Wei He Jiawei Wang Ziqing Mei | 2018 | Cell Research2018，28，12： | 15 |
| 16 | Copper-chelating therapeutic effect in Wilson disease with different clinical phenotypes and polymorphisms of ATP7B gene显示文摘CopperchelatingtherapeuticefectinWilsondiseasewithdiferentclinicalphenotypesandpolymorphismsofATP7BgeneRENMingShan1,HUWen?.. | REN MingShan1, HU WenBin1, ZHANG Zhi1, JU ShuangWu1, FAN YuXin2, WANG GongQiang1 and YANG RenMin1Keywords Wilson disease/therapy copper chelating agents ATP7B gene mutations | 1998 | World Journal of Gastroenterology1998，4，4： | 15 |
| 17 | Comparative analysis of GF-1,HJ-1,and Landsat-8 data for estimating the leaf area index of winter wheat显示文摘Using simultaneously collected remote sensing data and field measurements,this study firstly assessed the consistency and applicability of China high-resolution earth observation system satellite 1(GF-1) wide field of view(WFV) camera,environment and disaster monitoring and forecasting satellite(HJ-1) charge coupled device(CCD),and Landsat-8 operational land imager(OLI) data for estimating the leaf area index(LAI) of winter wheat via reflectance and vegetation indices(VIs). The accuracies of these LAI estimates were then assessed through comparison with an empirical model and the PROSAIL radiative transfer model. The effects of radiation calibration,spectral response functions,and spatial resolution on discrepancies in the LAI estimates between the different sensors were also analyzed. The results yielded the following observations:(1) The correlation between reflectance from different sensors is relative good,with the adjusted coefficients of determination(R2) between 0.375 to 0.818. The differences in reflectance are ranging from 0.002 to 0.054. The correlation between VIs from different sensors is high with the R2 between 0.729 and 0.933. The differences in the VIs are ranging from 0.07 to 0.156. These results show the three sensors' images can all be used for cross calibration of the reflectance and VIs.(2) The four VIs from the three sensors are all demonstrated to be highly correlated with LAI(R2 between 0.703 and 0.849). The linear models associated with the 2-band enhanced vegetation index(EVI2),which feature the highest R2(higher than 0.746) and the lowest root mean square errors(RMSE)(less than 0.21),were selected to estimate the winter wheat LAI. The accuracy of the estimated LAI from Landsat-8 was the highest,with the relative errors(RE) of 2.18% and an RMSE of 0.13,while the HJ-1 was the lowest,with the RE of 2.43% and the RMSE of 0.15.(3) The inversion errors in the different sensors' LAI estimates using the PROSAIL model are small. The accuracy of the GF-1 is the highest with the RE of 3.44%,and the RMSE of 0.22,whereas that of the HJ-1 is the lowest with the RE of 4.95%,and the RMSE of 0.26.(4) The effects of the spectral response function and radiation calibration for the different sensors are small and can be ignored,but the effects of spatial resolution are significant and must be taken into consideration in practical applications. | LI He CHEN Zhong-xin JIANG Zhi-wei WU Wen-bin REN Jian-qiang LIU Bin Tuya Hasi | 2017 | Journal of Integrative Agriculture2017，16，2： | 15 |
| 18 | SIS accuracy and service performance of the BDS-3 basic system显示文摘On December 27,2018,the basic system of the third-generation BeiDou navigation satellite system(BDS-3)completed the deployment of its constellation of 18 MEO networking satellites as well as the construction of the operation control system(OCS)and began to provide basic navigation services to users worldwide.Compared with BDS-2,BDS-3 aims to offer users better navigation signals and higher precision with a series of new technologies.For example,the spaceborne atomic clock of BDS-3 is upgraded for higher performance,the Ka-band inter-satellite link is adopted for inter-satellite ranging and communication,and new B1C and B2a signals are broadcast in addition to B1I and B3I signals(compatible with BDS-2).In addition,a 9-parameter model based on a spherical harmonic function is employed for ionospheric delay corrections.Using the observation data from 18 satellites of the basic system,this paper conducts a comprehensive evaluation of the pseudorange measurement characteristics,signal-in-space(SIS)accuracy of navigation messages and global service capability of BDS-3.The results indicate that the pseudorange measurement multipath effect and observation noise of BDS-3 satellites are better than those of BDS-2;additionally,with the support of inter-satellite links,the user range error(URE)of the BDS-3 satellite broadcast ephemeris is better than 10 cm,the precision of the broadcast clock parameter is better than 1.5 ns,and the SIS accuracy is better than 0.6 m overall.Different from the traditional Klobuchar model,the BeiDou global broadcast ionospheric delay correction model(BDGIM)can provide ionospheric delay corrections better than 70%for worldwide single-frequency users.The service capability evaluation of the basic system consists mainly of the accuracy improvement of the B1I and B3I signals according to BDS-2 as well as the global positioning accuracy of the new signals.These results prove that the BDS-3 basic system has achieved the design goal;that is,both the horizontal and the vertical global positioning accuracies are better than 10 m(95%).In the future,6 MEO satellites as well as 3 GEO satellites and 3 IGSO satellites for regional enhancement purposes will be deployed for full operation;consequently,BDS-3 will definitely provide a higher SIS accuracy and better service capability. | JinPing Chen XiaoGong Hu ChengPan Tang ShanShi Zhou YuFei Yang JunYang Pan Hui Ren YueXin Ma QiuNing Tian Bin Wu Yang Yu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，6： | 14 |
| 19 | Photoperiodism dynamics during the domestication and improvement of soybean显示文摘Soybean(Glycine max) is a facultative short-day plant with a sensitive photoperiod perception and reaction system, which allows it to adjust its physiological state and gene regulatory networks to seasonal and diurnal changes in environmental conditions. In the past few decades, soybean cultivation has spread from East Asia to areas throughout the world. Biologists and breeders must now confront the challenge of understanding the molecular mechanism of soybean photoperiodism and improving agronomic traits to enable this important crop to adapt to geographical and environmental changes. In this review, we summarize the genetic regulatory network underlying photoperiodic responses in soybean. Genomic and genetic studies have revealed that the circadian clock, in conjunction with the light perception pathways, regulates photoperiodic flowering. Here, we provide an annotated list of 844 candidate flowering genes in soybean, with their putative biological functions. Many photoperiod-related genes have been intensively selected during domestication and crop improvement. Finally, we describe recent progress in engineering photoperiod-responsive genes for improving agronomic traits to enhance geographic adaptation in soybean, as well as future prospects for research on soybean photoperiodic responses. | Sheng-Rui Zhang Huan Wang Zhongyu Wang Yao Ren Lifang Niu Jun Liu Bin Liu | 2017 | Science China(Life Sciences)2017，60，12： | 13 |
| 20 | Long-term phosphorus accumulation and agronomic and environmtal critical phosphorus levels in Haplic Luvisol soil, northern China显示文摘Sufficient soil phosphorus(P) content is essential for achieving optimal crop yields,but accumulation of P in the soil due to excessive P applications can cause a risk of P loss and contribute to eutrophication of surface waters.Determination of a critical soil P value is fundamental for making appropriate P fertilization recommendations to ensure safety of both environment and crop production.In this study,agronomic and environmental critical P levels were determined by using linear-linear and linear-plateau models,and two segment linear model,for a maize(Zea mays L.)-winter wheat(Triticum aestivum L.) rotation system based on a 22-yr field experiment on a Haplic Luvisol soil in northern China.This study included six treatments:control(unfertilized),no P(NoP),application of mineral P fertilizer(MinP),MinP plus return of maize straw(MinP+StrP),MinP plus low rate of farmyard swine manure(MinP+L.Man) and MinP plus high rate of manure(MinP+H.Man).Based on the two models,the mean agronomic critical levels of soil Olsen-P for optimal maize and wheat yields were 12.3 and 12.8 mg kg^(-1),respectively.The environmental critical P value as an indicator for P leaching was 30.6 mg Olsen-P kg^(-1),which was 2.4 times higher than the agronomic critical P value(on average 12.5 mg P kg^(-1)).It was calculated that soil Olsen-P content would reach the environmental critical P value in 41 years in the MinP treatment,but in only 5-6years in the two manure treatments.Application of manure could significantly raise soil Olsen-P content and cause an obvious risk of P leaching.In conclusion,the threshold range of soil Olsen-P is from 12.5 to 30.6 mg P kg^(-1) to optimize crop yields and meanwhile maintain relatively low risk of P leaching in Haplic Luvisol soil,northern China. | XI Bin ZHAI Li-mei LIU Jian LIU Shen WANG Hong-yuan LUO Chun-yan REN Tian-zhi LIU Hong-bin | 2016 | Journal of Integrative Agriculture2016，15，1： | 13 |
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