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| 1 | Holocene vegetation cover in Qin’an area of western Chinese Loess Plateau revealed by n-alkane显示文摘Previous studies have found that wetlands prevailed in western Chinese Loess Plateau and pine pollen could reach up to 80% in Qin’an area of the plateau during middle Holocene. It was then deduced that forest vegetation covered Qin’an area in a warm and wet climate during middle Holocene. The proxies of molecule biomarkers from two Holocene sections, a swamp-alluvial loess section and a typical loess-paleosol section are used to reconstruct regional vegetation history. It is found that the heavy-molecular-weight (HMW) homologues of the n-alkanes in all samples exhibit a pronounced odd-over-even predominance, maximizing at C31 and the abundance of the nC27-alkanes is the lowest in nC27, nC29, nC31, i.e. C27 | ZHONG YanXia CHEN FaHu AN ChengBang XIE ShuCheng HUANG XianYu | 2007 | Chinese Science Bulletin2007，52，12： | 10 |
| 2 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 3 | An Arctic sea ice thickness variability revealed from satellite altimetric measurements显示文摘A modified algorithm taking into account the first year(FY) and multiyear(MY) ice densities is used to derive a sea ice thickness from freeboard measurements acquired by satellite altimetry ICESat(2003–2008). Estimates agree with various independent in situ measurements within 0.21 m. Both the fall and winter campaigns see a dramatic extent retreat of thicker MY ice that survives at least one summer melting season. There were strong seasonal and interannual variabilities with regard to the mean thickness. Seasonal increases of 0.53 m for FY the ice and 0.29 m for the MY ice between the autumn and the winter ICESat campaigns, roughly 4–5 month separation, were found. Interannually, the significant MY ice thickness declines over the consecutive four ICESat winter campaigns(2005–2008) leads to a pronounced thickness drop of 0.8 m in MY sea ice zones. No clear trend was identified from the averaged thickness of thinner, FY ice that emerges in autumn and winter and melts in summer. Uncertainty estimates for our calculated thickness, caused by the standard deviations of multiple input parameters including freeboard, ice density, snow density, snow depth, show large errors more than 0.5 m in thicker MY ice zones and relatively small standard deviations under 0.5 m elsewhere. Moreover, a sensitivity analysis is implemented to determine the separate impact on the thickness estimate in the dependence of an individual input variable as mentioned above. The results show systematic bias of the estimated ice thickness appears to be mainly caused by the variations of freeboard as well as the ice density whereas the snow density and depth brings about relatively insignificant errors. | BI Haibo HUANG Haijun SU Qiao YAN Liwen LIU Yanxia XU Xiuli | 2014 | Acta Oceanologica Sinica2014，33，11： | 8 |
| 4 | Developing superior alleles of yield genes in rice by artificial mutagenesis using the CRISPR/Cas9 system显示文摘Rice yield is an important and complex agronomic trait controlled by multiple genes.In recent decades,dozens of yield-associated genes in rice have been cloned,many of which can increase production in the form of loss or degeneration of function.However,mutations occurring randomly under natural conditions have provided very limited genetic resources for yield increases.In this study,potentially yield-increasing alleles of two genes closely associated with yield were edited artificially.The recently developed CRISPR/Cas9system was used to edit two yield genes:Grain number 1a(Gn1a)and DENSE AND ERECT PANICLE1(DEP1).Several mutants were identified by a target sequence analysis.Phenotypic analysis confirmed one mutant allele of Gn1a and three of DEP1 conferring yield superior to that conferred by other natural high-yield alleles.Our results demonstrate that favorable alleles of the Gnla and DEP1 genes,which are considered key factors in rice yield increases,could be developed by artificial mutagenesis using genome editing technology. | Liyu Huang Ru Zhang Guangfu Huang Yanxia Li Getachew Melaku Shilai Zhang Haitao Chen Yanjuan Zhao Jing Zhang Yesheng Zhang Fengyi Hu | 2018 | The Crop Journal2018，6，5： | 8 |
| 5 | Satellite-observed trends in the Arctic sea ice concentration for the period 1979–2016显示文摘Arctic sea ice cover has decreased dramatically over the last three decades. This study quanti?es the sea ice concentration(SIC) trends in the Arctic Ocean over the period of 1979–2016 and analyzes their spatial and temporal variations. During each month the SIC trends are negative over the Arctic Ocean, wherein the largest(smallest) rate of decline found in September(March) is-0.48%/a(-0.10%/a).The summer(-0.42%/a) and autumn(-0.31%/a) seasons show faster decrease rates than those of winter(-0.12%/a) and spring(-0.20%/a) seasons. Regional variability is large in the annual SIC trend. The largest SIC trends are observed for the Kara(-0.60%/a) and Barents Seas(-0.54%/a), followed by the Chukchi Sea(-0.48%/a), East Siberian Sea(-0.43%/a), Laptev Sea(-0.38%/a), and Beaufort Sea(-0.36%/a). The annual SIC trend for the whole Arctic Ocean is-0.26%/a over the same period. Furthermore, the in?uences and feedbacks between the SIC and three climate indexes and three climatic parameters, including the Arctic Oscillation(AO), North Atlantic Oscillation(NAO), Dipole anomaly(DA), sea surface temperature(SST), surface air temperature(SAT), and surface wind(SW), are investigated. Statistically, sea ice provides memory for the Arctic climate system so that changes in SIC driven by the climate indices(AO, NAO and DA) can be felt during the ensuing seasons. Positive SST trends can cause greater SIC reductions, which is observed in the Greenland and Barents Seas during the autumn and winter. In contrast, the removal of sea ice(i.e., loss of the insulating layer) likely contributes to a colder sea surface(i.e., decreased SST), as is observed in northern Barents Sea. Decreasing SIC trends can lead to an in-phase enhancement of SAT, while SAT variations seem to have a lagged in?uence on SIC trends. SW plays an important role in the modulating SIC trends in two ways: by transporting moist and warm air that melts sea ice in peripheral seas(typically evident inthe Barents Sea) and by exporting sea ice out of the Arctic Ocean via passages into the Greenland and Barents Seas, including the Fram Strait, the passage between Svalbard and Franz Josef Land(S-FJL),and the passage between Franz Josef Land and Severnaya Zemlya(FJL-SZ). | WANG Yunhe BI Haibo HUANG Haijun LIU Yanxia LIU Yilin LIANG Xi FU Min ZHANG Zehua | 2019 | Journal of Oceanology and Limnology2019，37，1： | 7 |
| 6 | Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway显示文摘OBJECTIVE: To investigate the effect of Banxia Xiexin decoction(BXD) on Helicobacter pylori(Hp)-related peptic ulcers(PUs) and the possible mecha-nism underlying BXD actions via the transforming growth factor-β/small mothers against decapentaplegic(TGF-β/Smad) signaling pathway.METHODS: PU patients with cold-heat complex syndrome were randomly assigned to groups that received Chinese or Western medicines with 20 patients in each group. Serum was collected after 7 d of treatment. The healthy group included 20 individuals. Gastric mucosal epithelial cell line GES-1 was cultured in vitro and randomly divided into the following seven groups: control, model, healthy,Western Medicine, prior treatment, low dosage,and high dosage. After 72 h of treatment with the corresponding serum, the m RNA and protein expression levels of TGF-β1, Smad3, and Smad7 were measured by reverse transcription quantitative polymerase chain reaction and western blotting, respectively.RESULTS: The m RNA expression levels of TGF-β1 and Smad3 in GES-1 cells were increased after Hp introduction, and these increased levels were reduced by the BXD-containing serum. The protein levels of p-Smad3, but not TGF-β1 or Smad3, were significantly increased in Hp-treated GES-1 cells,and treatment with the BXD-containing serum markedly decreased the protein levels. Smad7 expression was significantly enhanced following treatment with the BXD-containing serum at transcriptional and protein levels in a dose-dependent manner.CONCLUSION: BXD regulates the TGF-β/Smad signaling pathway by inhibiting the expression of TGF-β1 and Smad3, and increasing the expression of Smad7. | Chen Shaofang Liang Huiqing Chen Shaodong Huang Yanping Wan Shichuan Huang Yanxia | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 7 |
| 7 | An electrochemical impedance spectroscopic study of the electronic and ionic transport properties of LiCoO_2 cathode显示文摘The storage behavior and process of the first delithiation-lithiation of LiCoO2 cathode were investigated by electrochemical impedance spectroscopy(EIS). The electronic and ionic transport properties of LiCoO2 cathode along with variation of electrode potential were obtained in 1 mol·L?1 LiPF6-EC:DMC:DEC electrolyte solution. It was found that after 9 h storage of the LiCoO2 cathode in electrolyte solu-tions,a new arc appears in the medium frequency range in Nyquist plots of EIS,which increases with increasing the storage time. In the charge/discharge processes,the diameter of the new arc is reversi-bly changed with electrode potential. Such variation coincides well with the electrode potential de-pendence of electronic conductivity of the LiCoO2. Thus this new EIS feature is attributed to the change of electronic conductivity of LixCoO2 during storage of the LiCoO2 cathode in electrolyte solutions,as well as in processes of intercalation-deintercalationtion of lithium ions. It has been revealed that the reversible increase and decrease of the resistance of SEI film in charge-discharge processes can be also ascribed to the variation of electronic conductance of active materials of the LiCoO2 cathode. | ZHUANG QuanChao XU JinMei FAN XiaoYong DONG QuanFeng JIANG YanXia HUANG Ling SUN ShiGang | 2007 | Chinese Science Bulletin2007，52，9： | 5 |
| 8 | Mixed lineage kinase domain-like protein induces RGC-5 necroptosis following elevated hydrostatic pressure显示文摘 | Lvshuang Liao Lei Shang Na Li Shuchao Wang Mi Wang Yanxia Huang Dan Chen Jufang Huang Kun Xiong | 2017 | Acta Biochimica et Biophysica Sinica2017，49，10： | 5 |
| 9 | Arctic sea ice volume export through the Fram Strait from combined satellite and model data:1979–2012显示文摘By combing satellite-derived ice motion and concentration with ice thickness fields from a popular model PIOMAS we obtain the estimates of ice volume flux passing the Fram Strait over the 1979–2012 period. Since current satellite and field observations for sea ice thickness are limited in time and space, the use of PIOMAS is expected to fill the gap by providing temporally continued ice thickness fields. Calculated monthly volume flux exhibits a prominent annual cycle with the peak record in March(roughly 145 km3/month) and the trough in August(10 km^3/month). Annual ice volume flux(1 132 km^3) is primarily attributable to winter(October through May) outflow(approximately 92%). Uncertainty in annual ice volume export is estimated to be 55 km^3(or 5.7%). Our results also verified the extremely large volume flux appearing between late 1980 s and mid-1990 s. Nevertheless, no clear trend was found in our volume flux results. Ice motion is the primary factor in the determination of behavior of volume flux. Ice thickness presented a general decline trend may partly enhance or weaken the volume flux trend. Ice concentration exerted the least influences on modulating trends and variability in volume flux. Moreover, the linkage between winter ice volume flux and three established Arctic atmospheric schemes were examined. Compared to NAO, the DA and EOF3 mechanism explains a larger part of variations of ice volume flux across the strait. | ZHANG Zehua BI Haibo SUN Ke HUANG Haijun LIU Yanxia YAN Liwen | 2017 | Acta Oceanologica Sinica2017，36，1： | 4 |
| 10 | Comparative evaluation of the impact of GRAPES and MM5 meteorology on CMAQ prediction over Pearl River Delta, China显示文摘The community multiscale air quality (CMAQ) model was used to forecast air quality over the Pearl River Delta region from December 2013 to January 2014.The pollution forecasting performance of CMAQ coupled with two different meteorological models,i.e.,the global/regional assimilation and prediction system (GRAPES) and the fifth-generation mesoscale model (MM5),was assessed by comparison with observational data.The effects of meteorological factors and physicochemical processes on the forecast results were discussed through process analysis.The results showed that both models exhibited good performance but that of GRAPES-CMAQ was better.GRAPES was superior in predicting the overall variation tendencies of meteorological fields,but it showed large deviations in atmospheric pressure and wind speed.This contributed to the higher correlation coefficients of the pollutants with GRAPES-CMAQ but with greater deviations.The underestimations of nitrate and ammonium salt contributed to the underestimations of both particulate matter and extinction coefficients.Source emissions made the only positive contributions to surface layer SO2,CO,and NO.It was found that O3 originated primarily from horizontal and vertical transport and that its consumption was predominantly via chemical processes.Conversely,NO2 was found derived primarily from chemical production. | Tao Deng Yiang Chen Qilin Wan Yanxia Zhang Xuejiao Deng Yanyan Huang Guangfeng Dai Fei Li | 2018 | Particuology2018，16，5： | 4 |
| 11 | Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis:a prospective multicenter randomized controlled trial显示文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events. | Xiaoyan TANG Dezheng CHEN Ling ZHANG Ping FU Yanxia CHEN Zhou XIAO Xiangcheng XIAO Weisheng PENG Li CHENG Yanmin ZHANG Hongbo LI Kehui LI Bizhen GOU Xin WU Qian YU Lijun JIAN Zaizhi ZHU Yu WEN Cheng LIU Hen XUE Hongyu ZHANG Xin HE Bin YAN Liping ZHONG Bin HUANG Mingying MAO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，11： | 4 |
| 12 | Impact of diabetes on promoting the growth of breast cancer显示文摘Background:Type Ⅱ diabetes mellitus(DM2)is a significant risk factor for cancers,including breast cancer.However,a proper diabetic breast cancer mouse model is notwell-established for treatment strategy design.Additionally,the precise diabetic signaling pathways that regulate cancer growth remain unresolved.In the present study,we established a suitable mouse model and demonstrated the pathogenic role of diabetes on breast cancer progression.Methods:We successfully generated a transgenic mouse model of human epidermal growth factor receptor 2 positive(Her2^(+) or ERBB2)breast cancer with DM2 by crossing leptin receptor mutant(Lepr^(db/+))mice with (MMTV-ErbB2/neu)mice.Themousemodelswere administrated with antidiabetic drugs to assess the impacts of controlling DM2 in affecting tumor growth.Magnetic resonance spectroscopic imaging was employed to analyze the tumor metabolism.Results:Treatment with metformin/rosiglitazone in MMTV-ErbB2/Lepr^(db/db) mousemodel reduced serum insulin levels,prolonged overall survival,decreased cumulative tumor incidence,and inhibited tumor progression.Anti-insulin resistance medications also inhibited glycolytic metabolism in tumors in vivo as indicated by the reduced metabolic flux of hyperpolarized ^(13)C pyruvate-to-lactate reaction.The tumor cells from MMTV-ErbB2/Lepr^(db/db) transgenic mice treated with metformin had reprogrammed metabolism by reducing levels of both oxygen consumption and lactate production.Metformin decreased the expression of Myc and pyruvate kinase isozyme 2(PKM2),leading to metabolism reprogramming.Moreover,metformin attenuated the mTOR/AKT signaling pathway and altered adipokine profiles.Conclusions:MMTV-ErbB2/Lepr^(db/db) mouse model was able to recapitulate diabetic HER2^(+) human breast cancer.Additionally,our results defined the signaling pathways deregulated in HER2^(+) breast cancer under diabetic condition,which can be intervened by anti-insulin resistance therapy. | Ping-Chieh Chou Hyun Ho Choi Yizhi Huang Enrique Fuentes-Mattei Guermarie Velazquez-Torres Fanmao Zhang Liem Phan Jaehyuk Lee Yanxia Shi James A.Bankson Yun Wu Huamin Wang Ruiying Zhao Sai-Ching Jim Yeung Mong-Hong Lee | 2021 | Cancer Communications2021，41，5： | 4 |
| 13 | Studies of the first lithiation of graphite materials by electrochemical impedance spectroscopy显示文摘First lithiation of graphite electrode in 1 mol/L LiPF6-EC:DEC:DMC electrolyte was investi- gated by electrochemical impedance spectroscopy (EIS). The results illustrated that the first arc in the high-frequency range observed in the Nyquist dia- gram appears near 0.9 V in the initial lithiation of graphite electrode, and its diameter increases with the decrease of polarization potential. These EIS features were attributed to the formation and growth of SEI film. Appropriate equivalent circuit was pro- posed to fit the experimental EIS data. The fitting results revealed the process of the formation and growth of SEI film, and evaluated quantitatively the resistance of charge transfer, as well as the capaci- tance of double layer along with the increase of po- larization potentials. | ZHUANG Quanchao CHEN Zuofeng DONG Quanfeng JIANG Yanxia HUANG Ling SUN Shigang | 2006 | Chinese Science Bulletin2006，51，9： | 3 |
| 14 | Target serum concentration of vancomycin may be reached earlier with a loading dose显示文摘Background:Vancomycin treatment failure against vancomycin-susceptible gram-positive cocci is not rare in the intensive care unit(ICU).One of the reasons for this is the substandard drug trough concentration.We aimed to examine the hypothesis that the target serum concentration could be reached earlier with a loading dose of vancomycin.Methods:This retrospective cohort study was conducted at our ICU between June 2018 and June 2020 and involved patients who were suspected of having,or confirmed to have,gram-positive cocci infection and treated with vancomycin.One group of the patients was administered a loading dose of vancomycin(loading group)and compared with the group that did not receive a loading dose(control group).The baseline characteristics,vancomycin serum concentrations,and clinical outcomes were collected and analyzed.Results:Fifty-five patients were finally included,of which 29 received a loading dose of vancomycin.The serum concentration of vancomycin before the second dose was significantly higher for the loading group than for the control group(10.3±6.1 mg/Lvs.5.7±4.4 mg/L,P=0.002).The results for both groups were similar before the fifth dose(12.4±7.3 mg/Lvs.10.3±6.3 mg/L in the loading and the control groups,respectively;P=0.251).The 28-day mortality was lower for the loading group than for the control group(6.7%vs.34.6%in the loading and control groups,respectively;P=0.026).No significant differences were observed in serum creatinine(Cr)concentrations of the two groups.Conclusion:With the loading dose of vancomycin,the target serum concentration of vancomycin may be reached earlier without increasing the risk of acute kidney injury. | Yanxia Huang Le He Yunxin Deng Renjing Zhang Mei Meng Jiao Liu Dechang Chen | 2022 | Chinese Medical Journal2022，，3： | 2 |
| 15 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 16 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 17 | Sex-specific responses of tree-ring growth to climate in the dioecious tree Populus cathayana显示文摘Aims Radial growth in response to climate has been reported in many trees,but the sex-specific responses of tree-ring growth associated with altitude in dioecious trees are still poorly known.This study aims to examine whether(i)there are sex-related responses of tree-ring growth to climate in dioecious trees;(ii)these responses could be changed with altitude elevation.Methods The tree-ring width and basal area increment(BAI)were measured over the past 30 years(1982-2011),and the sexual differences in relationship between BAI and time span and correlations between ring width and climatic factors were investigated in Populus cathayana trees at two altitude sites(1,450 m and 1,750 m a.s.l.)in Xiaowutai Mountain,Hebei,north China.Important Findings The BAI was increased over the past 30 years.Trees at high-altitude sites had significantly lower mean ring width and mean BAI than those trees at low-altitude sites(P<0.001).In addition,sexual dif-ferences in tree-ring growth and its response to climate were more pronounced by altitude elevation.Male trees had a significantly larger mean ring width and mean BAI than did females at high-alti-tude sites,whereas no significant sexual differences in these traits were detected at low-altitude sites.Female trees were sensitive to previous October-November temperatures at high altitude but to current February and April precipitation at low altitude(P<0.05),whereas male trees were sensitive to current June temperature at high altitude but to January precipitation at low altitude(P<0.05).Our results indicated that the responses of tree-ring growth to cli-mate are sex dependent and can be changed with altitude elevation. | Kechao Huang Yongmei Liao Tingfa Dong Yanxia Yang Jundong He Huihui Huan Qibing Zhang Xiao Xu | 2018 | Journal of Plant Ecology2018，11，5： | 2 |
| 18 | The Characteristics of Storm Wave Behavior and Its Effect on Cage Culture Using the ADCIRC+SWAN Model in Houshui Bay, China显示文摘The current storm wave hazard assessment tends to rely on a statistical method using wave models and fewer historical data which do not consider the effects of tidal and storm surge.In this paper,the wave-current coupled model ADCIRC+SWAN was used to hindcast storm events in the last 30 years.We simulated storm wave on the basis of a large set of historical storms in the North-West Pacific Basin between 1985 and 2015 in Houshui Bay using the wave-current coupled model ADCIRC+SWAN to obtain the storm wave level maps.The results were used for the statistical analysis of the maximum significant wave heights in Houshui Bay and the behavior of wave associated with storm track.Comparisons made between observations and simulated results during typhoon Rammasun(2014)indicate agreement.In addition,results demonstrate that significant wave height in Houshui Bay is dominated by the storm wind velocity and the storm track.Two groups of synthetic storm tracks were designed to further investigate the worst case of typhoon scenarios.The storm wave analysis method developed for the Houshui Bay is significant in assisting government's decision-making in rational planning of deep sea net-cage culture.The method can be applied to other bays in the Hainan Island as well. | YIN Chao HUANG Haijun WANG Daoru LIU Yanxia GUO Ziyue | 2020 | Journal of Ocean University of China2020，19，2： | 2 |
| 19 | Thermal properties optimization of envelope in energy-saving renovation of existing public buildings显示文摘 | Jianen Huang Henglin Lv Tao Gao Wei Feng Yanxia Chen Tai Zhou | 2014 | Energy & Buildings2014，，： | 1 |
| 20 | Effects of Suspended Culture of the Seaweed Laminaria japonica Aresch on the Flow Structure and Sedimentation Processes显示文摘The culture of suspended kelp, such as Laminaria japonica Aresch, has arisen in nearshore areas for approximately 30 years since the 1980 s. This long-term activity has significant impact on the regional hydrodynamic and sedimentary environments. In this study the impact was investigated, based on synchronized multi-station data from continuous observations made within and around the culture area. In total, three current velocity profiles were identified inside and on the landward side of the culture area. Based on the current velocity profiles we calculated the boundary layer parameters, the fluxes of erosion/deposition, and the rate of sediment transport in different times at each observation site. Comparison between culture and non-culture periods showed that the presence of suspended kelp caused the reduction in the average flow velocity by approximately 49.5%, the bottom friction velocity by 24.8%, the seabed roughness length by 62.7%, and the shear stress and the flux of resuspended sediment by approximately 50%. From analyses in combination with the corresponding vertical variation of the suspended sediment distribution, it is revealed that the lifted sediments by resuspension is mixed with the upper suspended material, which will modify the regional distribution of suspended sediment. These changes in flow structure and sediment movement will accelerate seabed siltation, which corresponds to the changes in seabed erosion/deposition. However, under the influences of the seasonal changes in kelp growth the magnitude of change with the seabed siltation was not obvious inside the culture area, but a fundamental change was apparent around the culture area. | ZHANG Zehua HUANG Haijun LIU Yanxia YAN Liwen BI Haibo | 2016 | Journal of Ocean University of China2016，15，4： | 1 |
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