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| 1 | Optimal treatment for Siewert type Ⅱ and Ⅲ adenocarcinoma of the esophagogastric junction: A retrospective cohort study with long-term follow-up显示文摘AIM To determine the optimal treatment strategy for Siewert type Ⅱ and?Ⅲ?adenocarcinoma of the esophagogastric junction.METHODS We retrospectively reviewed the medical records of 83 patients with Siewert type?Ⅱ?and?Ⅲ?adenocarcinoma of the esophagogastric junction and calculated both an index of estimated benefit from lymph node dissection for each lymph node(LN) station and a lymph node ratio(LNR: ratio of number of positive lymph nodes to the total number of dissected lymph nodes). We used Cox proportional hazard models to clarify independent poor prognostic factors. The median duration of observation was 73 mo.RESULTS Indices of estimated benefit from LN dissection were as follows, in descending order: lymph nodes(LN) along the lesser curvature, 26.5; right paracardial LN, 22.8; left paracardial LN, 11.6; LN along the left gastric artery, 10.6. The 5-year overall survival(OS) rate was 58%. Cox regression analysis revealed that vigorous venous invasion(v2, v3)(HR = 5.99; 95%CI: 1.71-24.90) and LNR of > 0.16(HR = 4.29, 95%CI: 1.79-10.89) were independent poor prognostic factors for OS.CONCLUSION LN along the lesser curvature, right and left paracardial LN, and LN along the left gastric artery should be dissected in patients with Siewert type?Ⅱ?or?Ⅲ?adenoca rcinoma of the esophagogastric junction. Patients with vigorous venous invasion and LNR of > 0.16 should be treated with aggressive adjuvant chemotherapy to improve survival outcomes. | Kei Hosoda Keishi Yamashita Hiromitsu Moriya Hiroaki Mieno Masahiko Watanabe | 2017 | World Journal of Gastroenterology2017，23，15： | 19 |
| 2 | Refractory gastric ulcer with abundant IgG4-positive plasma cell infiltration: A case report显示文摘We describe a 77-year-old man with refractory gastric ulcer that worsened after Helicobacter pylori eradication therapy.Pathology showed marked infiltration of IgG4-positive plasma cells in the gastric lesions,which led us to suspect IgG4-related sclerosing disease.To the best of our knowledge,this is the first report of IgG4-related gastric ulcer without the main manifestation of autoimmune pancreatitis. | Takayoshi Fujita Takafumi Ando Masatoshi Sakakibara Waki Hosoda Hidemi Goto | 2010 | World Journal of Gastroenterology2010，16，17： | 13 |
| 3 | Prognostic value of K - ras mutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer显示文摘 | Takeshi Ogura Kenji Yamao Kazuo Hara Nobumasa Mizuno Susumu Hijioka Hiroshi Imaoka Akira Sawaki Yasumasa Niwa Masahiro Tajika Shinya Kondo Tsutomu Tanaka Yasuhiro Shimizu Vikram Bhatia Kazuhide Higuchi Waki Hosoda Yasushi Yatabe | 2013 | Journal of Gastroenterology2013，，5： | 4 |
| 4 | 64-slice multidetector computed tomography evaluation of gastrointestinal tract perforation site: detectability of direct findings in upper and lower GI tract显示文摘 | Sota Oguro Tomohiro Funabiki Koji Hosoda Yukio Inoue Takashi Yamane Michihiro Sato Mitsuhide Kitano Masahiro Jinzaki | 2010 | European Radiology2010，，6： | 3 |
| 5 | Can EUS-guided FNA distinguish between gallbladder cancer and xanthogranulomatous cholecystitis?显示文摘 | Susumu Hijioka Mohamed A. Mekky Vikram Bhatia Akira Sawaki Nobumasa Mizuno Kazuo Hara Waki Hosoda Yasuhiro Shimizu Kiichi Tamada Yasumasa Niwa Kenji Yamao | 2010 | Gastrointestinal Endoscopy2010，，3： | 3 |
| 6 | Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines显示文摘AIM The single nucleotide polymorphism(SNP) c.415C>T in exon 3 of NUDT15 affects thiopurine-induced leukopenia in Asian patients with Crohn's disease. Meanwhile, three additional genetic variants of NUDT15 were reported in patients with acute lymphoblastic leukemia. We evaluated the effects of these additional genetic variants of NUDT15 in patients with inflammatory bowel disease(IBD) treated with thiopurines.METHODS Ninety-six Japanese patients with IBD were enrolled. Genotyping for the NUDT15 and TPMT genes was performed using Custom Taq Man SNP genotyping assays or Sanger sequencing. The changes in white blood cell(WBC) count, mean corpuscular volume(MCV), platelet count, hemoglobin, CRP, amylase, albumin, AST, ALT, and ESR were evaluated.RESULTS Genetic variants of exon 1 and exon 3 of NUDT15 were identified in 24 of 96 patients(25.0%). C.52G > A and c.36_37 insG GAGTC in exon 1 were found in three patients each. All three patients with c.36_37 insG GAGTC in exon 1 were heterozygotes of p.Arg139 Cys in exon 3. Eighteen patients had p.Arg139 Cys in exon 3 alone. The WBC count gradually decreased after initiation of thiopurine treatment in the mutated cases(n = 24), and was significantly lower at 6, 8, 10, and 16 wk(P = 0.0271, 0.0037, 0.0051, and 0.0185, respectively). The WBC counts were also evaluated in patients with and without prednisolone treatment. In the patients with prednisolone treatment, the WBC count tended to show a greater decrease in the mutated cases, with significant differences at 8 and 10 wk(P = 0.012 and 0.029, respectively). In the patients without prednisolone treatment, the WBC count was significantly lower at 2, 4, 8, and 14 wk in mutated cases(P = 0.0196, 0.0182, 0.0237 and 0.0241, respectively). MCV increased after starting thiopurine treatment in the mutated cases, and was significantly higher at 10 wk(P = 0.0085). Platelet count, hemoglobin, CRP, amylase, albumin, AST, ALT and ESR did not differ significantly between the wildtype and mutated cases. TPMT mutations were not found in any of the patients.CONCLUSION Mutations in exon 1 of NUDT15 also affect thiopurineinduced leukopenia in patients with IBD. To discuss thiopurine-induced leukopenia in more detail, investigation of SNPs in both exon 1 and exon 3 of NUDT15 is needed. | Yuichiro Kojima Yosuke Hirotsu Wataru Omata Makoto Sugimori Shinya Takaoka Hiroshi Ashizawa Keiko Nakagomi Dai Yoshimura Kenji Hosoda Yoji Suzuki Hitoshi Mochizuki Masao Omata | 2018 | World Journal of Gastroenterology2018，24，4： | 3 |
| 7 | Enhanced plasma ghrelin levels in Helicobacter py/ori-colonized, interleukin-1-receptortype 1-homozygous knockout (IL-1R1-/-) mice显示文摘AIM: Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor, and it plays a role in stimulating the growth hormone secretion, food intake, body weight gain and gastric motility. Eradication of Helicobacterpylori (H pylori) was shown to be associated with increase of the body weight. On the other hand, H pylori infection evokes the release of gastric IL-lp. The present study was designed to investigate the involvement of the gastric IL-1 signal in the ghrelin dynamics in Hpylori-colonized mice. METHODS: Twelve-week-old female IL-1-receptor type 1-homozygous-knockout mice (IL-1R1-/-') and their wild-type littermates (WT) were orally inoculated with H pylori (Hp group), while other cohorts received oral inoculation of culture medium (Cont group). Thirteen weeks after the inoculation, the mice were examined. The plasma and stomach ghrelin levels and the gastric preproghrelin mRNA were measured. RESULTS: Although the WT mice with H pylori infection showed a significantly decreased body weight as compared with that of the animals without H pylori infection, H pylori infection did not influence the body weight of the IL-1R1-knockout (IL-1R1-/-) mice. In the H pylori-infected IL-1R1-/-mice, the total and active ghrelin levels in the plasma were significantly increased, and the gastric ghrelin level was decreased. No significant differences were noted in the gastric preproghrelin mRNA expression. CONCLUSION: Ghrelin secretion triggered by H pylori infection might be suppressed by IL-1β, the release of which is also induced by the infection, resulting in the body weight loss of mice with H pylori infection. | Yuka Abiko Hidekazu Suzuki Tatsuhiro Masaoka Sachiko Nomura Kumiko Kurabayashi Hiroshi Hosoda Kenji Kangawa Toshifumi Hibi | 2005 | World Journal of Gastroenterology2005，11，27： | 3 |
| 8 | Macroscopic appearance of TypeⅣand giant Type Ⅲ is a high risk for a poor prognosis in pathological stage Ⅱ/Ⅲ advanced gastric cancer with postoperative adjuvant chemotherapy显示文摘AIM To evaluate whether a high risk macroscopic appearance(Type Ⅳ and giant Type Ⅲ) is associated with a dismal prognosis after curative surgery, because its prognostic relevance remains elusive in pathological stage Ⅱ/Ⅲ(p Stage Ⅱ/Ⅲ) gastric cancer.METHODS One hundred and seventy-two advanced gastric cancer(defined as pT2 or beyond) patients with p Stage Ⅱ/Ⅲ who underwent curative surgery plus adjuvant S1 chemotherapy were evaluated, and the prognostic relevance of a high-risk macroscopic appearance was examined. RESULTS Advanced gastric cancers with a high-risk macroscopic appearance were retrospectively identified by preoperative recorded images. A high-risk macroscopic appearance showed a significantly worse relapse free survival(RFS)(35.7%) and overall survival(OS)(34%) than an average risk appearance(P = 0.0003 and P < 0.0001, respectively). A high-risk macroscopic appearance was significantly associated with the 13^(th) Japanese Gastric Cancer Association(JGCA) pT(P = 0.01), but not with the 13^(th) JGCA pN. On univariate analysis for RFS and OS, prognostic factors included 13^(th) JGCA p Stage(P < 0.0001)and other clinicopathological factors including macroscopic appearance. A multivariate Cox proportional hazards model for univariate prognostic factors identified highrisk macroscopic appearance(P = 0.036, HR = 2.29 for RFS and P = 0.021, HR = 2.74 for OS) as an independent prognostic indicator. CONCLUSION A high-risk macroscopic appearance was associated with a poor prognosis, and it could be a prognostic factor independent of 13^(th) JGCA stage in p Stage Ⅱ/Ⅲ advanced gastric cancer. | Keishi Yamashita Akira Ema Kei Hosoda Hiroaki Mieno Hiromitsu Moriya Natsuya Katada Masahiko Watanabe | 2017 | World Journal of Gastrointestinal Oncology2017，9，4： | 2 |
| 9 | Optimal therapeutic range for oral anticoagulantsin Japanese patients with prosthetic heart valves: a preliminary report from a single institution using conversion from thrombotest to PT-INR显示文摘 | Uetsuka Y Hosoda S Kasanuki H | 2000 | Heart Vessels2000，15，： | 2 |
| 10 | Integrated experiments of fast ignition targets by Gekko-XII and LFEX lasers显示文摘 | H. Shiraga S. Fujioka M. Nakai T. Watari H. Nakamura Y. Arikawa H. Hosoda T. Nagai M. Koga H. Kikuchi Y. Ishii T. Sogo K. Shigemori H. Nishimura Z. Zhang M. Tanabe S. Ohira Y. Fujii T. Namimoto Y. Sakawa O. Maegawa T. Ozaki K.A. Tanaka H. Habara T. Iwawak | 2012 | High Energy Density Physics2012，，3： | 2 |
| 11 | How do resident stem cells repair the damaged myocardium?显示文摘It has been a decade since the monumental discovery of resident stem cells in the mammalian heart, and the following studies witnessed the continuous turnover of cardiomyocytes and vascular cells, maintaining the homeostasis of the organ. Recently, the autologous administration of c-kit-positive cardiac stem cells in patients with ischemic heart failure has led to an incredible outcome; the left ventricular ejection fraction of the celltreated group improved from 30% at the baseline to 38% after one year and to 42% after two years of cell injection. The potential underlying mechanisms, before and after cell infusion, are explored and discussed in this article. Some of them are related to the intrinsic property of the resident stem cells, such as direct differentiation, paracrine action, and immunomodulatory function, whereas others involve environmental factors, leading to cellular reverse remodeling and to the natural selection of 'juvenile' cells. It has now been demonstrated that cardiac stem cells for therapeutic purposes can be prepared from tiny biopsied specimens of the failing heart as well as from frozen tissues, which may remarkably expand the repertoire of the strategy against various cardiovascular disorders, including non-ischemic cardiomyopathy and congenital heart diseases. Further translational investigations are needed to explore these possibilities. | Emiko Hayashi Toru Hosoda | 2015 | World Journal of Stem Cells2015，7，1： | 2 |
| 12 | Anti-anginal Effect of Fasudil, a Rho-Kinase Inhibitor, in Patients With Stable Effort Angina: A Multicenter Study显示文摘 | Hiroaki Shimokawa Katsuhiko Hiramori Hiroyuki Iinuma Saichi Hosoda Hiroshi Kishida Hirofumi Osada Takashi Katagiri Kazunobu Yamauchi Yoshiki Yui Takazo Minamino Mitsuyoshi Nakashima Kazuzo Kato | 2002 | Journal of Cardiovascular Pharmacology2002，，5： | 2 |
| 13 | Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples 显示文摘 | Hosoda H Doi K Nagaya N | 2004 | Clin Chem2004，50，： | 1 |
| 14 | Ghrelin is a growth hormone releasing acylated peptide from the stomach 显示文摘 | KOJIMA M HOSODA H DATE Y | 1999 | Nature1999，402，6762： | 1 |
| 15 | Ghrelin is a growth-hormone- releasing acylated peptide from stomach 显示文摘 | Kojima M Hosoda H Date Y | 1999 | Nature1999，402，： | 1 |
| 16 | Nox and N2O emission in bubbling fluidized-bed coal combustion with oxygen and recycled flue gas: macroscopic characteristics of their formation and reduction显示文摘 | Hosoda H Hirama T Azuma N | 1998 | Energy & Fuels1998，12，1： | 1 |
| 17 | Estrogen protects neuronal cells from amyloid β-induced apoptotic cell death显示文摘 | Hosoda T Nakajima H Honjo H | 2001 | Neuroreport2001，12，90： | 1 |
| 18 | Ghrelin is a growth-hormone-releasing acylated peptide from stomach 显示文摘 | Kojima M Hosoda H Date Y | 1999 | Nature1999，402，6762： | 1 |
| 19 | Ghrelin is a growth-hormone-re- leasing acylated peptide from stomach 显示文摘 | Kojim M Hosoda H Date Y | 1999 | Nature1999，402，6762： | 1 |
| 20 | Early and midtermresults of off-pump coronary artery bypass grafting 显示文摘 | Fukui T Takanaski S Hosoda Y | 2007 | Ann Thorac Surg2007，83，1： | 1 |
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