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| 1 | 内镜辅助下保乳手术在乳腺癌患者中的应用显示文摘保乳手术(BCS)结合术后放射治疗已成为早期乳腺癌患者的标准治疗方式。于此同时,肿瘤整形外科的进步改善了美容效果并提高了患者的满意度。因此,对乳腺外科医生在BCS中的要求不仅仅是实施有足够手术切缘的肿瘤切除,还应保证术后乳房的外观。内镜辅助下的乳房保留手术(EBCS)因其减少术后疤痕的优势在十多年前开始发展起来。近来,一些临床机构报道了EBCS的可行性、肿瘤预后、美容效果及患者的满意情况。笔者回顾了目前为止的关于EBCS的临床研究,并予以讨论。 | Shinji Ozaki Masahiro Ohara 冯铁诚 李新营 | 2014 | 中国普通外科杂志2014，23，11： | 15 |
| 2 | Fundamental studies on enhancement and blinking mechanism of surface-enhanced Raman scattering (SERS) and basic applications of SERS biological sensing显示文摘我们考察最近我们在有试图识别使用的改进和眨眼的机制的实验上的强调的散布的提高表面的拉曼(重量的单位) 的基本学习的结果挑选 nanoparticle dimers 依附染分子的 Ag。这些结果是在电磁的机制的框架讨论的份量上。我们也考察最近我们在为在单个房间和单个分子下面的关于房间表面分子和疾病标记分子的区别的察觉的生物察觉到的基本重量的单位应用的结果铺平。 | Yuko S. Yamamoto Mitsuru Ishikawa Yukihiro Ozaki Tamitake Itoh | 2014 | Frontiers of physics2014，9，1： | 8 |
| 3 | 超重和肥胖的全球趋势及其与心血管疾病发生率之间的关系显示文摘虽然超重和肥胖的全球发病率逐日上升,但在不同地区、国家和性别中的发病趋势仍存在差异。据世界卫生组织报道,全球多个地区由体质量指数(body mass index,BMI)≥25kg/m2定义的超重/肥胖发生率几乎接近一半人口,有的甚至超过了一半,如美洲(61.1%),欧洲(54.8%)和东地中海地区(46.0%),然而,在非洲(26.9%),东南亚(13.7%)和西太平洋地区(25.4%),超重/肥胖发生率较低。 | 刘莉 叶鹏 Yatsuya H Li Y Hilawe EH Ota A Wang C Chiang C Zhang Y Uemura M Osako A Ozaki Y Aoyama A Circ J | 2014 | 中华高血压杂志2014，22，12： | 8 |
| 4 | Body mass index is associated with age-at-onset of HCV-infected hepatocellular carcinoma patients显示文摘AIM: To identify factors associated with the age at onset of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS: Five hundred and fifty-six consecutive patients positive for HCV antibody and treatment-nafive HCC diagnosed between 1995 and 2004 were analyzed. Patients were classified into three groups according to age at HCC onset: < 60 years (n = 79), 60-79 years (n = 439), or ≥ 80 years (n = 38). Differences among groups in terms of sex, body mass index (BMI), lifestyle characteristics, and liver function were assessed. Factors associated with HCC onset in patients < 60 or ≥ 80 years were analyzed by logistic regression analysis. RESULTS: Significant differences emerged for sex, BMI, degree of smoking and alcohol consumption, mean bilirubin, alanine aminotransferase (ALT), and γ-glutamyl transpeptidase (GGT) levels, prothrombin activity, and platelet counts. The mean BMI values of male patients > 60 years old were lower and mean BMI values of female patients < 60 years old were higher than those of the general Japanese population. BMI > 25 kg/m2 [hazard ratio (HR), 1.8, P = 0.045], excessive alcohol consumption (HR, 2.5, P = 0.024), male sex (HR, 3.6, P = 0.002), and GGT levels > 50 IU/L (HR, 2.4, P = 0.014) were independently associated with HCC onset in patients < 60 years. Low ALT level was the only factor associated with HCC onset in patients aged ≥ 80 years. CONCLUSION: Increased BMI is associated with increased risk for early HCC development in HCV-infected patients. Achieving recommended BMI and reducing alcohol intake could help prevent hepatic carcinogenesis. | Takumi Akiyama Toshihiko Mizuta Seiji Kawazoe Yuichiro Eguchi Yasunori Kawaguchi Hirokazu Takahashi Iwata Ozaki Kazuma Fujimoto | 2011 | World Journal of Gastroenterology2011，17，7： | 6 |
| 5 | Heat shock protein 72 normothermic ischemia,and the impact of congested portal blood reperfusion on rat liver显示文摘INTRODUCTIONFrom the technical aspect of liver surgery ,control of bleeding during hepatic parenchymal resection is one of the most important procedures in hepatectomy .Pringle,s maneuver ,a temporary cross-clamping of the hepatoduodnal ligament ,has often been used for this purpose[1],This is the simplest and userul technique to reduce intraoperative blood loss . | Chao Liu Dai~1 Zhen Long Xia~1 Makoto Kume~2 Yuzo Yamamoto~2 Kazuhiko Yamagami~2 Nobuhiro Ozaki~2 Yoshio Yamaoka~2 ~1Department of Surgery,The Second Clinical College of China Medical University,Shenyang 110003,Liaoning Province,China ~2Department of Gastroenterological Surgery,Kyoto University Graduate School of Medicine,Kyoto,Japan | 2001 | World Journal of Gastroenterology2001，7，3： | 6 |
| 6 | A novel use of TiO_2 fiber for photocatalytic ozonation of 2,4-dichlorophenoxyacetic acid in aqueous solution显示文摘More efficient oxidation methods are needed to degrade especially newly emerging recalcitrant organic contaminants at low concentrations in the water environment. Reduced photonic efficiency of immobilized TiO2 is a major challenge in TiO2-assisted advanced oxidation processes (AOP). Mineralization of 2,4-dichllorophenoxyacetic acid (2,4-D) in low aqueous solution by O3/UV/TiO2 using the world's first high-strength TiO2 fiber was investigated and compared with O3, UV/TiO2, and O3/TiO2 in laboratory batch experiments. The 2,4-D degradation and total organic carbon (TOC) removal followed pseudo first-order reaction kinetic, while their rates in O3/UV/TiO2 were respectively about 1.5 and 2.4 times larger than the summation of the values in O3 and UV/TiO2. The O3/UV/TiO2 was characterized by few aromatics with very low abundance, fast disappearance of aliphatics and more than 95% dechlorination. The discrepancies in organic carbon mass balance among the intermediates and 2,4-D were attributed mainly to few apparently major unidentified intermediates. The significantly enhanced 2,4-D mineralization in O3/UV/TiO2 was attributed to increased ozone dissolution followed by its decomposition, and reduced electron-hole recombination in presence of dissolved ozone resulting in a large number of hydroxyl radical (·OH) generation from more than one parallel path. The removal efficiencies of the systems can further be enhanced by optimizing design parameters, and O3/UV/TiO2 with the TiO2 fiber is promising to mineralize recalcitrant organic contaminants in water at low concentrations. | GIRI Rabindra Raj OZAKI Hiroaki TAKANAMI Ryohei TANIGUCHI Shogo | 2008 | Journal of Environmental Sciences2008，20，9： | 5 |
| 7 | Differential effects of physical activity and sleep duration on cognitive function in young adults显示文摘Purpose: Although exercise and sleep duration habits are associated with cognitive function, their beneficial effects on cognitive function remain unclear. We aimed to examine the effect of sleep duration and daily physical activity on cognitive function, elucidating the neural mechanisms using near-infrared spectroscopy(NIRS).Methods: A total of 23 healthy young adults(age 22.0 ± 2.2 years) participated in this study. Exercise amount was assessed using a uniaxial accelerometer. We evaluated total sleep time(TST) and sleep efficiency by actigraphy. Cognitive function was tested using the N-back task, the Wisconsin Card Sorting Test(WCST), and the Continuous Performance Test—Identical Pairs(CPT-IP), and the cortical oxygenated hemoglobin levels during a word fluency task were measured with NIRS.Results: Exercise amount was significantly correlated with reaction time on 0- and 1-back tasks(r = —0.602, p = 0.002; r = —0.446, p = 0.033,respectively), whereas TST was significantly correlated with % corrects on the 2-back task(r = 0.486, p = 0.019). Multiple regression analysis,including exercise amount, TST, and sleep efficiency, revealed that exercise amount was the most significant factor for reaction time on 0- and 1-back tasks(b = —0.634, p = 0.002; b = —0.454, p = 0.031, respectively), and TST was the most significant factor for % corrects on the 2-back task(b = 0.542, p = 0.014). The parameter measured by WCST and CPT-IP was not significantly correlated with TST or exercise amount. Exercise amount, but not TST, was significantly correlated with the mean area under the NIRS curve in the prefrontal area(r = 0.492, p = 0.017).Conclusion: Exercise amount and TST had differential effects on working memory and cortical activation in the prefrontal area. Daily physical activity and appropriate sleep duration may play an important role in working memory. | Kazuko Kato Kunihiro Iwamoto Naoko Kawano Yukihiro Noda Norio Ozaki Akiko Noda | 2018 | Journal of Sport and Health Science2018，7，2： | 5 |
| 8 | 胸腺嘧啶在改进银溶胶溶液中的表面增强拉曼散射光谱信号与浓度的定量关系显示文摘尝试使用高分子材料作为银溶胶的稳定剂,以吡啶作为内标化合物研究胸腺嘧啶浓度与其SERS信号强度的关系。在胸腺嘧啶的浓度为2×10^-4~1×10^-3 mol·L^-1的范围内,谱峰强度之比与胸腺嘧啶的浓度之间呈现良好的线性关系,线性回归方程为y=3.143x+0.348 7, 线性相关系数R^2=0.975 4。 | 张磊 张玉兰 张伟 王文明 杜一平 Yukihiro Ozaki | 2009 | 光谱学与光谱分析2009，29，7： | 5 |
| 9 | 辽宁双台河口黑嘴鸥的迁徙模式与种群生存率显示文摘1996-2008年6月份,对辽宁双台河口国家级自然保护区黑嘴鸥使用特定编码的彩色旗标,共标记2820只。其中成鸟31只,幼鸟2789只。根据23个越冬地点2729条彩色旗标的重见记录,推测辽宁双台河口黑嘴鸥的迁徙路线主要有两条:一条向东迁徙至韩国西南沿海及日本西部沿海越冬;另一条向南迁徙至我国天津以南的东部沿海,包括台湾西部沿海越冬。依据1996-2007年双台河口标记的黑嘴鸥幼鸟当年在日本西部沿海重见记录,计算12a间其相对生存率为(7.77±4.00)%(1.67%-14.89%)。其中1997、2001、2004、2006和2007年的相对生存率均低于平均水平,特别是2006年达到12年来的最低值(1.67%)。采用MARK软件中的Cormack-Jolly-Seber(CJS)模型,估计黑嘴鸥亚成体和成体的年生存率分别为0.613±0.058和0.746±0.042,重见率分别为0.897±0.04和0.799±0.053。亚成体较成体的重见率高,可能与亚成体到达越冬地相对比较集群有关。同时建议开展更多的彩色旗标观察活动,便于进一步了解同一越冬地中不同年龄段黑嘴鸥的移动规律。 | 江红星 侯韵秋 李玉祥 Masayoshi TAKEISHI Kiyoaki OZAKI 杨玉成 郑光美 | 2010 | 生态学报2010，30，15： | 4 |
| 10 | Intense terahertz generation from photoconductive antennas显示文摘In this paper,we review the past and recent works on generating intense terahertz(THz)pulses from photoconductive antennas(PCAs).We will focus on two types of large-aperture photoconductive antenna(LAPCA)that can generate high-intensity THz pulses(a)those with large-aperture dipoles and(b)those with interdigitated electrodes.We will first describe the principles of THz generation from PCAs.The critical parameters for improving the peak intensity of THz radiation from LAPCAs are summarized.We will then describe the saturation and limitation process of LAPCAs along with the advantages and disadvantages of working with widebandgap semiconductor substrates.Then,we will explain the evolution of LAPCA with interdigitated electrodes,which allows one to reduce the photoconductive gap size,and thus obtain higher bias fields while applying lower voltages.We will also describe recent achievements in intense THz pulses generated by interdigitated LAPCAs based on wide-bandgap semiconductors driven by ampli-fied lasers.Finally,we will discuss the future perspectives of THz pulse generation using LAPCAs. | Elchin ISGANDAROV Xavier ROPAGNOL Mangaljit SINGH Tsuneyuki OZAKI | 2021 | Frontiers of Optoelectronics2021，14，1： | 3 |
| 11 | Vitamin K and hepatocellular carcinoma: The basic and clinic显示文摘Vitamin K(VK), which was originally identified as a cofactor involved in the production of functional coagulation factors in the liver, has been shown to be involved in various aspects of physiological and pathological events, including bone metabolism, cardiovascular diseases and tumor biology. The mechanisms and roles of VK are gradually becoming clear. Several novel enzymes involved in the VK cycle were identified and have been shown to be linked to tumorigenesis. The VKs have been shown to suppress liver cancer cell growth through multiple signaling pathways via the transcription factors and protein kinases. A VK2 analog was applied to the chemoprevention of hepatocellular carcinoma(HCC) recurrence after curative therapy and was shown to have beneficial effects, both in the suppression of HCC recurrence and in patient survival. Although a large scale randomized control study failed to demonstrate the suppression of HCC recurrence, a meta-analysis suggested a beneficial effect on the long-term survival of HCC patients. However, the beneficial effects of VK administration alone were not sufficient to prevent or treat HCC in clinical settings. Thus its combination with other anti-cancer reagents and the development of more potent novel VK derivatives are the focus of ongoing research which seeks to achieve satisfactory therapeutic effects against HCC. | Xia Jinghe Toshihiko Mizuta Iwata Ozaki | 2015 | World Journal of Clinical Cases2015，3，9： | 3 |
| 12 | Study on steel plate reinforced concrete panels subjected to cyclic in-plane shear显示文摘 | Masahiko Ozaki Shodo Akita Hiroshi Osuga Tatsuo Nakayama Naoyuki Adachi | 2003 | Nuclear Engineering and Design2003，，1： | 3 |
| 13 | Satellite Tracking of the Migration Routes of Cranes from Southern Japan显示文摘 | Higuchi H Ozaki K Fujita G | 1992 | Biotelemetry1992，1，： | 3 |
| 14 | Automated crystal structure analysis based on blackbox optimisation显示文摘In the present study,we show that time-consuming manual tuning of parameters in the Rietveld method,one of the most frequently used crystal structure analysis methods in materials science,can be automated by considering the entire trial-and-error process as a blackbox optimisation problem.The automation is successfully achieved using Bayesian optimisation,which outperforms both a human expert and an expert-system type automation despite the absence of expertise.This approach stabilises the analysis quality by eliminating human-origin variance and bias,and can be applied to various analysis methods in other areas which also suffer from similar tiresome and unsystematic manual tuning of extrinsic parameters and human-origin variance and bias. | Yoshihiko Ozaki Yuta Suzuki Takafumi Hawai Kotaro Saito Masaki Onishi Kanta Ono | 2020 | npj Computational Materials2020，，1： | 3 |
| 15 | Near-Infrared Imaging Using a High-Speed Monitoring Near Infrared Hyperspectral Camera(Compovision)显示文摘This review paper reports near-infrared(NIR)imaging studies using a newly-developed NIR camera,Compovision.Compovision can measure a significantly wide area of 150mm×250mm at high speed of between 2and 5s.It enables a wide spectral region measurement in the 1 000~2 350nm range at 6nm intervals.We investigated the potential of Compovision in the applications to industrial problems such as the evaluation of pharmaceutical tablets and polymers.Our studies have demonstrated that NIR imaging based on Compovision can solve several issues such as long acquisition times and relatively low sensitivity of detection.NIR imaging with Compovision is strongly expected to be applied not only to pharmaceutical tablet monitoring and polymer characterization but also to various applications such as those to food products,biomedical substances and organic and inorganic materials. | Daitaro Ishikawa Asako Motomura Yoko Igarashi Yukihiro Ozaki | 2015 | 光谱学与光谱分析2015，35，4： | 3 |
| 16 | High-speed dual-view band-limited illumination profilometry using temporally interlaced acquisition显示文摘We report dual-view band-limited illumination profilometry(BLIP)with temporally interlaced acquisition(TIA)for high-speed,three-dimensional(3D)imaging.Band-limited illumination based on a digital micromirror device enables sinusoidal fringe projection at up to 4.8 kHz.The fringe patterns are captured alternately by two high-speed cameras.A new algorithm,which robustly matches pixels in acquired images,recovers the object’s 3D shape.The resultant TIA–BLIP system enables 3D imaging over 1000 frames per second on a field of view(FOV)of up to 180 mm×130 mm(corresponding to 1180×860 pixels)in captured images.We demonstrated TIA–BLIP’s performance by imaging various static and fast-moving 3D objects.TIA–BLIP was applied to imaging glass vibration induced by sound and glass breakage by a hammer.Compared to existing methods in multiview phase-shifting fringe projection profilometry,TIA–BLIP eliminates information redundancy in data acquisition,which improves the 3D imaging speed and the FOV.We envision TIA–BLIP to be broadly implemented in diverse scientific studies and industrial applications. | Cheng Jiang Patrick Kilcullen Yingming Lai Tsuneyuki Ozaki Jinyang Liang | 2020 | Photonics Research2020，8，11： | 3 |
| 17 | 高速单级磁流体密封的实验研究显示文摘实验研究了单级磁流体密封的密封特性,即破裂压力差和功率损失,以探索飞轮系统磁流体密封的最佳设计条件.对直径120mm的转轴,在最大转速12000r/min时,进行了测定。 | K. Ozaki T. Fujiwara | 1989 | 润滑与密封1989，14，1： | 2 |
| 18 | -449 C>G polymorphism of NFKB1 gene,coding nuclear factor-kappa-B,is associated with the susceptibility to ulcerative colitis显示文摘AIM:To clarify the association between a polymorphism-449 C>G(rs72696119) in 5'-UTR of NFKB1 with ulcerative colitis(UC).METHODS:The studied population comprised 639 subjects,including patients with UC(UC cases,n = 174) and subjects without UC(controls,n = 465).We employed polymerase chain reaction-single strand conformation polymorphism to detect the gene polymorphism.RESULTS:The rs72696119 G allele frequencies in controls and UC cases were 33.4% and 38.5%,respectively(P = 0.10).Genotype frequency of the GG homozygote in UC cases was significantly higher than that in controls(P = 0.017),and the GG homozygote was significantly associated with susceptibility to UC [odds ratio(OR),1.88;95%CI,1.13-3.14].In male subjects,the GG homozygote was associated with an increased risk for UC(OR,3.10;95%CI,1.47-6.54;P = 0.0053),whereas this association was not found in female subjects.In addition,the GG homozygote was significantly associated with the risk of non-continuous disease(OR,2.06;95%CI,1.12-3.79;P = 0.029),not having total colitis(OR,2.40;95%CI,1.09-3.80,P = 0.040),disease which developed before 20 years of age(OR,2.80;95%CI,1.07-7.32,P = 0.041),no hospitalization(OR,2.28;95%CI,1.29-4.05;P = 0.0090) and with a maximum of 8 or less on the UCDAI score(OR,2.45;95%CI,1.23-4.93;P = 0.022).CONCLUSION:Our results provide evidence that NFKB1 polymorphism rs72696119 was significantly associated with the development of UC.This polymorphism influences the susceptibility to and pathophysiological features of UC. | Ranji Hayashi Tomomitsu Tahara Tsukasa Yamaaki Takashi Saito Kazuhiro Matsunaga Nobuhiko Hayashi Atsushi Fukumura Kazuaki Ozaki Masakatsu Nakamura Hisakazu Shiroeda Mikihiro Tsutsumi Tomoyuki Shibata Tomiyasu Arisawa | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 19 | Mechanism of Surface-Enhanced Raman Scattering and Its Application to Highly Sensitive Protein Detection显示文摘Surface-enhanced resonance Raman scattering(SERRS)has recently attracted great interest in analytical science due toenormous enhancement factors that have decreased the detec-tionli mits of a wide variety of molecules to the single moleculelevel.The SERRS-electromagnetic(EM)model describessingle-molecule SERRS | Ozaki Y Itoh T Yoshida K Kitahama Y Han X X Zhao B | 2009 | 光谱学与光谱分析2009，29，2： | 2 |
| 20 | Efficacy of preoperative endoscopic nasobiliary drainage for hilar cholangiocarcinoma显示文摘 | Norikazu Arakura Mari Takayama Yayoi Ozaki Masafumi Maruyama Yoshimi Chou Ryou Kodama Yasuhide Ochi Hideaki Hamano Takenari Nakata Shouji Kajikawa Eiji Tanaka Shigeyuki Kawa | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，4： | 2 |
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