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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Full-thickness tissue engineered skin constructed with autogenic bone marrow mesenchymal stem cells显示文摘To explore the feasibility of repairing clinical cutaneous deficiency, autogenic bone marrow mesen-chymal stem cells (BMSCs) were isolated and differentiated into epidermal cells and fibroblasts in vitro supplemented with different inducing factors and biomaterials to construct functional tissue- engineered skin. The results showed that after 72 h induction, BMSCs displayed morphologic changes such as typical epidermal cell arrangement, from spindle shape to round or oval; tonofibrils, melano-somes and keratohyaline granules were observed under a transmission electronic microscope. The differentiated cells expressed epidermal stem cell surface marker CK19 (59.66% ± 4.2%) and epidermal cells differentiation marker CK10. In addition, the induced epidermal cells acquired the anti-radiation capacity featured by lowered apoptosis following exposure to UVB. On the other hand, the collagen microfibrils deposition was noticed under a transmission electronic microscope after differentiating into dermis fibroblasts; RT-PCR identified collagen type I mRNA expression in differentiated cells; radioimmunoassay detected the secretion of interleukin-6 (IL-6) and interleukin-8 (IL-8) (up to 115.06 pg/mL and 0.84 ng/mL, respectively). Further in vivo implanting BMSCs with scaffold material short-ened skin wound repair significantly. In one word, autogenic BMSCs have the potential to differentiate into epidermal cells and fibroblasts in vitro, and show clinical feasibility acting as epidermis-like and dermis-like seed cells in skin engineering. | HE LiJuan, NAN Xue, WANG YunFang, GUAN LiDong, BAI CiXian, SHI ShuangShuang, YUAN HongFeng, CHEN Lin, LIU DaQing & PEI XueTao Laboratory of Stem Cells and Regenerative Medicine, Institute of Blood Transfusion, Academy of Military Medical Sciences, Beijing 100850, China | 2007 | Science China(Life Sciences)2007，50，4： | 16 |
| 3 | A novel orientation measurement using optical sensor for spherical motor显示文摘The measurement of spherical rotor orientation is crucial to the close-loop control of spherical motors. This paper presents a novel method for the measuring of three-degree-of-freedom (DOF) rotor orientation of spherical motors using optical sensors. The spatial orientation of spherical rotor is output in the form of ZXZ Euler angles. Firstly, the structure of the measuring system composed of optical sensors and the patterns on the rotor surface are presented, and the operational principle of recognizing intersection points between the optical ring detectors and the latitude/longitude on the rotor surface is illustrated. The analytical model of input-output characteristic is established for the measuring system of three-DOF rotor orientation. Afterwards, the effect of parameters of the optical ring detectors on the linearity, sensitivity, resolving power and measuring range of the measuring system is analyzed using the analytical model. Finally, the feasibility of the measurement is validated through experiments of prototype measuring system. The analysis is expected to be a basis for the design parameter optimization of the orientation measuring system of a PM spherical motor. | XIN JianGuo XIA ChangLiang LI HongFeng SHI TingNa | 2013 | Science China(Technological Sciences)2013，56，6： | 10 |
| 4 | Rare Earth Elements Composition and Constraint on the Genesis of the Polymetallic Crusts and Nodules in the South China Sea显示文摘The rare earth elements(REE) composition of the polymetallic crusts and nodules obtained from the South China Sea(SCS) were analyzed through inductively coupled plasma mass spectrometry.Results revealed great differences in the REE abundances(∑REE) of the SCS polymetallic crusts and nodules; the crusts show the highest ∑REE, whereas the nodules exhibit the lowest ∑REE. The similarity in their NASC-normalized patterns, the enriched light REE(LREE), the markedly positive Ce anomaly(δCe), and the non-or weakly positive Eu anomaly(δEu), suggest that the polymetallic crusts and nodules are of hydrogenetic origin. Moreover, the REE contents and their relevant parameters are quite different among the various layers of the crusts and nodules, which probably results from the different marginal sea environments and mineral assemblages of the samples. The growth profiles of the SCS polymetallic crusts and nodules reveal the tendency ∑REE and δCe to slightly increase from the outer to the inner layers, suggesting that the growth environments of these samples changed smoothly from an oxidizing to a relatively reducing environment; in addition, the crust ST1 may have experienced a regressive event(sea-level change) during its growth, although the REE composition of the seawater remained relatively stable. On the basis of the regional ∑REE distribution in the SCS crusts and nodules,the samples collected near the northern margin were influenced by terrigenous material more strongly compared with the other samples, and the REE contents are relatively low. Therefore, the special geotectonic environment is a significant factor influencing the abundance of elements, including REE and other trace elements. Compared with the oceanic seamount crusts and deep-sea nodules from other oceans,the SCS polymetallic crusts and nodules exhibit special REE compositions and shale-normalized patterns, implying that the samples are of marginal sea-type Fe-Mn sedimentary deposits, which are strongly affected by the epicontinental environment, and that they grew in a more oxidative seawater environment. This analysis indicates that the oxidized seawater environment and the special nano property of their Fe-Mn minerals enrich the REE adsorption. | GUAN Yao SUN Xiaoming SHI Guiyong JIANG Xiaodong LU Hongfeng | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 5 |
| 5 | A 10×10 deep ultraviolet light-emitting micro-LED array显示文摘In this work,we design and fabricate a deep ultraviolet(DUV)light-emitting array consisting of 10×10 micro-LEDs(μ-LEDs)with each device having 20μm in diameter.Strikingly,the array demonstrates a significant enhancement of total light output power by nearly 52%at the injection current of 100 mA,in comparison to a conventional large LED chip whose emitting area is the same as the array.A much higher(~22%)peak external quantum efficiency,as well as a smaller efficiency droop forμ-LED array,was also achieved.The numerical calculation reveals that the performance boost can be attributed to the higher light extraction efficiency at the edge of eachμ-LED.Additionally,the far-field pattern measurement shows that theμ-LED array possesses a better forward directionality of emission.These findings shed light on the enhancement of the DUV LEDs performance and provide new insights in controlling the light behavior of theμ-LEDs. | Huabin Yu Muhammad Hunain Memon Hongfeng Jia Haochen Zhang Meng Tian Shi Fang Danhao Wang Yang Kang Shudan Xiao Shibing Long Haiding Sun | 2022 | Journal of Semiconductors2022，43，6： | 3 |
| 6 | Integration of satellite remote sensing data in underground coal fire detection:A case study of the Fukang region,Xinjiang,China显示文摘Xinjiang in China is one of the areas worst affected by coal fires.Coal fires cannot only waste a large amount of natural resources and cause serious economic losses,but they also cause huge damage to the atmosphere,the soil,the surrounding geology,and the environment.Therefore,there is an urgent need to effectively explore remote sensing based detection of coal fires for timely understanding of their latest development trend.In this study,in order to investigate the distribution of coal fires in an accurate and reliable manner,we exploited both Landsat-8 optical data and Sentinel-1A synthetic aperture radar(SAR)images,using the generalized single-channel algorithm and the InSAR time-series analysis approach,respectively,for coal fire detection in the southern part of the Fukang region of Xinjiang,China.The generalized single-channel algorithm was used for land surface temperature information extraction.Meanwhile,the timeseries InSAR analysis technology was employed for estimating the surface micro deformation information,which was then used for building a band-pass filter.The suspected coal fire locations could then be established by a band-pass filtering operation on the obtained surface temperature map.Finally,the locations of the suspected coal fires were validated by the use of field survey data.The results indicate that the integration of thermal infrared remote sensing and radar interferometry technologies is an efficient investigation approach for coal fire detection in a large-scale region,which would provide the necessary spatial information support for the survey and control of coal fires. | Shiyong YAN Ke SHI Yi LI Jinglong LIU Hongfeng ZHAO | 2020 | Frontiers of Earth Science2020，14，1： | 2 |
| 7 | Geochemistry and Geochronology of Diorite in Pengshan Area of Jiangxi Province:Implications for Magmatic Source and Tectonic Evolution of Jiangnan Orogenic Belt显示文摘Magmatic activities associated with tectonic events play a significant role in understanding the evolution of an orogenic belt.The Jiangnan orogenic belt has been regarded as the collisional suture zone between the Yangtze Block and the Cathaysia Block.Although the magmatic activities during the period of intra-plate extension after the collision have been well studied in recent years,some remaining issues,including source nature and geodynamic mechanism,need to be further addressed.In this paper,based on a detailed field geological,petrological,geochemical and geochronological study,we focus our work on diorites in the Pengshan area located at the northwestern margin of the Jiangnan orogenic belt.The mineral assemblages are mainly composed of plagioclase(55 vol.%-65 vol.%)and hornblende(35 vol.%-45 vol.%).One diorite sample yields zircon^(206)Pb/^(238)U mean age of 768±8 Ma(MSWD=0.29).The diorites have enriched large ion lithophile elements(Ba,K and Rb)and incompatible elements(Th and U),and are depleted in high field-strength elements including Ta,Ti and Nb.Diorites in this study have relatively high MgO content(6.56 wt.%-7.58 wt.%,7.07 wt.%on average)and Mg number values(65-67,65.8 on average).The diorites are metaluminous,high K calc-alkaline series rocks with high contents of K_2O(1.59 wt.%-1.97 wt.%)and total alkali(Na_2O+K_2O=5.56 wt.%-6.05 wt.%).The Nd/Th ratio(4.34-5.27)is higher than that of crust-derived rocks and lower than mantle-derived rocks.The Rb/Sr ratio(0.19-0.22)is slightly lower than crust,but significantly higher than upper mantle.Based on the above geochemical and geochronological analyses,we suggest that the diorites in the Pengshan area were mainly derived from crustal materials with a small amount of mantleoriginated materials involved,and possibly produced from an extensional tectonic setting after the collision between the Yangtze Block and Cathaysia Block. | Hongfeng Shi Junpeng Wang Yuan Yao Jing Zhang Song Jin Yingxin Zhu Kang Jiang Xiaolong Tian Deng Xiao Wenbin Ning | 2020 | Journal of Earth Science2020，31，1： | 2 |
| 8 | Construction of recombinant adenovirus vector with connexin 43 gene显示文摘 | Jin Wu Wentao Liu Yongqing Li Brett Schroeder Hongfeng Zhou Dan Liu Xiaolong Yue Guangyue Shi Xiwen Sun Yanbin Zhao Yali Wang Xin Qiu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 1 |
| 9 | Synthesis and properties of Fe 3 O 4 /polyaniline and its tiny magnetic field functions during oxygen transfer processes显示文摘 | Jicheng Shi Hongfeng Xu Hong Zhao Lu Lu | 2012 | Journal of Power Sources2012，，： | 1 |
| 10 | End-effect of the permanent-magnet spherical motor and its influence on back-EMF characteristics显示文摘The permanent-magnet(PM) spherical motor has special configuration and complicated distribution of electromagnetic field.The spatial distribution of the effective flux density produced by permanent magnets is obtained,and the end-effect of the permanent magnets is analyzed.In the 3-dimensional(3-D) finite element(FE) analysis,the calculation of Back-EMF charac-teristics of the PM spherical motor needs to be conducted by steps,which leads to large computational burden.A novel ana-lyzing method to quantize the end-effect of the PM spherical motor is proposed,that is,the end-effect coefficient of the PM spherical motor is calculated to revise the back-EMF waveform obtained from the 2-D FE model.Under different outer radii of the stator coil and different pole arc coefficients of the PM spherical motor,the revised 2-D results are validated by the results obtained from the 3-D FE model and the experimental results.With this method,the special structural feature of the PM spherical motor is fully considered;the pure 3-D calculation of electromagnetic field is conducted only once;higher precision and less computational burden can be achieved.The method provides a new approach to investigating the back-EMF charac-teristic of the PM spherical motor. | SHI TingNa SONG Peng LI HongFeng XIA ChangLiang | 2012 | Science China(Technological Sciences)2012，55，1： | 1 |
| 11 | 3D magnetic field and torque analysis of a novel Halbach array permanent-magnet spherical rnotor显示文摘 | Xia Changliang Li Hongfeng Shi Tingna | 2008 | 1EEE Transactions on Magnetics2008，44，8： | 1 |
| 12 | Microwave-treated graphite felt as the positive electrode for all-vanadium redox flow battery显示文摘 | Xiaoxin Wu Hongfeng Xu Pengcheng Xu Yang Shen Lu Lu Jicheng Shi Jie Fu Hong Zhao | 2014 | Journal of Power Sources2014，，： | 1 |
| 13 | Role of epimorphin in bile duct formation of rat liver epithelial stem‐like cells: Involvement of small G protein RhoA and C/EBPβ显示文摘 | Yali Jia Hailei Yao Junnian Zhou Lin Chen Quan Zeng Hongfeng Yuan Lei Shi Xue Nan Yunfang Wang Wen Yue Xuetao Pei | 2011 | J Cell Physiol2011，，11： | 1 |
| 14 | 3-D mag- netic field and torque analysis of a novel halbach army permanent-magnet spherical motor显示文摘 | Xia Changliang Li Hongfeng Shi Tingna | 2008 | IEEE Transac- tions on Magnetics2008，44，8： | 1 |
| 15 | 3-D magnetic field and torque analysis of a novel Halbach array permanent-magnet spherical motor显示文摘 | Xia Changliang Li Hongfeng Shi Tingna | 2008 | IEEE Transactions on Magnetics2008，44，8： | 1 |
| 16 | 3-D magnetic field and torque analysis of a novel Halbach array permanent-magnet spherical motor显示文摘 | Xia Changliang Li Hongfeng Shi Tingna | 2008 | IEEE Transactions on Magnetics2008，44，8： | 1 |
| 17 | Isolation and analysis of SSEA-4 positive cells derived from fetal marrow mesenchymal stem cells显示文摘A big issue in stem cell research is to derive prospective totipotential stem cells. In this study, fMSC-SSEA-4 cells expressing SSEA-4 anti- gen were isolated from fetal marrow masenchymal stem cells (fMSCs) using immunomagnetic bead sorting technique. The totipotent cells were identified and their biological characteristics were further stud- ied. The expression of Oct-4 and SSEA-4, carcino- genicity, and the ability to differentiation of fMSC- SSEA-4 cells were evaluated to verify the totipotent potential. fMSC-SSEA-4 cells were isolated suc- cessfully from fMSCs (2.5% among fMSCs), while no obvious differences were seen in morphology, growth curve, cell cycle and immunophenotype, Oct-4 and SSEA-4 expression between fMSC-SSEA-4 cells and fMSCs. fMSC-SSEA-4 cells showed normal diploid chromosome karyotype and no carcinoma was in- duced after inoculation into nude mice. fMSC- SSEA-4 cells could be induced to fat cells, osteo- genic cells and neuron-like cells in vitro with different induced factors. The results indicated that there may be a few totipotent cells among the fMSCs and it may offer the experimental basis for the further study and application of fMSCs. | LIU Daqing YANG Yinxiang GAO Yanhong YUAN Hongfeng QIN Lipeng WANG Yunfang NAN Xue SHI Shuangshuang YUE Wen PEI Xuetao | 2006 | Chinese Science Bulletin2006，51，12： | 0 |
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