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| 1 | 养殖废水固定化微生物脱氮技术研究进展显示文摘 | 任海波 汝少国 赵书云 Haruo Saida | 2004 | 海洋科学2004，28，4： | 8 |
| 2 | Endoscopic features of early-stage signet-ring-cell carcinoma of the stomach显示文摘AIM: To identify the features of early signet ring cell gastric carcinoma using magnification endoscopy with narrow band imaging(NBI).METHODS: A retrospective review was conducted of 12 cases of early signet ring cell gastric carcinoma who underwent treatment in a single institution between January 2009 and April 2013. All patients had magnification endoscopy with NBI and indigo carmine contrast to closely examine the mucosal architecture, including the microvasculature and arrangement of gastric pits. Histologic examination of the final endoscopic submucosal dissection or gastrectomy specimen was performed and compared with the endoscopic findings to identify patterns specific to signet ring cell carcinoma.RESULTS: Twelve patients with early signet ring cell gastric carcinoma were identified; 75% were male, and average age was 61 years. Most of the lesions were stage T1a(83%), while the remainder were T1b(17%). The mean lesion size was 1.4 cm2. On standard endoscopy, all 12 patients had a pale, flat lesion without any evidence of mucosal abnormality such as ulceration, elevation, or depression. On magnification endoscopywith NBI, all of the patients had irregularities in the glands and microvasculature consistent with early gastric cancer. In addition, all 12 patients exhibited the 'stretch sign', an elongation or expansion of the architectural structure. Histologic examination of the resected specimens demonstrated an expanded and edematous mucosal layer infiltrated with tumor cells.CONCLUSION: The 'stretch sign' appears to be specific for signet ring cell carcinoma and may aid in the early diagnosis and treatment of this aggressive pathology. | Chainarong Phalanusitthepha Kevin L Grimes Haruo Ikeda Hiroki Sato Chiaki Sato Chananya Hokierti Haruhiro Inoue | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 8 |
| 3 | Submucosal tunnel endoscopy:Peroral endoscopicmyotomy and peroral endoscopic tumor resection显示文摘Peroral endoscopic myotomy(POEM) is an innovative,minimally invasive, endoscopic treatment for esophageal achalasia and other esophageal motility disorders, emerged from the natural orifice transluminal endoscopic surgery procedures, and since the first human case performed by Inoue in 2008, showed exciting results in international level, with more than 4000 cases globally up to now. POEM showed superior characteristics than the standard 100-year-old surgical or laparoscopic Heller myotomy(LHM), not only for all types of esophageal achalasia [classical(Ⅰ), vigorous(Ⅱ), spastic(Ⅲ), Chicago Classification], but also for advanced sigmoid type achalasia(S1 and S2), failed LHM, or other esophageal motility disorders(diffuse esophageal spasm, nutcracker esophagus or Jackhammer esophagus). POEM starts with a mucosal incision, followed by submucosal tunnel creation crossing the esophagogastric junction(EGJ) and myotomy. Finally the mucosal entry is closed with endoscopic clip placement. POEM permitted relatively free choice of myotomy length and localization. Although it is technically demanding procedure, POEM can be performed safely and achieves very good control of dysphagia and chest pain. Gastroesophageal reflux is the most common troublesome side effect, and is well controllable with proton pump inhibitors. Furthermore, POEM opened the era of submucosal tunnel endoscopy, with many other applications. Based on the same principles with POEM, in combination with new technological developments, such as endoscopic suturing, peroral endoscopic tumor resection(POET), is safely and effectively applied for challenging submucosal esophageal, EGJ and gastric cardia tumors(submucosal tumors), emerged from muscularis propria. POET showed up to know promising results, however, it is restricted to specialized centers. The present article reviews the recent data of POEM and POET and discussed controversial issues that need further study and future perspectives. | Nikolas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Roberta Maselli Grace Santi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 7 |
| 4 | Kuroshio warm filament and the source of the warm water of the Tsushima Current显示文摘Characteristics and evolution of the Kuroshio frontal eddies and warm filaments are analyzed according to two series of satellite images (March 5 to 7, 1986 and April 14 to 16, 1988). The results show that the frontal eddies in the East China Sea are generated at the shelf break and move along the continental slope at a speed of 15 cm/s with the Kuroshio. The frontal eddies occur about every 10 d and evolve to be warm filaments a few hundred km in length and 30-40 km in width in the area west of the Yaku-shima. Meanwhile, the existence of the warm filament was also found in the area by analysing the hydrographic data in the area west of Kyushu during May 24-June 5, 1988.The Kuroshio warm filaments move westward opposite to the Kuroshio and then turn northward at the shelf break and become the main source of the warm water of the Tsushima Warm Current. A simple dynamic explanation for the process is presented in this paper. | Guo Binghuo, Xiu Shumeng, Haruo Ishii and Yasuaki Nakamura First Institute of Oceanography, State Oceanic Administration, Oingdao, 266003, ChinaHydrographic Department, Maritime Safety Agency, Tokyo, JapanSeikai Fisheries Research Institute, Fisheries Agency Nagasaki, Japan | 1991 | Acta Oceanologica Sinica1991，10，3： | 6 |
| 5 | Recent aspects for disseminated carcinomatosis of the bone marrow associated with gastric cancer: What has been done for the past, and what will be needed in future?显示文摘Disseminated carcinomatosis of the bone marrow is characterized by widespread bone metastasis(bone marrow infiltration) from solid tumors with hematological disorders coexisted. This disease is frequently complicated with gastric cancer among solid tumors although its incidence is very rare. In recent years,technological innovations in diagnosis and treatment for cancer have remarkably improved,which made survival rates of various cancers prolonged. Prognosis of disseminated carcinomatosis of the bone marrow associated with gastric cancer,however,is still poor(less than a year),possibly because this disease has not been given attention due to low incidence. In this review,I summarize the results obtained for the past,and propose ways to improve the prognosis of this disease. | Haruo Iguchi | 2015 | World Journal of Gastroenterology2015，21，43： | 5 |
| 6 | 玉柏石松中新△^(14)-Serratene型五环三萜酯显示文摘从玉柏石松中分得三个新的Δ^(14)-serratene型的五环三萜酯(1—3),根据其理化挂质和波谱数据,运用二维核磁共振新技术异核远程相关谱(HMBG),证明1为16-oxo-lyclanitin-30-yl-p-coumarate,2为16-oxo-diepilycocryptol-30-yl-p-coumarate,8为diepilycocryptol-30-yl-p-coumarate,并指定了1中所有碳和氢、2和3中所有碳和部分氢的NMR信号的归属。 | 蔡雄 潘德济 徐光漪 Seto Haruo Furihata Kazuo | 1992 | 化学学报1992，50，1： | 5 |
| 7 | Endoscopic submucosal dissection of a rectal carcinoid tumor using grasping type scissors forceps显示文摘Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure associated with a high complication rate. The shortcomings of this method are the inability to fix the knife to the target lesion, and compression of the lesion. These can lead to major complications such as perforation and bleeding. To reduce the risk of complications related to ESD, we developed a new grasping type scissors forceps (GSF), which can grasp and incise the targeted tissue using electrosurgical current. Colonoscopy on a 55-year-old woman revealed a 10-mm rectal submucosal nodule. The histological diagnosis of the specimen obtained by biopsy was carcinoid tumor. Endoscopic ultrasonography demonstrated a hypoechoic solid tumor limited to the submucosa without lymph node involvement. It was safely and accurately resected without unexpected incision by ESD using a GSF. No delayed hemorrhage or perforation occurred. Histological examination confirmed the carcinoid tumor was completely excised with negative resection margin. | Kazuya Akahoshi Yasuaki Motomura Masaru Kubokawa Noriaki Matsui Manami Oda Risa Okamoto Shingo Endo Naomi Higuchi Yumi Kashiwabara Masafumi Oya Hidefumi Akahane Haruo Akiba | 2009 | World Journal of Gastroenterology2009，15，17： | 4 |
| 8 | Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo显示文摘 | Masahiko Kurokawa Kazuhiko Nagasaka Tatsuji Hirabayashi Shin-ichi Uyama Hideki Sato Takashi Kageyama Shigetoshi Kadota Haruo Ohyama Toyoharu Hozumi Tsuneo Namba Kimiyasu Shiraki | 1995 | Antiviral Research1995，，1： | 3 |
| 9 | Urban-Rural Comparison of HBV and HCV Infection Prevalence in Eastern China显示文摘The present study was initiated to make an urban rural comparison of the prevalence of cases positive to hepatitis B and C virus (HBV and HCV, respectively) infection markers in densely populated eastern half of China. For this purpose, 10 survey sites were selected, i.e., six sites in urban areas (the city group; Beijing, Shanghai and four provincial capitals) and four sites in rural areas (the village group ; one village each in Jilin and Shandong Provinces, and two villages in Shaanxi Province). About 50 adult women per site volunteered to participate, from whom 494 valid blood samples were collected. Positivities to HBsAg (HBsAg +), anti HBs (anti HBs +) and anti HBc (anti HBc +) were examined by RIA methods, and that to anti HCV (anti HCV +) by either EIA or RIA. Those positive to any one of the three HBV infection markers were taken as HBV infection positive (HBV +). The prevalence of HBsAg +, HBV + and anti HBc + was 8%, 70% and 2.7% in the city group, and 8%, 65% and 2.0% in the village group, and no significant difference was found between the two groups. The overall prevalence was 8% for HBsAg +, 68% for HBV +, and 2.4% for anti HCV +. The results were discussed in reference to some 20 papers each on HBV + and anti HCV + prevalence in China published since 1991. The reviewing of these papers confirmed that the prevalence of HBV was high (i.e., in excess of 50%), whereas the prevalence of anti HCV was low (well below 5%), and that no substantial difference was found between the rural and urban populations. | QU JIANG-BIN ZHANG ZUO-WEN SHINICHIRO SHIMBO TAKAO WATANABE HARUO NAKATSUKA NAOKO MATSUDA-INOGUCHI KAE HIGASHIKAWA MASAYUKI IKEDA | 2000 | Biomedical and Environmental Sciences2000，13，4： | 3 |
| 10 | Role of androgen receptor in prostate cancer显示文摘The growth of prostate cancer is sensitive to androgen, and hormonal therapy has been used for treatment of ad-vanced cancer. About 80 % of prostate cancers initially respond to hormonal therapy, howcrver, more than half of the re-sponders gradtmlly become resistant to this therapy. Changes in tumors from an androgen-responsive to an androgen-unre-sponsive state have been widely discussed. Since androgen action is mediated by androgen receptor (AR), abnonnalitiesof AR is believed to play an important role of the loss of androgen responsiveness in prostate cancer. 'Ilais article focusedon the role of AR in the progression of prostate cancer. | Hiroyoshi Suzuki Haruo Ito | 1999 | Asian Journal of Andrology1999，1，3： | 3 |
| 11 | Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis显示文摘瞄准:显示出是否分子的马达达因在在一条微导管轨道,分子的马达肌浆球蛋白 Va,马达 recruiter 肌浆球蛋白 Va, VIIa-Rab27a/b 交往蛋白质(MyRIP ) ,和泡受体上,一条 F 肌动朊轨道上的 Rab27b 在包含 intramanchette 运输(IMT ) 的人和猴子精子形式期间是在场的。方法:Spermiogenic 房间与妨碍的精子缺乏和正常成年 cynomolgus 猴子(Macacafascieularis ) 从三个人被获得。Immunocytochemical 察觉和反向的抄写聚合酶链反应(RT-PCR ) 蛋白质的分析被执行。样品被轻显微镜分析。结果:用 RT-PCR,我们发现了那达因在,肌浆球蛋白 Va, MyRIP 和 Rab27b 在猴子睾丸被表示。,这些蛋白质对领局部性由免疫荧光出现,特别地在人和猴子精子形式期间。结论:我们推测在首领精子形式期间,填写基于微导管、基于肌动朊的泡的那些蛋白质搬运系统,这实际上是在领的现在并且可能可能涉及 intramanchette 运输。 | Shinichi Hayasaka Yukihiro Terada Kichiya Suzuki Haruo Murakawa Ikuo Tachibana Tadashi Sankai Takashi Murakami Nobuo Yaegashi Kunihiro Okamura | 2008 | Asian Journal of Andrology2008，10，4： | 3 |
| 12 | In vivo gastric mucosal histopathology using endocytoscopy显示文摘AIM:To study the ability of endocytoscopy to identify normal gastric mucosa and to exclude Helicobacter pylori(H.pylori) infection.METHODS:Endocytoscopic examination of the gastric corpus and antrum was performed in 70 consecutive patients.Target biopsy specimens were also obtained from the assessed region and multiple H.pylori tests were performed.The normal endocytoscopy patterns of the corpus and antrum were divided into the normal pit-dominant type(n-Pit) or the normal papilladominant type(n-Pap), respectively characterized as either regular pits with capillary networks or round, smooth papillary structures with spiral capillaries.On the other hand, normal mucosa was defined as mucosa not demonstrating histological abnormalities, including inflammation and atrophy.RESULTS:The sensitivity and specificity of n-Pit for normal mucosa in the gastric corpus were 94.4%and 97.1%,respectively,whereas those of n-Pap for normal mucosa in the antrum were 92.0%and 86.7%,respectively.The positive predictive values of n-Pit and n-Pap for H.pylori-negative tissue were 88.6%and 93.1%,respectively,and their negative predictive values for H.pylori-negative tissues were 42.9%and41.5%,respectively.The inter-observer agreement for determining n-Pit and n-Pap for normal mucosa were0.857 and 0.769,respectively,which is considered reliable.CONCLUSION:N-Pit and n-Pap,seen using EC,are considered useful predictors of normal mucosa and theabsence of H.pylori infection. | Hiroki Sato Haruhiro Inoue Haruo Ikeda Chiaki Sato Chainarong Phlanusittepha Bu'Hussain Hayee Esperanza Grace R Santi Yasutoshi Kobayashi Shin-ei Kudo | 2015 | World Journal of Gastroenterology2015，21，16： | 3 |
| 13 | Spatiotemporal changes of coxsackievirus and adenovirus receptor in rat hearts during postnatal development and in cultured cardiomyocytes of neonatal rat显示文摘 | Takeshi Kashimura Makoto Kodama Yuko Hotta Junichi Hosoya Kaori Yoshida Takuya Ozawa Ritsuo Watanabe Yuji Okura Kiminori Kato Haruo Hanawa Ryozo Kuwano Yoshifusa Aizawa | 2004 | Virchows Archiv2004，，3： | 2 |
| 14 | Load Sharing Behavior of Star Gearing Reducer for Geared Turbofan Engine显示文摘Load sharing behavior is very important for power-split gearing system,star gearing reducer as a new type and special transmission system can be used in many industry fields.However,there is few literature regarding the key multiple-split load sharing issue in main gearbox used in new type geared turbofan engine.Further mechanism analysis are made on load sharing behavior among star gears of star gearing reducer for geared turbofan engine.Comprehensive meshing error analysis are conducted on eccentricity error,gear thickness error,base pitch error,assembly error,and bearing error of star gearing reducer respectively.Floating meshing error resulting from meshing clearance variation caused by the simultaneous floating of sun gear and annular gear are taken into account.A refined mathematical model for load sharing coefficient calculation is established in consideration of different meshing stiffness and supporting stiffness for components.The regular curves of load sharing coefficient under the influence of interactions,single action and single variation of various component errors are obtained.The accurate sensitivity of load sharing coefficient toward different errors is mastered.The load sharing coefficient of star gearing reducer is 1.033 and the maximum meshing force in gear tooth is about 3010 N.This paper provides scientific theory evidences for optimal parameter design and proper tolerance distribution in advanced development and manufacturing process,so as to achieve optimal effects in economy and technology. | Shuai MO Yidu ZHANG Qiong WU Feiming WANG Shigeki MATSUMURA Haruo HOUJOH | 2017 | Chinese Journal of Mechanical Engineering2017，30，4： | 2 |
| 15 | Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, and Beyond: Full-Layer Resection for Gastric Cancer with Nonexposure Technique (CLEAN-NET)显示文摘 | Haruhiro Inoue Haruo Ikeda Toshihisa Hosoya Akira Yoshida Manabu Onimaru Michitaka Suzuki Shin-ei Kudo | 2012 | Surgical Oncology Clinics of North America2012，，1： | 2 |
| 16 | Endocytoscopic visualization of squamous cell islands within Barrett's epithelium显示文摘AIM: To study the endocytoscopic visualization of squamous cell islands within Barrett's epithelium. METHODS: Endocytoscopy (ECS) has been studied in the surveillance of Barrett's esophagus, with controversial results. In initial studies, however, a soft catheter type endocytoscope was used, while only methylene blue dye was used for the staining of Barrett's mucosa. Integrated type endocytoscopes (GIF-Q260 EC, Olympus Corp, Tokyo, Japan) have been recently developed, with the incorporation of a high-power magnifying endocytoscope into a standard endoscope together with narrow-band imaging (NBI). Moreover, double staining with a mixture of 0.05% crystal violet and 0.1% of methylene blue (CM) during ECS enables higher quality images comparable to conventional hematoxylin eosin histopathological images.RESULTS: In vivo endocytoscopic visualization of papillary squamous cell islands within glandular Barrett's epithelium in a patient with long-segment Barrett's esophagus is reported. Conventional white light endoscopy showed typical long-segment Barrett's esophagus, with small squamous cell islands within normal Barrett's mucosa, which were better visualized by NBI endoscopy. ECS after double CM staining showed regular Barrett's esophagus, while higher magnification (×480) revealed the orifices of glandular structures better. Furthermore, typical squamous cell papillary protrusion, classified as endocytoscopic atypia classification (ECA) 2 according to ECA, was identified within regular glandular Barrett's mucosa. Histological examination of biopsies taken from the same area showed squamous epithelium within glandular Barrett's mucosa, corresponding well to endocytoscopic findings. CONCLUSION: To our knowledge, this is the first report of in vivo visualization of esophageal papillary squamous cell islands surrounded by glandular Barrett's epithelium. | Nicholas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Toshihisa Hosoya Roberta Maselli Shin-ei Kudo | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，4： | 2 |
| 17 | Per-oral Endoscopic Myotomy is a Viable Option for Failed Surgical Esophagocardiomyotomy Instead of Re-Do Surgical Heller Myotomy: A Single Center Prospective Study显示文摘 | Manabu Onimaru Haruhiro Inoue Haruo Ikeda Akira Yoshida Esperanza Grace Santi Hiroki Sato Hiroaki Ito Roberta Maselli Shin-ei Kudo | 2013 | Journal of the American College of Surgeons2013，，： | 2 |
| 18 | 54 Clinical Results in 300 Cases of POEM for Esophageal Achalasia a Single Institute Registered Prospective Study显示文摘 | Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Hiroki Sato Esperanza Grace R. Santi Roberta Maselli Nicholas Eleftheriadis Shin-Ei Kudo | 2013 | Gastrointestinal Endoscopy2013，，5： | 2 |
| 19 | Endoscopic retrograde cholangiopancreatography for bile duct stones in patients with a performance status score of 3 or 4显示文摘BACKGROUND As the aging population grows worldwide,the rates of endoscopic retrograde cholangiopancreatography(ERCP)for common bile duct stones(CBDS)in older patients with a poor performance status(PS)have been increasing.However,the data on the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4 are lacking,with only a few studies having investigated this issue among patients with poor PS.AIM To examine the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4.METHODS This study utilized a retrospective multi-centered design of three institutions in Japan for 8 years to identify a total of 1343 patients with CBDS having native papillae who underwent therapeutic ERCP.As a result,1113 patients with a PS 0-2 and 230 patients with a PS 3-4 were included.One-to-one propensity-score matching was performed to compare the safety and efficacy of ERCP for CBDS between patients with a PS 0-2 and those with a PS 3-4.RESULTS The overall ERCP-related complication rates in all patients and propensity score-matched patients with a PS 0-2 and 3-4 were 9.0%(100/1113)and 7.0%(16/230;P=0.37),and 4.6%(9/196)and 6.6%(13/196;P=0.51),respectively.In the propensity score-matched patients,complications were significantly more severe in the group with a PS 3-4 than in the group with a PS 0-2 group(P=0.042).Risk factors for complications were indications of ERCP and absence of antibiotics in the multivariate analysis.Therapeutic success rates,including complete CBDS removal and permanent biliary stent placement,in propensity score-matched patients with a PS 0-2 and 3-4 were 97.4%(191/196)and 97.4%(191/196),respectively(P=1.0).CONCLUSION ERCP for CBDS can be effectively performed in patients with a PS 3 or 4.Nevertheless,the indication for ERCP in such patients should be carefully considered with prophylactic antibiotics. | Hirokazu Saito Yoshihiro Kadono Takashi Shono Kentaro Kamikawa Atsushi Urata Jiro Nasu Haruo Imamura Ikuo Matsushita Tatsuyuki Kakuma Shuji Tada | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，4： | 2 |
| 20 | Chemoimmunotherapy targeting Wilms’ tumor 1 (WT1)-specific cytotoxic T lymphocyte and helper T cell responses for patients with pancreatic cancer显示文摘 | Shigeo Koido Sadamu Homma Masato Okamoto Kazuki Takakura Jianlin Gong Haruo Sugiyama Toshifumi Ohkusa Hisao Tajiri | 2014 | OncoImmunology2014，，10： | 2 |
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