|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Comparison of RECIST version 1.0 and 1.1 in assessment of tumor response by computed tomography in advanced gastric cancer显示文摘Objective:Response Evaluation Criteria in Solid Tumors(RECIST)guideline version 1.0(RECIST 1.0)was proposed as a new guideline for evaluating tumor response and has been widely accepted as a standardized measure.With a number of issues being raised on RECIST 1.0,however,a revised RECIST guideline version 1.1(RECIST 1.1)was proposed by the RECIST Working Group in 2009.This study was conducted to compare CT tumor response based on RECIST 1.1 vs.RECIST 1.0 in patients with advanced gastric cancer(AGC).Methods:We reviewed 61 AGC patients with measurable diseases by RECIST 1.0 who were enrolled in other clinical trials between 2008 and 2010.These patients were retrospectively re-analyzed to determine the concordance between the two response criteria using theκstatistic.Results:The number and sum of tumor diameters of the target lesions by RECIST 1.1 were significantly lower than those by RECIST 1.0(P<0.0001).However,there was excellent agreement in tumor response between RECIST 1.1 and RECIST 1.0(κ=0.844).The overall response rates(ORRs)according to RECIST1.0 and RECIST 1.1 were 32.7%(20/61)and 34.5%(20/58),respectively.One patient with partial response(PR)based on RECIST 1.0 was reclassified as stable disease(SD)by RECIST 1.1.Of two patients with SD by RECIST 1.0,one was downgraded to progressive disease and the other was upgraded to PR by RECIST 1.1.Conclusions:RECIST 1.1 provided almost perfect agreement with RECIST 1.0 in the CT assessment of tumor response of AGC. | Gil-Su Jang Min-Jeong Kim Hong-Il Ha Jung Han Kim Hyeong Su Kim Sung Bae Ju Dae Young Zang | 2013 | Chinese Journal of Cancer Research2013，25，6： | 42 |
| 3 | RESTplus: an improved toolkit for resting-state functional magnetic resonance imaging data processing显示文摘Resting-state functional magnetic resonance imaging (RS-fMRI)[1,2] provides relatively high spatial and temporal resolution for mapping spontaneous brain activity non-invasively. It has been widely used in cognitive neuroscience and clinical studies. A number of comprehensive software packages have been developed for RS-fMRI data analysis, among which a MATLAB package named REST (RESing-state fMRI data analysis Toolkit, released in October 2008 at http://gffzz99d25abdda23474bhwocw06v9xc506fpx.ffgz.tsg.suse.edu.cn)[3] is the earliest one dedicated to RS-fMRI analysis. REST focuses on RS-fMRI postprocessing metrics. | Xi-Ze Jia Jue Wang Hai-Yang Sun Han Zhang Wei Liao Ze Wang Chao-Gan Yan Xiao-Wei Song Yu-Feng Zang | 2019 | Science Bulletin2019，64，14： | 14 |
| 4 | Spatial and temporal change patterns of net primary productivity and its response to climate change in the Qinghai–Tibet Plateau of China from 2000 to 2015显示文摘The vegetation ecosystem of the Qinghai–Tibet Plateau in China,considered to be the′′natural laboratory′′of climate change in the world,has undergone profound changes under the stress of global change.Herein,we analyzed and discussed the spatial-temporal change patterns and the driving mechanisms of net primary productivity(NPP)in the Qinghai–Tibet Plateau from 2000 to 2015 based on the gravity center and correlation coefficient models.Subsequently,we quantitatively distinguished the relative effects of climate change(such as precipitation,temperature and evapotranspiration)and human activities(such as grazing and ecological construction)on the NPP changes using scenario analysis and Miami model based on the MOD17A3 and meteorological data.The average annual NPP in the Qinghai–Tibet Plateau showed a decreasing trend from the southeast to the northwest during 2000–2015.With respect to the inter-annual changes,the average annual NPP exhibited a fluctuating upward trend from 2000 to 2015,with a steep increase observed in 2005 and a high fluctuation observed from 2005 to 2015.In the Qinghai–Tibet Plateau,the regions with the increase in NPP(change rate higher than 10%)were mainly concentrated in the Three-River Source Region,the northern Hengduan Mountains,the middle and lower reaches of the Yarlung Zangbo River,and the eastern parts of the North Tibet Plateau,whereas the regions with the decrease in NPP(change rate lower than–10%)were mainly concentrated in the upper reaches of the Yarlung Zangbo River and the Ali Plateau.The gravity center of NPP in the Qinghai–Tibet Plateau has moved southwestward during 2000–2015,indicating that the increment and growth rate of NPP in the southwestern part is greater than those of NPP in the northeastern part.Further,a significant correlation was observed between NPP and climate factors in the Qinghai–Tibet Plateau.The regions exhibiting a significant correlation between NPP and precipitation were mainly located in the central and eastern Qinghai–Tibet Plateau,and the regions exhibiting a significant correlation between NPP and temperature were mainly located in the southern and eastern Qinghai–Tibet Plateau.Furthermore,the relative effects of climate change and human activities on the NPP changes in the Qinghai–Tibet Plateau exhibited significant spatial differences in three types of zones,i.e.,the climate change-dominant zone,the human activity-dominant zone,and the climate change and human activity interaction zone.These research results can provide theoretical and methodological supports to reveal the driving mechanisms of the regional ecosystems to the global change in the Qinghai–Tibet Plateau. | GUO Bing ZANG Wenqian YANG Fei HAN Baomin CHEN Shuting LIU Yue YANG Xiao HE Tianli CHEN Xi LIU Chunting GONG Rui | 2020 | Journal of Arid Land2020，12，1： | 12 |
| 5 | Pharyngeal aerodynamic characteristics of obstructive sleep apnea/hypopnea syndrome patients显示文摘 | ZANG Hong-rui LI Li-feng ZHOU Bing LI Yun-chuan WANG Tong HAN De-min | 2012 | Chinese Medical Journal2012，，17： | 8 |
| 6 | Antimyoclonic Effect of Levetiracetam and Clonazepam Combined Treatment on Myoclonic Epilepsy with Ragged-Red Fiber Syndrome with m.8344A〉G Mutation显示文摘 | Li-Jun Su Yu-Liang Wang Tao Han Shan Qiao Ke-Jun Zang Huai-Kuan Wu Yong-Xin Su Ling-Ling Liu Xue-Wu Liu | 2018 | Chinese Medical Journal2018，，20： | 7 |
| 7 | Exosomal miRNA profiling before and after surgery revealed potential diagnostic and prognostic markers for lung adenocarcinoma显示文摘Exosome is a crucial manner for cancer cell to cell communication and circulating exosomes sever as promising diagnostic and prognostic markers for various types of diseases.A predominant type of cargo of exosome is small RNAs,especially miRNAs.Here,we profiled plasma exosomal miRNAs of six lung adenocarcinoma patients before and after surgery,as well as six healthy individuals as normal control.Our profiling revealed 38 upregulated and 37 downregulated exosomal miRNAs in the plasma of lung adenocarcinoma patients.Additionally,we found that most upregulated miRNAs were increased in the lung adenocarcinoma samples of TCGA database.We further evaluated the correlation between the upregulated exosomal miRNAs and overall survival with Kaplan-Meier survival analysis using online databases.Our resu ltS suggested that exosomal miR-151a-5p,miR-10b-5p,miR-192-5p,miR-106b-3p,and miR-484 are potential prognostic markers for lung adenocarcinoma.Importantly,we validated candidate miRNAs in lung adenocarcinoma patients before and after surgery as well as in healthy controls and found that miR-484 was significantly increased in the plasma of lung adenocarcinoma patients and strikingly decreased post-surgery.Hence,we provided novel information on lung adenocarcinoma-derived exosomal miRNA and potential non-invasive diagnostic and prognostic markers for lung adenocarcinoma. | Xinying Xue Chen Wang Zhiqiang Xue Jiaxin Wen Jun Han Xidong Ma Xuelei Zang Hui Deng Rui Guo Idorenyin Polycarp Asuquo Chong Qin Haijiao Wang Quansheng Gao Sanhong Liu Jianxin Wang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 6 |
| 8 | Quantitatively determine the dominant driving factors of the spatial–temporal changes of vegetation NPP in the Hengduan Mountain area during 2000-2015显示文摘The Hengduan mountain area,located in the upper reaches of the Yangtze River of China,is an important ecological barrier that significantly impacts the climate and ecological environment of the surrounding region and western China as a whole.This paper introduces the gravity center model used to analyze the spatial-temporal variation patterns of vegetation Net Primary Productivity(NPP)from 2000 to 2015,which were determined by the use of MOD17 A3 NPP products.Additionally,the dominant driving factors of the spatial–temporal changes of vegetation NPP of the Hengduan Mountain area were quantitatively determined with a geographical detector over 2000-2015.The results revealed that:(1)From 2000 to 2015,there was an increasing trend of vegetation NPP in the Hengduan mountain area.Throughout the whole study region,the vegetation NPP with a mean value of 611.37 gC·m^(-2)·a^(-1) indicated a decreasing trend from southeast to northwest in terms of spatial distribution.(2)The gravity centers of vegetation NPP in 2000-2015 were mainly concentrated in Zhongdian County.During the study period,the gravity center of vegetation NPP moved northward,which indicated that the increment and increasing rate of vegetation NPP in the northern parts were greater than that of the southern areas.(3)The vegetation NPP showed a moderately positive correlation with temperature,accumulated temperature(>10℃),and sunshine,while there was an overall negative relationship between NPP and precipitation.(4)The dominant factors and interactive dominant factors changed in different subregions over different segments of the study period.The dominant factors of most sub-regions in Hengduan mountain were natural factors,and the climate change factors played an increasingly greater role over the 16 years of the study period. | CHEN Shu-ting GUO Bing ZHANG Rui ZANG Wen-qian WEI Cui-xia WU Hong-wei YANG Xiao ZHEN Xiao-yan LI Xing ZHANG Da-fu HAN Bao-min ZHANG Hai-ling | 2021 | Journal of Mountain Science2021，18，2： | 5 |
| 9 | Expression of ICAM-1, HLA-DR, and CD80 on peripheral circulating CD_1αDCs induced in vivo by IFN-αin patients with chronic hepatitis B显示文摘AIM: To explore the effects of interferon-α(IFN-α) application on peripheral circulating CD1αdendritic cells (DCs) in patients with chronic hepatitis B, and the expression of HLA-DR, CD80, and ICAM-1 on CD1αDCs in order to explore the mechanism of immune modulation of IFN-α. METHODS: By flow cytometry technique, changes of CD1αDCs were monitored in 22 patients with chronic hepatitis B treated with IFN-αand in 16 such patients not treated with IFN-αwithin three months. Meanwhile, the expression of HLA-DR, CD80, and ICAM-1 on CD1αDCs was detected. RESULTS: In the group of IFN-αtreatment, the percentage of CD1αDCs in peripheral blood mono-nuclear cells was increased after three months of therapy. In patients who became negative for HBV-DNA after IFN-αtreatment, the increase of DCs was more prominent, while in control, these changes were not observed. Increased expression of HLA-DR, CD80, and ICAM-1 on CD1αDCs was also observed. CONCLUSION: CD1αDCs can be induced by IFN-αin vivo, and the immune related molecules such as HLA-DR, CD80, and ICAM-1 are up-regulated to some degree. This might be an important immune related mechanism of IFN-αtreatment for chronic hepatitis B. | Yong-Sheng Yu Zheng-Hao Tang Jing-Chao Han Min Xi Jie Feng Guo-Qing Zang | 2006 | World Journal of Gastroenterology2006，12，9： | 5 |
| 10 | Dependence of nitrogen concentration in type Ib diamonds on synthesis temperature显示文摘Type Ib diamonds were grown by the temperature gradient method (TGM) at 5.5 GPa and 1500-1560 K in a china-type cubic anvil high pressure apparatus using Ni70Mn25Co5 alloy as solvent/catalyst. The concentration of nitrogen (CN) in type Ib diamonds synthesized at different synthesis temperatures was measured by a Fourier transform infrared (FTIR) spectrometer. The dependence of CN in diamond on synthesis temperature was studied. For the type Ib diamonds synthesized using Ni70Mn25Co5 as catalyst, its CN decreases along with the increase of synthesis temperature. | TIAN Yu JIA XiaoPeng ZANG ChuanYi LI ShangSheng XIAO HongYu ZHANG YaFei HUANG GuoFeng LI Rui HAN QiGang MA LiQiu LI Yong CHEN XiaoZhou ZHANG Chong MA HongAn | 2009 | Chinese Science Bulletin2009，54，9： | 5 |
| 11 | The selection of a primary marker for the Anthropocene显示文摘Since Homo sapiens appeared,the planet has experienced continuing environmental changes[1,2].In 2000,Crutzen and Stoermer[3]systematically analysed the global changes caused by human activity over the previous 300 years and suggested that the Holocene epoch ended in the 1750s and a new geological age,the Anthropocene,began.Afterwards,the Anthropocene drew a lot of attention from both scientific community and the general public.The recognition and placement of the Anthropocene/Holocene boundary has been a subject of heated debates over the past two decades.At the 35th International Geological Congress(2016;IGC),the Anthropocene Working Group(AWG)recommended the Anthropocene to be formalised with an epoch rank,with the 1950s as its lower boundary[4]. | Tianli Wang Liangcheng Tan Hai Xu Jingjie Zang Dong Li Jianghu Lan Yongming Han Li Li | 2019 | Science Bulletin2019，64，22： | 4 |
| 12 | Enhancement of cytotoxic T lymphocyte activity by dendritic cells loaded with Tat-protein transduction domain-fused hepatitis B virus core antigen显示文摘人的免疫不全 virus-1-Tat 蛋白质的蛋白质 transduction 领域(PTD ) 有唯一的力量渗透细胞的膜。综合 Tat-PTD 47 的顺序 57 和肝炎 B 病毒核心抗原(HBcAg ) ,我们拼接这些序列并且连接了熔化基因进 pMAL-c2x 向量。熔化蛋白质被亲密关系层析净化并且与骨头搏动了导出髓的树枝状的房间(DC ) ,和 recombinant 蛋白质的 transduction 被免疫检测荧光抗体试金。当 recombinant HBcAg 在房间的表面上被检测时,结果证明 recombinant PTD-HBcAg 能渗透细胞质进 DC。DC 表面分子的百分比 CD86 和主要 histocompatibility 建筑群 II,和 recombinant PTD-HBcAg 导致的 cytokine (IL-12p70 ) 的生产例如 CD80,比 recombinant HBcAg 或肿瘤坏死 factor-α 导致的那些显著地高。与 PTD-HBcAg 对待的 DC 导致了 T 房间区分进特定的细胞毒素的 T 淋巴细胞(CTL ) 并且提高了杀死反应的 CTL。在结论,表示并且净化的 PTD-HBcAg 熔化蛋白质能通过血浆膜渗透进房间,支持 DC 成熟,并且提高 T 房间反应高效地产生 HBcAg 特定的 CTL。 | Xiaohua Chen Yongsheng Yu Qingchun Pan Zhenghao Tang Jinchao Han Guoqing Zang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 4 |
| 13 | Tunable luminescent CsPb_2Br_5 nanoplatelets:applications in light-emitting diodes and photodetectors显示文摘Unlike organic–inorganic hybrid perovskites, all-inorganic cesium lead halide perovskites hold great promise for developing high-performance optoelectronic devices, owing to their improved stability. Herein, we investigate the perovskite-related CsPb_2 Br_5 nanoplatelets(NPLs) with tunable emission wavelengths via changing the reaction temperatures to 100°C, 120°C, and 140°C. Reaction temperature plays a key role in determining the shapes and thicknesses of the resulting CsPb_2 Br_5 NPLs. A higher temperature is in favor of the formation of smaller and thicker NPLs. To develop their potential applications in optoelectronic devices, green light emitting diodes(LEDs) and photodetectors based on CsPb_2 Br_5 NPLs are fabricated. The green LEDs based on CsPb_2 Br_5 NPLs synthesized at 140°C exhibit an excellent pure green emission(full width at half-maximum of <20 nm) and display a luminous efficiency of 34.49 lm∕W under an operation current of 10 m A. Moreover, the photodetector based on CsPb_2 Br_5 NPLs synthesized at 100°C has better performance with a rise time of 0.426 s, a decay time of0.422 s, and a ratio of the current(with and without irradiation) of 364%. | CENG HAN CUNLONG LI ZHIGANG ZANG MING WANG KUAN SUN XIAOSHENG TANG JIHE DU | 2017 | Photonics Research2017，5，5： | 4 |
| 14 | Intercluster aurophilicity-driven aggregation lighting circularly polarized luminescence of chiral gold clusters显示文摘Herein,we prepared two novel pairs of enantiomeric gold cluster complexes,AU4PL4/Au4PD4 and(Au4L4)n/(Au4D4)n with atomic precision.In Au4PL4/Au4PD4,the discrete chiral Au4-based aggregation-induced emission(AIE)luminogens are separated by bulky substitutes.The corresponding aggregates are cyan-emitting with a photoluminescence quantum yield(PLQY)of 14.4%.Upon decreasing the size of the substituents,these chiral Au4 clusters are strung together by inter-cluster Au-Au interactions,which cause a low-energy green emission from the aggregated(Au4L4)n/(Au4D4)n with a much higher PLQY of 41.4%and more intense circularly polarised photoluminescence(CPL)with a dissymmetry factor|gPL|of 7.0×10^−3.Using(Au4L4)n/(Au4D4)n,circularly polarised organic light-emitting diodes(CP-OLEDs)were for the first time fabricated with|gEL|=|gPL|.These findings signify that inter-cluster metallophilic interactions are a new and important type of driving force for AIE and crystallization-induced emission(CIE),suggesting great potential of CPL-active metal clusters in CP-OLEDs. | Zhen Han Xueli Zhao Peng Peng Si Li Chong Zhang Man Cao Kai Li Zhao-Yang Wang&Shuang-Quan Zang | 2020 | Nano Research2020，13，12： | 3 |
| 15 | Applications of nanogenerators for biomedical engineering and healthcare systems显示文摘The dream of human beings for long living has stimulated the rapid development of biomedical and healthcare equipment.However,conventional biomedical and healthcare devices have shortcomings such as short service life,large equipment size,and high potential safety hazards.Indeed,the power supply for conventional implantable device remains predominantly batteries.The emerging nanogenerators,which harvest micro/nanomechanical energy and thermal energy from human beings and convert into electrical energy,provide an ideal solution for self-powering of biomedical devices.The combination of nanogenerators and biomedicine has been accelerating the development of self-powered biomedical equipment.This article first introduces the operating principle of nanogenerators and then reviews the progress of nanogenerators in biomedical applications,including power supply,smart sensing,and effective treatment.Besides,the microbial disinfection and biodegradation performances of nanogenerators have been updated.Next,the protection devices have been discussed such as face mask with air filtering function together with real-time monitoring of human health from the respiration and heat emission.Besides,the nanogenerator devices have been categorized by the types of mechanical energy from human beings,such as the body movement,tissue and organ activities,energy from chemical reactions,and gravitational potential energy.Eventually,the challenges and future opportunities in the applications of nanogenerators are delivered in the conclusive remarks. | Wanli Wang Jinbo Pang Jie Su Fujiang Li Qiang Li Xiaoxiong Wang Jingang Wang Bergoi Ibarlucea Xiaoyan Liu Yufen Li Weijia Zhou Kai Wang Qingfang Han Lei Liu Ruohan Zang Mark HRümmeli Yang Li Hong Liu Han Hu Gianaurelio Cuniberti | 2022 | InfoMat2022，4，2： | 2 |
| 16 | Determination of triazine herbicide residues in water samples by on-line sweeping concentration in micellar electrokinetic chromatography显示文摘为在由在 micellar electrokinetic 层析(MEKC ) 的联机大规模集中技术的水样品的 atrazine, simazine 和 prometryn 的决心的一个新方法被开发。影响样品丰富和分离效率的各种各样的参数系统地被学习。与常规 MEKC 方法相比,直到在集中的 60200 褶层改进,敏感被使用这种大规模注射技术以山峰高度完成。复合士的宁为试验性的重制度的改进被用作内部标准。为 atrazine, simazine 和 prometryn 的察觉(S/N = 3:1 ) 的限制是 9, 10 和 0.5 ng mL ? 1 分别地。这个方法成功地在湖被用于 atrazine, simazine 和 prometryn 的分析,冒热气并且扎根水。 | Shuai Hua Zhang Yuan Yuan Yang Dan Dan Han Chun Wang Xin Zhou Xiao Huan Zang Zhi Wang | 2008 | Chinese Chemical Letters2008，19，12： | 2 |
| 17 | Intercalation and hybrid heterostructure integration of two-dimensional atomic crystals with functional organic semiconductor molecules显示文摘Van der Waals(vdW)integration affords semiconductor heterostructures without constrains of lattice matching and opens up a new realm of functional devices by design.A particularly interesting approach is the electrochemical intercalation of two-dimensional(2D)atomic crystal and formation of superlattices,which can provide scalable production of novel vdW heterostructures.However,this approach has been limited to the use of organic cations with non-functional aliphatic chains,therefore failed to take the advantage of the vast potentials in molecular functionalities(electronic,photonic,magnetic,etc.).Here we report the integration of 2D crystal(MoS_(2),WS_(2),highly oriented pyrolytic graphite(HOPG),WSe_(2) as model systems)with electrochemically inert organic molecules that possess semiconducting characteristics(including perylene-3,4,9,10-tetracarboxylic dianhydride(PTCDA),pentacene and fullerene),through on-chip electrochemical intercalation.An unprecedented long-range spatial feature of intercalation has been achieved,which allowed facile assembly of a vertical MoS_(2)-PTCDA-Si junction.The intercalated heterostructure shows significant modulation of the lateral transport,and leads to a molecular tunneling characteristic at the vertical direction.The general intercalation of charge neutral and functional molecules defines a versatile platform of inorganic/organic hybrid vdW heterostructures with significantly extended molecular functional building blocks,holding great promise in future design of nano/quantum devices. | Wen He Han Zang Songhua Cai Zhangyan Mu Cheng Liu Mengning Ding Peng Wang Xinran Wang | 2020 | Nano Research2020，13，11： | 2 |
| 18 | Mutations of the epidermal growth factor receptor gene in NSCLC patients显示文摘 | Bing Han Xiang Zhou Rong-Xin Zhang Wang-Fu Zang Zhong-Yuan Chen Huai-Dong Song Huan-Ying Wan Cui-Xia Zheng | 2011 | Oncology Letters2011，，6： | 2 |
| 19 | Bioengineering of nano metal-organic frameworks for cancer immunotherapy显示文摘Immunotherapy techniques,such as immune checkpoint inhibitors,chimeric antigen receptor(CAR)T cell therapies and cancer vaccines,have been burgeoning with great success,particularly for specific cancer types.However,side effects with fatal risks,dysfunction in tumor microenvironment and low immune response rates remain the bottlenecks in immunotherapy.Nano metal-organic frameworks(nMOFs),with an accurate structure and a narrow size distribution,are emerging as a solution to these problems.In addition to their function of temporospatial delivery,a large library of their compositions,together with flexibility in chemical interaction and inherent immune efficacy,offers opportunities for various designs of nMOFs for immunotherapy.In this review,we overview state-of-the-art research on nMOFs-based immunotherapies as well as their combination with other therapies.We demonstrate that nMOFs are predominantly customized for vaccine delivery or tumor-microenvironment modulation.Finally,a prospect of nMOFs in cancer immunotherapy will be discussed. | Gaowei Chong Jie Zang Yi Han Runping Su Nopphon Weeranoppanant Haiqing Dong Yongyong Li | 2021 | Nano Research2021，14，5： | 2 |
| 20 | Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds显示文摘Damage to the skin causes physiological and functional issues.The most effective treatment approach is the use of wound dressings.Silk fibroin(SF)is a promising candidate biomaterial for regulating wound healing;however,its antibacterial properties and biological activity must be further improved.In this study,a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds.The composite hydrogel(Ag-AV-SF hydrogel)was prepared by introducing the silver nanoparticles(AgNPs)and aloe vera(AV)as the modifiers.In vitro study exhibited great antibacterial ability,biocompatibility and cell-proliferation and-migration-promoting capacities.It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment.The healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF hydrogel was stronger than the single-modifiers groups,and the healing rate of it reached 97.02%on Day 21,higher than the commercial wound dressing,silver sulfadiazine(SS)cream on sale.Additionally,the histological and protein expression results showed that the Ag-AV-SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage,reconstructing the blood vessels networks and inhibiting the formation of scars.In summary,the Ag-AV-SF hydrogel developed in this study had good physical properties,overwhelming antibacterial properties,satisfactory biocompatibility and significantly promoting effect on cell proliferation,migration and wound healing.Overall,our results suggest that the Ag-AV-SF hydrogel we developed has great potential for improving the wound healing in clinical treatment. | Yangkun Liu JinChuan Fan MingQi Lv Kepeng She Jiale Sun Qingqing Lu Changhao Han SongTao Ding Shuang Zhao GuiXue Wang YuChan Zhang GuangChao Zang | 2021 | Regenerative Biomaterials2021，8，6： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员