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| 1 | Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment显示文摘Taking inspiration from nature, the biomimetic concept has been integrated into drug delivery systems in cancer therapy. Disguised with cell membranes, the nanoparticles can acquire various functions of natural cells. The cell membrane-coating technology has pushed the limits of common nano-systems(fast elimination in circulation) to more effectively navigate within the body. Moreover, because of the various functional molecules on the surface, cell membrane-based nanoparticles(CMBNPs) are capable of interacting with the complex biological microenvironment of the tumor. Various sources of cell membranes have been explored to camouflage CMBNPs and different tumor-targeting strategies have been developed to enhance the anti-tumor drug delivery therapy. In this review article we highlight the most recent advances in CMBNP-based cancer targeting systems and address the challenges and opportunities in this field. | Ruixiang Li Yuwei He Shuya Zhang Jing Qin Jianxin Wang | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 36 |
| 2 | Genetic analysis of 'all-fish' growth hormone gene transferred carp (Cyprinus carpio L.) and its F_1 generation显示文摘Recornbinant 'all-fish' growth hormone gene (GH) was microinjected into the fertilized eggs of carp. A comparison between the growth traits of transgenics and non-transgenics was carried out, and the transgenic individuals with significant 'fast-growing' effect were successfully gained. A comparison on the reproductivities was also given out between the transgenics and their non-transgenic siblings, and showed that the reproductive capacity of transgenics was substantially equivalent to those of the non-transgenics. On the other hand, the genetic separation and the characteristic distribution of the FI generation were genetically analyzed, which gave solid evidence for the hypothesis that 2-3 chromosomes are integrated with trans-gene. In addition, the distinct biological effects for multi-site-integrated transgenes were further discussed. The present study opens a door for the breeding of 'fast-growing' transgenic fish. | WANG Yaping, HU Wei, WU Gang,SUN Yonghua, CHEN Shangping, ZHANG Fuying,ZHU Zuoyan, FENG Jianxin & ZHANG Xirui1. State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China 2. Henan Institute of Aquaculture, Zhengzhou 450044, China | 2001 | Chinese Science Bulletin2001，46，14： | 23 |
| 3 | Twenty-five years of change in scleractinian coral communities of Daya Bay (northern South China Sea) and its response to the 2008 AD extreme cold climate event显示文摘世界范围的珊瑚礁石逐渐地正在变得并且有害地影响在之上由包括的许多因素,重要气候变化,例如全球温暖和增加的 El Nino 南部的摆动活动。通常,珊瑚礁石的坚持,在特别低纬度,部分地,海运被管理不超过集体死亡能在发生的批评限制(∼30 ° C ) 的表面温度。因此,它被想珊瑚那生活在高纬度(即,当前更凉爽的海表面温度) 将多半比珊瑚生活在对假设未来温度增加更有利作出回应低纬度(即,当前更温暖的海表面温度) 。因而,高纬度的珊瑚社区可以有潜力在面临潜在的未来时为许多珊瑚种类充当 refugia 的区域全球温暖。Daya 海湾(22 ° 3 1 ′22 ° 5 0 ′N ) ,北华南海,包含几个高纬度的 non-reefal 珊瑚社区并且在这个区域以内代表 scleractinian 珊瑚的最在北方的分布之一。显著地, Daya 海湾经历了在整个过去的 50 年的在空和海表面温度中的戏剧的温暖。在这篇论文,我们在 Daya 海湾珊瑚社区分析 25 年变化,把两个基于历史性的调查并且我们的最近 2006 2008 地区性的生态的调查。我们的结果建议与预言相反,在过去的 25 年期间在在 Daya 海湾以内的珊瑚盖子有重要衰落(即,在到在 2008 的 15.3% 仅仅珊瑚盖子的 1983/1984 的 76.6% 珊瑚盖子) 。如此的变化也在最丰富的珊瑚种类反映重要移动,从 Acropora pruinosa 到 Favites abdita。大多数现代珊瑚社区变得以前在 15 和 30 年之间建立了,相应于增加的冬季海表面温度的一个时期。然而,很少的殖民地变得在最后 15 年以内建立了,尽管有温暖的一个更强烈的时期。由考虑另外的因素,我们假设那直接人为的影响,而非气候的事件,限制了发展,并且驾驶了衰落,最后 15 年里的 Daya 海湾珊瑚社区。Daya 海湾也在过去的 50 年期间受到了偶尔的极端冷事件,与最近的发生在 2008 年初(13 年 1 月 13 日 2 月) 。在 2008 冷事件期间,最低空气温度到达仅仅 6.6 ° C,和吝啬的海表面温度 2 月秋天,包括在 12.3 ° C 的六连续的天 < 14 ° C。显著地,海表面温度在通常在 scleractinian 珊瑚社区导致集体死亡的假设批评更低的温度阀值(∼13 ° C ) 下面掉落。令人惊讶地,我们的珊瑚社区调查,以前进行了两个(2007 年 8 月) 并且在以后(2008 年 2 月下旬) 极端 2008 冷事件,证明 Daya 海湾珊瑚生态系统恰好被影响在之上在冷时期期间。那些观察建议 Daya 海湾 scleractinian 珊瑚社区开发了改编到低海表面温度。总的来说,我们的数据支持高纬度的珊瑚社区例如 Daya 海湾,有的假设在潜在的未来的来临为 scleractinian 珊瑚充当 refugia 的区域的潜力全球温暖。 | CHEN TianRan YU KeFu SHI Qi LI Shu Gilbert J. Price WANG Rong ZHAO MeiXia CHEN TeGu ZHAO JianXin | 2009 | Chinese Science Bulletin2009，54，12： | 22 |
| 4 | Targets and molecular mechanisms of triptolide in cancer therapy显示文摘Triptolide(TPL/TL) is a natural drug with novel anticancer effects. Preclinical studies indicated that TPL inhibits cell proliferation, induces cell apoptosis, inhibits tumor metastasis and enhances the effect of other therapeutic methods in various cancer cell lines. Multiple molecules and signaling pathways, such as caspases, heat-shock proteins, NF-κB, and deoxyribonucleic acid(DNA) repair-associated factors, are associated with the anti-cancer effect. TPL also improves chemoradiosensitivity in cancer therapy. Phase I trials indicate the potential clinical value of TPL use. However, further trials with larger sample sizes are needed to confirm these results. | Cuicui Meng Hongcheng Zhu Hongmei Song Zhongming Wang Guanhong Huang Defan Li Zhaoming Ma Jianhua Ma Qin Qin Xinchen Sun Jianxin Ma | 2014 | Chinese Journal of Cancer Research2014，26，5： | 16 |
| 5 | High-sum-rate beamformers for multi-pair two-way relay networks with amplify-and-forward relaying strategy显示文摘In multi-pair two-way relay networks,the control over inter-pair-interference is a challenging problem.When mobile stations(MSs)cooperate fully,to achieve the sum capacity of networks and at the same time completely remove the inter-pair-interference,a singular value decomposition(SVD)based beamforming scheme at relay station(RS)is established where SVD beamformers are applied over both uplink and downlink channels,respectively.To avoid any cooperation among users,an efcient beamforming scheme is proposed.This scheme uses the Max-SINR based receive beamformer at RS in uplink channel and the Max-SLNR based transmit precoder at RS in downlink channel.It omits interference(uplink)and leakage(donwlink)inside each pair of users due to their abilities of self-interference cancellation.This beamforming scheme provides an analytical solution like some well-known linear beamformers such as zero-forcing,block diagonalization,etc.From simulation,we find:the proposed SVD shows an excellent sum-rate performance at the expense of a large cooperation overhead at MSs and can be used as a tighter upper bound of sum-rate;the proposed scheme of Max-SINR beamformer plus Max-SLNR precoder performs much better on sum-rate than the ZF-based and the BD-based schemes by using almost the same computational amount. | SHU Feng LU YaZhe CHEN Yu YOU XiaoHu WANG JianXin WANG Mao SHENG WeiXing CHEN Qian | 2014 | Science China(Information Sciences)2014，57，2： | 15 |
| 6 | Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals显示文摘Arginine(ARG) exerts many beneficial effects on animal body and enhanced angiogenesis, lactogenesis, which finally leads to the improvement in nitrogen(N) metabolism, reproduction, lactation, immunity and growth. Unfortunately, unprotected ARG will be degraded in the rumen and its price is high, thus feeding rumen-protected ARG seems to be uneconomical. Alternatively, N-carbamoyl glutamate(NCG) is structural analogue of N-acetyl glutamate, cofactor of cabamoyl phosphate synthetase 1, is lower in rumen degradation compared to ARG. Additionally, rumen epithelial and duodenal cells have potentially utilized the NCG for ureagenesis. Supplementation of NCG to high yielding dairy cows increased plasma concentration of ARG and nitric oxide, decreased the plasma ammonia N and improved lactation performance and N utilization. Supplementation of NCG enhanced pregnancy rates in rats, improved litter size and fetal survival rate, thereby improved the reproductive performance of sows. Oral NCG supplementation increases plasma ARG and somatotropin levels, and increased growth rate and muscle protein synthesis in nursing piglets. The NCG is potential a relatively cheaper source of feed additive to offer vital compensation over oral administration of ARG, resulting in improved ruminant animal health and production. In this article, we reviewed the mechanism of ARG biosynthesis by NCG and their significance in growth, reproduction, milk production and N utilization in ruminant animals. | Bahram Chacher Hongyun Liu Diming Wang Jianxin Liu | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 15 |
| 7 | Investigation on the catalytic effects of AAEM during steam gasification and the resultant char reactivity in oxygen using Shengli lignite at different forms显示文摘 | Jianxin Mi Ningbo Wang Mingfeng Wang Pengju Huo Dan Liu | 2015 | International Journal of Coal Science & Technology2015，2，3： | 14 |
| 8 | Effects of Saccharomyces cerevisiae fermentation products on performance and rumen fermentation and microbiota in dairy cows fed a diet containing low quality forage显示文摘Background: A possible option to meet the increased demand of forage for dairy industry is to use the agricultural byproducts, such as corn stover. However, nutritional value of crop residues is low and we have been seeking technologies to improve the value. A feeding trial was performed to evaluate the effects of four levels of Saccharomyces cerevisiae fermentation product(SCFP; Original XP; Diamond V) on lactation performance and rumen fermentation in mid-lactation Holstein dairy cows fed a diet containing low-quality forage. Eighty dairy cows were randomly assigned into one of four treatments: basal diet supplemented with 0, 60, 120, or 180 g/d of SCFP per head mixed with 180, 120, 60, or 0 g of corn meal, respectively. The experiment lasted for 10 wks, with the first 2 weeks for adaptation.Results: Dry matter intake was found to be similar(P > 0.05) among the treatments. There was an increasing trend in milk production(linear, P ≤ 0.10) with the increasing level of SCFP supplementation, with no effects on contents of milk components(P > 0.05). Supplementation of SCFP linearly increased(P < 0.05) the N conversion, without affecting rumen pH and ammonia-N(P > 0.05). Increasing level of SCFP linearly increased(P < 0.05) concentrations of ruminal total volatile fatty acids, acetate, propionate, and butyrate, with no difference in molar proportion of individual acids(P > 0.05). The population of fungi and certain cel ulolytic bacteria(Ruminococcus albus, R. flavefaciens and Fibrobacter succinogenes)increased linearly(P < 0.05) but those of lactate-utilizing(Selenomonas ruminantium and Megasphaera elsdeni) and lactate-producing bacteria(Streptococcus bovis) decreased linearly(P ≤ 0.01) with increasing level of SCFP. The urinary purine derivatives increased linearly(P < 0.05) in response to SCFP supplementation, indicating that SCFP supplementation may benefit for microbial protein synthesis in the rumen.Conclusions: The SCFP supplementation was effective in maintaining milk persistency of mid-lactation cows receiving diets containing low-quality forage. The beneficial effect of SCFP could be attributed to improved rumen function; 1)microbial population shift toward greater rumen fermentation efficiency indicated by higher rumen fungi and cel ulolytic bacteria and lower lactate producing bacteria, and 2) rumen microbial fermentation toward greater supply of energy and protein indicated by greater ruminal VFA concentration and increased N conversion. Effects of SCFP were dose-depended and greater effects being observed with higher levels of supplementation and the effect was more noticeable during the high THI environment. | Wen Zhu Zihai Wei Ningning Xu Fan Yang Ilkyu Yoon Yihua Chung Jianxin Liu Jiakun Wang | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 13 |
| 9 | The recognition of adakite-type gneisses in the North Dabie Mountain and its implication to ultrahigh pressure metamorphic geology显示文摘Adakite is an igneous rock generated by the partial melting of subducting ocean slab in an island arc setting. Meanwhile, residuals of the slab-melting are transformed to eclogite or garnet-amphibolite during a slab subduction process. This note reports the adakite-type grey gneisses discovered in the North Dabie Mountain. These adakitic rocks are characterized by high AI2O3(14.97%-17.56%), Sr (545-941 μg/g), Sr/Y (44.71-218.98), La/Yb (16.70-97.50), and low Y (3.32-12.19μg/g), Yb (0.31-1.34 μg/g), Sc (0.92-4.2μg/g), as well as positive Sr anomaly but absent or positive Eu anomaly. They are different from the low aluminum grey gneisses with low AI2O3 (13.73%-14.38%), Sr (262-409 μg/g), Sr/Y (6.46-15.97) and La/Yb (1.90-22.60), high Y(21.79-36.24 μg/g), Yb (2.00-5.59 μg/g) , Sc (8.30%-12.70%), and negative Sr, Eu anomaly in the North Dabie Mountain. The adakite-type grey gneisses in the North Dabie Mountain were most probably formed by the partial melting of subducting ocean slab before the | WANG Qiang XU Jifeng WANG Jianxin ZHAO Zhenhua WANG Renjing QIU Jiaxiang XIONG Xiaolin SANG Longkang PENG Lianhong | 2000 | Chinese Science Bulletin2000，45，21： | 12 |
| 10 | Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy显示文摘Chemotherapy outcomes for the treatment of glioma remains unsatisfactory due to the inefficient drug transport across the blood–brain barrier(BBB) and insufficient drug accumulation in the tumor region. Although many approaches, including various nanosystems, have been developed to promote the distribution of chemotherapeutics in the brain tumor, the delivery efficiency and the possible damage to the normal brain function still greatly restrict the clinical application of the nanocarriers.Therefore, it is urgent and necessary to discover more safe and effective BBB penetration and gliomatargeting strategies. In the present study, menthol, one of the strongest BBB penetration enhancers screened from traditional Chinese medicine, was conjugated to casein, a natural food protein with brain targeting capability. Then the conjugate self-assembled into the nanoparticles to load anti-cancer drugs.The nanoparticles were characterized to have appropriate size, spheroid shape and high loading drug capacity. Tumor spheroid penetration experiments demonstrated that penetration ability of mentholmodified casein nanoparticles(M-CA-NP) into the tumor were much deeper than that of unmodified nanoparticles. In vivo imaging further verified that M-CA-NPs exhibited higher brain tumor distribution than unmodified nanoparticles. The median survival time of glioma-bearing mice treated with HCPT-MCA-NPs was significantly prolonged than those treated with free HCPT or HCPT-CA-NPs. HE staining ofthe organs indicated the safety of the nanoparticles. Therefore, the study combined the advantages of traditional Chinese medicine strategy with modern delivery technology for brain targeting, and provide a safe and effective approach for glioma therapy. | Caifang Gao Jianming Liang Ying Zhu Chengli Ling Zhekang Cheng Ruixiang Li Jing Qin Weigen Lu Jianxin Wang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 12 |
| 11 | MECHANICAL PROPERTIES OF FINE PITCH DEVICES SOLDERED JOINTS BASED ON CREEP MODEL显示文摘Nonlinear analyses of quad flat package (QFP) on printed circuit board (PCB) assemblies subjected to thermal cycling conditions are presented.Two different solders are considered,namely, Sn37Pb and Sn3.5Ag.The stress and strain response of fine pitch devices soldered joints was investigated by using finite element method based on Garofalo-Arrheninus model.The simulated results indicate creep distribution of soldered joints is not uniform,the heel and toe of soldered joints, the area between soldered joints and leads are the creep concentrated sites.The similar phenomena of stress curves simulated based on Garofalo-Arrhenlnus model and Anand equations is confirmed,and the creep strain value of Sn3.5Ag soldered joints is lower than that of Sn37Pb soldered joints. Thermal cycling results show that Sn3.5Ag strongly outperforms Sn37Pb for QFP devices under the studied test condition.This is well matched with the experimental outcome analyzed.In addition,the soldered devices were tested by micro-joints tester,the tensile strength of Sn3.5Ag soldered joints is found to be higher than that of Sn37Pb soldered joints.By analyzing the fracture microstructure of soldered joints,it is found that fracture mechanism of Sn3.5Ag soldered joints is toughness fracture, while fracture mechanism of Sn37Pb soldered joints includes brittle fracture and toughness fracture. The results of this study provide an important basis of understanding the mechanical properties of fine pitch devices with traditional Sn37Pb and Sn3.5Ag lead-free soldered joints. | ZHANG Liang XUE Songbai HAN Zongjie WANG Jianxin GAO Lili SHENG Zhong | 2008 | Chinese Journal of Mechanical Engineering2008，21，6： | 12 |
| 12 | Stability analysis of the temperature cracks in Xiaowan arch dam显示文摘In the Xiaowan arch dam there are massive temperature cracks nearly parallel to the dam axis. Obviously, whether the cracks may spread or not during the water storage process is one of the crucial factors for the safety of a dam. In this paper, a new type of crack element, in which the contact component is implicitly included into the concrete component, is proposed to simulate the effects of the existing cracks. The crack element is proved by numerical example to share the merits of both conventional contact elements and joint elements. With a finite element model of the cracked arch dam together with its rock foundation established, the transient displacement and stress fields of the dam are obtained. The complicated rock foundation, the construction process of the arch dam, the massive cracks, the transient temperature field, as well as the water storage process have been taken into consideration in the simulation. In addition to the global model, several sub-models for typical crack tips are also generated with finer elements placed around the tips. Thus, more accurate displacement and stress distribution are obtained by simultaneous sub-model simulation. Based on the calculation of stress intensity factor for crack tips by extension method, the temperature cracks in the Xiaowan arch dam are finally proved to be stable. | WANG WeiMing DING JianXin WANG GuoJin ZOU LiChun CHEN ShengHong | 2011 | Science China(Technological Sciences)2011，54，3： | 12 |
| 13 | A property-oriented design strategy for high performance copper alloys via machine learning显示文摘Traditional strategies for designing new materials with targeted property including methods such as trial and error,and experiences of domain experts,are time and cost consuming.In the present study,we propose a machine learning design system involving three features of machine learning modeling,compositional design and property prediction,which can accelerate the discovery of new materials.We demonstrate better efficiency of on a rapid compositional design of high-performance copper alloys with a targeted ultimate tensile strength of 600–950 MPa and an electrical conductivity of 50.0%international annealed copper standard.There exists a good consistency between the predicted and measured values for three alloys from literatures and two newly made alloys with designed compositions.Our results provide a new recipe to realize the property-oriented compositional design for highperformance complex alloys via machine learning. | Changsheng Wang Huadong Fu Lei Jiang Dezhen Xue Jianxin Xie | 2019 | npj Computational Materials2019，，1： | 12 |
| 14 | Dynamic threshold for SPWVD parameter estimation based on Otsu algorithm显示文摘Time-frequency-based methods are proven to be effective for parameter estimation of linear frequency modulation (LFM) signals.The smoothed pseudo Winger-Ville distribution (SPWVD) is used for the parameter estimation of multi-LFM signals,and a method of the SPWVD binarization by a dynamic threshold based on the Otsu algorithm is proposed.The proposed method is effective in the demand for the estimation of different parameters and the unknown signal-to-noise ratio (SNR) circumstance.The performance of this method is confirmed by numerical simulation. | Ning Ma Jianxin Wang | 2013 | Journal of Systems Engineering and Electronics2013，24，6： | 10 |
| 15 | Local Government Debt, Factor Misallocation and Regional Economic Performance in China显示文摘 | Jianxin Wu Yanrui Wu Bing Wang | 2018 | China & World Economy2018，26，4： | 10 |
| 16 | Fabrication of pure copper rods containing continuous columnar crystals by continuous unidirectional solidification technology显示文摘Pure copper rods containing continuous columnar crystals were fabricated using the downward CUS (Continuous Unidirectional Solidification) equipment. When the technological parameters were set as the ranges of mould temperature 1100-1300℃,cooling distance (the distance from the exit of the cast mould to the start point of cooling) 10-20 mm, casting speed 0.2-2.5 mm/s,cooling water (20-25℃) volume 1000-1320 L/h, and when these parameters matched reasonably, the CUS process was performed stably, and pure copper rods containing continuous columnar crystals with bright and smooth surface were produced. The dendritic arm spacing of the crystals in copper rods decreased with increasing the casting speed. The results of the texture by X-ray diffraction analysis showed that the rods has strong <100> fiber texture. | Hong zhang Jianxin Xie Zidong Wang Materials Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China | 2004 | Journal of University of Science and Technology Beijing2004，11，3： | 9 |
| 17 | Transcriptomic and genetic approaches reveal an essential role of the NAC transcription factor SlNAP1 in the growth and defense response of tomato显示文摘With global climate change,plants are frequently being exposed to various stresses,such as pathogen attack,drought,and extreme temperatures.Transcription factors(TFs)play crucial roles in numerous plant biological processes;however,the functions of many tomato(Solanum lycopersicum L.)TFs that regulate plant responses to multiple stresses are largely unknown.Here,using an RNA-seq approach,we identified SlNAP1,a NAC TF-encoding gene,which was strongly induced by various stresses.By generating SlNAP1 transgenic lines and evaluating their responses to biotic and abiotic stresses in tomato,we found that SlNAP1-overexpressing plants showed significantly enhanced defense against two widespread bacterial diseases,leaf speck disease,caused by Pseudomonas syringae pv.tomato(Pst)DC3000,and root-borne bacterial wilt disease,caused by Ralstonia solanacearum.In addition,SlNAP1 overexpression dramatically improved drought tolerance in tomato.Although the SlNAP1-overexpressing plants were shorter than the wild-type plants during the early vegetative stage,eventually,their fruit yield increased by 10.7%.Analysis of different hormone contents revealed a reduced level of physiologically active gibberellins(GAs)and an increased level of salicylic acid(SA)and abscisic acid(ABA)in the SlNAP1-overexpressing plants.Moreover,EMSAs and ChIP-qPCR assays showed that SlNAP1 directly activated the transcription of multiple genes involved in GA deactivation and both SA and ABA biosynthesis.Our findings reveal that SlNAP1 is a positive regulator of the tomato defense response against multiple stresses and thus may be a potential breeding target for improving crop yield and stress resistance. | Jiao Wang Chenfei Zheng Xiangqi Shao Zhangjian Hu Jianxin Li Ping Wang Anran Wang Jingquan Yu Kai Shi | 2020 | Horticulture Research2020，7，1： | 9 |
| 18 | Contrasting responses of net primary productivity to inter-annual variability and changes of climate among three forest types in northern China显示文摘Aims A lack of explicit information on differential controls on net primary productivity(NPP)across regions and ecosystem types is largely responsible for uncertainties in global trajectories of terrestrial carbon balance with changing environment.The objectives of this study were to determine how NPP of different forest types would respond to inter-annual variability of climate and to examine the responses of NPP to future climate change scenarios across contrasting forest types in northern China.Methods We investigated inter-annual variations of NPP in relation to climate variability across three forest types in northern China,including a boreal forest dominated by Larix gmelinii Rupr.,and two temperate forests dominated by Pinus tabulaeformis Carr.and Quercus wutaishanica Mayr.,respectively,and studied the responses of NPP in these forests to predicted changes in climate for the periods 2011–40,2041–70 and 2070–100 under carbon emission scenarios A2 and B2 of Intergovernmental Panel on Climate Change.We simulated the responses of NPP to predicted changes in future climate as well as inter-annual variability of the present climate with the Biome-BGC version 4.2 based on site-and species-specific parameters.The modeled forest NPP data were validated against values in literature for similar types of forests and compared with inter-annual growth variations reflected by tree-ring width index(RWI)at the study sites.Important Findings Inter-annual variations in modeled NPP during the period 1960–06 were mostly consistent with the temporal patterns in RWI.There were contrasting responses of modeled NPP among the three forest types to inter-annual variability of the present climate as well as to predicted changes in future climate.The modeled NPP was positively related to annual mean air temperature in the L.gmelinii forest(P<0.001),but negatively in the P.tabulaeformis forest(P=0.05)and the Q.wutaishanica forest(P=0.03),while the relationships of modeled NPP with annual precipitation for the three forest types were all positive.Multiple stepwise regression analyses showed that temperature was a more important constraint of NPP than precipitation in the L.gmelinii forest,whereas precipitation appeared to be a prominent factor limiting the growth in P.tabulaeformis and Q.wutaishanica.Model simulations suggest marked,but differential increases in NPP across the three forest types with predicted changes in future climate. | Shuai Ouyang Xiangping Wang Yulian Wu Osbert Jianxin Sun | 2014 | Journal of Plant Ecology2014，7，3： | 9 |
| 19 | Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis显示文摘The effective drug treatment of rheumatoid arthritis (RA) is hindered by poordelivery efficiency to the diseased site and the serious side effects caused bywide-spread drug distribution. Traditional drug-targeting strategies, such asligand modification, are complex, laborious, and inefficient. Inspired by theintrinsic relationship between platelets and RA, platelet-mimetic nanoparticles(PNPs) were developed for targeted drug delivery in RA. Through plateletreceptor-mediated adhesion, an intact platelet membrane was coated onto poly(lactic-co-glycolic add) nanopartides, endowing the resulting PNPs with variousfunctional receptors. By coating with platelet membranes, the nanoparticleswere stabilized and had a better circulation profile, providing a benefit forpassive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivoaccumulation in joints of a collagen-induced arthritis (CIA) mouse model of RAwere significantly improved via P-selectin and GVPI recognition, indicating thatthe PNPs could effectively target to RA tissues through multiple mechanisms,similar to natural platelets. Moreover, FK506, a model drug, was loaded into thePNPs and used to treat RA. Pharmacodynamic studies demonstrated that theFK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides anew biomimetic targeting strategy with great potential for the treatment of RA. | Yuwei He Ruixiang Li Jianming Liang Ying Zhu Shuya Zhang Zicong Zheng Jing Qin Zhiqing Pang Jianxin Wang | 2018 | Nano Research2018，11，11： | 9 |
| 20 | A Survey of MRI-Based Brain Tumor Segmentation Methods显示文摘Brain tumor segmentation aims to separate the different tumor tissues such as active cells, necrotic core,and edema from normal brain tissues of White Matter(WM), Gray Matter(GM), and Cerebrospinal Fluid(CSF). MRIbased brain tumor segmentation studies are attracting more and more attention in recent years due to non-invasive imaging and good soft tissue contrast of Magnetic Resonance Imaging(MRI) images. With the development of almost two decades, the innovative approaches applying computer-aided techniques for segmenting brain tumor are becoming more and more mature and coming closer to routine clinical applications. The purpose of this paper is to provide a comprehensive overview for MRI-based brain tumor segmentation methods. Firstly, a brief introduction to brain tumors and imaging modalities of brain tumors is given. Then, the preprocessing operations and the state of the art methods of MRI-based brain tumor segmentation are introduced. Moreover, the evaluation and validation of the results of MRI-based brain tumor segmentation are discussed. Finally, an objective assessment is presented and future developments and trends are addressed for MRI-based brain tumor segmentation methods. | Jin Liu Min Li Jianxin Wang Fangxiang Wu Tianming Liu Yi Pan | 2014 | Tsinghua Science and Technology2014，19，6： | 9 |
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