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| 1 | Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human显示文摘A novel H7N9 influenza A virus has been discovered as the causative identity of the emerging acute respiratory infection cases in Shanghai,China.This virus has also been identified in cases of infection in the neighboring area Hangzhou City in Zhejiang Province.In this study,epidemiologic,clinical,and virological data from three patients in Hangzhou who were confirmed to be infected by the novel H7N9 influenza A virus were collected and analyzed.Human respiratory specimens and chicken feces from a contacted free market were tested for influenza virus by real-time reverse transcription PCR(RT-PCR) and sequencing.The clinical features of the three cases were similar featured with high fever and severe respiratory symptoms;however,only one of the patients died.A certain degree of diversity was observed among the three Hangzhou viruses sequenced from human samples compared with other reported H7N9 influenza A viruses.The sequences of the novel avian-origin H7N9 influenza viruses from Hangzhou City contained important amino acid substitutions related to human adaptation.One of the Hangzhou viruses had gained a novel amino acid substitution(Q226I) in the receptor binding region of hemagglutinin.More importantly,the virus sequenced from the chicken feces had a 627E substitution in the PB2 protein instead of the mammalian-adapted 627K substitution that was found in the PB2 proteins from the Hangzhou viruses from the three patients.Therefore,the newly-emerging H7N9 virus might be under adaptation pressure that will help it 'jump' from avian to human hosts.The significance of these substitutions needs further exploration,with both laboratory experiments and extensive field surveillance. | LI Jun YU XinFen PU XiaoYing XIE Li SUN YongXiang XIAO HaiXia WANG FenJuan DIN Hua WU Ying LIU Di ZHAO GuoQiu LIU Jun PAN JingCao | 2013 | Science China(Life Sciences)2013，56，6： | 32 |
| 2 | Viral effector protein manipulates host hormone signaling to attract insect vectors显示文摘 | Dewei Wu Tiancong Qi Wan-Xiang Li Haixia Tian Hua Gao Jiaojiao Wang Jin Ge Ruifeng Yao Chunmei Ren Xian-Bing Wang Yule Liu Le Kang Shou-Wei Ding Daoxin Xie | 2017 | Cell Research2017，27，3： | 20 |
| 3 | Effect of acupotomy on nitric oxide synthase and beta-endorphin in third lumbar vertebrae transverse process syndrome model rats显示文摘OBJECTIVE: To explore the long-term effects and pain relief mechanism of acupotomy by observing changes in nitric oxide synthase(NOS) and beta-endorphin(β-EP) in the hypothalamus, spinal cord,and peripheral blood of rats with third lumbar vertebrae(L3) transverse process syndrome.METHODS:Twenty-eight SD rats were randomly assigned to normal, model, electroacupuncture(EA),and acupotomy group. The last three groups were put through an operation to emulate L3transverse process syndrome. Fourteen days after the simulation operation, EA and acupotomy treatments were applied to the respective groups. Fifty-six days afterthe simulation operation, biochemistry tests and enzyme-linked immunosorbent assay were used to measure NOS and β-EP in the hypothalamus, spinal cord, and peripheral blood.RESULTS: Rats with the simulation operation showed significantly higher levels of NOS and β-EP in the hypothalamus, spinal cord, and peripheral blood than those in the normal group. The EA and acupotomy groups had significantly lower levels of NOS and β-EP than those in the model group.There was no statistical difference between the EA and acupotomy groups.CONCLUSION: EA and acupotomy treatments significantly lowered NOS and β-EP levels in the hypothalamus, spinal cord, and peripheral blood and alleviated L3transverse process syndrome. | Changqing Guo Naigang Liu Xiaohong Li Hongmei Sun Bo Hu Jing Lu Yan Guo Chuxi Liang Hong Xu Haixia Wu | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 15 |
| 4 | Microvessel changes in the gerbil hippocampus after cerebral ischemia and reperfusion by Buyang Huanwu decoction pretreatment显示文摘Buyang Huanwu decoction(BYHWD) is a classic recipe for the prevention and treatment of ischemic cerebrovascular disease.Gerbils were pretreated with BYHWD,and then subjected to cerebral ischemia and reperfusion.Microvascular changes were determined with laser Doppler monitoring,tannic acid-ferric chloride mordant,and electron microscopy.Results showed that BYHWD pretreatment could enhance the function of hippocampal microvessels,prevent injury,and increase microvasular density and microvasular area density.Thus,these results suggest that BYHWD pretreatment could prevent microvascular occlusion,enhance the capacity of microvascular reperfusion,increase cerebral blood flow,and inhibit neuronal damage,and may be an effective therapy against brain ischemic injury. | Xiaoguang Wu Yixue Li Haixia Liu Yuhua Yin Shumin Zhao Yuanyuan Guo | 2011 | Neural Regeneration Research2011，6，9： | 11 |
| 5 | Evaluation of Two Momentum Control Variable Schemes and Their Impact on the Variational Assimilation of Radar Wind Data:Case Study of a Squall Line显示文摘Different choices of control variables in variational assimilation can bring about different influences on the analyzed atmospheric state.Based on the WRF model's three-dimensional variational assimilation system,this study compares the behavior of two momentum control variable options—streamfunction velocity potential(ψ–χ) and horizontal wind components(U–V)—in radar wind data assimilation for a squall line case that occurred in Jiangsu Province on 24 August 2014.The wind increment from the single observation test shows that the ψ–χ control variable scheme produces negative increments in the neighborhood around the observation point because streamfunction and velocity potential preserve integrals of velocity.On the contrary,the U–V control variable scheme objectively reflects the information of the observation itself.Furthermore,radial velocity data from 17 Doppler radars in eastern China are assimilated.As compared to the impact of conventional observation,the assimilation of radar radial velocity based on the U–V control variable scheme significantly improves the mesoscale dynamic field in the initial condition.The enhanced low-level jet stream,water vapor convergence and low-level wind shear result in better squall line forecasting.However,the ψ–χ control variable scheme generates a discontinuous wind field and unrealistic convergence/divergence in the analyzed field,which lead to a degraded precipitation forecast. | Xin LI Mingjian ZENG Yuan WANG Wenlan WANG Haiying WU Haixia MEI | 2016 | Advances in Atmospheric Sciences2016，33，10： | 10 |
| 6 | Construct hepatic analog by cell-matrix controlled assembly technology显示文摘A mixture of hepatic cells and chito- san/gelatin solution was deposited to construct a hepatic analog by way of layer-by-layer deposition technique using a home-made devise. The size and cell concentration of the analogs can be controlled freely. Approximately 90% of the hepatic cells re- mained viable under 0.2 Mpa extrusion pressure. Cultured in vitro 8 weeks before animal test, hepatic cells in structure maintained their phenotype and kept proliferating, and albumin and other secretion of the cells increased. Cords and hepaton-like structures were observed after culture for 20 d. These results indicate that hepatic cells could be assembled di- rectly into a 3D viable structure and expanded to form a hepatic organoid. This accomplishment is consid- ered to be an interesting means for the fabrication of liver replacements. | LIU Haixia YAN Yongnian WANG Xiaohong CHENG Jie LIN Feng XIONG Zhuo Wu Rendong | 2006 | Chinese Science Bulletin2006，51，15： | 7 |
| 7 | A naturally occurring CD8^+CD122^+ T-cell subset as a memory-like Treg family显示文摘尽管有 CD4 + CD25 + 规章的 T 房间(Tregs ) 在过去的十年期间,在他们的临床的翻译以后的进步仍然保持停滞。增长证据建议那自然地发生的 CD8 + CD122 + T 房间也是有能力的 Tregs 禁止 T 房间回答并且象 alloimmunity 一样压制 autoimmunity。事实上,他们是像记忆的 Tregs 类似于一个中央记忆 T 房间(T 厘米 ) 显型。位于他们的抑制下面的机制仍然不好被理解,尽管他们可以包括 IL-10 生产。我们最近证明了那个规划 death-1 (PD-1 ) 表达式区分在之间规章并且存储器 CD8 + CD122 + T 房间和那 CD8 + CD122 + Tregs 经历更快的 homeostatic 增长并且比常规 CD4 + CD25 + Tregs。这些调查结果可以为在诊所加速有效 Treg 治疗打开调查的一根新线。在这评论,我们在 CD8 + CD122 + Treg 在诊所研究并且讨论他们的显型,在 autoimmunity 和 alloimmunity 的镇压角色,功能的要求,行动的机制和潜在的应用。 | Shanshan Li Qingfeng Xie Yuqun Zeng Chuan Zou Xusheng Liu Shouhai Wu Haixia Deng Yang Xu Xian C Li Zhenhua Dai | 2014 | Cellular & Molecular Immunology2014，11，4： | 6 |
| 8 | Enhancement of precursor amino acid supplies for improving bacitracin production by activation of branched chain amino acid transporter BrnQ and deletion of its regulator gene lrp in Bacillus licheniformis显示文摘Bacitracin,a new type of cyclic peptide antibiotic,is widely used as the feed additive in feed industry.Branched chain amino acids(BCAAs)are the key precursors for bacitracin synthesis.In this research,soybean meal was served as the raw material to supply precursor amino acids for bacitracin synthesis,and enhanced production of bacitracin was attempted by engineering BCAA transporter BrnQ and its regulator Lrp in the bacitracin industrial production strain Bacillus licheniformis DW2.Firstly,our results confirmed that Lrp negatively affected bacitracin synthesis in DW2,and deletion of lrp improved intracellular BCAA accumulations,as well as the expression level of BCAA transporter BrnQ,which further led to a 14.71%increase of bacitracin yield,compared with that of DW2.On the contrary,overexpression of Lrp decreased bacitracin yield by 12.28%.Secondly,it was suggested that BrnQ acted as a BCAA importer in DW2,and overexpression of BrnQ enhanced the intracellular BCAA accumulations and 10.43%of bacitracin yield.While,the bacitracin yield decreased by 18.27%in the brnQ deletion strain DW2△brnQ.Finally,BrnQ was further overexpressed in lrp deletion strain DW2△lrp,and bacitracin yield produced by the final strain DW2△lrp::BrnQ was 965.34 U/mL,increased by 22.42%compared with that of DW2(788.48 U/mL).Collectively,this research confirmed that Lrp affected bacitracin synthesis via regulating the expression of BCAA transporter BrnQ and BCAA distributions,and provided a promising strain for industrial production of bacitracin. | Jiang Zhu Dongbo Cai Haixia Xu Ziwei Liu Bowen Zhang Fei Wu Junhui Li Shouwen Chen | 2018 | Synthetic and Systems Biotechnology2018，3，4： | 6 |
| 9 | Self-Powered Intelligent Human-Machine Interaction for Handwriting Recognition显示文摘Handwritten signatures widely exist in our daily lives.The main challenge of signal recognition on handwriting is in the development of approaches to obtain information effectively.External mechanical signals can be easily detected by triboelectric nanogenerators which can provide immediate opportunities for building new types of active sensors capable of recording handwritten signals.In this work,we report an intelligent human-machine interaction interface based on a triboelectric nanogenerator.Using the horizontal-vertical symmetrical electrode array,the handwritten triboelectric signal can be recorded without external energy supply.Combined with supervised machine learning methods,it can successfully recognize handwritten English letters,Chinese characters,and Arabic numerals.The principal component analysis algorithm preprocesses the triboelectric signal data to reduce the complexity of the neural network in the machine learning process.Further,it can realize the anticounterfeiting recognition of writing habits by controlling the samples input to the neural network.The results show that the intelligent human-computer interaction interface has broad application prospects in signature security and humancomputer interaction. | Hang Guo Ji Wan Haobin Wang Hanxiang Wu Chen Xu Liming Miao Mengdi Han Haixia Zhang | 2021 | Research2021，，1： | 4 |
| 10 | Epidemiological characteristics and temporal-spatial analysis of overseas imported dengue fever cases in outbreak provinces of China, 2005–2019显示文摘Background Overseas imported dengue fever is an important factor in local outbreaks of this disease in the mainland of China.To better prevent and control such local outbreaks,the epidemiological characteristics and temporal-spatial distribution of overseas imported dengue fever cases in provincial-level administrative divisions(PLADs)where dengue fever is outbreak in the mainland of China were explored.Methods Using the Chinese National Notifiable Infectious Disease Reporting Information System(CNNDS),we identified overseas imported dengue fever cases in dengue fever outbreak areas in the mainland of China from 2005 to 2019 to draw the epidemic curve and population characteristic distribution of overseas imported cases in each PLAD.Based on spatial autocorrelation analysis of ArcGIS 10.5 and temporal-spatial scanning analysis of SaTScan 9.5,we analyzed the temporal-spatial distribution of overseas imported dengue fever in dengue fever outbreak areas in the mainland of China.Results A total of 11,407 imported cases,mainly from Southeast Asia,were recorded from 2005 to 2019 in these 13 PLADs.Of which 62.1%were imported into Yunnan and Guangdong Provinces.Among the imported cases,there were more males than females,mainly from the 21–50 age group.The hot spots were concentrated in parts of Yunnan,Guangdong and Fujian Provinces.We found the cluster of infected areas were expanding northward.Conclusions Based on the analysis of overseas imported dengue cases in 13 PLADs of the mainland of China from 2005 to 2019,we obtained the epidemiological characteristics and spatial distribution of imported dengue cases.Border controls need to pay attention to key population sectors,such as 21–50 years old men and education of key populations on dengue prevention.There is a need to improve the awareness of the prevention and control of imported cases in border areas.At the same time,northern regions cannot relax their vigilance. | Xinchang Lun Yiguan Wang Chunchun Zhao Haixia Wu Caiying Zhu Delong Ma Mingfang Xu Jun Wang Qiyong Liu Lei Xu Fengxia Meng | 2022 | Infectious Diseases of Poverty2022，11，1： | 3 |
| 11 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 12 | Photocatalytic degradation of 4-tert-octylphenol in a spiral photoreactor system显示文摘A spiral photoreactor system(SPS) was developed for the degradation of 4-tert-octylphenol(4-t-OP) in aqueous phase.4-t-OP was previously considered as a endocrine disrupting compound frequently present in water.The direct photodegradation reaction caused by the SPS was found to accord with the characteristic of apparent first-order reaction with reaction rate constant k = 4.8 × 10-2 min-1.However,the direct photodegradation reaction could not make the 4-t-OP mineralized.The photodegradation efficiency increased from 88% to 91.2% in 45 min irradiation period after the internal surface of SPS was sintered with TiO2 thin film as catalyst.Catalyst concentration,number of catalyst coating layers and initial concentration of 4-t-OP were proven to be the factors affecting the photocatalytic degradation performance of the SPS on aqueous 4-t-OP.The degradation mechanism was investigated and the byproducts were analyzed using total organic carbon analyzer(TOC) and LC-MS.The possible chemical structures of the products were suggested.SPS with single layer of TiO2 prepared by sintering 13.6% of TiO2 precursor was proven to be more efficient than most of previous systems for removal of 4-t-OP from aqueous phase.28.3% of the 4-t-OP was mineralized in 45 min according to the decreased amount of TOC value. | Yanlin Wu Haixia Yuan Xiaoxuan Jiang Guanran Wei Chunlei Li Wenbo Dong | 2012 | Journal of Environmental Sciences2012，24，9： | 3 |
| 13 | Recent Progress and Perspectives of Sodium Metal Anodes for Rechargeable Batteries显示文摘Sodium metal anodes have attracted significant attention due to their high specific capacity,low redox potential and abundant resources.However,the dendrites and unstable solid electrolyte interphase(SEI)of sodium anodes restrict the development of sodium metal batteries.This review includes the recent progress on the Na anode protection in sodium metal batteries.The strategies are summarized as modified three-dimensional current collectors,artificial solid electrolyte interphases,and electrolyte modifications.Conclusions and perspectives are envisaged for the further understanding and development of Na metal anodes. | FANG Hengyi GAO Suning ZHU Zhuo REN Meng WU Quan LI Haixia LI Fujun | 2021 | Chemical Research in Chinese Universities2021，37，2： | 3 |
| 14 | Composites of Graphene and LiFePO_4 as Cathode Materials for Lithium-Ion Battery:A Mini-review显示文摘This mini-review highlights selectively the recent research progress in the composites of Li Fe PO4 and graphene. In particularly, the different fabrication protocols, and the electrochemical performance of the composites are summarized in detail. The structural and morphology characters of graphene sheets that may affect the property of the composites are discussed briefly. The possible ongoing researches in area are speculated upon. | Haixia Wu Qinjiao Liu Shouwu Guo | 2014 | Nano-Micro Letters2014，6，4： | 2 |
| 15 | Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer显示文摘 | Zhi Xu Haixia Zhu John M. Luk Dongmei Wu Dongying Gu Weida Gong Yongfei Tan Jianwei Zhou Jinhai Tang Zhengdong Zhang Meilin Wang Jinfei Chen | 2012 | Cancer2012，，22： | 2 |
| 16 | Correlation between the genetic variants of base excision repair (BER) pathway genes and neuroblastoma susceptibility in eastern Chinese children显示文摘Dear Editor,Neuroblastoma is the most common non-central nerve system(CNS)solid tumor in pediatrics[1].Neuroblastoma accounts for approximately 8%of all pediatric cancers but disproportionally causes a high cancer mortality(15%)in children[2].Pediatric patients with low-risk neuroblastoma witness a 5-year overall survival rate>90%,whereas the 5-year overall survival rate in high-risk neuroblastoma pediatric patients is<40%[3]. | Zhenjian Zhuo Chunlei Zhou Yuan Fang Jinhong Zhu Hongting Lu Haixia Zhou Haiyan Wu Yizhen Wang Jing He | 2020 | Cancer Communications2020，40，11： | 2 |
| 17 | Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORCl and scavenging ROS显示文摘Weight loss and cachexia are common problems in colorectal cancer patients;thus,parenteral and enteral nutrition support play important roles in cancer care.However,the impact of nonessential amino acid components of nutritional intake on cancer progression has not been fully studied.In this study,we discovered that gastrointestinal cancer patients who received cysteine as part of the parenteral nutrition had shorter overall survival(P<0.001)than those who did not.Cystine indeed robustly promotes colon cancer cell growth in vitro and in immunodeficient mice,predominately by inhibiting SESN2 transcription via the GCN2-ATF4 axis,resulting in mTORCl activation.mTORCl inhibitors Rapamycin and Everolimus block cystine-induced cancer cell proliferation.In addition,cystine confers resistance to oxaliplatin and irinotecan chemotherapy by quenching chemotherapy-induced reactive oxygen species via synthesizing glutathione.We demonstrated that dietary deprivation of cystine suppressed colon cancer xenograft growth without weight loss in mice and boosted the antitumor effect of oxaliplatin.These findings indicate that cyst(e)ine;as part of supplemental nutrition,plays an important role in colorectal cancer and manipulation of cyst(e)ine content in nutritional formulations may optimize colorectal cancer patient survival. | Jiao Wu Sai-Ching Jim Yeung Sicheng Liu Aiham Qdaisat Dewei Jiang Wenli Liu Zhuo Cheng Wenjing Liu Haixia Wang Lu Li Zhongmei Zhou Rong Liu Chuanyu Yang Ceshi Chen Runxiang Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 18 | Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration显示文摘Oncostatin M (OSM ) 是 interleukin-6 家庭的 cytokine 并且在发炎期间起重要作用。然而,它在 myoblast 区别的角色和肌肉新生仍然保持未经勘探。我们这里证明 OSM potently 主要由激活 JAK1/STAT1/STAT3 小径禁止了 myoblast 区别。OSM downregulated myocyte 提高有约束力的因素 2A (MEF2A ) , upregulated Id1 和 Id2 的表示,并且禁止了 MyoD 和 MEF2 的 transcriptional 活动。另外, OSM 也提高了 STAT3 和 OSM 受体的表示,它组成了一个积极反馈环进一步放大导致 OSM 的发信号。而且,我们发现身体上与 MEF2 联系并且镇压的那 STAT1 它的 transcriptional 活动,它能说明 MEF2 的调停 OSM 的压抑。尽管在在 vivo 的正常肌肉无法发现, OSM 很快在肌肉损害上然后即时被导致就在 myoblasts 的多数前的 downregulated 区分。没有影响 myoblast 增长,在肌肉的 OSM 的延长表示损害了新生进程,建议 OSM 工作阻止增殖的 myoblasts 在肌肉新生的早阶段期间的早熟的区别。 | Fang Xiao Haixia Wang Xinrong Fu Yanfeng Li Kewei Ma Luguo Sun Xiang Gao Zhenguo Wu | 2011 | Cell Research2011，21，2： | 2 |
| 19 | GAS2-Calpain2 axis contributes to the growth of leukemic cells显示文摘 | LUi Sun Haixia Zhou Hong Liu Yue Ge Xiuyan Zhang Wenjuan Ma Depei Wu Yun Zhao | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 2 |
| 20 | Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses显示文摘 | Di Liu Weifeng Shi Yi Shi Dayan Wang Haixia Xiao Wei Li Yuhai Bi Ying Wu Xianbin Li Jinghua Yan Wenjun Liu Guoping Zhao Weizhong Yang Yu Wang Juncai Ma Yuelong Shu Fumin Lei George F Gao | 2013 | The Lancet2013，，9881： | 2 |
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