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| 1 | A naturally occurring CD8^+CD122^+ T-cell subset as a memory-like Treg family显示文摘尽管有 CD4 + CD25 + 规章的 T 房间(Tregs ) 在过去的十年期间,在他们的临床的翻译以后的进步仍然保持停滞。增长证据建议那自然地发生的 CD8 + CD122 + T 房间也是有能力的 Tregs 禁止 T 房间回答并且象 alloimmunity 一样压制 autoimmunity。事实上,他们是像记忆的 Tregs 类似于一个中央记忆 T 房间(T 厘米 ) 显型。位于他们的抑制下面的机制仍然不好被理解,尽管他们可以包括 IL-10 生产。我们最近证明了那个规划 death-1 (PD-1 ) 表达式区分在之间规章并且存储器 CD8 + CD122 + T 房间和那 CD8 + CD122 + Tregs 经历更快的 homeostatic 增长并且比常规 CD4 + CD25 + Tregs。这些调查结果可以为在诊所加速有效 Treg 治疗打开调查的一根新线。在这评论,我们在 CD8 + CD122 + Treg 在诊所研究并且讨论他们的显型,在 autoimmunity 和 alloimmunity 的镇压角色,功能的要求,行动的机制和潜在的应用。 | Shanshan Li Qingfeng Xie Yuqun Zeng Chuan Zou Xusheng Liu Shouhai Wu Haixia Deng Yang Xu Xian C Li Zhenhua Dai | 2014 | Cellular & Molecular Immunology2014，11，4： | 6 |
| 2 | Effect of chronic corticosterone-induced depression on circadian rhythms and age-related phenotypes in mice显示文摘Disrupted circadian rhythms are a recognized effect of depression,and our previous article demonstrated an association between depression and premature aging,but the underlying mechanisms are not well understood.In the present study,we used a mouse model of chronic corticosterone (CORT)-treated depression to elucidate a mechanism by which depression may be associated with the circadian clock and mediate age-related phenotypes.Mice received a daily injection of 20 mg/kg CORT for 21 consecutive days,and the depression-like behaviors of mice were identified by the sucrose intake test,tail suspension test and open field test.Our findings indicated that CORT injection may be correlatedwith the circadian clock by impairing circadian rhythms or shifting the phase values of clock genes.We also showed that CORT-treated mice exhibited a significant gradual reduction in body weight gain with increased oxidative stress, including reduced activity of antioxidant-related enzymes,reduced glutathione:glutathione disulfide ratio and cytochrome (Cyt)-C level,and elevated reactive oxygen species content.Moreover, chronic CORT injection affected inflammatory responses,the production of mitochondrial ATP and telomere shortening,which may be associated with the Sirtuin 3 (SIRT3)signaling pathway. Additionally,chronic CORT injection disrupted the circadian rhythms of some indexes of aging phenotypes and altered the phase values of these indexes.Our findings suggest that psychologically stressful conditions such as depression are linked to changes in circadian rhythms and agerelated phenotypes. | Lingyan iVla Qichen Shen Song Yang Xiaoxian Xie Qingfeng Xiao Chuanan Yu Lisha Cao Zhengwei Fu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 4 |
| 3 | Obacunone activates the Nrf2-dependent antioxidant responses显示文摘 | Xu, Shengmei Chen, Weimin Xie, Qingfeng Xu, Yang | 2016 | Protein & Cell2016，7，9： | 4 |
| 4 | Role of CD8^(+) regulatory T cells in organ transplantation显示文摘CD8^(+)T cells are regulatory T cells(Tregs)that suppress both alloimmunity and autoimmunity in many animal models.This class of regulatory cells includes the CD8^(+)CD28^(-),CD8^(+)CD103^(+),CD8^(+)FoxP3^(+)and CD8^(+)CD122^(+)subsets.The mechanisms of action of these regulatory cells are not fully understood;however,the secretion of immunosuppressive cytokines,such as interleukin(IL)-4,IL-10 and transforming growth factor beta(TGF-β)as well as the direct killing of target cells via Fas L/Fas and the perforin/granzyme B pathways have been demonstrated in various models.Further studies are necessary to fully understand the mechanisms underlying the suppressive effects of Tregs and to provide experimental support for potential clinical trials.We recently observed that CD8^(+)CD122^(+)Tregs more potently suppressed allograft rejection compared to their CD4^(+)CD25^(+)counterparts,supporting the hypothesis that CD8^(+)Tregs may represent a new and promising Treg family that can be targeted to prevent allograft rejection in the clinic.In this review,we summarize the progress in the field during the past 7-10 years and discuss CD8^(+)Treg phenotypes,mechanisms of action,and their potential clinical applications;particularly in composite tissue transplants in burn and trauma patients. | Jiyan Su Qingfeng Xie Yang Xu Xian C.Li Zhenhua Dai | 2014 | Burns & Trauma2014，2，1： | 3 |
| 5 | Contents Variation Analysis ofγ-Amino Butyric Acid in Semen sojae praeparatum Fermentation Using Online Pre-Column Derivatization-HPLC显示文摘This paper reported the contents variation analysis ofγ-amino butyric acid(GABA)in Semen sojae praeparatum(SSP)which is a famous traditional Chinese medicine.High performance liquid chromatography(HPLC)was used and GABA was derivatized by online pre-column derivatization with o-phthalaldehyde(OPA).To validate this method,the precision,stability,repeatability and recovery were discussed.In the concentration range from 0.0125 to 0.400 mg/m L,the calibration curve for GABA was linear and the regression equation was obtained with correlation coefficient(R2)of 0.9999.Relatively high levels of GABA exist in SSP and the content changes of GABA at different time points during the fermenting process were detected.At the'yellow cladding'stage,GABA level was very low or even undetectable;the'secondary fermentation'stage witnessed a rapid increase of GABA content to 1.39-5.52 mg/g,which remained stable after 18 days of'secondary fermentation'.This study demonstrated that GABA was generated at the'secondary fermentation'stage,revealing the significance and rationality of the'secondary fermentation'stage in the fermenting process of SSP.On the other hand,it suggested the downside of taking soy isoflavones as the only measurement in existing quality assessment and optimization approach for the fermenting process of SSP. | WENG Meizhi HE Jing REN Jiaxiu LIANG Yonghong CHEN Qingfeng SU Mingsheng WANG Liyuan XIE Xiaomei | 2021 | Wuhan University Journal of Natural Sciences2021，26，1： | 2 |
| 6 | Impact of Anthracene Addition on Microbial Community Structure in Soil Microcosms from Contaminated and Uncontaminated Sites显示文摘Objective This paper aims to investigate the impact of anthracene addition on microbial community in agricultural soil irrigated with tap water or reclaimed wastewater.Methods The changes of microbial community were characterized by terminal restriction fragment length polymorphism in combination with 16S rRNA gene clone library analysis.Results A significant change in microbial community composition was observed during the biodegradation of anthracene,with dominantly enriched members from the genus Methylophilus.Conclusion This work might be useful for developing techniques for the isolation of novel putative PAH degrader. | WANG QingFeng ZHANG ShuYing ZOU Li XIE ShuGuang | 2011 | Biomedical and Environmental Sciences2011，24，5： | 2 |
| 7 | Quantum transport through a graphene nanoribbon-superconductor junction 显示文摘 | Sun Qingfeng Xie Xiaoyi | 2009 | Journal of Physics: Condensed Matter2009，21，34： | 1 |
| 8 | Size-dependent catalytic activity of cobalt phosphides for hydrogen evolution reaction显示文摘Transition metal phosphides are a class of promising electrocatalysts for hydrogen evolution reaction(HER) to replace noble metals.In this work,we for the first time synthesize carbon supported CoP nanoparticles with the average particle sizes from 3.3 to 9.2 nm,via a solvothermal process followed by low-temperature topological phosphorization,and the size-dependent HER activity of the CoP is investigated by virtue of TEM,XRD,XPS and the electrochemical techniques.It is discovered that the 9.2nm-CoP particles possess high intrinsic HER catalytic activity as compared to the 3.3nm-CoP,although the smaller one displays a high mass activity due to the large surface area.Detailed studies manifest that the small CoP particles suffer from serious oxidation once exposing to air.In contrast,most cobalt remains in the quasi-metallic state in the relatively large CoP particles,which is beneficial for the desorption of Hads,the rate determining step of the HER process over CoP surface.In addition,the low charge transfer resistance across the liquid/solid interfaces also contributes to the excellent HER activity of the relatively large CoP particles. | Xiaoke Li Luhua Jiang Jing Liu Qingfeng Hua Erdong Wang Guangwen Xie | 2020 | Journal of Energy Chemistry2020，29，4： | 1 |
| 9 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 10 | The effect of centrifugation on viability of fat grafts:an evaluation with the glucose transport test 显示文摘 | Yun Xie Danning Zheng Qingfeng Li | 2010 | J Plast Reconstr Aesthet Surg2010，63，： | 1 |
| 11 | The effect Of centrifugation on viability of fat grafts:an evaluation with the glucose transport test显示文摘 | Yun Xie Danning Zheng Qingfeng Li | 2010 | J Plast Reconstr Aesthet Surg2010，63，： | 1 |
| 12 | AN APPROACH TO THE ECOAGRICULTURAL CONSTRUCTION IN BAICHA VILLAGE OF PENGYANG COUNTY,NINGXIA显示文摘Agricultural production activities are organic combinations between the courses of nat-ural reproduction and economic one. Natural reproduction course is the material base forthe agro-ecological and economic system uniformly operating. So the development ofagro-production has closely concerned with the ecological circumstances. The serious wat- | Xie Yingzhong Ren Qingfeng Ma Gaoyun Ningxia Agricultural College | 1993 | 干旱区资源与环境1993，7，Z1： | 0 |
| 13 | 基质血管细胞辅助脂肪移植体内生物成像分析:移植的基质血管细胞群和移植脂肪的相互作用及相互性显示文摘目的虽然脂肪移植被广泛应用于缺失软组织的重建中,但其移植后的存活率不稳定,使其应用受到限制。最近有研究表明,脂肪来源基质血管成分能提高移植脂肪的成活率。目前,很少有对体内移植脂肪成活量的动态改变和移植脂肪对移植的SVFs影响的报道。方法本研究中,对从荧光素酶(Luc)转基因大鼠中分离出脂肪组织和SVF进行脂肪成活率的生物成像分析。一组是将荧光素酶大鼠脂肪(0.2m1)联合从0.2ml野生大鼠的脂肪中分离出新鲜的SVFs,皮下注入裸鼠的背部;另一组单纯注入脂肪。观察体内脂肪63d,比较两组的成活率。63d后,提取脂肪,用免疫组化染色对其结构的完整性进行评估。此外,为了评估周围脂肪组织对移植的SVFs的影响,我们将从0.2ml荧光素酶大鼠中分离出的SVFs单独或联合野生大鼠的脂肪组织移植到裸鼠的背部,并用生物成像动态观察63d。用特殊的细胞标记物分析SVFs的分化。结果Luc脂肪的生物成像结果表明,联合sVF移植的脂肪组织比单纯脂肪移植的成活率高(P〈0.001)。SVF辅助脂肪移植的细胞结构更完整,坏死和囊肿较少。SVFs移植的结果表明,不加入脂肪,注入的SVFs在21d内就快速消退。而加入脂肪组织,移植的SVF能存活较长时间,在移植63d后还存在。SVFs对脂肪移植的成活率和分化成脂肪细胞、前脂肪细胞和内皮细胞再生有影响。结论我们介绍了一种观测体内移植的脂肪组织的全新技术。生物成像结果表明,SVF辅助脂肪移植要比单独脂肪移植有显著的优势。同时,周围脂肪组织的微环境对提高SVFs的存活和分化也有重要作用。我们的研究也表明,SVFs对分化成多细胞类型脂肪的再生和存活有重要作用。 | Shuangbai Zhou Chengan Chiang Kai Liu Yun Xie Qingfeng Li 叶美辰 高景恒 张晨 袁继龙 | 2015 | 中国美容整形外科杂志2015，26，10： | 0 |
| 14 | Minimizing electrostatic interactions from piezoresponse force microscopy via capacitive excitation显示文摘Piezoresponse force microscopy(PFM)has emerged as one of the most powerful techniques to probe ferroelectric materials at the nanoscale,yet it has been increasingly recognized that piezoresponse measured by PFM is often influenced by electrostatic interactions.In this letter,we report a capacitive excitation PFM(ce-PFM)to minimize the electrostatic interactions.The effectiveness of ce-PFM in minimizing electrostatic interactions is demonstrated by comparing the piezoresponse and the effective piezoelectric coefficient measured by ce-PFM and conventional PFM.The effectiveness is further confirmed through the ferroelectric domain pattern imaged via ce-PFM and conventional PFM in vertical modes,with the corresponding domain contrast obtained by ce-PFM is sharper than conventional PFM.These results demonstrate ce-PFM as an effective tool to minimize the interference from electrostatic interactions and to image ferroelectric domain pattern,and it can be easily implemented in conventional atomic force microscope(AFM)setup to probe true piezoelectricity at the nanoscale. | Qingfeng Zhu Ehsan Nasr Esfahani Shuhong Xie Jiangyu Li | 2020 | Theoretical & Applied Mechanics Letters2020，10，1： | 0 |
| 15 | Specific pupylation as IDEntity reporter(SPIDER)for the identification of protein-biomolecule interactions显示文摘Protein-biomolecule interactions play pivotal roles in almost all biological processes.For a biomolecule of interest,the identification of the interacting protein(s)is essential.For this need,although many assays are available,highly robust and reliable methods are always desired.By combining a substrate-based proximity labeling activity from the pupylation pathway of Mycobacterium tuberculosis and the streptavidin(SA)-biotin system,we developed the Specific Pupylation as IDEntity Reporter(SPIDER)method for identifying protein-biomolecule interactions.Using SPIDER,we validated the interactions between the known binding proteins of protein,DNA,RNA,and small molecule.We successfully applied SPIDER to construct the global protein interactome for m^(6)A and m RNA,identified a variety of uncharacterized m^(6)A binding proteins,and validated SRSF7 as a potential m^(6)A reader.We globally identified the binding proteins for lenalidomide and Cob B.Moreover,we identified SARS-CoV-2-specific receptors on the cell membrane.Overall,SPIDER is powerful and highly accessible for the study of proteinbiomolecule interactions. | He-Wei Jiang Hong Chen Yun-Xiao Zheng Xue-Ning Wang Qingfeng Meng Jin Xie Jiong Zhang ChangSheng Zhang Zhao-Wei Xu Zi-Qing Chen Lei Wang Wei-Sha Kong Kuan Zhou Ming-Liang Ma Hai-Nan Zhang Shu-Juan Guo Jun-Biao Xue Jing-Li Hou Zhe-Yi Liu Wen-Xue Niu Fang-Jun Wang Tao Wang Wei Li Rui-Na Wang Yong-Jun Dang Daniel MCzajkowsky JianFeng Pei Jia-Jia Dong Sheng-Ce Tao | 2023 | Science China(Life Sciences)2023，66，8： | 0 |
| 16 | A randomized clinical trial assessing the efficacy of single and multiple intralesional collagenase injections for treating contracted scars显示文摘Background:Scar contractions caused by trauma or burns can cause secondary physical dysfunction and disfigurement.Many minimally invasive methods for scar contraction have shown limited applicability and efficacy.This study investigated the feasibility and efficacy of intralesional collagenase injections for scar contraction treatment.Methods:Patients with contracted scars who had limited joint movement and physical disfiguration for>1 year were enrolled in this single-blind,randomized clinical trial from July 2017 to February 2018 at Shanghai Ninth People’s Hospital.Collagenase was injected into the firm-contracted scar(15 U/cm^(2))three times at 4-week intervals in the multiple treatment group and once in the single treatment group,and a placebo injection was performed in the control group.Scar length and skin texture were documented at the 4-and 12-week follow-ups.The safety of the collagenase treatment was also evaluated.Results:The contracted scar was significantly elongated after both single and multiple collagenase treatments.The results showed that,compared to a one-time treatment,repeated injections were more effective at 12 weeks,with an average improvement of 26.83(15.79%).At 12 weeks,78.9% of the patients in the multiple group and 52.9%in the single group achieved significant improvement at 12 weeks.No severe adverse events were observed.Conclusion:Intralesional collagenase injection showed promising results in improving scar contraction and provides an alternative treatment for patients. | Shuangbai Zhou Poh-Ching Tan Cheng-An Chiang Yun Xie Peiqi Zhang Qingfeng Li Kai Liu | 2023 | Chinese Journal Of Plastic and Reconstructive Surgery2023，5，3： | 0 |
| 17 | Tectonic implications of the subduction of the Kyushu-Palau Ridge beneath the Kyushu,southwest Japan显示文摘The Kyushu-Palau Ridge(KPR),a remnant arc on the Philippine Sea Plate(PSP),is subducting beneath the Kyushu,southwest Japan.Influenced by the subducting KPR,the Kyushu subduction zone corresponding to the KPR is significantly different from Shikoku subduction zone in terms of gravity anomalies,seismicity,the stress state,and the subducting slab morphology.Significant negative free-air and Bouguer gravity anomalies are observed in a prolonged area of KPR,southeast of the Miyazaki Plain,indicating that this is where KPR overlaps the overriding plate.The gravity anomaly in this area is much lower than that in other areas where the inferred KPR extends,suggesting that the subduction of the buoyant KPR may cause the lower mantle density to decrease.More earthquakes have occurred in Hyuga-nada region where the KPR subducts than in Shikoku forearc and other areas in the Kyushu forearc,indicating that the subduction of the KPR enhances the local coupling between the subducting and overriding plates.The centroid moment tensor(CMT)mechanism of earthquakes shows that stress is concentrated in the accumulated crust beneath the Kyushu forearc corresponding to the KPR,and the shallow thrusting events in the obducting plate are caused by the KPR subduction.The buoyant KPR,with a large volume of low-density sediments,was responsible for the differences of the subduction depth and dip angle of the subducting Philippine Sea(PS)slab between northern Kyushu and Shikoku.The seismic gaps and the sudden change of the dipping angle of the subducting PS slab indicate that slab tear may have occurred along the west side of the KPR beneath southwest Kyushu.A two-tear model was proposed,and the subduction of the buoyant KPR was believed to play an important role in the slab tear. | Chenglong Xia Yanpeng Zheng Baohua Liu Qingfeng Hua Long Ma Xianfeng Li Qiuhong Xie | 2021 | Acta Oceanologica Sinica2021，40，3： | 0 |
| 18 | Analyzing the correlation among the five indications of the regenerative effectiveness of expanded skin:A retrospective study of 277 expansion cases显示文摘Background:Skin expansion is a useful method for harvesting extra tissue.However,the outcome is hardly predictable.Methods:A total of 158 patients with 277 expanded skin cases were reviewed and evaluated via photographs.The review and evaluation were conducted to determine the skin’s regenerative condition.The overall texture of the expanded skin,which was deemed good,fair,or poor,was evaluated.The occurrence of five indications of the limitation of skin regeneration(thinning,color change,stretch marks,varicose vessels,and skin lesions)during expansion was recorded.The correlation between the five indications and the overall texture was statistically analyzed.Results:Among the 277 retrospectively reviewed expansion cases,the occurrence rate of skin deterioration showed significant differences between the expansion sites(P<0.01).Skin deterioration was most commonly seen on the neck and at the back.The occurrence of each indication varied among locations.The odds ratios of color change,stretch marks,varicose vessels,thinning,and skin lesions between good and poor skin conditions were 44.97,5.09,22.26,89.79,and 4.61,respectively(all P<0.001).Conclusion:Skin color,stretch marks,varicose vessels,thickness,and skin lesions are closely correlated with the skin regenerative capacity.An integrated evaluation can help predict the regenerative capacity of expanded skin. | Shuangbai Zhou Sizheng Zhou Cheng’an Chiang Jihan Guo Yun Xie Kai Liu Qingfeng Li | 2022 | Chinese Journal Of Plastic and Reconstructive Surgery2022，4，2： | 0 |
| 19 | Current state and exploration of fat grafting显示文摘Fat grafting has become one of the most frequently used techniques in plastic and reconstructive surgery.Many studies have focused on optimizing procedures,such as donor site selection,harvesting,processing,and grafting.Representative basic techniques include Coleman’s and“3L3M”techniques.A new technique called compartment-based targeted fat grafting(CTFG)has gradually been established based on anatomical findings of the facial and hand compartments.CTFG achieved precise restoration of the fat volume in the anatomical state.Cell-based fat grafting has introduced new fields involving tissue repair and regeneration,including facial rejuvenation and scar improvement,among others.In this review,we summarize the timeline for the development of fat grafting. | Chen Cheng Yun Xie Qingfeng Li | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，4： | 0 |
| 20 | Exposure to jet lag aggravates depression-like behaviors and age-related phenotypes in rats subject to chronic corticosterone显示文摘Our previous finding demonstrated that chronic corticosterone(CORT)may be involved in mediating the pathophysiology of premature aging in rats.Frequent jet lag increases the risk for many diseases,including obesity and type 2 diabetes,and is associated with the aging processes.However,the effect of jet lag on CORT-induced depression and its association with aging phenotypes remain unclear.In this study,the rats were exposed to both CORT and jet lag treatment,and the differences were analyzed and compared to rats with single CORT treatment.Our results showed that jet lag treatment aggravated CORT-induced depression-like behavior evidenced by sucrose intake test,forced swimming test,and open field test.Additionally,this treatment aggravated the shortening of telomeres,which possibly resulted in decreased telomerase activity,and downregulated the expression of telomere-binding factor 2(TRF2)and telomerase reverse transcriptase compared to that in CORT rats,as revealed by quantitative real-time-polymerase chain reaction and western blot analysis,respectively.The shortening of telomeres may have been caused by increased oxidative stress,which was associated with the inhibition of sirtuin 3.Exposure to jet lag also aggravated the degeneration of mitochondrial functions,as shown by the decreases in the mRNA expression of COX1,ND1,and Tfam.Our findings provide physiological evidence that jet lag exposure may worsen stress-induced depression and age-related abnormalities. | Qichen Shen Junli Wu Yuehan Ni Xiaoxian Xie Chunan Yu Qingfeng Xiao Jiafeng Zhou Xia Wang Zhengwei Fu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 0 |
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