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| 1 | Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails显示文摘 | Yanbin Fu Chenwen Huang Xinxiu Xu Haifeng Gu Youqiong Ye Cizhong Jiang Zilong Qiu Xin Xie | 2015 | Cell Research2015，25，9： | 24 |
| 2 | Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells显示文摘体的房间能由定义因素是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed。reprogramming 的低效率和 oncogenes 和病毒的向量的 genomic 集成限制了 iPSCs 的潜在的申请。这里,我们报导那锂(李) ,药过去常对待心情混乱,极大地从老鼠提高 iPSC 产生胚胎的成纤维细胞和人的脐的静脉 endothelial 房间。李与(Oct4 ) 或二个因素(OS 或好) 便于 iPSC 产生。支持 reprogramming 上的李的效果仅仅部分取决于它的主要目标 GSK3β。不同于另外的 GSK3β禁止者,李不仅增加 Nanog 的表示,而且提高 Nanog 的 transcriptional 活动。我们也发现李由经由 LSD1 的 downregulation 支持 epigenetic 修正施加它的效果, H3K4 特定的 histone demethylase。将 LSD1 击倒部分在提高 reprogramming 模仿李的效果。我们的结果不仅提供一个直接方法改进 iPSC 产生效率,而且为体的房间 reprogramming 作为一个批评调节的人识别了 histone demethylase。 | Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie | 2011 | Cell Research2011，21，10： | 23 |
| 3 | Comprehensive eco-environmental effects of the shelter-forest ecological engineering along the Tarim Desert Highway显示文摘In this work, we report a comprehensive study about the eco-environmental effects of the shelter forest along the Tarim Desert Highway, including the effects on aeolian environment, soil, micro-climate, biodiversity, and groundwater. The results show that: (1) The movement of windblown sand near the ground surface was affected by the shelter forest. The wind speed and sediment transport rate in the shelter forest decreased by 64%―80% and 87.45%―99.02%, respectively. In addition, there were also significant changes in the sand flux structure, the sand grain size, and the deflation and deposition on the ground surface. (2) Compared to the natural mobile sand, the soil bulk density in the forest area decreased while the total salt content, the total porosity, and the water content increased. In addition, the soil fertility was significantly improved in the forest area, and showed the 'first rapid, then slow' variation pattern. (3) The shelter forest showed positive effects on the micro-climate. Within the 6 m height above the ground, the air temperature in the shelter forest at different heights was lower than that in the mobile sand, while the air humidity was higher, while, the soil temperature was also lower in the shelter forest than mobile sand. (4) The number of soil microbial species increased significantly with the improvement of habitat in the shelterbelt. However, the population of different species was not distributed evenly across the surveyed area. (5) Currently, no significant effects of groundwater-pumping and forest-irrigation water have been found on the groundwater level and its salinity. The variation amplitude of both groundwater level and salinity was at the level of centimeters and 1g/L, respectively. No obvious variation trend has been observed. | LEI JiaQiang LI ShengYu JIN ZhengZhong FAN JingLong WANG HaiFeng FAN DongDong ZHOU HongWei GU Feng QIU YongZhi XU Bo | 2008 | Chinese Science Bulletin2008，53，S2： | 14 |
| 4 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 5 | Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stern cell generation显示文摘 | Xiaoyuan Wei Yueting Chen Yongyu Xu YangZhan Ru Zhang Min Wang Qiuhong Hua Haifeng Gu Fajun Nan Xin Xie | 2014 | Journal of Molecular Cell Biology2014，8，5： | 13 |
| 6 | Stress-mediated p38 activation promotes somatic cell reprogramming显示文摘环境调停压力的改编在生活的进化起必要作用。细胞的改编机制通常包含染色质结构,抄写, mRNA 稳定性和翻译的规定,它最后在基因表示导致有效变化。全球 epigenetic 变化也涉及体的细胞的 reprogramming 进导致的 pluripotent 由定义因素的茎(iPS ) 细胞。这里,我们报导象 hyperosmosis 那样的那个环境压力不仅便于四调停因素的 reprogramming,而且提高二或一导致因素的 iPS 房间代。导致 Hyperosmosis 的 p38 激活在这个过程起一个关键作用。组成的活跃 p38 模仿 hyperosmosis 的积极效果,当主导的否定 p38 和 p38 禁止者堵住 hyperosmosis 的效果时。进一步的学习显示调停压力的 p38 激活可以由减少全球 DNA methylation 水平并且提高 pluripotency 基因的表示支持 reprogramming。我们的结果表明象 hyperosmosis 一样的简单环境应力怎么帮助经由细胞内部的发信号和 epigenetic 调整改变房间的命运。 | Xinxiu Xu Quan Wang Yuan Long Ru Zhang Xiaoyuan Wei Mingzhe Xing Haifeng Gu Xin Xie | 2013 | Cell Research2013，23，1： | 12 |
| 7 | Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019显示文摘Since late 2011,outbreaks of pseudorabies virus(PRV)have occurred in southern China causing major economic losses to the pig industry.We previously reported that variant PRV forms and recombination in China could be the source of continued epidemics.Here,we analyzed samples from intensive pig farms in eastern China between 2017 and 2019,and sequenced the main glycoproteins(gB,gC,gD,and gE)to study the evolution characteristics of PRV.Based on the gC gene,we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV epidemic.In addition,we detected inter-and intra-clade recombination;in particular,inter-clade recombination in the gB genes of strains FJ-ZXF and FJ-W2,which were recombinant with clade 1 strains.We also found specific amino-acid changes and positively selected sites,possibly associated with functional changes.This analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV. | Xiaofeng Zhai Wen Zhao Kemang Li Cheng Zhang Congcong Wang Shuo Su Jiyong Zhou Jing Lei Gang Xing Haifeng Sun Zhiyu Shi Jinyan Gu | 2019 | Virologica Sinica2019，34，6： | 12 |
| 8 | Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell selfrenewal and somatic cell reprogramming显示文摘 | Guofang Chen Xinxiu Xu Lihong Zhang Yanbin Fu Min Wang Haifeng Gu Xin Xie | 2014 | Cell Research2014，24，9： | 8 |
| 9 | Morphology,phylogenetic position,and ecophysiology of Alexandrium ostenfeldii(Dinophyceae) from the Bohai Sea,China显示文摘Alexandrium ostenfeldii is a potentially toxic dinoflagellate that often occurs in coastal areas at high latitudes.Here we report the presence of A.ostenfeldii in the Bohai Sea,China,for the first time.The vegetative cells of A.ostenfeldii are characterized by a narrow first apical plate and a large ventral pore located on the anterior right side.Partial large subunit sequence comparison revealed that the Chinese strain differs from the Finnish strains at only three positions,and from A.peruvianum of Spain at five positions.Maximum parsimony analysis revealed that A.ostenfeldii from China and Finland and A.peruvianum from Spain grouped together.They were the nearest sister group to a clade with A.ostenfeldii from New Zealand,Europe,and North America.In culture,growth did not occur at temperatures below 9℃ and occurred at salinities between 7 and 27 psu.It took 10-20 days for newly formed cysts to mature at 20℃.Lower temperature delayed germination,but the germination rate exceeded 90% at temperatures from 12 to 24℃.No germination occurred below 9℃ after 1 month of incubation.The Chinese strain of A.ostenfeldii produced neither spirolides nor paralytic shellfish poisoning toxins. | Haifeng GU | 2011 | Journal of Systematics and Evolution2011，49，6： | 7 |
| 10 | Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells显示文摘 | Yan Yuan Quan Zhou Haifeng Wan Bin Shen Xuepeng Wang Mei Wang Chunjing Feng Mingming Xie Tiantian Gu Tao Zhou Rui Fu Xingxu Huang Qi Zhou Jiahao Sha Xiao-Yang Zhao | 2015 | Cell Research2015，25，7： | 7 |
| 11 | Topographical changes of ground surface affected by the shelterbelt along the Tarim Desert Highway显示文摘To study the effects of sand protection project on modern aeolian landform, the types, distribution, and intensity of topographical changes of the ground surface affected by the shelterbelt along the Tarim Desert Highway were determined by measuring the deflation and deposition of sand surface in the Tazhong area located in the hinterland of the Taklimakan Desert. The results showed that (1) the newly-formed landform in sand protection systems is dominated by aeolian deposition including the small-scale Nabkha Dunes, the medium-scale sheet-like sand deposition and the large-scale ridge-like sand deposition. To some degree, aeolian deflation landform can also be formed in the open space in the shelterbelt. Furthermore, it is difficult for aeolian deflation landform to develop in a large scale in the interdunes. However, aeolian deflation landform can be developed in a large-scale on the windward slope of secondary dunes in longitudinal complex sand ridges; (2) on the windward side of the sand protection systems, both the morphology and strike of dwarf mobile dunes in the interdunes are changed by the sand-obstructing forest belts and the ridge-like sand deposition around it. The wind- ward slope of the ridge-like deposition around the sand-obstructing forest belt forms a stable ground surface. After being damaged by forward-moving dunes in a short period, the ground surface is re- covered gradually; (3) on the leeward side of the sand protection systems, aeolian deflations are formed widely. Particularly, the deflation depression is formed in the interdunes. In addition, the dunes in the region with highly topographic relief are cut flat by aeolian deflations; thereafter its relief of to- pography is reduced. The above analysis indicates that shelterbelts have obvious effects on the windward wind-sand flux in terms of dissipating energy and intercepting sand. With the recovery of wind velocity on the leeward side of the sand protection systems, the wind-sand flux gradually tends to be unsaturated; therefore the sand surface deflation is formed. | LI ShengYu LEI JiaQiang XU XinWen WANG HaiFeng FAN JingLong GU Feng QIU YongZhi XU Bo GONG Qing ZHENG Wei | 2008 | Chinese Science Bulletin2008，53，S2： | 4 |
| 12 | Pose Robust Low-resolution Face Recognition via Coupled Kernel-based Enhanced Discriminant Analysis显示文摘Most face recognition techniques have been successful in dealing with high-resolution(HR) frontal face images. However, real-world face recognition systems are often confronted with the low-resolution(LR) face images with pose and illumination variations. This is a very challenging issue, especially under the constraint of using only a single gallery image per person.To address the problem, we propose a novel approach called coupled kernel-based enhanced discriminant analysis(CKEDA).CKEDA aims to simultaneously project the features from LR non-frontal probe images and HR frontal gallery ones into a common space where discrimination property is maximized.There are four advantages of the proposed approach: 1) by using the appropriate kernel function, the data becomes linearly separable, which is beneficial for recognition; 2) inspired by linear discriminant analysis(LDA), we integrate multiple discriminant factors into our objective function to enhance the discrimination property; 3) we use the gallery extended trick to improve the recognition performance for a single gallery image per person problem; 4) our approach can address the problem of matching LR non-frontal probe images with HR frontal gallery images,which is difficult for most existing face recognition techniques.Experimental evaluation on the multi-PIE dataset signifies highly competitive performance of our algorithm. | Xiaoying Wang Haifeng Hu Jianquan Gu | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，2： | 4 |
| 13 | Local Robust Sparse Representation for Face Recognition With Single Sample per Person显示文摘The purpose of this paper is to solve the problem of robust face recognition(FR) with single sample per person(SSPP). In the scenario of FR with SSPP, we present a novel model local robust sparse representation(LRSR) to tackle the problem of query images with various intra-class variations,e.g., expressions, illuminations, and occlusion. FR with SSPP is a very difficult challenge due to lacking of information to predict the possible intra-class variation of the query images.The key idea of the proposed method is to combine a local sparse representation model and a patch-based generic variation dictionary learning model to predict the possible facial intraclass variation of the query images. The experimental results on the AR database, Extended Yale B database, CMU-PIE database and LFW database show that the proposed method is robust to intra-class variations in FR with SSPP, and outperforms the state-of-art approaches. | Jianquan Gu Haifeng Hu Haoxi Li | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，2： | 4 |
| 14 | Dinoflagellate cysts in recent marine sediment from Guangxi, China显示文摘Total of 33 species of dinoflagellate cysts were discovered from surface sediment in the searegion of Guangxi, among them 12 cyst types (Diplopsalopsis sp. 1, D. sp.2, D. sp.3, Cochlodiniumsp., Protoperidinium sp. 1, P. sp. 2, P.compressum, Scrippsiella sp. 1, S. sp. 2, Alexandriumsp. 1, A. sp. 2, A. sp. 3) were first reported from the South China Sea. And one cyst type(Cochlodinium sp. ) was first reported in the world. Scrippsiella trochoidea is the dominant species inthis area, accounting for 45 % of all the cysts. There are 2 cysts of toxic dinoflagellate (Alexandriumtamarensis and Gymnodinium catenatum ). But there is no relationship between cyst number and grainsize distribution. | Haifeng Gu, Qi Fang, Jun Sun, Dongzhao Lan, Feng Cai, Zhiyong Gao Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005,China. E-mail:Haifenggu@yahoo. comCollege of Marine Life Science, Ocean University of China, Qingdao 266003, China. | 2003 | Acta Oceanologica Sinica2003，22，3： | 4 |
| 15 | Single-mode lasing via loss engineering in fiber-taper-coupled polymer bottle microresonators显示文摘Due to the lack of mode selection capability, single whispering-gallery-mode(WGM) lasing is a challenge to achieve. In bottle microresonators, the highly nondegenerated WGMs are spatially well-separated along the long-axis direction and provide mode selection according to their axial mode numbers. In this work, we use a loss-engineering approach to suppress the higher-order WGMs and demonstrate single-mode lasing emission in small polymer bottle microresonators. The fiber tapers are not only used to couple pump light into the bottle microresonators to excite the WGMs but also to bring optical losses that are induced from the diameter mismatch between fiber tapers and microresonators. By adjusting the coupling positions, the diameters of fiber tapers, and the coupling angles, single fundamental-mode lasing is efficiently generated with side-mode suppression factors over 15 dB. Our loss-engineering approach is convenient just by moving the fiber taper and may findpromising applications in miniature tunable single-mode lasers and sensors. | FUMING XIE NI YAO WEI FANG HAIFENG WANG FUXING GU SONGLIN ZHUANG | 2017 | Photonics Research2017，5，6： | 4 |
| 16 | Promoting effect of vanadium on catalytic activity of Pt/Ce–Zr–O diesel oxidation catalysts显示文摘A series of Pt–V/Ce–Zr–O diesel oxidation catalysts was prepared using the impregnation method. The catalytic activity and sulfur resistance of Pt–V/Ce–Zr–O were investigated in the presence of simulated diesel exhaust. The effect of vanadium on the structure and redox properties of the catalysts was also investigated using the Brunauer–Emmett–Teller method,X-ray diffraction, H2temperature-programmed reduction, CO temperature-programmed desorption, X-ray photoelectron spectroscopy, and Energy Dispersive Spectroscopy. Results showed that the Pt particles were well dispersed on the Ce–Zr–O carrier through the vanadium isolation effect, which significantly improved the oxidation activity toward CO and hydrocarbons. An electron-withdrawing phenomenon occurred from V to Pt, resulting in an increase in the metallic nature of platinum, which was beneficial to hydrocarbon molecular activation. | Haifeng Huang Bo Jiang Lei Gu Zhonghua Qi Hanfeng Lu | 2015 | Journal of Environmental Sciences2015，27，7： | 3 |
| 17 | Bubble coalescence efficiency near multi-orifice plate显示文摘Bubble coalescence reduces specific area and weakens the work performance of bubble column. The bubble coalescence near gas sparger which is caused mainly by bubble growing is different from the ones occurring in major liquid. Bubble coalescence efficiency near gas sparger is influenced by many factors including sparger configuration, gas flow rate, bubble deformation, solution composition, etc. This work has conducted a set of visual experiments to study the coalescence characteristics near multi-orifice plate. The experiment parameters cover a wide range of conditions including large scope of gas flow rate,different kinds of solution and orifice configurations. The experimental results suggest that coalescence time is applicable to reflect the influence of the pitch of orifices and gas flow rate on bubble coalescence efficiency. As the number of orifices increases, bubble coalescence efficiency is reduced by the disturbance from the bubbles at adjacent orifices. A hindering coefficient is used to consider the hindering effect of additives on bubble coalescence efficiency. Finally a new calculation expression is established to predict bubble coalescence efficiency near multi-orifice plate whose fundamental form is based on the logistic curve of binary response. The calculated values that refer to this calculation expression are well consistent with the experimental results. | Jiming Wen Qiunan Sun Zhongning Sun Haifeng Gu | 2019 | Chinese Journal of Chemical Engineering2019，27，8： | 2 |
| 18 | COOPERATIVE WIDEBAND SPECTRUM SENSING BASED ON SEQUENTIAL COMPRESSED SENSING显示文摘Compressed sensing offers a new wideband spectrum sensing scheme in Cognitive Radio (CR). A major challenge of this scheme is how to determinate the required measurements while the signal sparsity is not known a priori. This paper presents a cooperative sensing scheme based on se-quential compressed sensing where sequential measurements are collected from the analog-to-information converters. A novel cooperative compressed sensing recovery algorithm named Simul-taneous Sparsity Adaptive Matching Pursuit (SSAMP) is utilized for sequential compressed sensing in order to estimate the reconstruction errors and determinate the minimal number of required meas-urements. Once the fusion center obtains enough measurements, the reconstruction spectrum sparse vectors are then used to make a decision on spectrum occupancy. Simulations corroborate the effec-tiveness of the estimation and sensing performance of our cooperative scheme. Meanwhile, the per-formance of SSAMP and Simultaneous Orthogonal Matching Pursuit (SOMP) is evaluated by Mean-Square estimation Errors (MSE) and sensing time. | Gu Bin Yang Zhen Hu Haifeng | 2011 | Journal of Electronics(China)2011，28，3： | 2 |
| 19 | Molecular dynamics simulations exploring drug resistance in HIV-1 proteases显示文摘Although HIV-1 subtype B still dominates the epidemic AIDS in developed countries,an increasing number of people in developing countries are suffering from an epidemic of non-subtype B viruses.What is worse,the efficacy of the combinational use of antiretroviral drugs is gradually compromised by the rapid development of drug resistance.To gain an insight into drug resistance, 10-ns MD simulations were simultaneously conducted on the complexes of the TL-3 inhibitor with 4 different proteases(Bwt,Bmut, Fwt and Fmut),among which the complex of the Bwt protease with the TL-3 inhibitor was treated as the control group.Detailed analyses of MD data indicated that the drug resistance of Bmut against TL-3 mainly derived from loss of an important hydrogen bond and that of Fwt was caused by the decrease of hydrophobic interactions in S1/S1'pocket,while both of the two reasons mentioned above were the cause of the Fmut protease's resistance.These results are in good agreement with the previous experiments, revealing a possible mechanism of drug resistance for the aforementioned protease subtypes against the TL-3 inhibitor.Additionally,another indication was obtained that the mutations of M36I,V82A and L90M may induce structural transforms so as to alter the inhibitor's binding mode. | GU Hui CHEN HaiFeng WEI DongQing WANG JingFang | 2010 | Chinese Science Bulletin2010，55，24： | 2 |
| 20 | Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha , and Boswellia carterii显示文摘 | Shulan Su Yongqing Hua Yanyan Wang Wei Gu Wei Zhou Jin-ao Duan Haifeng Jiang Ting Chen Yuping Tang | 2011 | Journal of Ethnopharmacology2011，，2： | 1 |
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