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| 1 | China’s urban expansion from 1990 to 2010 determined with satellite remote sensing显示文摘Based on the same data source of Landsat TM/ETM+ in 1990s,2000s and 2010s,all urban built-up areas in China are mapped mainly by human interpretation.Mapping results were checked and refined by the same analyst with the same set of criteria.The results show during the last 20 years urban areas in China have increased exponentially more than 2 times.The greatest area of urbanization changed from Northeastern provinces in 1990s to the Southeast coast of China in Jiangsu,Guangdong,Shandong,and Zhejiang in 2010s.Urban areas are mostly converted from croplands in China.Approximately 17750 km 2 croplands were converted into urban lands.Furthermore,the conversion from 2000 to 2010 doubled that from 1990 to 2000.During the 20 years,the most urbanized provinces are Jiangsu,Guangdong,Shandong and Zhejiang.We also analyzed built-up areas,gross domestic production (GDP) and population of 147 cities with a population of greater than 500000 in 2009.The result shows coastal cities and resource-based cities are with high economic efficiency per unit of built-up areas,resource-based cities have the highest population density,and the economic efficiency of most coastal provinces are lower than central provinces and Guangdong.The newly created urban expansion dataset is useful in many fields including trend analysis of urbanization in China;simulation of urban development dynamics;analysis of the relationship among urbanization,population growth and migration;studies of carbon emissions and climate change;adaptation of climate change;as well as land use and urban planning and management. | WANG Lei LI CongCong YING Qing CHENG Xiao WANG XiaoYi LI XueYan HU LuanYun LIANG Lu YU Le HUANG HuaBing GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 64 |
| 2 | Overexpression of SOS (Salt Overly Sensitive) Genes Increases Salt Tolerance in Transgenic Arabidopsis显示文摘土壤咸度是减少种的一个主要不能生活的压力生长和生产率。最近,植物 overexpressing AtNHX1 或 SOS1 显著地增加了盐忍耐,这被报导。为了测试多重基因的 overexpression 是否能改善,甚至更种盐忍耐,我们生产了六不同转基因的 Arabidopsis 植物那 overexpress AtNHX1, SOS3, AtNHX1 ?+? SOS3, SOS1, SOS2 ?+? SOS3,或 SOS1 ?+? SOS2 ?+? SOS3。北污点分析在转基因的植物证实了相关基因抄本的高水平的存在。转基因的 Arabidopsis 植物 overexpressing AtNHX1 独自没在盐忍耐介绍任何重要增加,与更早的报告相反。我们发现那转基因的植物 overexpressing SOS3 展览增加了类似于植物 overexpressing SOS1 的盐忍耐。而且,转基因的植物 overexpressing AtNHX1 的盐忍耐 ?+? SOS3, SOS2 ?+? SOS3,或 SOS1 ?+? SOS2 ?+? 分别地, SOS3 独自显得类似于转基因的植物 overexpressing 任何一个 SOS1 或 SOS3 的忍耐。 | Qing Yang | 2009 | Molecular Plant2009，2，1： | 44 |
| 3 | Comprehensive metabolomics expands precision medicine for triple-negative breast cancer显示文摘Metabolic reprogramming is a hallmark of cancer.However,systematic characterizations of metabolites in triple-negative breast cancer(TNBC)are still lacking.Our study profiled the polar metabolome and lipidome in 330 TNBC samples and 149 paired normal breast tissues to construct a large metabolomic atlas of TNBC.Combining with previously established transcriptomic and genomic data of the same cohort,we conducted a comprehensive analysis linking TNBC metabolome to genomics.Our study classified TNBCs into three distinct metabolomic subgroups:C1,characterized by the enrichment of ceramides and fatty acids;C2,featured with the upregulation of metabolites related to oxidation reaction and glycosyl transfer;and C3,having the lowest level of metabolic dysregulation.Based on this newly developed metabolomic dataset,we refined previous TNBC transcriptomic subtypes and identified some crucial subtype-specific metabolites as potential therapeutic targets.The transcriptomic luminal androgen receptor(LAR)subtype overlapped with metabolomic C1 subtype.Experiments on patient-derived organoid and xenograft models indicate that targeting sphingosine-1-phosphate(S1P),an intermediate of the ceramide pathway,is a promising therapy for LAR tumors.Moreover,the transcriptomic basal-like immune-suppressed(BLIS)subtype contained two prognostic metabolomic subgroups(C2 and C3),which could be distinguished through machine-learning methods.We show that N-acetyl-aspartyl-glutamate is a crucial tumor-promoting metabolite and potential therapeutic target for high-risk BLIS tumors.Together,our study reveals the clinical significance of TNBC metabolomics,which can not only optimize the transcriptomic subtyping system,but also suggest novel therapeutic targets.This metabolomic dataset can serve as a useful public resource to promote precision treatment of TNBC. | Yi Xiao Ding Ma Yun-Song Yang Fan Yang Jia-Han Ding Yue Gong Lin Jiang Li-Ping Ge Song-Yang Wu Qiang Yu Qing Zhang François Bertucci Qiuzhuang Sun Xin Hu Da-Qiang Li Zhi-Ming Shao Yi-Zhou Jiang | 2022 | Cell Research2022，32，5： | 18 |
| 4 | Carbon storage in evergreen broad-leaf forests in mid-subtropical region of China at four succession stages显示文摘To better understand the effect of forest succession on carbon sequestration, we investigated carbon stock and allocation of evergreen broadleaf forest, a major zonal forest in subtropical China.We sought to quantify the carbon sequestration potential.We sampled four forest types,shrub(SR), pine(Pinus massoniana) forest(PF), pine and broadleaf mixed forest(MF) and evergreen broadleaf forest(BF).A regression equation was constructed using tree height and diameter at breast height(DBH) and elements of total tree biomass.The equation was subsequently utilized to estimate tree carbon storage.The carbon storage of understory, litter, and soil was also estimated.Carbon storage in biomass increased significantly from the early succession stage SR(6.21 t ha-1) to the late stage BF(134.87 t ha-1).The biomass carbon stock of forest layers generally increased with succession except for the understory.The soil organic carbon storage for the total profile increased with forest succession, from 51.16 to 90.49 t ha-1, but the contribution of SOC to the carbon stock of the forest ecosystem declined from 89.18% to 40.15%.The carbon stock at ecosystem scale increased significantly with succession from SR(57.37 t ha-1), to PF(154.20 t ha-1), to MF(170.96 t ha-1)and to BF(225.36 t ha-1), with carbon stock of BF3.93 times that of SR.The forests in our study have great potential for increasing carbon sequestration, and large areas of secondary or degraded evergreen broadleaf forests in the subtropical zone of China could be a great carbon sink in future. | ZENG Zhangquan WANG Silong ZHANG Canming GONG Chao HU Qing | 2013 | Journal of Forestry Research2013，24，4： | 17 |
| 5 | Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components显示文摘AIM:To investigate the effect of severe acute pan- creatitis(SAP)on pharmacokinetics of Da-Cheng-Qi Decoction(DCQD)components in rats. METHODS:Rats were divided into SAP group and sham-operation group as a control group(n=6). Rhein,chrysophanol,rheochrysidin,magnolol,hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics. RESULTS:Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage.The Cmax(chrysophanol,P= 0.0059;rheochrysidin,P=0.0288;magnolol,P= 0.0487;hesperidin,P=0.0277;naringin,P=0.0023) and AUC(rhein,P=0.0186;chrysophanol,P=0.0013; magnolol,P=0.001;hesperidin,P=0.0081;naringin, P=0.0272)of DCQD component were obviously lower in SAP group than in control group.The T1/2α of chrysophanol and rheochrysidin(P=0.0467 and 0.0005,respectively)and Tmax of chrysophanol and rheochrysidin(P=0.0101 and 0.0037,respectively) lasted longer in SAP group than in control group. CONCLUSION:SAP can significantly impact the ab-sorption of DCQD components in rats and their phar-macokinetic parameters. | Han-Lin Gong Wen-Fu Tang Qin Yu Jin Xiang Qing xia Guang-Yuan Chen Xi Huang Mao-Zhi Liang | 2009 | World Journal of Gastroenterology2009，15，47： | 16 |
| 6 | Modified Da-Cheng-Qi Decoction reduces intra-abdominal hypertension in severe acute pancreatitis: a pilot study显示文摘 | WAN Mei-hua LI Juan HUANG Wei Rajarshi Mukherjee GONG Han-lin XIA Qing ZHU Lin CHENG Gui-lan TANG Wen-fu | 2012 | Chinese Medical Journal2012，，11： | 16 |
| 7 | Geographical characteristics of China’s wetlands derived from remotely sensed data显示文摘In this paper, we report the first wetland mapping of the entire China using Landsat enhanced thematic mapper plus (ETM+) data. These data were obtained from the Global Land Cover Facility at the University of Maryland spanning from 1999 to 2002. A total of 597 scenes of Landsat images were georeferenced and mosaiced. Manual image interpretation of satellite images was aided with elevation data, soil data, land cover/land use data and Google Earth. The minimum mapping unit is 10 pixel × 10 pixel, equivalent to 9 ha. The aim of our first round of mapping was only targeted at the boundary delineation of any type of wetland except those wetlands that are under agricultural use (i.e., paddy fields), which has already been well mapped by others. Our interpretation results indicate that a total of 359478 km2 of wetlands are of non-agricultural use. Among our preliminarily mapped wetland, 339353 km2 are inland wetland, 2786 km2 are non-agricultural artificial wetland, and 17609 km2 are coastal wetland. Because low-tide is rarely captured in satellite images, an under-estimation of coastal wetland is inevitable. We conducted some statistics based on our mapped wetlands and compared them with those previously obtained from a number of sources including a land cover/land use map made with satellite images during the late 1990s and early 2000s, a marshland map developed in approximately the same period, survey data of coastal wetland in early 1980s, and area data for approximately 400 larger patches of marshland in China compiled in 1996. Because some inconsistencies exist in the guidelines of those different wetland surveys, difference in area is expected. Some further comparison indicates that the wetland distributions derived from the preliminary wetland map are reasonable and more objective than other sources. The mapping process also indicated that the method adopted by us was efficient and cost-effective. We also found that in order to ensure comparability of the wetland maps developed at different times, a set of standard guidelines on the wetland categories to be mapped, and the mapping methods to be used must be well conceived, developed and effectively employed. We carried out some initial geographical analysis on the distribution of wetlands. | NIU ZhenGuo GONG Peng CHENG Xiao GUO JianHong WANG Lin HUANG HuaBing SHEN ShaoQing WU YunZhao WANG XiaoFeng WANG XianWei YING Qing LIANG Lu ZHANG LiNa WANG Lei YAO Qian YANG ZhenZhong GUO ZiQi DAI YongJiu | 2009 | Science China Earth Sciences2009，52，6： | 15 |
| 8 | Edaravone (MC1-186), a free radical scavenger, attenuates retinal ischemia/reperfusion injury in rats显示文摘瞄准:调查 edaravone (MCI-186 ) 的效果,自由基 scavenger,对 ischemia/reperfusion (I/R ) 在老鼠视网膜的损害。方法:网膜的局部缺血被为 60 min 提高 intraocular 压力到 110 毫米汞柱在男 Sprague-Dawley 老鼠导致。老鼠 intraperitoneally 在局部缺血前在 30 min 在 3 mg/kg 的剂量与 edaravone 被注射,然后与 edaravone 对待(3 mg/kg, ip ) 为在 I/R 以后的 1 或 5 d 两次每日。malondialdehyde (MDA ) 和在网膜的纸巾的过氧化物歧化酶(草皮) 的层次在 d 上被决定 1 在 I/R 损害以后。网膜的神经原的 apoptosis 在 d 上被检测 1 在由终端 deoxynucleotidyl 的 I/R 损害以后标记染色的调停 transferase 的 digoxigenin-dUTP 刻痕结束。网膜电图(尔格) 在 d 上被记录 5 在灌注以后。结果:Edaravone 降低了 MDA 层次,提起的草皮活动,和在内的网膜的神经原的稀释 I/R-induced apoptosis 内部原子,老鼠视网膜的中心房间,和外胞核层。而且, edaravone 在一波浪和尔格的 b 波浪振幅压制了 I/R-induced 减小。结论:Edaravone 能通过减少氧化应力在老鼠保护视网膜免于 I/R 损害,禁止网膜的神经原的 apoptosis,它建议那 edaravone 可能是为 I/R-induced 眼睛混乱的处理的一种潜在的选择。 | Yi SONG Yuan-yuan GONG Zheng-gao XIE Cai-hong LI Qing GU Xing-wei WU | 2008 | Acta Pharmacologica Sinica2008，29，7： | 15 |
| 9 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 10 | Ultrasound-mediated microbubble delivery of pigment epithelium-derived factor gene into retina inhibits choroidal neovascularization显示文摘许多研究建议了的背景 angiogenic 因素和 anti-angiogenic 因素表示的不平衡显著地作出贡献到 choroidal 的开发 neovascularization (CNV ) ,和超声 microbubble 联合系统能成功地增加基因 transfection 效率。这研究被设计调查调停超声的 microbubble 破坏是否,并且是否能有效地交付治疗学的 plasmid 进老鼠的视网膜导出上皮的因素( PEDF )能禁止的颜料的基因转移 CNV.Methods 人的网膜的颜料上皮的房间独自与超声或 plasmid 被孤立并且对待任何一个,或与接近 提高microbubble 的超声的可行性的 plasmid ,超声和 microbubbles 的联合提高 PEDFgene expressio 因为在 vivo 动物学习, CNV 被氩 lasgon 激光在老鼠导致。这些老鼠随机被分到五个组并且被灌输与 PEDF 的裸体 plasmid DNA 依附进的 microbubbles 对待立即的超声暴露(intravitreal 注射) 跟随的老鼠玻璃;与 PEDF 的裸体 plasmid DNA 灌输 liposomes 进玻璃(lipofectamine + PEDF ) ;灌输立即与超声照耀与 PEDF 依附进老鼠的轨道的 microbubbles (retrobular 注射) ;灌输 microbubbles 与 PEDF 属于进老鼠的大腿骨的静脉与立即暴露了到超声(静脉注射) 。没有任何处理的 CNV 老鼠用作控制。老鼠被牺牲,眼睛是在在处理以后的 7, 14,和 28 天的 enucleated。PEDF 的基因和蛋白质表示被量的即时 RT-PCR,西方的弄污和分别地染色的 immunofluorescence 检测。CNV 上的 PEDF 基因转移的效果被荧光黄宫底 angiography.Results 在房间实验显示出的 vitro 检验有超声照耀的那 microbubbles 能显著地独自作为与 microbubbles 或超声相比提高 PEDF 交货。在老鼠 CNV 模型, transfection 效率由 ultrasound/microbubbles 调停了由在在处理以后的 28 天的调停 lipofectamine 的基因转移比那显著地高。学习也证明与调停超声的 microbubbles 破坏的管理,老鼠的 CNV 被禁止 effectively.Conclusions Ultrasound-microbubble 技术能增加 PEDF 基因转移进老鼠的视网膜和 chorioid ,与 CNV 的发展的重要抑制联合,建议这个 noninvasive 基因转移方法可以为临床的基因治疗提供一个有用工具。 | ZHOU Xi-yuan LIAO Qing PU Yi-min TANG Yong-qiang GONG Xiao LI Jia XU Yan WANG Zhi-gang | 2009 | Chinese Medical Journal2009，，22： | 12 |
| 11 | Primary dolostone related to the Cretaceous lacustrine hydrothermal sedimentation in Qingxi sag, Jiuquan Basin on the northern Tibetan Plateau显示文摘Based on comprehensive studies in petrography,petrofabric analysis and geochemistry,this paper describes a unique and rare laminated micritic ferruginous primary dolostone crystallized and precipitated from the alkaline hot brine under the conditions of the Mesozoic faulted lake basin.The main rock-forming mineral of this dolostone is ferruginous dolomite with a micritic structure.This dolomite mostly exhibits laminae of 0.1–1 mm thick and is often discovered with other minerals,such as albite,analcite,barite and dickite,which have at least two types of interbedded laminae.Petrogeochemistry reveals that this dolostone contains a large number of typomorphic elements of hydrothermal sedimentation,including Sb,Ba,Sr,Mn,and V.In addition,the LREE is in relatively high concentrations and possesses the typical REE distribution pattern with negative Eu anomaly.Oxygen isotope values(δ18OPDB)range from 5.89‰to 14.15‰with an average of 9.69‰.The ratio of87Sr/86Sr is between0.711648 and 0.719546,with an average of 0.714718.These data indicate that the depositional environment is a stable,blocked,anoxic low-lying hot brine pool in the bottom of deep lake controlled by basement faults.The hydrothermal fluid is the alkaline hot brine formed by the combination of the infiltration lake water and mantle-derived magmatic water,consisting of many ions,including Ca2+,Mg2+and Fe2+.Under the driving flow power of magmatic heat,gravity and compaction,the hydrothermal fluid overcame the overburden pressure and hydrostatic pressure of the lake water body,and boiled to explosion,and then the explosion shattered the original laminated micritic ferruginous primary dolostone near the vent and then formed a new type of dolostone called shattered'hydroexplosion breccias'.In the low-lying,unperturbed hot brine pool,far from the vent,the laminated micritic ferruginous primary dolostone was quickly crystallized and chemicals precipitated from the hydrotherm.This study of special rocks contributes to research into the causes of the formation of lacustrine carbonate rocks and dolostone.In particular,it provides new examples and research insights for future studies of the lacustrine dolomite from the similar Mesozoic and Cenozoic basins in China. | WEN HuaGuo ZHENG RongCai QING HaiRuo FAN MingTao LI YanAn GONG BoShi | 2013 | Science China Earth Sciences2013，56，12： | 12 |
| 12 | Evidences of rapid erosion driven by climate in the Yarlung Zangbo (Tsangpo) Great Canyon,the eastern Himalayan syntaxis显示文摘Climate and tectonism are both particularly intense in the Yarlung Zangbo (Tsangpo) Great Canyon in the eastern Himalayan syntaxis,which is characterized by the most rapid landscape evolution of anywhere in the world.Thus,the eastern Himalayan syntaxis is one of the best locations to study the interactions between climate and tectonics.This paper investigates the cooling ages of the Doxong La-Baibung profile using apatite fission track (AFT) dating on 11 bedrock samples at elevations ranging from 4210 to 710 m.There are topographic,climatic,metamorphic,and thermochronological gradients in the profile,providing good conditions to study interactions between climate and tectonics.AFT ages ranged from 4.6±0.6 Ma to 1.7±0.3 Ma,and the mean fission track lengths ranged from 11.0 to 12.4 μm.It was found that the cooling rates revealed by AFT ages increased with decreasing elevation.However,the tendency of the cooling rates revealed by the 40 Ar-39 Ar ages was different from that indicated by the AFT ages.Moreover,for most districts of the eastern Himalayan syntaxis,the compiled AFT age distribution correlates well with the annual average precipitation,indicating the coupling of the cooling and erosion rates of the near-surface rock and precipitation.The geothermal history modeling results indicate an obvious increase in the cooling and erosion rate between 1.0 and 0.5 Ma.This age is consistent with other research findings for this time,when the vapor channel of the Yarlung Zangbo Great Canyon began to take effect.These evidences suggest that climate,especially precipitation,has acting as a key factor influencing the rapid cooling and erosion in the Yarlung Zangbo Great Canyon since 1-0.5 Ma. | YU XiangJiang JI JianQing GONG JunFeng SUN DongXia QING JianChun WANG LiNing ZHONG DaLai ZHANG ZhiCheng | 2011 | Chinese Science Bulletin2011，56，11： | 11 |
| 13 | Osteoarthritis:pathogenic signaling pathways and therapeutic targets显示文摘Osteoarthritis(OA)is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide.OA was believed to be caused by the wearing and tearing of articular cartilage,but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues,which leads to the histological and structural changes of the joint and ends up with the whole tissue dysfunction.Currently,there is no cure for OA,partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the disease.Therefore,a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug development.In this review,we first summarize the epidemiology of OA,including its prevalence,incidence and burdens,and OA risk factors.We then focus on the roles and regulation of the pathological signaling pathways,such as Wnt/β-catenin,NF-κB,focal adhesion,HIFs,TGFβ/ΒΜP and FGF signaling pathways,and key regulators AMPK,mTOR,and RUNX2 in the onset and development of OA.In addition,the roles of factors associated with OA,including MMPs,ADAMTS/ADAMs,and PRG4,are discussed in detail.Finally,we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for OA.Research advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies. | Qing Yao Xiaohao Wu Chu Tao Weiyuan Gong Mingjue Chen Minghao Qu Yiming Zhong Tailin He Sheng Chen Guozhi Xiao | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 11 |
| 14 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 15 | Switched adaptive active disturbance rejection control of variable structure near space vehicles based on adaptive dynamic programming显示文摘Based on the switched nonlinear system, a switched adaptive Active Disturbance Rejection Control(ADRC) law is proposed for the Variable Structure Near Space Vehicle(VSNSV) with unknown uncertainties and external disturbances. The reduced-order Extended State Observers(ESOs) are constructed for the attitude angle system and the angular rate system to estimate the total disturbance in real time. With the extended state introduced to counteract the effects of uncertainties and disturbances, a systematic procedure is presented for the synthesis of the switched adaptive ADRC strategy. Rigorous proof shows that the estimation errors of the reduced-order ESOs would converge to a small neighborhood of zero in finite time, and that the output of the closedloop system can track a given signal stably for a class of switching signals with average dwell time via the proposed approach. The variable gain control strategy based on Adaptive Dynamic Programming(ADP) with the actor-critic structure is also designed to improve the dynamic performance of the system. Simulation results verify the effectiveness and advantage of the proposed control scheme. | Chaoyang DONG Chen LIU Qing WANG Ligang GONG | 2019 | Chinese Journal of Aeronautics2019，32，7： | 10 |
| 16 | Operational spectrum reconstruction of data from the Fourier transform hyperspectral imager onboard HJ-1A satellite显示文摘The HJ-1A satellite was successfully launched on September 6, 2008. The inclusion of a HyperSpectral Imager (HSI) as one of the payloads of the HJ-1A Satellite is a major milestone in the field of the remote sensing in China. It is also the first Fourier transform imaging spectrometer routinely used to acquire scientific data from a satellite orbiting Earth. This paper briefly introduces the basic imaging theories of the spatially modulated Fourier transform imaging spectrometer, and then discusses the theoretical analysis and algorithms of spectrum reconstruction. Results of the operational spectrum reconstruction for the raw data of the HJ-1A satellite Fourier transform HSI are presented. At present, the algorithms and processing flow have been used successfully in the Ground Data Processing System (GDPS) built by the China Center for Resource Satellite Data and Applications (CRESDA). | ZHAO Xiang LU Jing GONG ADu XIAO ZhengQing KANG Qian LI Qing | 2010 | Chinese Science Bulletin2010，55，17： | 10 |
| 17 | Differential neuronal reprogramming induced by NeuroD1 from astrocytes in grey matter versus white matter显示文摘A new technology called in vivo glia-to-neuron conversion has emerged in recent years as a promising next generation therapy for neural regeneration and repair. This is achieved through reprogramming endogenous glial cells into neurons in the central nervous system through ectopically expressing neural transcriptional factors in glial cells. Previous studies have been focusing on glial cells in the grey matter such as the cortex and striatum, but whether glial cells in the white matter can be reprogrammed or not is unknown. To address this fundamental question, we express NeuroD1 in the astrocytes of both grey matter(cortex and striatum) and white matter(corpus callosum) to investigate the conversion efficiency, neuronal subtypes, and electrophysiological features of the converted neurons. We discover that NeuroD1 can efficiently reprogram the astrocytes in the grey matter into functional neurons, but the astrocytes in the white matter are much resistant to neuronal reprogramming. The converted neurons from cortical and striatal astrocytes are composed of both glutamatergic and GABAergic neurons, capable of firing action potentials and having spontaneous synaptic activities. In contrast, the few astrocyte-converted neurons in the white matter are rather immature with rare synaptic events. These results provide novel insights into the differential reprogramming capability between the astrocytes in the grey matter versus the white matter, and highlight the impact of regional astrocytes as well as microenvironment on the outcome of glia-toneuron conversion. Since human brain has large volume of white matter, this study will provide important guidance for future development of in vivo glia-to-neuron conversion technology into potential clinical therapies. Experimental protocols in this study were approved by the Laboratory Animal Ethics Committee of Jinan University(approval No. IACUC-20180321-03) on March 21, 2018. | Min-Hui Liu Wen Li Jia-Jun Zheng Yu-Ge Xu Qing He Gong Chen | 2020 | Neural Regeneration Research2020，15，2： | 10 |
| 18 | Preoperative surgical planning for intracranial meningioma resection by virtual reality显示文摘 | TANG Hai-liang SUN Hua-ping GONG Ye MAO Ying WU Jing-song ZHANG Xiao-luo XIE Qing XIE Li-qian ZHENG Ming-zhe WANG Dai-jun ZHU Hong-da TANG Wei-jun FENG Xiao-yuan CHEN Xian-cheng ZHOU Liang-fu | 2012 | Chinese Medical Journal2012，，11： | 10 |
| 19 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 20 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
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