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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Composites of small Ag clusters confined in the channels of well-ordered mesoporous anatase TiO2 and their excellent solar-light-driven photocatalytic performance显示文摘 | Wei Zhou Ting Li Jianqiang Wang Yang Qu Kai Pan Ying Xie Guohui Tian Lei Wang Zhiyu Ren Baojiang Jiang Honggang Fu | 2014 | Nano Research2014，7，5： | 17 |
| 3 | DNA image cytometry test for primary screening of esophageal cancer: a population-based multi-center study in high-risk areas in China显示文摘Objective: To evaluate the feasibility of DNA image cytometry(DNA-ICM) as a primary screening method for esophageal squamous cell cancer(ESCC).Methods: A total of 5,382 local residents aged 40–69 years from three high-risk areas in China(Linzhou in Henan province, Feicheng in Shandong province and Cixian in Hebei province) from 2008 to 2011 were recruited in this population-based screening study. And 2,526 subjects declined to receive endoscopic biopsy examination with Lugol's iodine staining, while 9 and 815 subjects were excluded from liquid-based cytology and DNA-ICM test respectively due to slide quality. Finally, 2,856, 5,373 and 4,567 subjects were enrolled in the analysis for endoscopic biopsy examination, liquid-based cytology and DNA-ICM test, respectively. Sensitivity(SE), specificity(SP), negative predictive values(NPV) and positive predictive values(PPV) as well as their 95% confidence intervals(95% CI) for DNA-ICM, liquid-based cytology and the combination of the two methods were calculated. Receiver operating characteristic(ROC) curves were applied to determine the cutoff point of DNA-ICM for esophageal cancer.Results: DNA-ICM results were significantly correlative with esophageal cancer and precancer lesions(χ~2=18.016, P<0.001). The cutoff points were 5,802, 5,803 and 8,002 based on dissimilar pathological types of low grade intraepithelial neoplasia(LGIN), high grade intraepithelial neoplasia(HGIN), and ESCC, respectively, and 5,803 was chosen in this study considering the SE and SP. The SE, SP, PPV, NPV of DNA-ICM test(cutoff point 5,803) combined with liquid-based cytology [threshold atypical squamous cells of undetermined significance(ASCUS)] were separately 72.1%(95% CI: 70.3%-73.9%), 43.3%(95% CI: 41.3%-45.3%), 22.8%(95% CI: 21.1%-24.5%) and 87.0%(95% CI: 85.7%-88.3%) for LGIN, 85.7%(95% CI: 84.3%-87.1%), 41.3%(95% CI: 39.3%-43.3%), 4.6%(95% CI: 3.8%-5.4%) and 98.9%(95% CI: 98.5%-99.3%) for HGIN, and 96.0%(95% CI: 95.2%-96.8%), 40.8%(95% CI: 38.8%-42.8%), 1.7%(95% CI: 1.2%-2.2%) and 99.9%(95% CI: 99.8%-100.0%) for ESCC.Conclusions: It is possible to use DNA-ICM test as a primary screening method before endoscopic screening for esophageal cancer. | Meng Wang Changqing Hao Qing Ma Guohui Song Shanrui Ma Deli Zhao Lin Zhao Xinqing Li Wenqiang Wei | 2016 | Chinese Journal of Cancer Research2016，28，4： | 15 |
| 4 | Boron neutron capture therapy for malignant melanoma: first clinical case report in China显示文摘A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy(BNCT) was designed to evaluate whether the world's first in-hospital neutron irradiator(IHNI) was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography(PET/CT) scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals. | Zhong Yong Zewen Song Yongmao Zhou Tong Liu Zizhu Zhang Yanzhong Zhao Yang Chen Congjun Jin Xiang Chen Jianyun Lu Rui Han Pengzhou Li Xulong Sun Guohui Wang Guangqing Shi Shaihong Zhu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 13 |
| 5 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 6 | Therapeutic evaluation of lumbar tender point deep massage for chronic non-specific low back pain显示文摘OBJECTIVE:To observe the therapeutic effect of lumbar tender point deep tissue massage plus lumbar traction on chronic non-specific low back pain using change in pressure pain threshold,muscle hardness and pain intensity as indices.METHODS:We randomly divided 64 patients into a treatment group(32 cases) and a control group(32 cases).Two drop-outs occurred in each group.Patients in the treatment group received tender point deep tissue massage plus lumbar traction and patients in the control group received lumbar traction,alone.We used a tissue hardness meter/algometer and visual analog scale(VAS) to assess the pressure pain threshold,muscle hardness and pain intensity.RESULTS:Following treatment,we obtained the following results in the treatment and control groups,respectively:the pressure pain threshold difference was 1.5±0.8 and 1.1±0.7;the muscle hardness difference was 4.2±1.6 and 3.5±1.3;and the VAS score difference was 1.9±0.9 and 1.4±0.8.Compared to the control group,the treatment group had higher pressure pain threshold(t=2.09,P<0.05),and lower muscle hardness(t=2.05,P<0.05) and pain intensity(t=2.46,P<0.05).CONCLUSION:Lumbar tender point deep tissue massage combined with lumbar traction produced better improvement in pressure pain threshold,muscle hardness and pain intensity in patients with chronic non-specific low back pain than with lumbar traction alone. | Zhixin Zheng Jun Wang Qian Gao Jingshan Hou Ling Ma Congbo Jiang Guohui Chen | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 10 |
| 7 | Comparative Transcriptome Analysis of Actinidia arguta Fruits Reveals the Involvement of Various Transcription Factors in Ripening显示文摘The fruit of Actinidia arguta is typically climacteric.During ripening,the fruits produce a large amount of ethylene.Although the molecular basis of climacteric fruit ripening has been extensively studied,some aspects such as its transcriptional regulation remain unclear.Here,we compared the transcriptomes of A.arguta fruits collected at commercial harvest(sample d0)and at 6 days after harvest(sample d6)using RNA-seq.A total of 3 659 differentially expressed genes(DEGs)between samples d0 and d6 were detected,of which 2 983 and 1 104 could be functionally annotated with Gene Ontology(GO)and Clusters of Orthologous Groups(COG)pathways.DEGs involved in ethylene biosynthesis and signal transduction were identified,including ACO(c79627),ERF061(c105131),and ERF6(c99193).Transcription factors such as ERF,b HLH,NAC,MADS,and MYB were also differentially expressed between samples d0 and d6.Selected DEGs were subjected to further analysis using quantitative reverse transcription-polymerase chain reaction(q RT-PCR),and the results coincided with those of RNA-seq.Our data revealed additional transcription factors that are involved in the regulation of fruit ripening.These results provide useful information for future research on the transcriptional regulation of fruit ripening. | HUANG Guohui QU Yi LI Tong YUAN Hui WANG Aide TAN Dongmei | 2018 | Horticultural Plant Journal2018，4，1： | 9 |
| 8 | Nucleocytoplasmic Trafficking of the Arabidopsis WD40 Repeat Protein XIW1 Regulates ABI5 Stability and Abscisic Acid Responses显示文摘WD40 repeat-containing proteins(WD40 proteins)serve as versatile scaffolds for protein-protein interac-tions,modulating a variety of cellular processes such as plant stress and hormone responses.Here we report the identification of a WD40 protein,XIW1(for XPO1-interacting WD40 protein 1),which positively regulates the abscisic acid(ABA)response in Arabidopsis.XIW1 is located in the cytoplasm and nucleus.We found that it interacts with the nuclear transport receptor XPO1 and is exported by XPO1 from the nucleus.Mutation of XIW1 reduces the induction of ABA-responsive genes and the accumulation of ABA Insensitive 5(ABI5),causing mutant plants with ABA-insensitive phenotypes during seed germination and seedling growth,and decreased drought stress resistance.ABA treatment upregulates the expression of XIW1,and both ABA and abiotic stresses promote XIW1 accumulation in the nucleus,where it interacts with ABI5.Loss of XIW1 function results in rapid proteasomal degradation of ABI5.Taken together,these findings suggest that XIW1 is a nucleocytoplasmic shuttling protein and plays a positive role in ABA responses by interacting with and maintaining the stability of ABI5 in the nucleus. | Xuezhong XU Wang Wan Guobin Jiang Yue Xi Haijian Huang Jiajia Cai Yanan Chang Cheng-Guo Duan Satendra KMangrauthia Xinxiang Peng Jian-Kang Zhu Guohui Zhu | 2019 | Molecular Plant2019，12，12： | 8 |
| 9 | Variation analyses of growth and wood properties of Larix olgensis clones in China显示文摘The growth traits(tree height, diameter at breast height, and stem straightness degree) and wood properties[wood density(WD), fiber length, fiber width, ash content(AC), lignin content, cellulose content, hemicellulose content(HEC), and holocellulose content] of 208 26-yearold Larix olgensis clones were analyzed. Except for WD and AC, there were significant differences(p \ 0.01) for all traits among clones. The phenotypic coefficient of variation and repeatability of all traits were 9.34–35.33%and 0.218–0.930, respectively. Tree height and diameter at breast height showed significant positive correlation;however, the correlation coefficients among growth characteristics and wood properties were mostly not significant.Ten clones(L70, L56, L82, L90, L59, L91, L61, L92, L86,and L64) were selected as excellent clones under a selection rate of 5%, using tree height, diameter at breast height,and stem straightness degree as evaluation indexes, providing genetic gains of 28.69, 17.96, and 0.67%, respectively. Ten clones(L88, L305, L59, L66, L253, L304,L277, L298, L248, and L293) were selected as excellent clones using wood properties as an evaluation index, with a selection rate of 5%, providing genetic gains in WD, fiber length, fiber width, cellulose content, and HEC of 4.14,3.64, 9.28, 6.77, and 9.61%, respectively. This study provides a theoretical basis for selecting excellent L. olgensis clones. | Shaopeng Yin Zhenhai Xiao Guohui Zhao Xin Zhao Xiaoyang Sun Ying Zhang Fuwei Wang Shuchun Li Xiyang Zhao Guan-Zheng Qu | 2017 | Journal of Forestry Research2017，28，4： | 6 |
| 10 | Decrement of Sugar Consumption in Rice Young Panicle Under High Temperature Aggravates Spikelet Number Reduction显示文摘Two rice genotypes Huanghuazhan(HHZ, heat-resistant) and IR36(heat-susceptible) were subjected to high-temperature(HT, 40℃) and normal-temperature(NT, 32℃) treatments at the spikelet differentiation stage. HT treatment inhibited spikelet differentiation, aggravated spikelet degeneration, reduced spikelet size, and disordered carbohydrate allocation. Meanwhile, HT treatment increased nonstructural carbohydrate content in leaves, but decreased that in stems and young panicles, and the same tendencies of sucrose and starch contents were observed in leaves and stem. However, HT treatment significantly increased the sucrose content and sharply decreased the glucose and fructose contents in young panicles. Lower activity levels of soluble acid invertase(EC3.2.1.26) and sucrose synthase(EC2.4.1.13) were observed under HT treatment. Moreover, HT treatment reduced the activities of key enzymes associated with glycolysis and the tricarboxylic acid cycle, which indicated sucrose consumption was inhibited in young panicles under HT treatment. Exogenous glucose and fructose applied under HT treatment increased the spikelet number more than exogenous sucrose. In conclusion, the results demonstrated that the reduction of spikelet number under high temperature was more affected by the decrease in sugar consumption than the blocking of sucrose transport. The impairment of sucrose hydrolysis was the main reason for the inhibition of sugar utilization. | WANG Yaliang ZHANG Yikai SHI Qinghua CHEN Huizhe XIANG Jing HU Guohui CHEN Yanhua WANG Xiaodan WANG Junke YI Zihao ZHU Defeng ZHANG Yuping | 2020 | Rice science2020，27，1： | 6 |
| 11 | MICRO ELECTRICAL DISCHARGE MACHINING DEPOSITION IN AIR显示文摘一个新免职方法用用机器制造的微电的分泌物(EDM ) 被描述在空中在细工品上扔工具电极材料。微电的分泌物免职(EDD ) 的基本原则被分析,认识到的条件被预言。与塑造机器的平常的 EDM,是的黄铜电极,是的高速度的钢细工品,实验的很多系统地并且彻底地在微 EDD 上被执行。处理参数的专业的效果例如分泌物水流,解除持续时间,脉搏间隔和工作媒介,被获得。作为结果,有在直径的 0.19 公里和在高度的 7.35 公里的微柱体被扔。由交换电极和细工品的极性,微柱体能有选择地被移开。免职和移动的可逆用机器制造因此被完成,它突破传统的 EDM 的限制。扔的材料对细工品紧缩、靠近的大小表演基于,其部件取决于工具电极材料。 | JIN Baidong ZHAO Wansheng WANG Zhenlong CAO Guohui | 2006 | Chinese Journal of Mechanical Engineering2006，19，4： | 6 |
| 12 | Correction Method of Light Hydrocarbons Losing and Heavy Hydrocarbon Handling for Residual Hydrocarbon (S_1) from Shale显示文摘In China, hot researches on shale oil were raised by the important breakthrough of shale oil in America. Obviously, the first important issue is the actual shale oil resource potential of China, and the selection of the key appraisement parameter is vital to the shale oil resource amount. Among the appraisement parameters, the oil content parameter(S1) is the key one, but the evaluation result is generally lower because of light hydrocarbon losing and heavy hydrocarbon handling. And the more important thing is that the light hydrocarbon with small molecular weight is more recoverable, and therefore its amount is important to the total shale oil yields. Based on pyrolysis experiments and the kinetic model of hydrocarbon generation, correction factors and a model of light hydrocarbon losing and heavy hydrocarbon handling were established. The results show that the correction factor of heavy hydrocarbon handling is 3.2, and that of light hydrocarbon losing is controlled by kerogen type, maturity and hydrocarbon generation environment(closed or open). | WANG Min TIAN Shansi CHEN Guohui XUE Haitao HUANG Aihua WANG Wenguang | 2014 | Acta Geologica Sinica(English Edition)2014，88，6： | 6 |
| 13 | Levels of Metabolic Enzymes and Nitrogenous Compounds in the Swimming Crab Portunus trituberculatus Exposed to Elevated Ambient Ammonia-N显示文摘This study investigated the effects of ammonia-N(control and 1 and 5 mg L^(-1)) on the changes of metabolic enzymes activities and nitrogenous compounds levels in the gills, hepatopancreas, muscles, and hemolymph of the swimming crab Portunus trituberculatus. Results showed that the levels of hemolymph ammonia increased significantly at 6 h and then decreased to control level at 12 h. The activities of key enzymes involved in biosynthesis pathways of glutamine(Gln) and urea, such as glutamate dehydrogenase(GDH), glutamine synthetase(GS), and arginase(ARG), increased remarkably in different tissues of P. trituberculatus. Gln level was the highest in muscles, while urea content was the largest in hepatopancreas. The m RNA expression level of xanthine dehydrogenase(XDH) was downregulated sharply in gills but upregulated in the hepatopancreas and muscles. A small amount of uric acid was detected in the hemolymph. This result suggests that Gln in muscles may be used as an intermediary nitrogen repository, while urea may be primarily synthesized in the hepatopancreas and then transferred to other tissues via the hemolymph. Uric acid could be synthesized by the anabolism of purine nucleotides, in additon to the inhibitory activities of gills. In addition, the levels of Gln, urea and uric acid exhibited dose-and time-dependent effects with ammonia content. Therefore, P. trituberculatus could possibly convert ammonia into Gln, urea, or uric acid to detoxify ammonia during high ambient ammonia-N stress. | PAN Luqing SI Lingjun LIU Shengnan LIU Maoqi WANG Guohui | 2018 | Journal of Ocean University of China2018，17，4： | 5 |
| 14 | Effect of acid density of HZSM-5 on the oligomerization of ethylene in FCC dry gas显示文摘The oligomerization of ethylene in FCC dry gas over HZSM-5 catalyst with different Si/Al2 ratios was studied. The effect of acid density of catalyst on the oligomerization of ethylene was discussed. By increasing the acid density of catalyst, ethylene conversion showed a linear increase, while the yields of olefins decreased when the acid density of catalyst exceeded 0.14 mmolNH3/g owing to a promotion of hydrogen transfer reaction. Through comparing the average distance between acid sites on catalyst with kinetic diameters of olefins, it was found that the dimerization of ethylene was not restrained by the sparse distribution of acid sites, while the hydrogen transfer reaction of C3 and C4 olefins was limited. On these bases, a conclusion is proposed that the dimerization of ethylene proceeded via Eley-Rideal mechanism, while the hydrogen transfer reaction of C3 and C4 olefins followed the Langmuir-Hinshelwood mechanism. | Xue Ding Shan Geng Chunyi Li Chaohe Yang Guohui Wang | 2009 | Journal of Natural Gas Chemistry2009，18，2： | 5 |
| 15 | Laser Additive Manufacturing on Metal Matrix Composites: A Review显示文摘Important progresses in the study of laser additive manufacturing on metal matrix composites(MMCs)have been made.Recent efforts and advances in additive manufacturing on 5 types of MMCs are presented and reviewed.The main focus is on the material design,the combination of reinforcement and the metal matrix,the synthesis principle during the manufacturing process,and the resulted microstructures as well as properties.Thereafter,the trend of development in future is forecasted,including:Formation mechanism and reinforcement principle of strengthening phase;Material and process design to actively achieve expected performance;Innovative structure design based on the special properties of laser AM MMCs;Simulation,monitoring and optimization in the process of laser AM MMCs. | Neng Li Wei Liu Yan Wang Zijun Zhao Taiqi Yan Guohui Zhang Huaping Xiong | 2021 | Chinese Journal of Mechanical Engineering2021，34，3： | 4 |
| 16 | NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma显示文摘Objective:Esophageal squamous cell carcinoma(ESCC)has high morbidity and mortality rates worldwide.Cancer stem cells(CSCs)may cause tumor initiation,metastasis,and recurrence and are also responsible for chemotherapy and radiotherapy failures.Myeloid-derived suppressor cells(MDSCs),in contrast,are known to be involved in mediating immunosuppression.Here,we aimed to investigate the mechanisms of interaction of CSCs and MDSCs in the tumor microenvironment.Methods:ESCC tissues and cell lines were evaluated.Neural precursor cell expressed,developmentally downregulated 9(NEDD9)was knocked down and overexpressed by lentiviral transfection.Quantitative PCR,Western blot,immunohistochemistry,cell invasion,flow cytometry,cell sorting,multiplex chemokine profiling,and tumor growth analyses were performed.Results:Microarray analysis revealed 10 upregulated genes in esophageal CSCs.Only NEDD9 was upregulated in CSCs using the sphere-forming method.NEDD9 expression was correlated with tumor invasion(P=0.0218),differentiation(P=0.0153),and poor prognosis(P=0.0373).Additionally,NEDD9 was required to maintain the stem-like phenotype.Screening of chemokine expression in ESCC cells with NEDD9 overexpression and knockdown showed that NEDD9 regulated C-X-C motif chemokine ligand 8(CXCL8)expression via the ERK pathway.CXCL8 mediated the recruitment of MDSCs induced by NEDD9 in vitro and in vivo.MDSCs promoted the stemness of ESCC cells through NEDD9 via the Notch pathway.Conclusions:As a marker of ESCC,NEDD9 maintained the stemness of ESCC cells and regulated CXCL8 through the ERK pathway to recruit MDSCs into the tumor,suggesting NEDD9 as a therapeutic target and novel prognostic marker for ESCC. | Dongli Yue Shasha Liu Tengfei Zhang Yong Wang Guohui Qin Xinfeng Chen Huanyu Zhang Dong Wang Lan Huang Feng Wang Liping Wang Song Zhao Yi Zhang | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 17 | Recent advances in anisotropic two-dimensional materials and device applications显示文摘Two-dimensional(2D)materials,such as transition metal dichalcogenides(TMDs),black phosphorus(BP),MXene and borophene,have aroused extensive attention since the discovery of graphene in 2004.They have wide range of applications in many research fields,such as optoelectronic devices,energy storage,catalysis,owing to their striking physical and chemical properties.Among them,anisotropic 2D material is one kind of 2D materials that possess different properties along different directions caused by the intrinsic anisotropic atoms5 arrangement of the 2D materials,mainly including BP,borophene,low-symmetry TMDs(ReSe2 and ReSa)and group IV monochalcogenides(SnS,SnSe,GeS,and GeSe).Recently,a series of new devices has been fabricated based on these anisotropic 2D materials.In this review,we start from a brief introduction of the classifications,crystal structures,preparation techniques,stability,as well as the strategy to discriminate the anisotropic characteristics of 2D materials.Then,the recent advanced applications including electronic devices,optoelectronic devices,thermoelectric devices and nanomechanical devices based on the anisotropic 2D materials both in experiment and theory have been summarized.Finally,the current challenges and prospects in device designs,integration,mechanical analysis,and micro-/nano-fabrication techniques related to anisotropic 2D materials have been discussed.This review is aimed to give a generalized knowledge of anisotropic 2D materials and their current devices applications,and thus inspiring the exploration and development of other kinds of new anisotropic 2D materials and various novel device applications. | Jinlai Zhao Dingtao Ma Cong Wang Zhinan Guo Bin Zhang Jianqing Li Guohui Nie Ni Xie Han Zhang | 2021 | Nano Research2021，14，4： | 4 |
| 18 | Medicinals with properties of warming Yang and tonifying Qi in terms of Traditional Chinese Medicine: their effects on left ventricular ejection fraction and aldosterone in rats with induced failure heart显示文摘OBJECTIVE: To investigate on Left ventricular ejection fraction value and aldosterone of two medicinals of Traditional Chinese Medicine(TCM) with the properties of warming Yang and tonifying Qi in terms of TCM theory.METHODS: An animal model of coronary ligation of heart failure after myocardial infarction was employed to study the influence of these two kinds of drugs on three batches of rats. On the basis of the average score of left ventricle ejection fraction during the investigation, there were some different groups, including Wen Yang(the warming Yang)group, Yi Qi(tonifying Qi) group, Wen Yang and Yi Qi group, captopril group, digoxin group. In additional, an artificial operation group was set for compari-son. The systemic intervention using these medicinal and drugs was taken effects on the 2nd day after the operation of myocardial infraction(MI) with once a day. At week one, two, and four after the MI treatment, evaluated were EF values, and ferritin,angiotensin-II and aldosterone in the rats' plasma.RESULTS: At week one and week two, the medicinal of Wen Yang, Yi Qi, Wen Yang pluse Yi Qi, and digoxin could improve left ventricular ejection fraction in rats with heart failure; Compared to the model group, captopril Left ventricular EF value increased, but there was not significant. At week four,heart failure and left ventricular EF values was improved in the intervention group and the other four captopril drug intervention. At week one in the rats with drug intervention, the medicinals of Yi Qi, Wen Yang plus Yi Qi, and captopril could inhibit activation in vivo hormone aldosterone in heart failure rats; aldosterone in Wen Yang group and digoxin group were not different from that in the model group at week two and four.CONCLUSION: Chinese medicinals with properties of Wen Yang, Yi Qi have significant effect on improving left ventricular EF in rats with heart failure; compared to Yi Qi medicinals, Wen Yang medicinals that inhibit the effectiveness of the time required for the activation of the role of aldosterone. The medicinals of Wen Yang and Yi Qi seems better by inhibiting the activation of the hormone aldosterone after failing to inhibit ventricular remodeling to improve heart failure. | Han Lihua Wang Zhentao Chai Songbo Xing Guohui Wang Hongxing Yuan Bin Li Zhiwei Su Shihao | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 4 |
| 19 | Lacustrine Shale Oil Resource Potential of Es3L Sub-Member of Bonan Sag, Bohai Bay Basin, Eastern China显示文摘Following shale gas, shale oil has become another highlight in unconventional hydrocarbon exploration and development. A large amount of shale oil has been produced from a host of marine shale in North America in recent years. In China, lacustrine shale, as the main source rock of conventional oil and gas, should also have abundant oil retained in place. In this study, geochemical and geologic characteristics of lacustrine shale from Es_3~L sub-member in Bonan sag were characterized by using total organic carbon(TOC), Rock-Eval pyrolysis, X-ray diffraction, and ?log R method. The results show that the Es_3~L sub-member shale have TOC contents ranging from 0.5 wt.% to 9.3 wt.%, with an average of 2.9 wt.%. The organic matter is predominantly Type I kerogen, with minor amounts of Type II1 kerogen. The temperature of maximum yield of pyrolysate(Tmax) values ranges from 424 to 447 °C, with an average of 440 °C, and vitrinite reflectance(Ro%) ranges from 0.7% to 0.9%, indicating most of shales are thermally mature. The dominant minerals of Es_3~L shale in Bonan sag are carbonates(including calcite and dolomite), averaging 51.82 wt.%, and the second minerals are clay(mostly are montmorillonite-illite-mixed layer and illite) and quartz, averaging about 18 wt.%. Finally, its shale oil resources were evaluated by using the volumetric method, and the evaluation result shows that the shale oil resource is up to 5.94 billion tons, and mostly Class I resource. Therefore, the exploration of the lacustrine shale oil of Es_3~L in Bonan sag should be strengthened. | Shuangfang Lu Wei Liu Min Wang Linye Zhang Zhentao Wang Guohui Chen Dianshi Xiao Zhandong Li Huiting Hu | 2017 | Journal of Earth Science2017，28，6： | 4 |
| 20 | TCMSTD 1.0: a systematic analysis of the traditional Chinese medicine system toxicology database显示文摘Dear Editor,The safety and modernization of traditional Chinese medicine (TCM) are significant concerns for users’ lives and health. Recently, the adverse effects caused by TCM and traditional nontoxic TCM have been frequently reported (Joo et al., 2020;Liu et al., 2021). As the safety of TCM continues to attract widespread attention, many researchers have been investigating the toxicity of TCM in regard to the toxic ingredients, effects, mechanisms, and detoxification strategies in TCM (Figure S1 in Supporting Information). Although some TCMs cause toxic reactions, they also play key roles in treating certain unignorable diseases (Fang et al., 2022).Therefore, toxicity research is crucial and urgently needed to develop and safely use TCM. | Lili Song Wenxiu Qian Hongqing Yin Yu Sun Xiuyan Sun Guohui Li Junjie He Yanxue Zheng Yue Zhang Jiayi Wang Yubo Li | 2023 | Science China(Life Sciences)2023，66，9： | 3 |
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