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20篇 您的检索式:作者名="Zhinan Guo"
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1New insights into the roles of CHOP-induced apoptosis in ER stress显示文摘Endoplasmic 蜂窝胃应力(嗯应力) 在 ER 由于动态平衡的损失被触发,在 ER 腔导致累积 ofmisfolded 蛋白质。嗯因为 ER 的展开的蛋白质 response.Perturbation 是抄写因素 C/EBP 相应蛋白质(砍) 的强大的 inducer,应力激活知道的一系列适应机制。尽管它过时的人或物证明到 ER 的过多或不利的应力触发 apoptosis,由砍位于这些 processesinduced 下面的特定的机制仍然保持不清楚。现在,导致砍的 apoptosis 在嗯应力在众多的人的疾病被含有例如 neurodegenerative 疾病,糖尿病, ischemic 疾病,肿瘤等等。在这评论,我们从实验室在几疾病的发展总结了砍的角色的 currentunderstanding 到诊所。Yiming Li Yunshan Guo Juan Tang Jianli Jiang Zhinan Chen 2014Acta Biochimica et Biophysica Sinica2014,46,8:45
2IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang 2012Cell Research2012,22,3:22
3Global Dynamic Molecular Profiling of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing显示文摘The regulation of stomatal lineage cell development has been extensively investigated.However,a comprehensive characterization of this biological process based on single-cell transcriptome analysis has not yet been reported.In this study,we performed RNA sequencing on 12844 individual cells from the cotyledons of 5-day-old Arabidopsis seedlings.We identified 11 cell clusters corresponding mostly to cells at specific stomatal developmental stages using a series of marker genes.Comparative analysis of genes with the highest variable expression among these cell clusters revealed transcriptional networks that regulate development from meristemoid mother cells to guard mother cells.Examination of the developmental dynamics of marker genes via pseudo-time analysis revealed potential interactions between these genes.Collectively,our study opens the door for understanding how the identified novel marker genes participate in the regulation of stomatal lineage cell development.Zhixin Liu Yaping Zhou Jinggong Guo Jiaoai Li Zixia Tian Zhinan Zhu Jiajing Wang Rui Wu Bo Zhang Yongjian Hu Yijing Sun Yan Shangguan Weiqiang Li Tao Li Yunhe Hu Chenxi Guo Jean-David Rochaix Yuchen Miao Xuwu Sun 2020Molecular Plant2020,13,8:11
4Two-Dimensional Tellurium:Progress,Challenges,and Prospects显示文摘Since the successful fabrication of two-dimensional(2D)tellurium(Te)in 2017,its fascinating properties including a thickness dependence bandgap,environmental stability,piezoelectric effect,high carrier mobility,and photoresponse among others show great potential for various applications.These include photodetectors,field-effect transistors,piezoelectric devices,modulators,and energy harvesting devices.However,as a new member of the 2D material family,much less known is about 2D Te compared to other 2D materials.Motivated by this lack of knowledge,we review the recent progress of research into 2D Te nanoflakes.Firstly,we introduce the background and motivation of this review.Then,the crystal structures and synthesis methods are presented,followed by an introduction to their physical properties and applications.Finally,the challenges and further development directions are summarized.We believe that milestone investigations of 2D Te nanoflakes will emerge soon,which will bring about great industrial revelations in 2D materials-based nanodevice commercialization.Zhe Shi Rui Cao Karim Khan Ayesha Khan Tareen Xiaosong Liu Weiyuan Liang Ye Zhang Chunyang Ma Zhinan Guo Xiaoling Luo Han Zhang 2020Nano-Micro Letters2020,12,8:8
5Biomass of meiobenthic in the Bohai Sea, China显示文摘A grid of 22 stations, giving a broad geographic coverage of the Bohai Sea and the Bohai Strait was selected. Undisturbed sediments were collected from sampling stations during cruises in June 1997, in September/October 1998 and again in April/May 1999. Based on the results of Juario (1975), the average biomass, 0.404 g/(m2a) of meiofauna (including nematode, harpacticoida, bivalve larvae, polycheata and kinorhyncha) in the Bohai Sea is given and accounts for 4.5 percent of the macrofauna in the Bohai Sea. The horizontal distribution of the biomass of meiofauna showed that it was higher at the stations of middle east part of the Bohai Sea and the strait in 1998 and 1999 cruises and it decreased at the stations near to the strait mouth and increased at Station B1 in 1999 cruise. The annual average production in the Bohai Sea is 3.636 g/m2 calculated in term of the formula P = 9B. Compared with the biomass of other sea areas in the world, the biomass of the Bohai Sea is similar but slightly lower. The individual average dry weight of nematodes given by different authors is analyzed.Guo Yuqing, Zhang Zhinan, Mu Fanghong 1. Department of Life Science, Ocean University of Qingdao, Qingdao 266003, China 2. Agricultural College, jimei University, Xiamen 361021, China 2001Acta Oceanologica Sinica2001,20,3:6
6A critical epitope in CD147 facilitates memory CD4^(+) T-cell hyper-activation in rheumatoid arthritis显示文摘The abnormal activation of CD4^(+)CD45RO+memory T(Tm)cells plays an important role in the pathogenesis of rheumatoid arthritis(RA).Previous studies have shown that CD147 participates in T-cell activation.However,it remains unclear whether CD147 is involved in abnormal Tm-cell activation in RA patients.In this study,we demonstrated that CD147 was predominantly upregulated in Tm cells derived from RA patients.The anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained osteoclastogenesis.Using a structural–functional approach,we depicted the interface between 5A12 and CD147.This allowed us to identify two critical residues,Lys63 and Asp65,as potential targets for RA treatment,as the double mutation K63A/D65A inhibited Tm-cell activation,mimicking the neutralization by 5A12.This study provides not only a theoretical basis for a“CD147-Tm/Osteoclast-RA chain”for the potential prevention and treatment of RA or other T-cell-mediated autoimmune diseases but also a new target for related drug design and development.Na Guo Sheng Ye Kui Zhang Xiaoling Yu Hongyong Cui Xiangmin Yang Peng lin Minghua Lv Jinlin Miao Yang Zhang Qing Han Rongguang Zhang Zhinan Chen Ping Zhu 2019Cellular & Molecular Immunology2019,16,6:6
7Recent advances in anisotropic two-dimensional materials and device applications显示文摘Two-dimensional(2D)materials,such as transition metal dichalcogenides(TMDs),black phosphorus(BP),MXene and borophene,have aroused extensive attention since the discovery of graphene in 2004.They have wide range of applications in many research fields,such as optoelectronic devices,energy storage,catalysis,owing to their striking physical and chemical properties.Among them,anisotropic 2D material is one kind of 2D materials that possess different properties along different directions caused by the intrinsic anisotropic atoms5 arrangement of the 2D materials,mainly including BP,borophene,low-symmetry TMDs(ReSe2 and ReSa)and group IV monochalcogenides(SnS,SnSe,GeS,and GeSe).Recently,a series of new devices has been fabricated based on these anisotropic 2D materials.In this review,we start from a brief introduction of the classifications,crystal structures,preparation techniques,stability,as well as the strategy to discriminate the anisotropic characteristics of 2D materials.Then,the recent advanced applications including electronic devices,optoelectronic devices,thermoelectric devices and nanomechanical devices based on the anisotropic 2D materials both in experiment and theory have been summarized.Finally,the current challenges and prospects in device designs,integration,mechanical analysis,and micro-/nano-fabrication techniques related to anisotropic 2D materials have been discussed.This review is aimed to give a generalized knowledge of anisotropic 2D materials and their current devices applications,and thus inspiring the exploration and development of other kinds of new anisotropic 2D materials and various novel device applications.Jinlai Zhao Dingtao Ma Cong Wang Zhinan Guo Bin Zhang Jianqing Li Guohui Nie Ni Xie Han Zhang 2021Nano Research2021,14,4:4
8Deformation mode-determined misorientation and microstructural characteristics in rolled pure Zr sheet显示文摘In this work, commercially pure Zr sheets were subjected to β air cooling and then rolled to different reductions(10% and 50%)at room temperature. Microstructures of both the β-air-cooled and the rolled specimens were well characterized by electron channelling contrast imaging and electron backscatter diffraction techniques, with special attentions paid to their misorientation characteristics. Results show that the β-air-cooled specimen owns a Widmanst?tten structure featured by lamellar grains with typical phase transformation misorientations. The 10% rolling allows prismatic slip and tensile twinning({11-21}<11-2-6> and{10-12}<10-11>) to be activated profusely, which produce new low-angle(~3°–5°) and high-angle(~35° and ~85°) misorientation peaks, respectively. After increasing the rolling reduction to 50%, twinning is suppressed and dislocation slip becomes the dominant deformation mode, with the lamellar grains highly elongated and aligned towards the rolling direction.Meanwhile, only one strong low-angle misorientation peak related to the prismatic slip is presented in the 50%-rolled specimen,with all other peaks disappeared. Analyses on local misorientations reveal that hardly any residual strains exist in the β-air-cooled specimen, which should be related to their sufficient relaxation during slow cooling. Residual strains introduced by 10% rolling are heterogeneously distributed near grain/twin boundaries while heavier deformation(50% rolling) produces much larger residual strains pervasively existing throughout the specimen microstructure.CHAI LinJiang XIA JiYing ZHI Yan GOU YinNing CHEN LiangYu YANG ZhiNan GUO Ning 2018Science China(Technological Sciences)2018,61,9:3
9Bimodal plate structures induced by pulsed laser in duplex-phase Zr alloy显示文摘A duplex-phase Zr-2.5Nb alloy was treated by pulsed laser, followed by careful microstructural characterization using field emission gun scanning electron microscope and attached electron backscatter diffraction. Beneath the modification zones with common uniform α-plate structures(UPS), a layer of unreported bimodal α-plate structures(BPS) featured by coarse(submicron)plates forming multiple cores surrounded by dense fine(nanoscale) plates was found. Presence of such BPS is attributed to non-equilibrium thermodynamic conditions induced by the pulsed laser treatments. Limited diffusion of Nb due to the short pulse during laser heating allows β phases with distinctly different Nb contents to be presented: Nb-enriched prior β films and Nb-depleted β phases, transforming into the fine and the coarse plates during cooling, respectively. Orientation analyses show that both types of plates in the BPS are aroused essentially from a single β orientation, suggesting epitaxial growth of the Nb-depletedβ phases from the preexisting β films.CHAI LinJiang WANG ShuYan WU Hao YANG ZhiNan PAN HuCheng SONG Bo GUO Ning 2017Science China(Technological Sciences)2017,60,4:2
10New species of Terschellingia ( nematode ) from the BohaiSea, China 显示文摘Guo Yu qing & Zhang Zhinan 2000Journal of Ocean University of Qingdao2000,30,3:1
11Transition metaldoping effect and high catalytic activity of CeO_(2)-TiO_(2) for chlorinated VOCs degradation显示文摘A series of transition metals(Fe,Co,Ni,Cu,Cr and Mn)-doped CeO_(2)-TiO_(2) catalysts were prepared by the sol-gel method and applied for the catalytic removal of 1,2-dichloroethane(DCE) as a model for chlorinated VOCs(CVOCs).The various characterization methods including X-ray diffraction(XRD),N_(2) adsorption-desorption,UV-Raman,NH_(3) temperature-programmed desorption(NH_(3)-TPD) and H_(2) temperature-programmed reduction(H_(2)-TPR) were utilized to investigate the physicochemical properties of the catalysts.The results show that doping Fe,Co,Ni or Mn can obviously promote the activity of CeO_(2)-TiO_(2) mixed oxides for DCE degradation,which is related to their improved texture properties,acid sites(especially for strong acidity) and low-temperature reducibility.Particularly,CeTi-Fe doped with moderate Fe exhibits excellent activity for 1,2-dichloroethane(DCE) degradation,giving a T_(90%) value as low as 250℃.More importantly,only trace chlorinated byproducts were produced during the low-temperature degradation of various CVOCs(dichloromethane(DCM),trichloroethylene(TCE) and chlorobenzene(CB)) over CeTi-Fe1/9 catalyst with high durability.Yijun Shi Xiaolin Guo Zhinan Shi Renxian Zhou 2022Journal of Rare Earths2022,40,5:1
12One-step detection of melamine in milk by hollow gold chip based on surface-enhanced Raman scattering显示文摘Zhinan Guo Ziyi Cheng Ran Li Lei Chen Haiming Lv Bing Zhao Jaebum Choo 2014Talanta2014,,:1
13High-performance polarization-sensitive photodetectors on two-dimensionalβ-InSe显示文摘Two-dimensional(2D)indium selenide(InSe)has been widely studied for application in transistors and photodetectors,which benefit from its excellent optoelectronic properties.Among the three specific polytypes(γ-,ε-andβ-phase)of InSe,only the crystal lattice of InSe inβ-phase(β-InSe)belongs to a non-symmetry point group of D_(6 h)_^(4),which indicates stronger anisotropic transport behavior and potential in the polarized photodetection ofβ-InSe-based optoelectronic devices.Therefore,we prepare the stable p-type 2D-layeredβ-InSe via temperature gradient method.The anisotropic Raman,transport and photoresponse properties ofβ-InSe have been experimentally and theoretically proven,showing that theβ-InSe-based device has a ratio of 3.76 for the maximum to minimum dark current at two orthogonal orientations and a high photocurrent anisotropic ratio of 0.70 at 1 V bias voltage,respectively.The appealing anisotropic properties demonstrated in this work clearly identifyβ-InSe as a competitive candidate for filter-free polarization-sensitive photodetectors.Zhinan Guo Rui Cao Huide Wang Xi Zhang Fanxu Meng Xue Chen Siyan Gao David KSang Thi Huong Nguyen Anh Tuan Duong Jinlai Zhao Yu-Jia Zeng Sunglae Cho Bing Zhao Ping-Heng Tan Han Zhang Dianyuan Fan 2022National Science Review2022,9,5:1
14In-situ neutron-transmutation for substitutional doping in 2D layered indium selenide based phototransistor显示文摘Neutron-transmutation doping(NTD)has been demonstrated for the first time in this work for substitutional introduction of tin(Sn)shallow donors into two-dimensional(2D)layered indium selenide(InSe)to manipulate electron transfer and charge carrier dynamics.Multidisciplinary study including density functional theory,transient optical absorption,and FET devices have been carried out to reveal that the field effect electron mobility of the fabricated phototransistor is increased 100-fold due to the smaller electron effective mass and longer electron life time in the Sn-doped InSe.The responsivity of the Sn-doped InSe based phototransistor is accordingly enhanced by about 50 times,being as high as 397 A/W.The results show that NTD is a highly effective and controllable doping method,possessing good compatibility with the semiconductor manufacturing process,even after device fabrication,and can be carried out without introducing any contamination,which is radically different from traditional doping methods.Zhinan Guo Yonghong Zeng Fanxu Meng Hengze Qu Shengli Zhang Shipeng Hu Sidi Fan Haibo Zeng Rui Cao Paras N.Prasad Dianyuan Fan Han Zhang 2022eLight2022,2,1:1
15Interlayer sensitized van der Waals heterojunction photodetector with enhanced performance显示文摘Although photodetection based on two-dimensional(2D)van der Waals(vdWs)P-N heterojunction has attracted extensive attention recently,their low responsivity(R)due to the lack of carrier gain mechanism in reverse bias or zero bias operation hinders their applications in advanced photodetection area.Here,a black phosphorus/rhodamine 6G/molybdenum disulfide(BP/R6G/MoS_(2))photodiode with high responsivity at reverse bias or zero bias has been achieved by using interfacial charge transfer of R6G molecules assembled between heterojunction layers.The formed vdWs interface achieves high performance photoresponse by efficiently separating the additional photogenerated electrons and holes generated by R6G molecules.The devices sensitized by the dye molecule R6G exhibit enhanced photodetection performance without sacrificing the photoresponse speed.Among them,the R increased by 14.8-20.4 times,and the specific detectivity(D^(*))increased by 24.9-34.4 times.The strategy based on interlayer assembly of dye molecules proposed here may pave a new way for realizing high-performance photodetection based on 2D vdWs heterojunctions with high responsivity and fast response speed.Huide Wang Yonghong Zeng FanXu Meng Rui Cao Yi Liu Zhinan Guo Tingting Wang Haiguo Hu Sidi Fan Yatao Yang SWageh Omar AAl-Hartomy Abul Kalam Yonghong Shao Yu-Jia Zeng Dianyuan Fan Han Zhang 2023Nano Research2023,16,7:0
16Water‑Dispersible CsPbBr_(3) Perovskite Nanocrystals with Ultra‑Stability and its Application in Electrochemical CO_(2) Reduction显示文摘Thanks to the excellent optoelectronic properties,lead halide perovskites(LHPs)have been widely employed in highperformance optoelectronic devices such as solar cells and lightemitting diodes.However,overcoming their poor stability against water has been one of the biggest challenges for most applications.Herein,we report a novel hot-injection method in a Pb-poor environment combined with a well-designed purification process to synthesize water-dispersible CsPbBr_(3) nanocrystals(NCs).The as-prepared NCs sustain their superior photoluminescence(91%quantum yield in water)for more than 200 days in an aqueous environment,which is attributed to a passivation effect induced by excess CsBr salts.Thanks to the ultra-stability of these LHP NCs,for the first time,we report a new application of LHP NCs,in which they are applied to electrocatalysis of CO_(2) reduction reaction.Noticeably,they show significant electrocatalytic activity(faradaic yield:32%for CH4,40%for CO)and operation stability(>350 h).Keqiang Chen Kun Qi Tong Zhou Tingqiang Yang Yupeng Zhang Zhinan Guo Chang‑Keun Lim Jiayong Zhang Igor Zutic Han Zhang Paras N.Prasad 2021Nano-Micro Letters2021,13,11:0
17Natural history and cycle threshold values analysis of COVID-19 in Xiamen City,China显示文摘Objective:This study elaborated the natural history parameters of Delta variant,explored the differences in detection cycle thresholds(Ct)among cases.Methods:Natural history parameters were calculated based on the different onset time and exposure time of the cases.Intergenerational relationships between generations of cases were calculated.Differences in Ct values of cases by gender,age,and mode of detection were analyzed statistically to assess the detoxification capacity of cases.Results:The median incubation period was 4 days;the detection time for cases decreased from 25 to 7 h as the outbreak continued.The average generation time(GT),time interval between transmission generations(TG)and serial interval(SI)were 3.6±2.6 days,1.67±2.11 days and 1.7±3.0 days.Among the Ct values,we found little differences in testing across companies,but there were some differences in the gender of detected genes.The Ct values continuous to decreased with age,but increased when the age was greater than 60.Conclusion:This epidemic was started from aggregation of factories.It is more reasonable to use SI to calculate the effective reproduction number and the time-varying reproduction number.And the analysis of Ct values can improve the positive detection rate and improve prevention and control measures.Bin Deng Weikang Liu Zhinan Guo Li Luo Tianlong Yang Jiefeng Huang Buasiyamu Abudunaibi Yidun Zhang Xue Ouyang Demeng Wang Chenghao Su Tianmu Chen 2022Infectious Disease Modelling2022,7,3:0
18Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury显示文摘Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue lymphoma translocation 1(MALT1) has been shown to regulate the survival and differentiation of immune cells and to play a critical role in many diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we generated KI(knock in) mice with a point mutation(C472 G) in the active center of MALT1 and found that the KI mice exhibited improved functional recovery after SCI.Fewer macrophages were recruited to the injury site in KI mice and these macrophages differentiated into anti-inflammatory macrophages. Moreover, macrophages from KI mice exhibited reduced phosphorylation of p65, which in turn resulted in decreased SOCS3 expression and increased pSTAT6 levels.Similar results were obtained upon inhibition of MALT1 paracaspase with the small molecule inhibitor‘‘MI-2' or the more specific inhibitor ‘‘MLT-827'. In patients with SCI, peripheral blood mononuclear cells(PBMC) displayed increased MALT1 paracaspase. Human macrophages showed reduced proinflammatory and increased anti-inflammatory characteristics following the inhibition of MALT1 paracaspase. These findings suggest that inhibition of MALT1 paracaspase activity in the clinic may improve lesion recovery in subjects with SCI.Hua Zhang Guodong Sun Xiaowei Li Zhen Fu Chengbin Guo Guangchao Cao Baocheng Wang Qian Wang Shuxian Yang Dehai Li Xichun Xia Peng Li Jing Zhu Wei Zhou Liangyan Zheng Jingxia Li Lei Zhang Jianlei Hao Libing Zhou Frederic Bornancin Zhizhong Li Zhinan Yin Yunfei Gao 2019Science Bulletin2019,64,16:0
19Deep-ultraviolet photonics for the disinfection of SARS-CoV-2 and its variants(Delta and Omicron)in the cryogenic environment显示文摘Deep-ultraviolet(DUV)disinfection technology provides an expeditious and efficient way to suppress the transmission of coronavirus disease 2019(COVID-19).However,the influences of viral variants(Delta and Omicron)and low temperatures on the DUV virucidal efficacy are still unknown.Here,we developed a reliable and uniform planar light source comprised of 275-nm light-emitting diodes(LEDs)to investigate the effects of these two unknown factors and delineated the principle behind different disinfection performances.We found the lethal effect of DUV at the same radiation dose was reduced by the cryogenic environment,and a negative-U large-relaxation model was used to explain the difference in view of the photoelectronic nature.The chances were higher in the cryogenic environment for the capture of excited electrons within active genetic molecules back to the initial photo-ionised positions.Additionally,the variant of Omicron required a significantly higher DUV dose to achieve the same virucidal efficacy,and this was thanks to the genetic and proteinic characteristics of the Omicron.The findings in this study are important for human society using DUV disinfection in cold conditions(e.g.,the food cold chain logistics and the open air in winter),and the relevant DUV disinfection suggestion against COVID-19 is provided.Wenyu Kang Jing Zheng Jiaxin Huang Lina Jiang Qingna Wang Zhinan Guo Jun Yin Xianming Deng Ye Wang Junyong Kang 2023Opto-Electronic Advances2023,6,9:0
20Fully depleted vdW heterojunction based high performance photovoltaic photodetector显示文摘Van der Waals(vdW)heterojunctions,with their unique electronic and optoelectronic properties,have become promising candidates for photodetector applications.Amplifying the contribution of the depletion region in vdW heterojunction,which would enhance both of the collection efficiency and speed of the photogenerated carriers,presents an effective strategy for achieving high performance vdW heterojunction photodetectors.Herein,a fully depleted vdW heterojunction photodetector is built on two-dimensional(2D)semiconductor materials(GaTe and InSe)layered on a pattered bottom electrode in vertical structure,in which the generation and motion of carriers are exclusively achieved in the depletion region.Attributed to the intrinsic built-in electric field,the elimination of series resistance and the depletion region confinement of carriers,the as-fabricated photodetector exhibits prominent photovoltaic properties with a high open-circuit voltage of 0.465 V,as well as photoresponse characteristics with outstanding responsivity,detectivity and photoresponse speed of 63.7 A/W,3.88×10^(13)Jones,and 32.7 ms respectively.The overall performance of this fully depleted GaTe/InSe vdW heterojunctions photodetectors are ranking high among the top level of 2D materials based photodetectors.It indicates the device architecture can provide new opportunities for the fabrication of high-performance photodetectors.Yonghong Zeng Fanxu Meng Sidi Fan Pengfei Wang Cuiyun Kou Mingyi Sun Haiguo Hu Rui Cao Swelm Wageh Omar A.Al-Hartomy Abul Kalam Bowen Du Wenchao Ding Songrui Wei Zhinan Guo Qiuliang Wang Han Zhang 2023Journal of Materiomics2023,9,6:0
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