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| 1 | Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer显示文摘The prognosis of patients with metastatic colorectal cancer(m CRC) remain poor despite the impressive improvement of treatments observed over the last 20 years that led to an increase in median overall survival from 6 mo, with the only best supportive care, to approximately 30 mo with the introduction of active chemotherapy drugs and targeted agents. The monoclonal antibodies(mo Abs) cetuximab and panitumumab, directed against the epidermal growth factor receptor(EGFR), undoubtedly represent a major step forward in the treatment of m CRC, given the relevant efficacy in terms of progression-free survival, overall survival, response rate, and quality of life observed in several phase Ⅲ clinical trials among different lines of treatment. However, the anti-EGFR mo Abs were shown only to be effective in a subset of patients. For instance, KRAS and NRAS mutations have been identified as biomarkers of resistance to these drugs, improving the selection of patients who might derive a benefit from these treatments. Nevertheless, several other alterations might affect the response to these drugs, and unfortunately, even the responders eventually become resistant by developing secondary(or acquired) resistance in approximately 13-18 mo. Several studies highlighted that the landscape of responsible alterations of both primary and acquired resistance to anti-EGFR drugs biochemically converge into MEK-ERK and PIK3CA-AKT pathways. In this review, we describe the currently known mechanisms of primary and acquired resistance to anti-EGFR mo Abs together with the various strategies evaluated to prevent, overcame or revert them. | Vincenzo Sforza Erika Martinelli Fortunato Ciardiello Valentina Gambardella Stefania Napolitano Giulia Martini Carminia della Corte Claudia Cardone Marianna L Ferrara Alfonso Reginelli Giuseppina Liguori Giulio Belli Teresa Troiani | 2016 | World Journal of Gastroenterology2016，22，28： | 6 |
| 2 | Cardiovascular risk after orthotopic liver transplantation, a review of the literature and preliminary results of a prospective study显示文摘Improved surgical techniques and greater efficacy of new anti-rejection drugs have significantly improved the survival of patients undergoing orthotopic liver transplantation(OLT). This has led to an increased incidence of metabolic disorders as well as cardiovascular and cerebrovascular diseases as causes of morbidity and mortality in OLT patients. In the last decade, several studies have examined which predisposing factors lead to increased cardiovascular risk(i.e., age, ethnicity, diabetes, NASH, atrial fibrillation, and some echocardiographic parameters) as well as which factors after OLT(i.e., weight gain, metabolic syndrome, immunosuppressive therapy, and renal failure) are linked to increased cardiovascular mortality. However, currently, there are no available data that evaluate the development of atherosclerotic damage after OLT. The awareness of high cardiovascular risk after OLT has not only lead to the definition of new but generally not accepted screening of high risk patients before transplantation, but also to the need for careful patient follow up and treatment to control metabolic and cardiovascular pathologies after transplant. Prospective studies are needed to better define the predisposing factors for recurrence and de novo occurrence of metabolic alterations responsible for cardiovascular damage after OLT. Moreover, such studies will help to identify the timing of disease progression and damage,which in turn may help to prevent morbidity and mortality for cardiovascular diseases. Our preliminary results show early occurrence of atherosclerotic damage, which is already present a few weeks following OLT, suggesting that specific, patient-tailored therapies should be started immediately post OLT. | Giuseppina Pisano Anna L Fracanzani Lucio Caccamo Maria F Donato Silvia Fargion | 2016 | World Journal of Gastroenterology2016，22，40： | 4 |
| 3 | Physiological roles of ovotransferrin显示文摘 | Francesco G Leboffe L Giuseppina P | 2012 | Biochimica et Biophysica Acta(BBA)-General Subjects2012，1820，3： | 1 |
| 4 | Enhancement of the efficacy of cancer chemotherapy by the pineal hormone melatonin and its rela- tion with the psychospiritual status of cancer patients 显示文摘 | Giuseppina M Paolo L Paolo M | 2010 | J Res Med Sci2010，15，4： | 1 |
| 5 | Energy, timing and position resolution studies with 16-pixel silicon photomuhiplier ma- trices for small animal PET 显示文摘 | Gabfiela L Nicola B Giuseppina B | 2009 | IEEE Trans Vuclsci2009，56，5： | 1 |
| 6 | Anthracycline- induced cardiomyopathy显示文摘 | Daniela C Alessandro C Giuseppina L | 2010 | JACC2010，55，3： | 1 |
| 7 | At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule一1 induction by advanced glycation end products显示文摘 | Giuseppina B Guido L Serena DT | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 8 | Riboflavin-overproducing strains of Lactobacillus fermentum for riboflavin-enriched bread显示文摘 | Pasquale Russo Vittorio Capozzi Mattia Pia Arena Giuseppina Spadaccino María Teresa Due?as Paloma López Daniela Fiocco Giuseppe Spano | 2014 | Applied Microbiology and Biotechnology2014，，8： | 1 |
| 9 | An improved five-parameter model for photovohaic modules显示文摘 | VALERIO L B ALDO O GIUSEPPINA C | 2010 | Solar Energy Materials & Solar Cells2010，94，： | 1 |
| 10 | The effect of ginkgo biloba in isolated ischemic/reperfused rat heart显示文摘 | Claudia K Giuseppina B Guide L | 2004 | J Cardiovasc Pharmacol2004，44，3： | 1 |
| 11 | Hepatitis E virus in Italy: molecular analysis of travel related and autochthonous cases显示文摘 | Giuseppina L R Michele M Valentina S V | 2011 | J Gen Virol2011，92，7： | 1 |
| 12 | Detection of human papillomavirus DNA in cervical samples:analysis of the new PGMY-PCR compared to the hybrid capture Ⅱ and MY-PCR assays and a two-step nested PCR assay显示文摘 | Lucia G Anna L Giuseppina C | 2004 | J Clin Microbiol2004，42，： | 1 |
| 13 | Opioid peptide response to spinal cord stimulation in chronic critical limb ischemia显示文摘 | Fiorella F Pasquale B Giuseppina L | | 0，，04： | 1 |
| 14 | At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products显示文摘 | Giuseppina B Guido L Serena D T | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 15 | IL-10 and TNF-α polymorphisms and the recovery from HCV infection显示文摘 | Domenico Lio Calogero Caruso Rosa Di Stefano Giuseppina Colonna Romano Donatella Ferraro Letizia Scola Antonio Crivello Anna Licata L.Mario Valenza Giuseppina Candore Antonio Craxì Piero L Almasio | 2003 | Human Immunology2003，，7： | 1 |
| 16 | Plasma lipoproteins and incidence of non-insulin-dependent diabetes mellitus in Pima Indians: protective effect of HDL cholesterol in women显示文摘 | Anne Fagot-Campagna K.M.Venkat Narayan Robert L Hanson Giuseppina Imperatore Barbara V Howard Robert G Nelson David J Pettitt William C Knowler | 1997 | Atherosclerosis1997，，1： | 1 |
| 17 | An application of cluster analysis and multivariate classification methods to spring water monitoring data显示文摘 | GAETANO R MICHELE D L GIUSEPPINA I | 2007 | Microchemical Journal2007，87，： | 1 |
| 18 | Components of the 'Metabolic Syndrome' and Incidence of Type 2 Diabetes显示文摘 | Robert L Hanson Giuseppina Imperatore | 2002 | DIABETES2002，51，10： | 1 |
| 19 | Nutritional composition,phenolic compounds,nitrate content in eatable vegetables obtained by conventional and certified organic grown culture subject to thermal treatment显示文摘 | Giuseppina P P L Tassia V C L Maria R M R | 2009 | International Journal of Food Science and Technology2009，44，： | 1 |
| 20 | A novel method for coupling doxorubicin to lactosaminatod human albumin by an acid sensitive hydrazone bond: synthesis, characterization and preliminary biological properties of the conjugate显示文摘 | GIUSEPPINA D S MARCELLA L FELIX K | 2004 | Eur J Pharma Sci2004，23，： | 1 |
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