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| 1 | 成人IDH野生型星形细胞瘤从生物学和临床上归为其他肿瘤类型显示文摘WHO III级的IDH野生型间变性星形细胞瘤预后差。为了对星形细胞瘤进行分子亚组分型或诊断上的重新分类,作者分析160例成人IDH野生型星形细胞肿瘤的分子标志性变异,并行甲基化和拷贝数分析,其中包括120例 WHO III级的间变性星形细胞瘤和40例WHO II级的弥漫型星形细胞瘤。基于分子谱系和标志性变异特征,将这些肿瘤分为四个主要亚型。78%肿瘤诊断为传统胶质母细胞瘤分子亚型。9%为GBM-H3F3A突变(GBM-H3)亚型。8%具有独特的甲基化特征,与GBM-H3-K27相似,但缺乏H3F3A突变,这组肿瘤主要发生在幕下及中线部位,并且预后较好。120例IDH野生型的间变性星形细胞瘤除1例外均可归入上述3种亚型中。40例WHO II级的弥漫型星形细胞瘤中7例具有不同的分子特征,其中6例重新归类为其他不同的低级别肿瘤类型。有趣的是,TERT突变只发生在分子亚型的GBM (78%),且预后不良。 GBM-H3组缺乏 TERT突变,然而其预后更差。 | David E R Annekathrin K Felix S 李晓玲 王行富 | 2015 | 临床与实验病理学杂志2015，31，9： | 4 |
| 2 | Heterogeneous populations of neural stem cells contribute to myelin repair显示文摘As ingenious as nature's invention of myelin sheaths within the mammalian nervous system is, as fatal can be damage to this specialized lipid structure. Long-term loss of electrical insulation and of further supportive functions myelin provides to axons, as seen in demyelinating diseases such as multiple sclerosis(MS), leads to neurodegeneration and results in progressive disabilities. Multiple lines of evidence have demonstrated the increasing inability of oligodendrocyte precursor cells(OPCs) to replace lost oligodendrocytes(OLs) in order to restore lost myelin. Much research has been dedicated to reveal potential reasons for this regeneration deficit but despite promising approaches no remyelination-promoting drugs have successfully been developed yet. In addition to OPCs neural stem cells of the adult central nervous system also hold a high potential to generate myelinating OLs. There are at least two neural stem cell niches in the brain, the subventricular zone lining the lateral ventricles and the subgranular zone of the dentate gyrus, and an additional source of neural stem cells has been located in the central canal of the spinal cord. While a substantial body of literature has described their neurogenic capacity, still little is known about the oligodendrogenic potential of these cells, even if some animal studies have provided proof of their contribution to remyelination. In this review, we summarize and discuss these studies, taking into account the different niches, the heterogeneity within and between stem cell niches and present current strategies of how to promote stem cell-mediated myelin repair. | Rainer Akkermann Felix Beyer Patrick Küry | 2017 | Neural Regeneration Research2017，12，4： | 3 |
| 3 | Bevacizumab (Avastin) eye drops inhibit corneal neovascularization显示文摘 | Felix Bock Yanyan K?nig Friedrich Kruse Martin Baier Claus Cursiefen | 2008 | Graefe’s Archive for Clinical and Experimental Ophthalmology2008，，2： | 2 |
| 4 | Radical prostatectomy in patients aged 75 years or older:review of the literature显示文摘Given the demographic trends toward a considerably longer life expectancy,the percentage of elderly patients with prostate cancer will increase further in the upcoming decades.Therefore,the question arises,should patients ≥75 years old be offered radical prostatectomy and under which circumstances? For treatment decision-making,life expectancy is more important than biological age.As a result,a patient's health and mental status has to be determined and radical treatment should only be offered to those who are fit.As perioperative morbidity and mortality in these patients is increased relative to younger patients,patient selection according to comorbidities is a key issue that needs to be addressed.It is known from the literature that elderly men show notably worse tumor characteristics,leading to worse oncologic outcomes after treatment.Moreover,elderly patients also demonstrate worse postoperative recovery of continence and erectile function.As the absolute rates of both oncological and functional outcomes are still very reasonable in patients ≥75 years,a radical prostatectomy can be offered to highly selected and healthy elderly patients. Nevertheless,patients clearly need to be informed about the worse outcomes and higher perioperative risks compared to younger patients. | Philipp Mandel Thenappan Chandrasekar Felix K Chun Hartwig Huland Derya Tilki | 2019 | Asian Journal of Andrology2019，21，1： | 2 |
| 5 | Enforceable security policies revisited 显示文摘 | David B Vincent J Felix K | 2013 | ACM Transactions on Information and System Se- curity2013，16，1： | 1 |
| 6 | Global Supplier Selection: A Fuzzy-AHP Approach显示文摘 | Felix T S C Kumar N Tiwari M K | 2008 | International Journal ofProductionResearch2008，46，14： | 1 |
| 7 | E - selectin polymorphism and atherosclerosis : an association study显示文摘 | Wenzel K Felix S Kleber FX | 1994 | Hum Mol Genet1994，3，： | 1 |
| 8 | Determination of the grouting parameters for polymeric materials显示文摘 | Felix K | 1999 | Journal of Polymer Engineering1999，19，1： | 1 |
| 9 | Effectiveness of the Swiss Agri-Environment Scheme in Promoting Biodiversity显示文摘 | EVA K DAVID K FELIX H | 2006 | Journal of Applied Ecology2006，43，1： | 1 |
| 10 | Global suppli- er selection : A fuzzy - AHP approach 显示文摘 | FELIX T S CHAN KUMAR N TIWARI M K | 2008 | International Journal of Production Research2008，46，14： | 1 |
| 11 | E-selectin polymorphism andatherosclerosis :an association study显示文摘 | Wenzel K Felix S Kleber FX | 1994 | Hum Mol Genet1994，3，： | 1 |
| 12 | Altered cytokine expression in tissues of mice subjected to simulated microgravity显示文摘 | Felix K Wise K Manna S | 2004 | Mol Cell Biochem2004，266，12： | 1 |
| 13 | Immunolocalizaion of triadin,DHP receptors,and ryanodine receptors in adult and developing skeletal muscle of rats显示文摘 | Carl SL Felix K Caswell AH | 1995 | Muscle verve1995，18，： | 1 |
| 14 | Design of a PCB plant with expert system and simulation approaeh 显示文摘 | Felix T S C Chan H K | 2008 | Expert Systems with Applieations2008，28，3： | 1 |
| 15 | Histidine–tryptophan–ketoglutarate solution for organ preservation in human liver transplantation—a prospective multi-centre observation study显示文摘 | Herwig Pokorny Susanne Rasoul-Rockenschaub Felix Langer Thomas Windhager Andreas Rosenstingl Reinhard Lange Alfred K?nigsrainer Burckhardt Ringe Ferdinand Mühlbacher Rudolf Steininger | 2004 | Transplant International2004，，5： | 1 |
| 16 | Diabetes in sub-Saharan Africa显示文摘 | Jean Claude N Mbanya Ayesha A Motala Eugene Sobngwi Felix K Assah Sostanie T Enoru | 2010 | 2010 (9733)2010，，9733： | 1 |
| 17 | SWAT model application in a data scarce tropical complex catchment in Tanzania显示文摘 | PREKSEDIS N FELIX M AANUND K | 2008 | Physics and Chemistry of the Earth2008，33，813： | 1 |
| 18 | Mutations of p53 Tumor Suppressor Gene, Apoptosis, and Proliferation in Intrahepatic Cholangiocellular Carcinoma of the Liver显示文摘 | Andrea Tannapfel Lars Weinans Felix Gei?ler Alexander Sch?tz Alexander Katalinic Ferdinand K?ckerling Johann Hauss Christian Wittekind | 2000 | Digestive Diseases and Sciences2000，，2： | 1 |
| 19 | Identification of potential markers for the detection of pancreatic cancer through comparative serum protein expression profiling 显示文摘 | Ehmann M Felix K Hartmann D | 2007 | Pancreas2007，34，2： | 1 |
| 20 | Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles 显示文摘 | FELIX K | 2008 | J Control Release2008，132，： | 1 |
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